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1. 发明专利

IL191196A Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mtor inhibitors, pharmaceutical compositions containing them and use thereof as medicaments and in the manufacture of medicaments for the production of an anti-cancer effect in a warm-blooded animal 未知
公开(公告)号：IL191196A
公开(公告)日：2016-02-29
申请号：IL19119608
申请日：2008-05-01
申请人： KUDOS PHARM LTD , GRAEME CAMERON MURRAY SMITH , SYLVIE GOMEZ , XIAO-LING FAN COCKROFT , KEITH ALLAN MENEAR , MARC GEOFFREY HUMMERSONE , KARINE MALAGU , HEATHER MARY ELLEN DUGGAN , GESINE JOHANNA HERMANN
发明人： GRAEME CAMERON MURRAY SMITH , SYLVIE GOMEZ , XIAO-LING FAN COCKROFT , KEITH ALLAN MENEAR , MARC GEOFFREY HUMMERSONE , KARINE MALAGU , HEATHER MARY ELLEN DUGGAN , GESINE JOHANNA HERMANN
摘要： There is provided a compound of formula I: wherein: one or two of X 5 , X 6 and X 8 is N, and the others are CH; R 7 is selected from halo, OR O1 , SR S1 , NR N1 R N2 , NR N7a C(-O)R C1 , NR N7b SO 2 R S2a , an optionally substituted C 5-20 heteroaryl group, or an optionally substituted C 5-20 aryl group, where R O1 and R S1 are selected from H, an optionally substituted C 5-20 aryl group, an optionally substituted C 5-20 heteroaryl group, or an optionally substituted C 1-7 alkyl group; R N1 and R N2 are independently selected from H, an optionally substituted C 1-7 alkyl group, an optionally substituted C 5-20 heteroaryl group, an optionally substituted C 5-20 aryl group or R N1 and R N2 together with the nitrogen to which they are bound form a heterocyclic ring containing between 3 and 8 ring atoms; R C1 is selected from H, an optionally substituted C 5-20 aryl group, an optionally substituted C 5-20 heteroaryl group, an optionally substituted C 1-7 alkyl group or NR N8 R N9 , where R N8 and R N9 are independently selected from H, an optionally substituted C 1-7 alkyl group, an optionally substituted C 5-20 heteroaryl group, an optionally substituted C 5-20 aryl group or R N8 and R N9 together with the nitrogen to which they are bound form a heterocyclic ring containing between 3 and 8 ring atoms; R S2a is selected from H, an optionally substituted C 5-20 aryl group, an optionally substituted C 5-20 heteroaryl group, or an optionally substituted C 1-7 alkyl group; R N7a and R N7b are selected from H and a C 1-4 alkyl group; R N3 and R N4 , together with the nitrogen to which they are bound, form a heterocyclic ring containing between 3 and 8 ring atoms; R 2 is selected from H, halo, OR O2 , SR S2b , NR N5 R N6 , an optionally substituted C 5-20 heteroaryl group, and an optionally substituted C 5-20 aryl group, wherein R O2 and R S2b are selected from H, an optionally substituted C 5-20 aryl group, an optionally substituted C 5-20 heteroaryl group, or an optionally substituted C 1-7 alkyl group; R N5 and R N6 are independently selected from H, an optionally substituted C 1-7 alkyl group, an optionally substituted C 5-20 heteroaryl group, and an optionally substituted C 5-20 aryl group, or R N5 and R N6 together with the nitrogen to which they are bound form a heterocyclic ring containing between 3 and 8 ring atoms, or a pharmaceutically acceptable salt thereof, with the proviso that when R 2 is unsubstituted morpholino. R N3 and R N4 together with the nitrogen atom to which they are attached form an unsubstituted morpholino and R 7 is unsubstituted phenyl, and X 5 is CH, then X 6 is not N and X 8 is not CH, or X 6 is not CH and X 8 is not N, and when R 2 is unsubstituted piperidinyl, R N3 and R N4 together with the nitrogen atom to which they are attached form an unsubstituted piperidinyl and R 7 is unsubstituted phenyl, and X 5 is CH, then X 6 is not CH and X is not N. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.

2. 发明授权

US07642254B2 ATM inhibitors 失效
标题翻译： ATM抑制剂
公开(公告)号：US07642254B2
公开(公告)日：2010-01-05
申请号：US11351052
申请日：2006-02-09
申请人： Marc Geoffrey Hummersone , Keith Allan Menear , Laurent Jean Martin Rigoreau , Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Roger John Griffin
发明人： Marc Geoffrey Hummersone , Keith Allan Menear , Laurent Jean Martin Rigoreau , Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Roger John Griffin
IPC分类号： A61K31/535 , A61K31/38 , A61K31/35 , C07D413/14 , C07D409/14 , C07D407/14
CPC分类号： C07D409/04 , C07D409/14
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 together form, along with the nitrogen atom to which they are attached, an optionally substituted nitrogen containing heterocyclic ring having from 4 to 8 ring atoms; and R3 is selected from hydroxy and —NRN1RN2, where RN1 and RN2 are independently selected from hydrogen, optionally substituted C1-7 alkyl groups, optionally substituted C3-20 heterocyclyl groups and optionally substituted C5-20 aryl groups, or together form, along with the nitrogen atom to which they are attached, an optionally substituted nitrogen containing heterocyclic ring having from 4 to 8 ring atoms, and its use in inhibiting ATM.
摘要翻译：式I化合物及其异构体，盐，溶剂合物，化学保护形式及其前药，其中：R 1和R 2一起与它们所连接的氮原子一起形成任选取代的含氮杂环，其具有4个至8个环原子; 并且R 3选自羟基和-NRN 1 R N 2，其中RN 1和RN 2独立地选自氢，任选取代的C 1-7烷基，任选取代的C 3-20杂环基和任选取代的C 5-20芳基，或一起形成，与它们相连的氮原子，具有4至8个环原子的任选取代的含氮杂环，以及其在抑制ATM中的用途。

3. 发明申请

US20120129855A1 PHTHALAZINONE DERIVATIVES 审中-公开
标题翻译：邻苯二酚衍生物
公开(公告)号：US20120129855A1
公开(公告)日：2012-05-24
申请号：US13361911
申请日：2012-01-30
申请人： Keith Allan Menear , Muhammad Hashim Javaid , Sylvie Gomez , Marc Geoffrey Hummersone , Carlos Fernandez Lence , Niall Morrison Barr Martin , David Alan Rudge , Craig Anthony Roberts , Kevin Blades
发明人： Keith Allan Menear , Muhammad Hashim Javaid , Sylvie Gomez , Marc Geoffrey Hummersone , Carlos Fernandez Lence , Niall Morrison Barr Martin , David Alan Rudge , Craig Anthony Roberts , Kevin Blades
IPC分类号： A61K31/502 , A61K31/5377 , A61P35/00
CPC分类号： C07D401/10 , C07D401/14 , C07D405/14 , C07D487/04 , C07D491/10
摘要： A compound of the formula (I): wherein: A and B together represent an optionally substituted, fused aromatic ring; X and Y are selected from CH and CH, CF and CH, CH and CF and N and CH respectively; RC is selected from H, C1-4 alkyl; and R1 is selected from C1-7 alkyl, C3-20 heterocyclyl and C5-20 aryl, which groups are optionally substituted; or RC and R1 together with the carbon and oxygen atoms to which they are attached form a spiro-C5-7 oxygen-containing heterocyclic group, which is optionally substituted or fused to a C5-7 aromatic ring.
摘要翻译：式（I）的化合物：其中：A和B一起表示任选取代的稠合芳环; X和Y分别选自CH和CH，CF和CH，CH和CF以及N和CH; RC选自H，C 1-4烷基; 并且R 1选自C 1-7烷基，C 3-20杂环基和C 5-20芳基，该基团任选被取代; 或RC和R 1与它们所连接的碳原子和氧原子一起形成含有C 5-7的含氧杂环基团，其任选被取代或稠合至C5-7芳环。

4. 发明申请

US20090069303A1 PHTHALAZINONE DERIVATIVES 失效
标题翻译：邻苯二酚衍生物
公开(公告)号：US20090069303A1
公开(公告)日：2009-03-12
申请号：US12271308
申请日：2008-11-14
申请人： Muhammad Hashim Javaid , Keith Allan Menear , Sylvie Gomez , Marc Geoffrey Hummersone , Niall Morrison Barr Martin , Graeme Cameron Murray Smith , Xiao-Ling Fan Cockcroft , Frank Kerrigan
发明人： Muhammad Hashim Javaid , Keith Allan Menear , Sylvie Gomez , Marc Geoffrey Hummersone , Niall Morrison Barr Martin , Graeme Cameron Murray Smith , Xiao-Ling Fan Cockcroft , Frank Kerrigan
IPC分类号： A61K31/551 , C07D237/30 , A61K31/502 , C07D253/06 , A61K31/53 , A61P9/00 , A61P29/00 , A61P3/10 , A61P25/00 , A61P35/00 , C07D413/14 , A61K31/5377 , C07D243/08
CPC分类号： C07D403/10 , C07D403/14 , C07D411/14 , C07D413/14 , C07D487/04
摘要： A compound of the formula (I): wherein: A and B together represent an optionally substituted, fused aromatic ring; D is selected from: (i) where Y1 is selected from CH and N, Y2 is selected from CH and N, Y3 is selected from CH, CF and N; and (ii) where Q is O or S; RD is: wherein RN1 is selected from H and optionally substituted C1-10 alkyl; X is selected from a single bond, NRN2, CRC3RC4 and C═O; RN2 is selected from H and optionally substituted C1-10 alkyl; RC3 and RC4 are independently selected from H, R, C(═O)OR, where R is optionally substituted C1-10 alkyl, optionally substituted C5-20 aryl or optionally substituted C3-20 heterocyclyl; Y is selected from NRN3 and CRC1RC2. RC1 and RC2 are independently selected from H, R, C(═O)OR, where R is optionally substituted C1-10 alkyl, optionally substituted C5-20 aryl or optionally substituted C3-20 heterocyclyl; RC1 and RC2 together with the carbon atom to which they are attached may form an optionally substituted spiro-fused C5-7 carbocylic or heterocyclic ring; and when X is a single bond RN1 and RC2 may together with the N and C atoms to which they are bound, form an optionally substituted C5-7 heterocylic ring; and when X is CRC3RC4, RC2 and RC4 may together form an additional bond, such that there is a double bond between the atoms substituted by RC1 and RC3.
摘要翻译：式（I）的化合物：其中：A和B一起表示任选取代的稠合芳环; D选自：（i）其中Y1选自CH和N，Y2选自CH和N，Y3选自CH，CF和N; 和（ii）其中Q为O或S; RD是：其中RN1选自H和任选取代的C 1-10烷基; X选自单键NRN2，CRC3RC4和C-O; RN2选自H和任选取代的C 1-10烷基; RC3和RC4独立地选自H，R，C（-O）OR，其中R是任选取代的C 1-10烷基，任选取代的C 5-20芳基或任选取代的C 3-20杂环基; Y选自NRN3和CRC1RC2。 RC1和RC2独立地选自H，R，C（-O）OR，其中R是任选取代的C 1-10烷基，任选取代的C 5-20芳基或任选取代的C 3-20杂环基; RC1和RC2与它们所连接的碳原子一起可以形成任选取代的螺 - 稠合的C 5-7碳环或杂环; 当X是单键时，RN1和RC2可以与它们所结合的N和C原子一起形成任选被取代的C5-7杂环; 并且当X是CRC3RC4时，RC2和RC4可以一起形成附加键，使得在被RC1和RC3取代的原子之间存在双键。

5. 发明申请

US20080255128A1 PHTHALAZINONE DERIVATIVES 审中-公开
标题翻译：邻苯二酚衍生物
公开(公告)号：US20080255128A1
公开(公告)日：2008-10-16
申请号：US12100614
申请日：2008-04-10
申请人： Muhammad Hashim Javaid , Marc Geoffrey Hummersone , Keith Allan Menear , Sylvie Gomez , Niall Morrison Barr Martin
发明人： Muhammad Hashim Javaid , Marc Geoffrey Hummersone , Keith Allan Menear , Sylvie Gomez , Niall Morrison Barr Martin
IPC分类号： A61K31/502 , C07D237/30 , A61P35/04 , A61P3/00 , A61P9/00 , A61P19/00 , A61P25/00
CPC分类号： C07D403/10 , C07D403/14 , C07D407/14 , C07D413/14 , C07D417/14
摘要： A compound of the formula (I): wherein: A and B together represent an optionally substituted, fused aromatic ring; X is selected from H and F; R1 and R2 are independently selected from H and methyl; RN1 is selected from H and optionally substituted C1-7 alkyl; RN2 is selected from H, optionally substituted C1-7 alkyl, C3-7 heterocyclyl and C5-6 aryl; or RN1 and RN2 and the nitrogen atom to which they are bound form an optionally substituted nitrogen containing C5-7 heterocyclic group.
摘要翻译：式（I）的化合物：其中：A和B一起表示任选取代的稠合芳环; X选自H和F; R 1和R 2独立地选自H和甲基; R 11选自H和任选取代的C 1-7烷基; R N2选自H，任选取代的C 1-7 - 烷基，C 3-7 - 杂环基和C 5-6杂环基， / SUB>芳基; 或R 1 N 2和R 2 N 2和它们所连接的氮原子形成任选取代的含有C 5〜5-7杂环基的氮。

6. 发明授权

US07402607B2 DNA-PK inhibitors 失效
标题翻译： DNA-PK抑制剂
公开(公告)号：US07402607B2
公开(公告)日：2008-07-22
申请号：US11231041
申请日：2005-09-20
申请人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
发明人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
IPC分类号： A61K31/381 , C07D333/76
CPC分类号： C07D413/14 , C07D409/04 , C07D409/14
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(═O)— or —O—; Y is an optionally substituted C1-5 alkylene group; X is selected from SR3 or NR4R5, wherein, R3, or R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(═O)—NR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R6 and R7 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and if Q is —NH—C(═O)—, —Y—X may additionally be selected from C1-7 alkyl.
摘要翻译：式I化合物及其异构体，盐，溶剂合物，化学保护形式及其前药，其中：R 1和R 2独立地选自氢，任选地取代的C 1-7烷基，C 3-20杂环基或C 5-20-20芳基，或者可以一起形成与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; Q是-NH-C（-O） - 或-O-; Y是任选取代的C 1-5亚烷基; X选自SR 3或NR 4 R 5，其中R 3，R 3，R 3， 4和R 5独立地选自氢，任选取代的C 1-7 - 烷基，C 5-20-20芳基，或 C 3-20杂环基或R 4和R 5可以一起与它们所连接的氮原子一起形成一个具有4至8个环原子的任选取代的杂环; 如果Q是-O-，X另外选自-C（-O）-NR 6 R 7，其中R 6和R 独立地选自氢，任选取代的C 1-7 - 烷基，C 5-20-20芳基或C 3-20 或者R 6和R 7可以与它们所连接的氮原子一起形成任选取代的杂环，其具有4个至8个环原子; 并且如果Q是-NH-C（-O） - ，-Y-X可另外选自C 1-7烷基。

7. 发明申请

US20110130386A1 DNA-PK INHIBITORS 审中-公开
标题翻译： DNA-PK抑制剂
公开(公告)号：US20110130386A1
公开(公告)日：2011-06-02
申请号：US12989510
申请日：2009-04-24
申请人： Mark Frigerio , Heather Mary Ellen Duggan , Marc Geoffrey Hummersone , Keith Allan Menear , Niall Morrison Barr Martin , Celine Cano , Roger John Griffin , Bernard Thomas Golding , Ian Robert Hardcastle
发明人： Mark Frigerio , Heather Mary Ellen Duggan , Marc Geoffrey Hummersone , Keith Allan Menear , Niall Morrison Barr Martin , Celine Cano , Roger John Griffin , Bernard Thomas Golding , Ian Robert Hardcastle
IPC分类号： A61K31/551 , C07D413/14 , C07D243/06 , C12N5/071 , A61K31/5355 , A61K31/55 , A61P35/00
CPC分类号： C07D413/14 , C07D417/14
摘要： A compound of formula (I) wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and RN1 and RN2 are selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms.
摘要翻译：式（I）的化合物，其中：R 1和R 2独立地选自氢，任选取代的C 1-7烷基，C 3-20杂环基或C 5-20芳基，或者可以与氮原子一起形成与它们相连的任选取代的具有4至8个环原子的杂环; 并且RN1和RN2选自氢，任选取代的C 1-7烷基，C 3-20杂环基或C 5-20芳基，或者可以与它们所连接的氮原子一起形成任选取代的具有4至8个环原子的杂环。

8. 发明申请

US20100130473A1 COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：US20100130473A1
公开(公告)日：2010-05-27
申请号：US11817134
申请日：2006-02-24
申请人： Marc Geoffrey Hummersone , Sylvie Gomez , Keith Allan Menear , Xiao-Ling Fan Cockcroft , Graeme Cameron Murray Smith
发明人： Marc Geoffrey Hummersone , Sylvie Gomez , Keith Allan Menear , Xiao-Ling Fan Cockcroft , Graeme Cameron Murray Smith
IPC分类号： A61K31/5377 , C07D413/04 , C07D413/14 , C07D471/04 , A61P35/00 , A61K31/53 , A61K31/551 , A61K31/553 , A61K31/519
CPC分类号： C07D251/70 , C07D239/48 , C07D239/50 , C07D239/94 , C07D295/135 , C07D403/04 , C07D403/12 , C07D405/04 , C07D413/12 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I): A-B—C and isomers, salts, solvates, chemically protected forms, and prodrugs thereof wherein: B is selected from the group consisting of formula (i) where RN is H or Me; or B is a divalent C5 heterocyclic residue containing one or two ring heteroatoms; A is formula (ii) RA3 and RA5 are independently selected from halo, ORO and RAC, where RO is H or Me, and RAC is H or C1-4 alkyl; XA is selected from N and CRA4, where RA4 is selected from H, ORO, CH2OH, CO2H, NHSO2Me and NHCOMe; RA2 and RA6 are independently selected from H, halo and ORO; or RA3 and RA4 together with the carbon atoms to which they are attached, or RA2 and RA3 together with the carbon atoms to which they are attached, may form a C5-6 heterocylic or heteroaromatic ring, containing at least one nitrogen ring atom; where if X is not N, 1, 2, or 3 of RA2 to RA6 are not H; C is formula (iii) where X is selected from N and CH, Y is selected from N and CH, and Z is selected from N and CRC6; RC3 is selected from H, halo and an optionally substituted N-containing C5-7 heterocyclic group; RC5 is a group selected from formula (iv) which group may be selected by one or two C1-4 alkyl groups or a carboxy group; RC6 is H; or, when X and Y are N, RC5 and RC6 (when Z is CRC6) together with the carbon atoms to which they are attached may form a fused C6 aromatic ring selected from the group consisting of formula (v).
摘要翻译：式（I）化合物：A-B-C及其异构体，盐，溶剂合物，化学保护形式及其前药。其中：B选自式（ⅰ），其中RN为H或Me; 或B是含有一个或两个环杂原子的二价C5杂环残基; A是式（ⅱ）RA 3和RA 5独立地选自卤素，ORO和RAC，其中RO是H或Me，RAC是H或C 1-4烷基; XA选自N和CRA4，其中RA4选自H，ORO，CH2OH，CO2H，NHSO2Me和NHCOMe; RA2和RA6独立地选自H，卤素和ORO; 或RA3和RA4与它们所连接的碳原子一起，或RA2和RA3与它们所连接的碳原子一起可以形成含有至少一个氮环原子的C 5-6杂环或杂芳环; 其中如果X不是RA，RA6的N，1,2或3不是H; C是式（ⅲ），其中X选自N和CH，Y选自N和CH，Z选自N和CRC 6; RC3选自H，卤素和任选取代的含N的C 5-7杂环基; RC5是选自式（iv）的基团，该基团可以被一个或两个C 1-4烷基或羧基选择; RC6为H; 或者当X和Y为N时，RC5和RC6（当Z为CRC6时）与它们所连接的碳原子一起形成选自式（v）的稠合C 6芳环。

9. 发明授权

US07504397B2 mTOR inhibitor compounds 失效
标题翻译： mTOR抑制剂化合物
公开(公告)号：US07504397B2
公开(公告)日：2009-03-17
申请号：US11361599
申请日：2006-02-24
申请人： Marc Geoffrey Hummersone , Sylvie Gomez , Keith Allan Menear , Xiao-Ling Fan Cockcroft , Graeme Cameron Murray Smith
发明人： Marc Geoffrey Hummersone , Sylvie Gomez , Keith Allan Menear , Xiao-Ling Fan Cockcroft , Graeme Cameron Murray Smith
IPC分类号： A01N43/58 , A61K31/50 , C07D239/00 , C07D239/02
CPC分类号： C07D251/54 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D417/04 , C07D471/04
摘要： Compounds of formula I: A-B-C (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof are provided, wherein variables A, B and C are defined herein and wherein such compounds act as mTor inhibitors.
摘要翻译：式I化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> ABC（I）<？in-line-formula description =“In-line Formulas”end =“tail 提供了异构体，盐，溶剂化物，化学保护形式和前体药物，其中变量A，B和C在本文中定义，并且其中这些化合物作为mTor抑制剂。

10. 发明申请

US20090042865A1 DNA-PK INHIBITORS 审中-公开
标题翻译： DNA-PK抑制剂
公开(公告)号：US20090042865A1
公开(公告)日：2009-02-12
申请号：US12175542
申请日：2008-07-18
申请人： Mark Frigerio , Marc Geoffrey Hummersone , Keith Allan Menear , Christine Sarah Bailey , Heather Mary Ellen Duggan , Sylvie Gomez , Niall Morrison Barr Martin
发明人： Mark Frigerio , Marc Geoffrey Hummersone , Keith Allan Menear , Christine Sarah Bailey , Heather Mary Ellen Duggan , Sylvie Gomez , Niall Morrison Barr Martin
IPC分类号： A61K31/5377 , C07D413/14 , A61K31/551 , A61P35/00 , C07D243/08
CPC分类号： C07D409/04 , C07D409/14
摘要： A compound of formula I: wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; X is CH or N; n is 1 or 2; RC1 and RC2 are independently selected from H and methyl; when X is N, RX is selected from the group consisting of H, and optionally substituted C1-7 alkyl, C3-20 heterocyclyl, C5-20 aryl, acyl, ester, amido and sulfonyl; and when X is CH, RX is selected from the group consisting of H, and optionally substituted C1-7 alkyl, C3-20 heterocyclyl, C5-20 aryl, acyl, ester, amido, sulfonyl, amino and ether.
摘要翻译：式I的化合物：其中：R 1和R 2独立地选自氢，任选取代的C 1-7烷基，C 3-20杂环基或C 5-20芳基，或者可以一起与氮原子一起形成它们所连接的是具有4至8个环原子的任选取代的杂环; X是CH或N; n为1或2; RC1和RC2独立地选自H和甲基; 当X是N时，RX选自H和任选取代的C 1-7烷基，C 3-20杂环基，C 5-20芳基，酰基，酯，酰氨基和磺酰基; 当X是CH时，RX选自H和任选取代的C 1-7烷基，C 3-20杂环基，C 5-20芳基，酰基，酯，酰氨基，磺酰基，氨基和醚。

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