专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090043091A1 ATM INHIBITORS 审中-公开
标题翻译： ATM抑制剂
公开(公告)号：US20090043091A1
公开(公告)日：2009-02-12
申请号：US12233736
申请日：2008-09-19
申请人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Xiao-Ling Fan Cockcroft , Ian Timothy Williams Matthews , Keith Allan Menear , Laurent Jean Martin Rigoreau , Marc Geoffrey Hummersone , Roger John Griffin
发明人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Xiao-Ling Fan Cockcroft , Ian Timothy Williams Matthews , Keith Allan Menear , Laurent Jean Martin Rigoreau , Marc Geoffrey Hummersone , Roger John Griffin
IPC分类号： C07D243/08 , C07D413/14 , C07D223/02 , C07D279/18
CPC分类号： C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D491/04 , C07D495/04
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and RN1 is selected from hydrogen, an optionally substituted C1-7 alkyl group, an optionally substituted C3-20 heterocyclyl group, an optionally substituted C5-20 aryl group, an acyl group, an ester group and an amido group, and its use as a pharmaceutical.
摘要翻译：式I化合物及其异构体，盐，溶剂合物，化学保护形式及其前药，其中：R 1和R 2一起与它们所连接的氮原子一起形成任选取代的具有4至8个的杂环环原子并且RN1选自氢，任选取代的C 1-7烷基，任选取代的C 3-20杂环基，任选取代的C 5-20芳基，酰基，酯基和酰胺基，其用作制药。

2. 发明授权

US07429660B2 ATM inhibitors 失效
标题翻译： ATM抑制剂
公开(公告)号：US07429660B2
公开(公告)日：2008-09-30
申请号：US10918180
申请日：2004-08-13
申请人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Xiao-Ling Fan Cockcroft , Ian Timothy Williams Matthews , Keith Allan Menear , Laurent Jean Martin Rigoreau , Marc Geoffrey Hummersone , Roger John Griffin
发明人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Xiao-Ling Fan Cockcroft , Ian Timothy Williams Matthews , Keith Allan Menear , Laurent Jean Martin Rigoreau , Marc Geoffrey Hummersone , Roger John Griffin
IPC分类号： A61K413/00
CPC分类号： C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D491/04 , C07D495/04
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and RN1 is selected from hydrogen, an optionally substituted C1-7 alkyl group, an optionally substituted C3-20 heterocyclyl group, an optionally substituted C5-20 aryl group, an acyl group, an ester group and an amido group, and its use as a pharmaceutical.
摘要翻译：式I化合物及其异构体，盐，溶剂化物，化学保护形式及其前药，其中：R 1和R 2一起与氮原子一起形成与它们相连的任选取代的具有4至8个环原子的杂环; 并且R“N1”选自氢，任选取代的C 1-7烷基，任选取代的C 3-20杂环基，任选取代的C 5-20芳基，酰基，酯基和酰胺基，以及其作为药物的用途。

3. 发明授权

US07049313B2 ATM inhibitors 失效
标题翻译： ATM抑制剂
公开(公告)号：US07049313B2
公开(公告)日：2006-05-23
申请号：US10373114
申请日：2003-02-24
申请人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Stephen Philip Jackson , Mark James O'Connor , Alan Yin Kai Lau , Xiao-Ling Fan Cockcroft , Ian Timothy Williams Matthews , Keith Allan Menear , Laurent Jean Martin Rigoreau , Marc Geoffery Hummersone , Roger John Griffin
发明人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Stephen Philip Jackson , Mark James O'Connor , Alan Yin Kai Lau , Xiao-Ling Fan Cockcroft , Ian Timothy Williams Matthews , Keith Allan Menear , Laurent Jean Martin Rigoreau , Marc Geoffery Hummersone , Roger John Griffin
IPC分类号： A61K31/535 , C07D413/00 , A61P35/00
CPC分类号： C07D409/04 , C07D417/04
摘要： The application concerns a compound of formula I: wherein one of P and Q is O, and the other of P and Q is CH, where there is a double bond between whichever of Q and P is CH and the carbon atom bearing the R3 group; Y is either O or S; R1 and R2 are independently hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; R3 is a phenyl or pyridyl group, attached by a first bridge group selected from —S—, —S(═O)—, —S(═O)2—, —O—, —NRN— and CRC1RC2— to an optionally substituted C5-20 carboaryl group, the phenyl or pyridyl group and optionally substituted C5-20 carboaryl group being optionally further linked by a second bridge group, so as to form an optionally substituted C5-7 ring, the phenyl or pyridyl group being further optionally substituted.
摘要翻译：本申请涉及式I化合物：其中P和Q中的一个为O，P和Q中的另一个为CH，其中Q和P中的任一个为CH且具有R 1的碳原子之间为双键， SUP> 3 组; Y是O或S; R 1和R 2独立地是氢，任选取代的C 1-7烷基，C 3-20 或杂环基，或C 5-20-20芳基，或者可以一起形成任选取代的具有4至8个环原子的杂环; R 3是通过选自-S - ， - S（-O） - ， - S（-O）2 N的第一桥基团连接的苯基或吡啶基） - ， - O - ， - NR N - 和CR C1 - C2 - 与任选取代的C 5-20 - 苯基或吡啶基和任选取代的C 5-20碳芳基任选地通过第二桥基进一步连接，从而形成任选取代的C 5-7 苯基或吡啶基进一步任选被取代。

4. 发明授权

US07642254B2 ATM inhibitors 失效
标题翻译： ATM抑制剂
公开(公告)号：US07642254B2
公开(公告)日：2010-01-05
申请号：US11351052
申请日：2006-02-09
申请人： Marc Geoffrey Hummersone , Keith Allan Menear , Laurent Jean Martin Rigoreau , Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Roger John Griffin
发明人： Marc Geoffrey Hummersone , Keith Allan Menear , Laurent Jean Martin Rigoreau , Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Roger John Griffin
IPC分类号： A61K31/535 , A61K31/38 , A61K31/35 , C07D413/14 , C07D409/14 , C07D407/14
CPC分类号： C07D409/04 , C07D409/14
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 together form, along with the nitrogen atom to which they are attached, an optionally substituted nitrogen containing heterocyclic ring having from 4 to 8 ring atoms; and R3 is selected from hydroxy and —NRN1RN2, where RN1 and RN2 are independently selected from hydrogen, optionally substituted C1-7 alkyl groups, optionally substituted C3-20 heterocyclyl groups and optionally substituted C5-20 aryl groups, or together form, along with the nitrogen atom to which they are attached, an optionally substituted nitrogen containing heterocyclic ring having from 4 to 8 ring atoms, and its use in inhibiting ATM.
摘要翻译：式I化合物及其异构体，盐，溶剂合物，化学保护形式及其前药，其中：R 1和R 2一起与它们所连接的氮原子一起形成任选取代的含氮杂环，其具有4个至8个环原子; 并且R 3选自羟基和-NRN 1 R N 2，其中RN 1和RN 2独立地选自氢，任选取代的C 1-7烷基，任选取代的C 3-20杂环基和任选取代的C 5-20芳基，或一起形成，与它们相连的氮原子，具有4至8个环原子的任选取代的含氮杂环，以及其在抑制ATM中的用途。

5. 发明授权

US07402607B2 DNA-PK inhibitors 失效
标题翻译： DNA-PK抑制剂
公开(公告)号：US07402607B2
公开(公告)日：2008-07-22
申请号：US11231041
申请日：2005-09-20
申请人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
发明人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
IPC分类号： A61K31/381 , C07D333/76
CPC分类号： C07D413/14 , C07D409/04 , C07D409/14
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(═O)— or —O—; Y is an optionally substituted C1-5 alkylene group; X is selected from SR3 or NR4R5, wherein, R3, or R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(═O)—NR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R6 and R7 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and if Q is —NH—C(═O)—, —Y—X may additionally be selected from C1-7 alkyl.
摘要翻译：式I化合物及其异构体，盐，溶剂合物，化学保护形式及其前药，其中：R 1和R 2独立地选自氢，任选地取代的C 1-7烷基，C 3-20杂环基或C 5-20-20芳基，或者可以一起形成与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; Q是-NH-C（-O） - 或-O-; Y是任选取代的C 1-5亚烷基; X选自SR 3或NR 4 R 5，其中R 3，R 3，R 3， 4和R 5独立地选自氢，任选取代的C 1-7 - 烷基，C 5-20-20芳基，或 C 3-20杂环基或R 4和R 5可以一起与它们所连接的氮原子一起形成一个具有4至8个环原子的任选取代的杂环; 如果Q是-O-，X另外选自-C（-O）-NR 6 R 7，其中R 6和R 独立地选自氢，任选取代的C 1-7 - 烷基，C 5-20-20芳基或C 3-20 或者R 6和R 7可以与它们所连接的氮原子一起形成任选取代的杂环，其具有4个至8个环原子; 并且如果Q是-NH-C（-O） - ，-Y-X可另外选自C 1-7烷基。

6. 发明授权

US07732483B2 DNA-PK inhibitors 失效
标题翻译： DNA-PK抑制剂
公开(公告)号：US07732483B2
公开(公告)日：2010-06-08
申请号：US12133837
申请日：2008-06-05
申请人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
发明人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
IPC分类号： A61K31/381 , C07D333/74 , C07D409/04
CPC分类号： C07D413/14 , C07D409/04 , C07D409/14
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(═O)— or —O—; Y is an optionally substituted C1-5 alkylene group; X is selected from SR3 or NR4R5, wherein, R3, or R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(═O)—NR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R6 and R7 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and if Q is —NH—C(═O)—, —Y—X may additionally be selected from C1-7 alkyl.
摘要翻译：式I化合物及其异构体，盐，溶剂合物，化学保护形式及其前药，其中：R 1和R 2独立地选自氢，任选取代的C 1-7烷基，C 3-20杂环基或C 5- 20芳基，或者可以与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; Q是-NH-C（= O） - 或-O-; Y是任选取代的C 1-5亚烷基; X选自SR 3或NR 4 R 5，其中，R 3或R 4和R 5独立地选自氢，任选取代的C 1-7烷基，C 5-20芳基或C 3-20杂环基，或者R 4和R 5可以一起形成与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; 如果Q是-O-，X另外选自-C（= O）-NR 6 R 7，其中R 6和R 7独立地选自氢，任选取代的C 1-7烷基，C 5-20芳基或C 3-20杂环基，或R6和R7可以与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; 并且如果Q是-NH-C（= O） - ，-Y-X可另外选自C 1-7烷基。

7. 发明申请

US20080242664A1 DNA-PK INHIBITORS 失效
标题翻译： DNA-PK抑制剂
公开(公告)号：US20080242664A1
公开(公告)日：2008-10-02
申请号：US12133837
申请日：2008-06-05
申请人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
发明人： Graeme Cameron Murray Smith , Niall Morrison Barr Martin , Keith Allan Menear , Marc Geoffrey Hummersone , Laurent Jean Martin Rigoreau , Roger John Griffin , Bernard Thomas Golding , David Richard Newell , Hilary Alan Calvert , Nicola Jane Curtin , Ian Robert Hardcastle , Kappusamy Saravanan
IPC分类号： A61K31/5377 , C07D409/10 , A61K31/381 , C07D409/14 , A61P35/04 , A61K31/496 , C07D413/14
CPC分类号： C07D413/14 , C07D409/04 , C07D409/14
摘要： A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(═O)— or —O—; Y is an optionally substituted C1-5 alkylene group; X is selected from SR3 or NR4R5, wherein, R3, or R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(═O)—NR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R6 and R7 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and if Q is —NH—C(═O)—, —Y—X may additionally be selected from C1-7 alkyl.
摘要翻译：式I化合物及其异构体，盐，溶剂合物，化学保护形式及其前药，其中：R 1和R 2独立地选自氢，任选地取代的C 1-7烷基，C 3-20杂环基或C 5-20-20芳基，或者可以一起形成与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; Q是-NH-C（-O） - 或-O-; Y是任选取代的C 1-5亚烷基; X选自SR 3或NR 4 R 5，其中R 3，R 3，R 3， 4和R 5独立地选自氢，任选取代的C 1-7 - 烷基，C 5-20-20芳基，或 C 3-20杂环基或R 4和R 5可以一起与它们所连接的氮原子一起形成一个具有4至8个环原子的任选取代的杂环; 如果Q是-O-，X另外选自-C（-O）-NR 6 R 7，其中R 6和R 独立地选自氢，任选取代的C 1-7 - 烷基，C 5-20-20芳基或C 3-20 或者R 6和R 7可以与它们所连接的氮原子一起形成任选取代的杂环，其具有4个至8个环原子; 并且如果Q是-NH-C（-O） - ，-Y-X可另外选自C 1-7烷基。

8. 发明授权

US07470688B2 Phthalazinone derivatives 失效
标题翻译：酞嗪衍生物
公开(公告)号：US07470688B2
公开(公告)日：2008-12-30
申请号：US11550004
申请日：2006-10-17
申请人： Muhammad Hashim Javaid , Keith Allan Menear , Sylvie Gomez , Marc Geoffrey Hummersone , Niall Morrison Barr Martin , Graeme Cameron Murray Smith , Xiao-Ling Fan Cockcroft , Frank Kerrigan
发明人： Muhammad Hashim Javaid , Keith Allan Menear , Sylvie Gomez , Marc Geoffrey Hummersone , Niall Morrison Barr Martin , Graeme Cameron Murray Smith , Xiao-Ling Fan Cockcroft , Frank Kerrigan
IPC分类号： A61K31/502 , A61K31/5355 , A61K31/53 , C07D487/00 , C07D413/10 , C07D253/04 , C07D253/06 , C07D251/10 , A61P9/10
CPC分类号： C07D403/10 , C07D403/14 , C07D411/14 , C07D413/14 , C07D487/04
摘要： A compound of the formula (I): wherein: A and B together represent an optionally substituted, fused aromatic ring; D is selected from: (i) where Y1 is selected from CH and N, Y2 is selected from CH and N, Y3 is selected from CH, CF and N; and (ii) where Q is O or S; RD is: wherein RN1 is selected from H and optionally substituted C1-10 alkyl; X is selected from a single bond, NRN2, CRC3RC4 and C═O; RN2 is selected from H and optionally substituted C1-10 alkyl; RC3 and RC4 are independently selected from H, R, C(═O)OR, where R is optionally substituted C1-10 alkyl, optionally substituted C5-20 aryl or optionally substituted C3-20 heterocyclyl; Y is selected from NRN3 and CRC1RC2; RC1 and RC2 are independently selected from H, R, C(═O)OR, where R is optionally substituted C1-10 alkyl, optionally substituted C5-20 aryl or optionally substituted C3-20 heterocyclyl; RC1 and RC2 together with the carbon atom to which they are attached may form an optionally substituted spiro-fused C5-7 carbocylic or heterocyclic ring; and when X is a single bond RN1 and RC2 may together with the N and C atoms to which they are bound, form an optionally substituted C5-7 heterocyclic ring; and when X is CRC3RC4, RC2 and RC4 may together form an additional bond, such that there is a double bond between the atoms substituted by RC1 and RC3.
摘要翻译：式（I）的化合物：其中：A和B一起表示任选取代的稠合芳环; D选自：（i）其中Y1选自CH和N，Y2选自CH和N，Y3选自CH，CF和N; 和（ii）其中Q为O或S; RD是：其中RN1选自H和任选取代的C 1-10烷基; X选自单键NRN2，CRC3RC4和C-O; RN2选自H和任选取代的C 1-10烷基; RC3和RC4独立地选自H，R，C（-O）OR，其中R是任选取代的C 1-10烷基，任选取代的C 5-20芳基或任选取代的C 3-20杂环基; Y选自NRN3和CRC1RC2; RC1和RC2独立地选自H，R，C（-O）OR，其中R是任选取代的C 1-10烷基，任选取代的C 5-20芳基或任选取代的C 3-20杂环基; RC1和RC2与它们所连接的碳原子一起可以形成任选取代的螺 - 稠合的C 5-7碳环或杂环; 当X是单键时，RN1和RC2可以与它们所结合的N和C原子一起形成任选取代的C 5-7杂环; 并且当X是CRC3RC4时，RC2和RC4可以一起形成附加键，使得在被RC1和RC3取代的原子之间存在双键。

9. 发明申请

US20090069303A1 PHTHALAZINONE DERIVATIVES 失效
标题翻译：邻苯二酚衍生物
公开(公告)号：US20090069303A1
公开(公告)日：2009-03-12
申请号：US12271308
申请日：2008-11-14
申请人： Muhammad Hashim Javaid , Keith Allan Menear , Sylvie Gomez , Marc Geoffrey Hummersone , Niall Morrison Barr Martin , Graeme Cameron Murray Smith , Xiao-Ling Fan Cockcroft , Frank Kerrigan
发明人： Muhammad Hashim Javaid , Keith Allan Menear , Sylvie Gomez , Marc Geoffrey Hummersone , Niall Morrison Barr Martin , Graeme Cameron Murray Smith , Xiao-Ling Fan Cockcroft , Frank Kerrigan
IPC分类号： A61K31/551 , C07D237/30 , A61K31/502 , C07D253/06 , A61K31/53 , A61P9/00 , A61P29/00 , A61P3/10 , A61P25/00 , A61P35/00 , C07D413/14 , A61K31/5377 , C07D243/08
CPC分类号： C07D403/10 , C07D403/14 , C07D411/14 , C07D413/14 , C07D487/04
摘要： A compound of the formula (I): wherein: A and B together represent an optionally substituted, fused aromatic ring; D is selected from: (i) where Y1 is selected from CH and N, Y2 is selected from CH and N, Y3 is selected from CH, CF and N; and (ii) where Q is O or S; RD is: wherein RN1 is selected from H and optionally substituted C1-10 alkyl; X is selected from a single bond, NRN2, CRC3RC4 and C═O; RN2 is selected from H and optionally substituted C1-10 alkyl; RC3 and RC4 are independently selected from H, R, C(═O)OR, where R is optionally substituted C1-10 alkyl, optionally substituted C5-20 aryl or optionally substituted C3-20 heterocyclyl; Y is selected from NRN3 and CRC1RC2. RC1 and RC2 are independently selected from H, R, C(═O)OR, where R is optionally substituted C1-10 alkyl, optionally substituted C5-20 aryl or optionally substituted C3-20 heterocyclyl; RC1 and RC2 together with the carbon atom to which they are attached may form an optionally substituted spiro-fused C5-7 carbocylic or heterocyclic ring; and when X is a single bond RN1 and RC2 may together with the N and C atoms to which they are bound, form an optionally substituted C5-7 heterocylic ring; and when X is CRC3RC4, RC2 and RC4 may together form an additional bond, such that there is a double bond between the atoms substituted by RC1 and RC3.
摘要翻译：式（I）的化合物：其中：A和B一起表示任选取代的稠合芳环; D选自：（i）其中Y1选自CH和N，Y2选自CH和N，Y3选自CH，CF和N; 和（ii）其中Q为O或S; RD是：其中RN1选自H和任选取代的C 1-10烷基; X选自单键NRN2，CRC3RC4和C-O; RN2选自H和任选取代的C 1-10烷基; RC3和RC4独立地选自H，R，C（-O）OR，其中R是任选取代的C 1-10烷基，任选取代的C 5-20芳基或任选取代的C 3-20杂环基; Y选自NRN3和CRC1RC2。 RC1和RC2独立地选自H，R，C（-O）OR，其中R是任选取代的C 1-10烷基，任选取代的C 5-20芳基或任选取代的C 3-20杂环基; RC1和RC2与它们所连接的碳原子一起可以形成任选取代的螺 - 稠合的C 5-7碳环或杂环; 当X是单键时，RN1和RC2可以与它们所结合的N和C原子一起形成任选被取代的C5-7杂环; 并且当X是CRC3RC4时，RC2和RC4可以一起形成附加键，使得在被RC1和RC3取代的原子之间存在双键。

10. 发明授权

US07902193B2 Phthalazinone derivatives 失效
标题翻译：酞嗪衍生物
公开(公告)号：US07902193B2
公开(公告)日：2011-03-08
申请号：US12271308
申请日：2008-11-14
申请人： Muhammad Hashim Javaid , Keith Allan Menear , Sylvie Gomez , Marc Geoffrey Hummersone , Niall Morrison Barr Martin , Graeme Cameron Murray Smith , Xiao-Ling Fan Cockcroft , Frank Kerrigan
发明人： Muhammad Hashim Javaid , Keith Allan Menear , Sylvie Gomez , Marc Geoffrey Hummersone , Niall Morrison Barr Martin , Graeme Cameron Murray Smith , Xiao-Ling Fan Cockcroft , Frank Kerrigan
IPC分类号： C07D237/32 , A61K31/502 , A61P35/00
CPC分类号： C07D403/10 , C07D403/14 , C07D411/14 , C07D413/14 , C07D487/04
摘要： A compound of the formula (I): wherein: A and B together represent an optionally substituted, fused aromatic ring; D is selected from: (i) where Y1 is selected from CH and N, Y2 is selected from CH and N, Y3 is selected from CH, CF and N; and (ii) where Q is O or S; RD is: wherein RN1 is selected from H and optionally substituted C1-10 alkyl; X is selected from a single bond, NRN2, CRC3RC4 and C═O; RN2 is selected from H and optionally substituted C1-10 alkyl; RC3 and RC4 are independently selected from H, R, C(═O)OR, where R is optionally substituted C1-10 alkyl, optionally substituted C5-20 aryl or optionally substituted C3-20 heterocyclyl; Y is selected from NRN3 and CRC1RC2. RC1 and RC2 are independently selected from H, R, C(═O)OR, where R is optionally substituted C1-10 alkyl, optionally substituted C5-20 aryl or optionally substituted C3-20 heterocyclyl; RC1 and RC2 together with the carbon atom to which they are attached may form an optionally substituted spiro-fused C5-7 carbocylic or heterocyclic ring; and when X is a single bond RN1 and RC2 may together with the N and C atoms to which they are bound, form an optionally substituted C5-7 heterocylic ring; and when X is CRC3RC4, RC2 and RC4 may together form an additional bond, such that there is a double bond between the atoms substituted by RC1 and RC3.
摘要翻译：式（I）的化合物：其中：A和B一起表示任选取代的稠合芳环; D选自：（i）其中Y1选自CH和N，Y2选自CH和N，Y3选自CH，CF和N; 和（ii）其中Q为O或S; RD是：其中RN1选自H和任选取代的C 1-10烷基; X选自单键NRN2，CRC3RC4和C = O; RN2选自H和任选取代的C 1-10烷基; RC3和RC4独立地选自H，R，C（= O）OR，其中R是任选取代的C 1-10烷基，任选取代的C 5-20芳基或任选取代的C 3-20杂环基; Y选自NRN3和CRC1RC2。 RC1和RC2独立地选自H，R，C（= O）OR，其中R是任选取代的C 1-10烷基，任选取代的C 5-20芳基或任选取代的C 3-20杂环基; RC1和RC2与它们所连接的碳原子一起可以形成任选取代的螺 - 稠合的C 5-7碳环或杂环; 当X是单键时，RN1和RC2可以与它们所结合的N和C原子一起形成任选被取代的C5-7杂环; 并且当X是CRC3RC4时，RC2和RC4可以一起形成附加键，使得在被RC1和RC3取代的原子之间存在双键。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式