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1. 发明授权

US5577497A Dry powder inhaler 失效
公开(公告)号：US5577497A
公开(公告)日：1996-11-26
申请号：US137282
申请日：1993-10-14
申请人： Mark B. Mecikalski , David R. Williams , David O. Thueson
发明人： Mark B. Mecikalski , David R. Williams , David O. Thueson
IPC分类号： A61M13/00 , A61K9/00 , A61M15/00
CPC分类号： A61K9/0075 , A61M15/0006 , A61M15/0016 , A61M15/0028 , A61M15/0033 , A61M15/0045 , A61M15/0048 , A61M16/0066
摘要： A dry powder medicine inhaler has an impeller non-concentrically disposed in a mixing chamber. A motor spins the impeller at high speed. A plunger introduces a dose of powdered medicine into the chamber so that all powder particles are available for intermixing disaggregation and comminution. An aperture receives a first stream of air and passes it towards the mouthpiece for inhalation by the user. A wall has at least one aperture for diverting a portion of a main air stream into the aerosolizing chamber to mix with the particles to form a fine, low-density, low velocity, dry mist of powdered medicine for inhalation by the user.

2. 发明授权

US6055980A Dry powder inhaler 失效
标题翻译：干粉吸入器
公开(公告)号：US6055980A
公开(公告)日：2000-05-02
申请号：US120549
申请日：1998-07-22
申请人： Mark B. Mecikalski , David R. Williams , David O. Thueson
发明人： Mark B. Mecikalski , David R. Williams , David O. Thueson
IPC分类号： A61K9/00 , A61M15/00
CPC分类号： A61K9/0075 , A61M15/0045 , A61M15/0048 , A61M2202/064
摘要： A dry powder medicine inhaler has an impeller non-concentrically disposed in a mixing chamber. A motor spins the impeller at high speed. A plunger introduces a dose of powdered medicine into the chamber so that all powder particles are available for intermixing disaggregation and comminution. An aperture receives a first stream of air and passes it towards the mouthpiece for inhalation by the user. A wall has at least one aperture for diverting a portion of a main air stream into the aerosolizing chamber to mix with the particles to form a fine, low-density, low velocity, dry mist of powdered medicine for inhalation by the user.
摘要翻译：干粉吸入器具有非同心配置在混合室中的叶轮。电机高速旋转叶轮。柱塞将一定剂量的粉末药物引入腔室，使得所有粉末颗粒可用于混合分解和粉碎。一个孔接收第一个空气流，并将其传递给接口，以供使用者吸入。壁具有至少一个用于将一部分主空气流转移到雾化室中的孔，以与颗粒混合以形成用于用户吸入的粉末状药物的细小，低密度，低速干雾。

3. 发明授权

US5492112A Dry powder inhaler 失效
公开(公告)号：US5492112A
公开(公告)日：1996-02-20
申请号：US227559
申请日：1994-04-14
申请人： Mark B. Mecikalski , David R. Williams , David O. Thueson
发明人： Mark B. Mecikalski , David R. Williams , David O. Thueson
IPC分类号： A61M11/00 , A61K9/00 , A61M15/00 , A61M16/00
CPC分类号： A61M15/0045 , A61K9/0075 , A61M11/001 , A61M15/0006 , A61M15/0008 , A61M15/0015 , A61M15/0016 , A61M15/002 , A61M15/0021 , A61M15/0033 , A61M15/0043 , A61M15/0048 , A61M2016/0021 , A61M2202/064 , A61M2205/3365 , A61M2205/8206 , A61M2206/16
摘要： A dry powder medicine inhaler has an impeller non-concentrically disposed in a mixing chamber. A motor spins the impeller at high speed. A plunger introduces a dose of powdered medicine into the chamber so that all powder particles are available for intermixing disaggregation and comminution. An aperture receives a first stream of air and passes it towards the mouthpiece for inhalation by the user. A wall has at least one aperture for diverting a portion of a main air stream into the aerosolizing chamber to mix with the particles to form a fine, low-density, low velocity, dry mist of powdered medicine for inhalation by the user.

4. 发明授权

US5327883A Apparatus for aerosolizing powdered medicine and process and using 失效
标题翻译：用于雾化药物和加工和使用的装置
公开(公告)号：US5327883A
公开(公告)日：1994-07-12
申请号：US702297
申请日：1991-05-20
申请人： David R. Williams , Mark B. Mecikalski , David O. Thueson
发明人： David R. Williams , Mark B. Mecikalski , David O. Thueson
IPC分类号： A61K9/00 , A61M15/00
CPC分类号： A61K9/0075 , A61M15/0006 , A61M15/0016 , A61M15/0028 , A61M15/0033 , A61M15/0048 , A61M2202/064
摘要： An apparatus for aerosolizing a dose of powdered medicine for inhalation, comprising in combination a solid core defining a diskshaped aerosolizing chamber, the chamber defined by spaced-apart, flat front and rear walls terminated by a circumferential wall, the core including a first end piece having formed therein a hollow mouth/nose piece at the front thereof, an impeller non-concentrically disposed in the chamber mounted on a shaft for high-speed powered rotation about a fixed axis, a plunger for instantaneously introducing a full dose of powdered medicine into the aerosolizing chamber so that all particles thereof are available for intermixing disaggregation and comminution, an aperture for receiving a first stream of air interior the core and passing it towards the mouthpiece for inhalation by the user, and, a wall having formed therein at least one aperture for diverting a portion of the first stream into a second stream of air for sweeping through the aerosolizing chamber to mix with the particles to form a fine, low-density, low-velocity, dry mist of powdered medicine for inhalation by the user.
摘要翻译：一种用于雾化剂量的用于吸入的粉末药物的装置，其包括限定盘形雾化室的实心芯，所述固体芯限定了由周向壁终止的间隔开的平坦的前壁和后壁，所述芯包括第一端片在其前面形成有中空的口/鼻片，叶片非同心地设置在安装在轴上的用于围绕固定轴线高速旋转的轴上的立柱，用于将全剂量的粉末药物瞬间引入的柱塞雾化室，使得其所有颗粒可用于混合解聚和粉碎，孔用于接收核心内部的第一空气流并将其传递给接口以供使用者吸入;以及壁，其中形成有至少一个用于将第一流的一部分转移到第二气流中的孔，用于扫过雾化室以进行混合使颗粒形成用于用户吸入的粉末状药物的细小的低密度低速干雾。

5. 发明授权

US09105142B2 Random access and random load dispensing unit 有权
标题翻译：随机访问和随机负载分配单元
公开(公告)号：US09105142B2
公开(公告)日：2015-08-11
申请号：US12949939
申请日：2010-11-19
申请人： Linda J. Pinney , John A. Beane , Angus R. Colson , David R. Williams , Keith Kopitzke , Keith W. Reynolds , Erik Howard Barnes
发明人： Linda J. Pinney , John A. Beane , Angus R. Colson , David R. Williams , Keith Kopitzke , Keith W. Reynolds , Erik Howard Barnes
IPC分类号： G07F11/00 , B65H1/00 , G07F9/02 , G06F19/00 , G07F11/16 , G07F11/60 , G07F11/62 , G07F17/00
CPC分类号： G07F9/026 , G06F19/00 , G06F19/3462 , G07F11/002 , G07F11/165 , G07F11/60 , G07F11/62 , G07F17/0092
摘要： The present invention provides a random access and random load dispensing unit including a housing, at least one support located in the housing and defining a first axis, a plurality of platforms movable along the support along the first axis, a plurality of bins supported on the platforms, the bins being movable with the platforms, and a shuttle assembly movable along the first axis and further movable along a second axis substantially perpendicular to the first axis between the plurality of platforms to access and retrieve products stored in the bins.
摘要翻译：本发明提供了一种随机接入和随机负载分配单元，其包括壳体，位于壳体中并限定第一轴线的至少一个支撑件，沿着支撑件沿着第一轴线移动的多个平台，多个支撑在平台，平台可与平台一起移动，梭子组件可沿着第一轴线移动并且可沿着基本垂直于多个平台之间的第一轴线的第二轴线移动，以访问和取回存储在箱中的产品。

6. 发明授权

US07857161B2 Random access and random load dispensing unit 有权
标题翻译：随机访问和随机负载分配单元
公开(公告)号：US07857161B2
公开(公告)日：2010-12-28
申请号：US11520928
申请日：2006-09-13
申请人： Linda J. Pinney , John A. Beane , Angus R. Colson , David R. Williams , Keith Kopitzke , Keith W. Reynolds , Erik Howard Barnes
发明人： Linda J. Pinney , John A. Beane , Angus R. Colson , David R. Williams , Keith Kopitzke , Keith W. Reynolds , Erik Howard Barnes
IPC分类号： G07F11/00 , G05B19/04 , B65G65/00
CPC分类号： G07F9/026 , G06F19/00 , G06F19/3462 , G07F11/002 , G07F11/165 , G07F11/60 , G07F11/62 , G07F17/0092
摘要： The present invention provides a random access and random load dispensing unit including a housing, at least one support located in the housing and defining a first axis, a plurality of platforms movable along the support along the first axis, a plurality of bins supported on the platforms, the bins being movable with the platforms, and a shuttle assembly movable along the first axis and further movable along a second axis substantially perpendicular to the first axis between the plurality of platforms to access and retrieve products stored in the bins.
摘要翻译：本发明提供了一种随机接入和随机负载分配单元，其包括壳体，位于壳体中并限定第一轴线的至少一个支撑件，沿着支撑件沿着第一轴线移动的多个平台，多个支撑在平台，平台可与平台一起移动，梭子组件可沿着第一轴线移动并且可沿着基本垂直于多个平台之间的第一轴线的第二轴线移动，以接近和取回存储在箱中的产品。

7. 发明授权

US07787986B2 Communication network for use in automatically delivering prescriptions 有权
标题翻译：用于自动传送处方的通信网络
公开(公告)号：US07787986B2
公开(公告)日：2010-08-31
申请号：US11688183
申请日：2007-03-19
申请人： Linda J. Pinney , John A. Beane , Angus R. Colson , David R. Williams , Keith Kopitzke , Keith W. Reynolds , Erik Howard Barnes
发明人： Linda J. Pinney , John A. Beane , Angus R. Colson , David R. Williams , Keith Kopitzke , Keith W. Reynolds , Erik Howard Barnes
IPC分类号： G06F17/00
CPC分类号： G07F9/02 , G06F19/00 , G06F19/3462 , G06Q50/22 , G06Q50/24 , G07F9/026 , G07F11/002 , G07F11/165 , G07F11/60 , G07F11/62 , G07F17/0092
摘要： The present invention provides a random access and random load dispensing unit including a housing, at least one support located in the housing and defining a first axis, a plurality of platforms movable along the support along the first axis, a plurality of bins supported on the platforms, the bins being movable with the platforms, and a shuttle assembly movable along the first axis and further movable along a second axis substantially perpendicular to the first axis between the plurality of platforms to access and retrieve products stored in the bins.
摘要翻译：本发明提供了一种随机接入和随机负载分配单元，其包括壳体，位于壳体中并限定第一轴线的至少一个支撑件，沿着支撑件沿着第一轴线移动的多个平台，多个支撑在平台，平台可与平台一起移动，梭子组件可沿着第一轴线移动并且可沿着基本垂直于多个平台之间的第一轴线的第二轴线移动，以接近和取回存储在箱中的产品。

8. 发明申请

US20080251955A1 METHOD AND APPARATUS IMPROVING VISION AND THE RESOLUTION OF RETINAL IMAGES 审中-公开
公开(公告)号：US20080251955A1
公开(公告)日：2008-10-16
申请号：US12145302
申请日：2008-06-24
申请人： David R. Williams , Junzhong Liang
发明人： David R. Williams , Junzhong Liang
IPC分类号： B29D11/00
CPC分类号： G01J9/00 , A61B3/103 , A61B3/156
摘要： A method of and apparatus for improving vision and the resolution of retinal images is described in which a point source produced on the retina of a living eye by a laser beam is reflected from the retina and received at a lenslet array of a Hartmann-Shack wavefront sensor such that each of the lenslets in the lenslet array forms an aerial image of the retinal point source on a CCD camera located adjacent to the lenslet array. The output signal from the CCD camera is acquired by a computer which processes the signal and produces a correction signal which may be used to control a compensating optical or wavefront compensation device such as a deformable mirror. It may also be used to fabricate a contact lens or intraocular lens, or to guide a surgical procedure to correct the aberrations of the eye. Any of these methods could correct aberrations beyond defocus and astigmatism, allowing improved vision and improved imaging of the inside of the eye.

9. 发明授权

US06511180B2 Determination of ocular refraction from wavefront aberration data and design of optimum customized correction 有权
$Determination of ocular refraction from wavefront aberration data and design of optimum customized correction$
公开(公告)号：US06511180B2
公开(公告)日：2003-01-28
申请号：US09969600
申请日：2001-10-04
申请人： Antonio Guirao , David R. Williams
发明人： Antonio Guirao , David R. Williams
IPC分类号： A61B310
CPC分类号： A61B3/0025 , G02C2202/22
摘要： Ocular refraction is determined from wavefront aberration data, and an optimum customized correction is designed. The eye's wave aberration is measured by using a detector such as a Shack-Hartmann detector. From the aberration, an image metric is calculated, and the second-order aberrations which optimize that metric are determined. From that optimization, the refractive correction required for the eye is determined. The image metric is one of several metrics indicating the quality of the image on the retinal plane or a proxy for such a metric. The required refractive correction can be used to form a lens or to control eye surgery. If it is possible to detect more aberrations than can be corrected, those aberrations are corrected which most affect vision, or for which the eye's error tolerance is lowest.

10. 发明授权

US06390116B1 Large amplitude pneumatic oscillator 失效
标题翻译：大振幅气动振荡器
公开(公告)号：US06390116B1
公开(公告)日：2002-05-21
申请号：US09906423
申请日：2001-07-16
申请人： Byung-Hun Kim , David R. Williams
发明人： Byung-Hun Kim , David R. Williams
IPC分类号： G05D706
CPC分类号： B64C21/04 , B64C2230/02 , B64C2230/04 , B64C2230/06 , B64C2230/18 , F15C1/22 , Y02T50/166 , Y10T137/0396 , Y10T137/86405 , Y10T137/86421
摘要： A system for producing variable amplitude pneumatic pulses, such as may be used to prevent flow separation on airfoil and diffuser surfaces to control stalling, utilizes a source of pressurized air which is regulated and fed to parallel outlet lines. Each outlet line has a control valve therein attached to a controller for activation of the valves. The first parallel line leads to an actuator which supplies the pulsed air to a desired surface. The second parallel line leads to the atmosphere. By cycling the valves at about ninety degrees out of phase, pneumatic pulses of large amplitude are obtained with a simple device capable of being transported on the aircraft.
摘要翻译：用于产生可变幅度气动脉冲的系统，例如可以用于防止在翼型件和扩散器表面上的流动分离以控制失速，利用调节并供给到平行出口管线的加压空气源。每个出口管路上都有一个控制阀，连接到一个用于启动阀门的控制器。第一并行线通向致动器，该致动器将脉冲空气供给到期望的表面。第二条平行线通向大气。通过循环大约九十度的阀门，可以使用能够在飞机上运输的简单装置获得大振幅的气动脉冲。

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