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1. 发明授权

US09278910B2 GLP-1 receptor stabilizers and modulators 有权
标题翻译： GLP-1受体稳定剂和调节剂
公开(公告)号：US09278910B2
公开(公告)日：2016-03-08
申请号：US14122176
申请日：2012-05-31
申请人： Marcus F. Boehm , Esther Martinborough , Manisha Moorjani , Junko Tamiya , Liming Huang , Thomas Fowler , Andrew Novak , Premji Meghani , Enugurthi Brahmachary , Adam Richard Yeager
发明人： Marcus F. Boehm , Esther Martinborough , Manisha Moorjani , Junko Tamiya , Liming Huang , Thomas Fowler , Andrew Novak , Premji Meghani , Enugurthi Brahmachary , Adam Richard Yeager
IPC分类号： C07D271/06 , C07C235/38 , A61K9/00 , A61K47/20 , A61K47/26 , A61K47/40 , A61K47/48 , A61K45/06 , A61K31/155 , A61K38/26 , C07C255/57 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D309/06 , C07D309/08 , C07D311/16 , C07C271/28 , C07D215/48 , C07D217/02 , C07C275/42 , C07D317/68 , C07D231/12 , C07D333/38 , C07D233/60 , C07C311/08 , C07C311/13 , C07C311/21 , C07D235/06 , C07C311/29 , C07D235/12 , C07D235/18 , C07C311/48 , C07D239/26 , C07D239/28 , C07C317/28 , C07C317/44 , C07D239/74 , C07D413/04 , C07D239/91 , C07D413/12 , C07D241/42 , C07D241/44 , C07D417/12 , C07C323/62 , C07C229/14 , C07D249/08 , C07D257/04 , C07C233/47 , C07C233/51 , C07D261/18 , C07C233/81 , C07C233/83 , C07C235/12 , C07D263/32 , C07D263/34 , C07C235/48 , C07D263/48 , C07D263/57 , C07C237/22 , C07C237/36 , C07C237/42 , C07D271/07 , C07D271/107 , C07D207/267 , C07D277/30 , C07D209/08 , C07D277/56 , C07D277/66 , C07D279/12 , C07D211/14 , C07D211/34 , C07D211/62 , C07D295/15 , C07D295/155 , C07D295/205 , C07D213/55 , C07D213/65 , C07D307/24 , C07D307/54 , C07D307/68 , C07D307/79 , C08B37/16 , C08L5/16 , B82Y5/00 , A61K31/235 , A61K31/341 , A61K31/4406 , A61K31/4465 , A61K31/495 , A61K31/505 , A61K31/5375 , A61K31/54 , C07D295/24
CPC分类号： A61K31/4245 , A61K9/0019 , A61K9/0095 , A61K31/155 , A61K31/235 , A61K31/341 , A61K31/4406 , A61K31/4439 , A61K31/4465 , A61K31/4725 , A61K31/495 , A61K31/505 , A61K31/5375 , A61K31/54 , A61K38/22 , A61K38/26 , A61K45/06 , A61K47/20 , A61K47/26 , A61K47/40 , A61K47/6951 , B82Y5/00 , C07C229/14 , C07C233/47 , C07C233/51 , C07C233/81 , C07C233/83 , C07C235/12 , C07C235/38 , C07C235/48 , C07C237/22 , C07C237/36 , C07C237/42 , C07C255/57 , C07C271/28 , C07C275/42 , C07C311/08 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/48 , C07C317/28 , C07C317/44 , C07C323/62 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/267 , C07D209/08 , C07D211/14 , C07D211/34 , C07D211/62 , C07D213/55 , C07D213/65 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/02 , C07D231/12 , C07D233/60 , C07D235/06 , C07D235/12 , C07D235/18 , C07D239/26 , C07D239/28 , C07D239/74 , C07D239/91 , C07D241/42 , C07D241/44 , C07D249/08 , C07D257/04 , C07D261/18 , C07D263/32 , C07D263/34 , C07D263/48 , C07D263/57 , C07D271/06 , C07D271/07 , C07D271/107 , C07D277/30 , C07D277/56 , C07D277/66 , C07D279/12 , C07D295/15 , C07D295/155 , C07D295/205 , C07D295/24 , C07D307/24 , C07D307/54 , C07D307/68 , C07D307/79 , C07D309/06 , C07D309/08 , C07D311/16 , C07D317/68 , C07D333/38 , C07D413/04 , C07D413/12 , C07D417/12 , C08B37/0015 , C08L5/16 , A61K2300/00
摘要： Compounds that bind the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, methods of their therapeutic and/or prophylactic use, and methods of their use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor are provided. Certain compounds may have activity as modulators or potentiators with respect to glucagon receptor, GIP receptor, GLP-1 and GLP-2 receptors, and PTH receptor on their own or in the presence of receptor ligands such as GIP(1-42), PTH(1-34), Glucagon(1-29), GLP-2(1-33), GLP-1 (7-36), GLP-1 (9-36), oxyntomodulin and exendin variants.
摘要翻译：结合胰高血糖素样肽1（GLP-1）受体的化合物，其合成方法，其治疗和/或预防用途的方法及其在体外稳定GLP-1受体中用于GLP- 1受体。某些化合物自身或存在受体配体如GIP（1-42），PTH可能具有作为胰高血糖素受体，GIP受体，GLP-1和GLP-2受体以及PTH受体的调节剂或增效剂的活性（1-34），胰高血糖素（1-29），GLP-2（1-33），GLP-1（7-36），GLP-1（9-36），胃泌酸调节蛋白和毒蜥外泌肽变体。

2. 发明授权

US08501982B2 GLP-1 receptor stabilizers and modulators 有权
标题翻译： GLP-1受体稳定剂和调节剂
公开(公告)号：US08501982B2
公开(公告)日：2013-08-06
申请号：US13157264
申请日：2011-06-09
申请人： Marcus F. Boehm , Esther Martinborough , Manisha Moorjani , Liming Huang , Junko Tamiya , Mark T. Griffith , Thomas Fowler , Andrew Novak , Michael Knaggs , Premji Meghani
发明人： Marcus F. Boehm , Esther Martinborough , Manisha Moorjani , Liming Huang , Junko Tamiya , Mark T. Griffith , Thomas Fowler , Andrew Novak , Michael Knaggs , Premji Meghani
IPC分类号： C07C69/76 , A61K31/235
CPC分类号： A61K38/02 , A61K31/24 , A61K31/34 , A61K31/343 , A61K31/381 , A61K31/42 , A61K31/428 , A61K31/455 , A61K31/498 , A61K31/5375 , A61K45/06 , C07C233/87 , C07C235/52 , C07C235/84 , C07C237/36 , C07C237/42 , C07C255/57 , C07C275/42 , C07C317/44 , C07D207/44 , C07D211/62 , C07D213/56 , C07D213/82 , C07D215/48 , C07D231/14 , C07D233/90 , C07D241/44 , C07D257/06 , C07D261/18 , C07D261/20 , C07D263/48 , C07D265/30 , C07D277/62 , C07D277/82 , C07D285/14 , C07D295/15 , C07D295/155 , C07D307/66 , C07D307/68 , C07D307/85 , C07D309/08 , C07D317/60 , C07D333/38 , C07D333/70 , C07D471/04
摘要： Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided.
摘要翻译：提供了结合胰高血糖素样肽1受体（GLP-1）受体的化合物，包括作为GLP-1受体的调节剂的化合物和能够诱导对受体的稳定作用的化合物，用于GLP的结构分析 -1受体。提供了合成方法，治疗和/或预防用途的方法，以及用于稳定GLP-1受体体外用于结合这些化合物的GLP-1受体的方法。

3. 发明申请

US20110306542A1 NOVEL GLP-1 RECEPTOR STABILIZERS AND MODULATORS 有权
标题翻译：新型GLP-1受体稳定剂和调节剂
公开(公告)号：US20110306542A1
公开(公告)日：2011-12-15
申请号：US13157264
申请日：2011-06-09
申请人： Marcus F. Boehm , Esther Martinborough , Manisha Moorjani , Liming Huang , Junko Tamiya , Mark T. Griffith , Thomas Fowler , Andrew Novak , Michael Knaggs , Premji Meghani
发明人： Marcus F. Boehm , Esther Martinborough , Manisha Moorjani , Liming Huang , Junko Tamiya , Mark T. Griffith , Thomas Fowler , Andrew Novak , Michael Knaggs , Premji Meghani
IPC分类号： A61K38/16 , A61K31/495 , A61K31/498 , A61K31/437 , A61K31/47 , A61K31/445 , A61K31/4406 , A61K31/433 , A61K31/428 , A61K31/421 , A61K31/423 , A61K31/41 , A61K31/415 , A61K31/40 , A61K31/381 , A61K31/351 , A61K31/343 , A61K31/341 , A61K31/24 , C07D265/30 , C07D241/44 , C07D471/04 , C07D215/38 , C07D211/62 , C07D213/56 , C07D285/14 , C07D277/82 , C07D263/48 , C07D261/20 , C07D261/18 , C07D257/06 , C07D231/38 , C07D207/44 , C07D333/70 , C07D333/22 , C07D309/14 , C07D307/85 , C07D307/66 , C07C69/76 , A61P3/04 , A61P3/00 , A61P3/10 , A61K31/5375
CPC分类号： A61K38/02 , A61K31/24 , A61K31/34 , A61K31/343 , A61K31/381 , A61K31/42 , A61K31/428 , A61K31/455 , A61K31/498 , A61K31/5375 , A61K45/06 , C07C233/87 , C07C235/52 , C07C235/84 , C07C237/36 , C07C237/42 , C07C255/57 , C07C275/42 , C07C317/44 , C07D207/44 , C07D211/62 , C07D213/56 , C07D213/82 , C07D215/48 , C07D231/14 , C07D233/90 , C07D241/44 , C07D257/06 , C07D261/18 , C07D261/20 , C07D263/48 , C07D265/30 , C07D277/62 , C07D277/82 , C07D285/14 , C07D295/15 , C07D295/155 , C07D307/66 , C07D307/68 , C07D307/85 , C07D309/08 , C07D317/60 , C07D333/38 , C07D333/70 , C07D471/04
摘要： Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided.
摘要翻译：提供了结合胰高血糖素样肽1受体（GLP-1）受体的化合物，包括作为GLP-1受体的调节剂的化合物和能够诱导对受体的稳定作用的化合物，用于GLP的结构分析 -1受体。提供了合成方法，治疗和/或预防用途的方法，以及用于稳定GLP-1受体体外用于结合这些化合物的GLP-1受体的方法。

4. 发明申请

US20050116818A1 Instrument panel system having concealed switches 失效
标题翻译：具有隐蔽开关的仪表板系统
公开(公告)号：US20050116818A1
公开(公告)日：2005-06-02
申请号：US10717078
申请日：2003-11-19
申请人： Karl Kennedy , David Hein , Christopher Spielman , Gregory Breakey , Thomas Fowler
发明人： Karl Kennedy , David Hein , Christopher Spielman , Gregory Breakey , Thomas Fowler
IPC分类号： B60K37/06 , B60Q3/04 , B60Q1/00 , B60Q1/26 , G08B23/00
CPC分类号： B60K37/06 , B60K2350/1024 , B60K2350/203 , B60Q3/12 , B60Q3/14
摘要： An instrument panel system. The instrument panel system provides an aesthetically appealing instrument panel by including a number of concealed switches. The switches are concealed such that an area proximate the switch on the 5 surface of the instrument panel appears to be uninterrupted by the switch. In operation, the position of the switches is revealed by illuminating a switch display.
摘要翻译：仪表盘系统。仪表板系统通过包括多个隐蔽开关来提供美观的仪表板。这些开关被隐藏，使得靠近仪表板5表面上的开关的区域看起来不被开关断开。在操作中，通过照亮开关显示来显示开关的位置。

5. 发明申请

US20050087654A1 Instrument panel system 审中-公开
标题翻译：仪表板系统
公开(公告)号：US20050087654A1
公开(公告)日：2005-04-28
申请号：US10692955
申请日：2003-10-24
申请人： Thomas Fowler , Karl Kennedy , Gregory Breakey , David Hein , Chris Spielman
发明人： Thomas Fowler , Karl Kennedy , Gregory Breakey , David Hein , Chris Spielman
IPC分类号： B60K35/00 , G12B9/00
CPC分类号： B60K35/00 , B60K2370/81
摘要： An instrument panel system which can accommodate different sized displays within a common instrument panel structure. The instrument panel system can accommodate different sized devices within the common instrument panel architecture without showing an empty intermediate area between the device and the instrument panel when the device received within the opening is smaller than an area of the opening.
摘要翻译：仪表板系统，可在普通仪表板结构内容纳不同尺寸的显示器。仪表板系统可以在通用仪表板结构内容纳不同尺寸的装置，而在开口内接收的装置小于开口区域时，在装置和仪表板之间不显示空的中间区域。

6. 发明授权

US06617928B2 Configurable power amplifier and bias control 有权
公开(公告)号：US06617928B2
公开(公告)日：2003-09-09
申请号：US09971523
申请日：2001-10-05
申请人： Hugh J. Finlay , Mark Bloom , Thomas Fowler
发明人： Hugh J. Finlay , Mark Bloom , Thomas Fowler
IPC分类号： H03F304
CPC分类号： H03F1/302
摘要： The bias control selectively provides for bias of a power amplifier based upon a bandgap voltage generated by the bias control, or by a bias voltage external to the bias control. A controller controls the selection of either the bandgap voltage or external bias voltage. The bias control is fabricated in a first semiconductor material capable of operating at low voltage supply levels, such as complementary metal oxide semiconductor (CMOS) material and may be fabricated on an integrated circuit common with a power amplifier.

7. 发明申请

US20070095536A1 Cogeneration systems and processes for treating hydrocarbon containing formations 失效
标题翻译：用于处理含烃地层的热电联产系统和方法
公开(公告)号：US20070095536A1
公开(公告)日：2007-05-03
申请号：US11584802
申请日：2006-10-20
申请人： Harold Vinegar , Thomas Fowler , John Karanikas
发明人： Harold Vinegar , Thomas Fowler , John Karanikas
IPC分类号： E21B43/24
CPC分类号： E21B43/24 , C10G1/002 , C10G1/02 , C10G9/24 , C10G2300/308 , E21B43/2401 , E21B43/281 , E21B43/34
摘要： A system for treating a hydrocarbon containing formation includes a steam and electricity cogeneration facility. At least one injection well is located in a first portion of the formation. The injection well provides steam from the steam and electricity cogeneration facility to the first portion of the formation. At least one production well is located in the first portion of the formation. The production well in the first portion produces first hydrocarbons. At least one electrical heater is located in a second portion of the formation. At least one of the electrical heaters is powered by electricity from the steam and electricity cogeneration facility. At least one production well is located in the second portion of the formation. The production well in the second portion produces second hydrocarbons. The steam and electricity cogeneration facility uses the first hydrocarbons and/or the second hydrocarbons to generate electricity.
摘要翻译：用于处理含烃地层的系统包括蒸汽和热电联产设施。至少一个注入井位于地层的第一部分。注入井将蒸汽和电力热电联产设备的蒸汽提供到地层的第一部分。至少一个生产井位于地层的第一部分。第一部分的生产良好产生第一种烃。至少一个电加热器位于地层的第二部分。至少一个电加热器由来自蒸汽和热电联产设施的电力供电。至少一个生产井位于地层的第二部分。第二部分的生产井产生第二种碳氢化合物。蒸汽和热电联产设施使用第一烃和/或第二碳氢化合物发电。

8. 发明申请

US20050248198A1 Seat assembly with folding head restraint and method for folding same 失效
标题翻译：具有折叠头枕的座椅组件及其折叠方法
公开(公告)号：US20050248198A1
公开(公告)日：2005-11-10
申请号：US10839622
申请日：2004-05-05
申请人： Thomas Fowler , Nagarjun Yetukuri , Dale Smallwood
发明人： Thomas Fowler , Nagarjun Yetukuri , Dale Smallwood
IPC分类号： B60N2/02 , B60N2/30 , B60N2/48
CPC分类号： B60N2/3009 , B60N2/856
摘要： A seat assembly includes a seat back that is pivotable from an upright use position to a stowed position. A head restraint includes first and second portions, each of which are movable from a respective upright use position to a respective stowed position. Each of the portions includes a respective contact surface for contacting an occupant of the seat assembly. A release mechanism is configured to facilitate movement of the first and second portions from their respective upright use positions to their respective stowed positions. An automatic return mechanism is provided to automatically return the first and second portions from their respective stowed positions to their respective upright use positions when the seat back is pivoted from its stowed position to its upright use position.
摘要翻译：座椅组件包括可从直立使用位置枢转到收起位置的座椅靠背。头枕包括第一和第二部分，每个部分可以从相应的直立使用位置移动到相应的收起位置。每个部分包括用于接触座椅组件的乘员的相应的接触表面。释放机构构造成便于使第一和第二部分从它们各自的直立使用位置移动到它们各自的收起位置。提供自动返回机构，用于当座椅靠背从其收起位置枢转到其直立使用位置时，自动将第一和第二部分从它们各自的收起位置返回到它们各自的直立使用位置。

9. 发明授权

US06437647B1 Current mirror compensation system for power amplifiers 有权
标题翻译：功率放大器电流镜补偿系统
公开(公告)号：US06437647B1
公开(公告)日：2002-08-20
申请号：US09772717
申请日：2001-01-30
申请人： Thomas Fowler
发明人： Thomas Fowler
IPC分类号： H03F304
CPC分类号： H03F1/302
摘要： Two compensating resistors in a mirror bias circuit coupled to a radio frequency (RF) amplifier are configured such that transistor base-emitter voltages are adjusted to stabilize RF transistor quiescent current for variations in collector voltage, Vcc. For example, when battery power is drained during device use, Vcc decreases. As Vcc decreases, less current is drawn through the compensating resistors, thereby decreasing the voltage drop across the compensating resistors and increasing the transistor base-emitter voltages in the mirror bias circuit and the radio frequency (RF) amplifier. Thus, the tendency of the RF transistor quiescent current to decrease as Vcc decreases is off-set because the compensating resistors cause an increase in the RF transistor base-emitter voltage, thereby increasing quiescent current. In one embodiment, the first compensating resistor size is equal to the second compensating resistor size multiplied by the ratio of the buffer transistor current rating to the mirror transistor current rating.
摘要翻译：耦合到射频（RF）放大器的镜偏置电路中的两个补偿电阻器被配置为使得晶体管基极 - 发射极电压被调整以稳定RF晶体管静态电流以用于集电极电压Vcc的变化。例如，在设备使用期间电池电量耗尽时，Vcc减小。随着Vcc的减小，补偿电阻器的电流越小，从而降低补偿电阻器两端的电压降，并增加镜面偏置电路和射频（RF）放大器中的晶体管基极 - 发射极电压。因此，由于补偿电阻引起RF晶体管基极 - 发射极电压的增加，RF晶体管静态电流随着Vcc的降低而降低的趋势是偏移的，因此增加了静态电流。在一个实施例中，第一补偿电阻器尺寸等于第二补偿电阻器尺寸乘以缓冲晶体管额定电流与镜面晶体管额定电流的比率。

10. 发明申请

US20070045266A1 In situ conversion process utilizing a closed loop heating system 有权
标题翻译：使用闭环加热系统的原位转化过程
公开(公告)号：US20070045266A1
公开(公告)日：2007-03-01
申请号：US11409556
申请日：2006-04-21
申请人： Chester Sandberg , Thomas Fowler , Harold Vinegar , Willem Jan Antoon Schoeber
发明人： Chester Sandberg , Thomas Fowler , Harold Vinegar , Willem Jan Antoon Schoeber
IPC分类号： B60L1/02
CPC分类号： E21B43/24 , C07C4/02 , E21B17/028 , E21B36/001 , E21B36/04 , E21B43/243 , Y10T29/49179 , C07C9/04
摘要： An in situ conversion system for producing hydrocarbons from a subsurface formation is described. The system includes a plurality of u-shaped wellbores in the formation. Piping is positioned in at least two of the u-shaped wellbores. A fluid circulation system is coupled to the piping. The fluid circulation system is configured to circulate hot heat transfer fluid through at least a portion of the piping to form at least one heated portion of the formation. An electrical power supply is configured to provide electrical current to at least a portion of the piping located below an overburden in the formation to resistively heat at least a portion of the piping. Heat transfers from the piping to the formation.
摘要翻译：描述了用于从地下地层生产烃的原位转化系统。该系统在地层中包括多个u形井筒。管道位于至少两个u形井眼中。流体循环系统耦合到管道。流体循环系统被配置为使热传热流体循环通过管道的至少一部分以形成地层的至少一个加热部分。电源构造成向位于地层中的覆盖层下方的管道的至少一部分提供电流，以电阻地加热管道的至少一部分。从管道传输到地层。

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