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1. 发明授权

US08163276B2 Systems and methods for isolating and using clinically safe adipose derived regenerative cells 有权
标题翻译：用于分离和使用临床安全的脂肪来源的再生细胞的系统和方法
公开(公告)号：US08163276B2
公开(公告)日：2012-04-24
申请号：US12554755
申请日：2009-09-04
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Schreiber , Isabella Wulur
IPC分类号： C12N5/00
CPC分类号： C12M47/04 , A61B17/00 , A61K35/28 , A61M1/00 , C12M29/04 , C12M45/00 , C12N5/0667
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译：描述了用于从多种组织分离细胞的系统和方法。特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。

2. 发明申请

US20050260175A1 Systems and methods for isolating and using clinically safe adipose derived regenerative cells 有权
标题翻译：用于分离和使用临床安全的脂肪来源的再生细胞的系统和方法
公开(公告)号：US20050260175A1
公开(公告)日：2005-11-24
申请号：US10884638
申请日：2004-07-02
申请人： Marc Hedrick , John Fraser , Michael Schulzki , Bobby Byrnes , Grace Carlson , Ronda Schreiber , Isabella Wulur
发明人： Marc Hedrick , John Fraser , Michael Schulzki , Bobby Byrnes , Grace Carlson , Ronda Schreiber , Isabella Wulur
IPC分类号： A61K35/12 , A61K35/28 , A61K35/36 , C12N5/08 , A61K45/00 , C12Q1/00
CPC分类号： C12M47/04 , A61B17/00 , A61K35/28 , A61M1/00 , C12M29/04 , C12M45/00 , C12N5/0667
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译：描述了用于从多种组织分离细胞的系统和方法。特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。

3. 发明申请

US20110130708A1 Directional Delivery of Energy and Bioactives 有权
标题翻译：定向交付能源和生物活性物质
公开(公告)号：US20110130708A1
公开(公告)日：2011-06-02
申请号：US12778037
申请日：2010-05-11
申请人： Mike Perry , Brian D. Conn , Rolfe T. Gustus , Ronda Schreiber , Corbett Stone , Michael F. Hoey
发明人： Mike Perry , Brian D. Conn , Rolfe T. Gustus , Ronda Schreiber , Corbett Stone , Michael F. Hoey
IPC分类号： A61M37/00
CPC分类号： A61B18/1492 , A61B18/1815 , A61B18/24 , A61B2018/00083 , A61B2018/00214 , A61B2018/0022
摘要： Systems and methods are disclosed for the treatment of a target tissue by directionally delivering energy and/or bioactive materials to achieve a therapeutic effect. A balloon catheter system having a balloon portion and a plurality of electrodes may be energized to selectively deliver energy, bioactive materials, or a combination thereof to target tissue including tissues disposed about a lumen. The tissue may be targeted by applying energy, making tissue impedance analysis, and further selectively energizing electrodes through the use of an energy source with a controller.
摘要翻译：公开了用于通过定向递送能量和/或生物活性材料以实现治疗效果来治疗靶组织的系统和方法。具有球囊部分和多个电极的球囊导管系统可被激励以选择性地将能量，生物活性材料或其组合输送到包括围绕管腔设置的组织的靶组织。通过施加能量，进行组织阻抗分析以及通过使用能量源与控制器进一步选择性地激励电极，可以对组织进行靶向。

4. 发明授权

US5851994A Compositions that inhibit wound contraction and methods of using same 失效
标题翻译：抑制伤口收缩的组合物及其使用方法
公开(公告)号：US5851994A
公开(公告)日：1998-12-22
申请号：US473025
申请日：1995-06-06
申请人： Ronda Schreiber , James Polarek
发明人： Ronda Schreiber , James Polarek
IPC分类号： A61K38/00 , C07K14/47 , A61K38/02 , C07K5/00 , C07K7/00
CPC分类号： C07K14/4725 , A61K38/00
摘要： The present invention provides methods for reducing or inhibiting wound contraction in a subject having a wound comprising administering to the subject a pharmaceutical composition comprising a peptide or a polypeptide. The invention provides, for example, a method of reducing or inhibiting wound contraction comprising the administration of a pharmaceutical composition comprising a peptide having more than three consecutive basic amino acids. The invention also provides a method of reducing or inhibiting wound contraction comprising the administration of a pharmaceutical composition comprising a peptide containing the sequence arginine-glycine-aspartic acid and a basic amino acid sequence or a pharmaceutical composition comprising a peptide containing therein a sequence of six consecutive amino acid residues of which at least about four of the six amino acid residues are basic amino acid residues. The invention also provides a method of reducing or inhibiting wound contraction comprising the administration of a pharmaceutical composition comprising decorin.
摘要翻译：本发明提供了用于减少或抑制患有伤口的受试者的伤口收缩的方法，包括向受试者施用包含肽或多肽的药物组合物。本发明提供了例如减少或抑制伤口收缩的方法，其包括施用包含具有多于三个连续碱性氨基酸的肽的药物组合物。本发明还提供了减少或抑制伤口收缩的方法，其包括施用包含含有精氨酸 - 甘氨酸 - 天冬氨酸序列的肽和碱性氨基酸序列的肽的药物组合物或包含其中含有六个序列的肽的药物组合物连续的氨基酸残基在六个氨基酸残基中至少约四个是碱性氨基酸残基。本发明还提供减少或抑制伤口收缩的方法，包括施用包含核心蛋白聚糖的药物组合物。

5. 发明授权

US08551096B2 Directional delivery of energy and bioactives 有权
标题翻译：定向输送能量和生物活性物质
公开(公告)号：US08551096B2
公开(公告)日：2013-10-08
申请号：US12778037
申请日：2010-05-11
申请人： Mike Perry , Brian D. Conn , Rolfe T. Gustus , Ronda Schreiber , Corbett Stone , Michael F. Hoey
发明人： Mike Perry , Brian D. Conn , Rolfe T. Gustus , Ronda Schreiber , Corbett Stone , Michael F. Hoey
IPC分类号： A61B17/56
CPC分类号： A61B18/1492 , A61B18/1815 , A61B18/24 , A61B2018/00083 , A61B2018/00214 , A61B2018/0022
摘要： Systems and methods are disclosed for the treatment of a target tissue by directionally delivering energy and/or bioactive materials to achieve a therapeutic effect. A balloon catheter system having a balloon portion and a plurality of electrodes may be energized to selectively deliver energy, bioactive materials, or a combination thereof to target tissue including tissues disposed about a lumen. The tissue may be targeted by applying energy, making tissue impedance analysis, and further selectively energizing electrodes through the use of an energy source with a controller.
摘要翻译：公开了用于通过定向递送能量和/或生物活性材料以实现治疗效果来治疗靶组织的系统和方法。具有球囊部分和多个电极的球囊导管系统可被激励以选择性地将能量，生物活性材料或其组合输送到包括围绕管腔设置的组织的靶组织。通过施加能量，进行组织阻抗分析以及通过使用能量源与控制器进一步选择性地激励电极，可以对组织进行靶向。

6. 发明申请

US20110245929A1 METHODS AND COMPOSITIONS FOR JOINT HEALING AND REPAIR 审中-公开
标题翻译：联合治疗和修复的方法和组合
公开(公告)号：US20110245929A1
公开(公告)日：2011-10-06
申请号：US13042295
申请日：2011-03-07
申请人： Kevin Rakin , Charles E. Hart , Conan Young , Ronda Schreiber
发明人： Kevin Rakin , Charles E. Hart , Conan Young , Ronda Schreiber
IPC分类号： A61F2/02 , A61B17/04 , A61B17/32
CPC分类号： A61F2/08 , A61B17/3468 , A61B2017/00933 , A61B2017/0404 , A61B2017/044
摘要： The invention in some aspects provides implantable articles comprising in vitro-prepared tissues for joint repair. Devices and methods for introducing implantable articles into a subject are also provided. In some aspects of the invention devices and systems for minimally invasive surgery are provided. In some aspects, methods are provided for regenerating a bone-tendon interface in a subject by implanting an in vitro-prepared tissue between a detached tendon or detached ligament and a bone in a subject. In other aspects, methods are provided for maintaining exogenous, viable fibroblasts between a detached tendon and a bone in a subject. In other aspects, methods are provided for delivering exogenous cytokines and/or growth factors to a damaged bone-tendon interface.
摘要翻译：本发明在一些方面提供了包含用于关节修复的体外制备的组织的可植入制品。还提供了用于将可植入物品引入被检体的装置和方法。在本发明的一些方面，提供了用于微创手术的装置和系统。在一些方面，提供了通过在受试者的分离的肌腱或分离的韧带和骨之间植入体外制备的组织来提供用于在受试者中再生骨 - 肌腱界面的方法。在其它方面，提供了用于在受试者的分离的肌腱和骨之间维持外源的，活的成纤维细胞的方法。在其他方面，提供了用于将外源性细胞因子和/或生长因子递送至损伤的骨 - 肌腱界面的方法。

7. 发明授权

US08396548B2 Selective drug delivery in a lumen 有权
标题翻译：选择性药物输送在管腔
公开(公告)号：US08396548B2
公开(公告)日：2013-03-12
申请号：US12616720
申请日：2009-11-11
申请人： Mike Perry , Corbett W. Stone , Rolfe Tyson Gustus , Ronda Schreiber , Meital Mazor , Brian Conn
发明人： Mike Perry , Corbett W. Stone , Rolfe Tyson Gustus , Ronda Schreiber , Meital Mazor , Brian Conn
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61B5/053 , A61B5/6853 , A61B18/1492 , A61B18/24 , A61B2018/00154 , A61B2018/00214 , A61B2018/0022 , A61B2018/00898 , A61B2018/1861 , A61L29/08 , A61L29/14 , A61L29/16 , A61L2300/45 , A61L2300/606 , A61M25/104 , A61M37/0092 , A61M2025/105 , A61M2025/1086 , A61M2025/1088 , A61N7/022
摘要： Methods and systems are disclosed for selective drug or fluid delivery in a lumen through a coating or fluid delivery channels. One system includes an elongate catheter having a proximal end and a distal end with an axis therebetween, the catheter having a radially expandable balloon near the distal end and an energy delivery portion proximate the balloon for transmission of energy, a thermally changeable coating having a releasable drug coupled to the balloon, the thermally changeable coating being oriented to be urged against the body tissue when the expandable balloon expands and an energy source operatively coupled to the energy delivery portion configured to energize the energy delivery portion to heat and liquefy the thermally changeable coating to release the drug to the body tissue.
摘要翻译：公开了用于通过涂层或流体递送通道在腔中选择性药物或流体递送的方法和系统。一个系统包括细长导管，其具有近端和远端，其间具有轴线，导管具有靠近远端的径向可扩张的气囊，靠近球囊的能量传递部分用于传递能量;热可变涂层，具有可释放的联接到气囊的药物，当可膨胀气囊膨胀时，热可变涂层被定向为抵靠身体组织，并且能量源可操作地联接到能量输送部分，其被配置为激发能量输送部分以加热和液化热变性涂层将药物释放到身体组织。

8. 发明申请

US20050048644A1 Methods of using regenerative cells in the treatment of musculoskeletal disorders 有权
标题翻译：使用再生细胞治疗肌肉骨骼疾病的方法
公开(公告)号：US20050048644A1
公开(公告)日：2005-03-03
申请号：US10884637
申请日：2004-07-01
申请人： Marc Hedrick , John Fraser , Susan Riley , Ronda Schreiber
发明人： Marc Hedrick , John Fraser , Susan Riley , Ronda Schreiber
IPC分类号： A61K35/12 , A61K35/28 , A61K35/36 , C12N5/08 , A61F2/44 , C12M3/00
CPC分类号： A61K35/28 , A61L27/18 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/3691 , A61L27/3834 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/40 , A61L2300/412 , A61L2300/64 , A61L2400/06 , A61L2430/02 , A61L2430/06 , A61L2430/40 , C12N5/0667
摘要： Regenerative cells present in adipose tissue are used to treat patients, including patients with musculoskeletal diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, regenerative cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic musculoskeletal benefit.
摘要翻译：存在于脂肪组织中的再生细胞用于治疗患者，包括肌肉骨骼疾病或病症的患者。治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的再生细胞输送给患者。所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。因此，在优选的方法中，存在于脂肪组织中的再生细胞与用于促进，产生或支持治疗性肌肉骨骼益处所必需的这种添加剂一起直接放置在受体中。

9. 发明申请

US20100125239A1 Selective Drug Delivery In a Lumen 有权
标题翻译：选择性药物递送在流明
公开(公告)号：US20100125239A1
公开(公告)日：2010-05-20
申请号：US12616720
申请日：2009-11-11
申请人： Mike Perry , Corbett W. Stone , Rolfe Tyson Gustus , Ronda Schreiber , Meital Mazor , Brian Conn
发明人： Mike Perry , Corbett W. Stone , Rolfe Tyson Gustus , Ronda Schreiber , Meital Mazor , Brian Conn
IPC分类号： A61M25/10 , A61N1/30
CPC分类号： A61M25/10 , A61B5/053 , A61B5/6853 , A61B18/1492 , A61B18/24 , A61B2018/00154 , A61B2018/00214 , A61B2018/0022 , A61B2018/00898 , A61B2018/1861 , A61L29/08 , A61L29/14 , A61L29/16 , A61L2300/45 , A61L2300/606 , A61M25/104 , A61M37/0092 , A61M2025/105 , A61M2025/1086 , A61M2025/1088 , A61N7/022
摘要： Methods and systems are disclosed for selective drug or fluid delivery in a lumen through a coating or fluid delivery channels. One system includes an elongate catheter having a proximal end and a distal end with an axis therebetween, the catheter having a radially expandable balloon near the distal end and an energy delivery portion proximate the balloon for transmission of energy, a thermally changeable coating having a releasable drug coupled to the balloon, the thermally changeable coating being oriented to be urged against the body tissue when the expandable balloon expands and an energy source operatively coupled to the energy delivery portion configured to energize the energy delivery portion to heat and liquefy the thermally changeable coating to release the drug to the body tissue.
摘要翻译：公开了用于通过涂层或流体输送通道在腔中选择性药物或流体递送的方法和系统。一个系统包括细长导管，其具有近端和远端，其间具有轴线，导管具有靠近远端的径向可扩张的气囊，靠近球囊的能量传递部分用于传递能量;热可变涂层，具有可释放的联接到气囊的药物，当可膨胀气囊膨胀时，热可变涂层被定向为抵靠身体组织，并且能量源可操作地联接到能量输送部分，其被配置为激发能量输送部分以加热和液化热变性涂层将药物释放到身体组织。

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