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1. 发明授权

US08691216B2 Methods of using regenerative cells to promote wound healing 有权
标题翻译：使用再生细胞促进伤口愈合的方法
公开(公告)号：US08691216B2
公开(公告)日：2014-04-08
申请号：US13360022
申请日：2012-01-27
申请人： John K. Fraser , Marc H. Hedrick , Eric Daniels
发明人： John K. Fraser , Marc H. Hedrick , Eric Daniels
IPC分类号： C12N5/00
CPC分类号： A61K35/28 , A61K9/0014 , A61K35/12 , A61K35/35 , A61K35/36 , A61K35/44 , A61K38/1866 , A61K45/06 , A61L15/40 , A61L15/44 , A61L27/3604 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/412 , A61L2300/64 , C12N5/0667 , C12N5/069 , C12N2506/1384 , A61K2300/00
摘要： Cells present in adipose tissue are used to promote wound healing in a patient. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the regenerative cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic benefit.
摘要翻译：存在于脂肪组织中的细胞用于促进患者的伤口愈合。治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的再生细胞输送给患者。所述方法可以在封闭系统中实施，使得再生细胞在施用于患者之前不暴露于外部环境。因此，在优选的方法中，存在于脂肪组织中的细胞与促进，产生或支持治疗益处所必需的这种添加剂一起直接放置在受体中。

2. 发明申请

US20120308536A1 METHODS OF USING ADIPOSE TISSUE-DERIVED CELLS IN AUGMENTING AUTOLOGOUS FAT TRANSFER 有权
标题翻译：使用ADIPOSE TISSUE衍生细胞进行自动脂肪转移的方法
公开(公告)号：US20120308536A1
公开(公告)日：2012-12-06
申请号：US13588989
申请日：2012-08-17
申请人： Marc H. Hedrick , John K. Fraser
发明人： Marc H. Hedrick , John K. Fraser
IPC分类号： A61K35/12 , A61P3/06 , A61P17/00 , A61P9/00 , A61P1/00
CPC分类号： A61K35/44 , A61K35/28 , A61L27/3604 , A61L27/3834 , A61L27/3886 , A61L27/54 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2430/34 , C12N5/0667 , C12N5/069 , C12N2506/1384
摘要： Methods of treating patients for conditions such as breast augmentation, soft tissue defects, and urinary incontinence, are described. The methods include removing adipose tissue from a patient, processing a portion of the adipose tissue to obtain a substantially isolated population of cells comprising disaggregated adipose-derived stem cells, mixing the concentrated population of adipose-derived cells comprising disaggregated adipose-derived cells with a portion of unprocessed, intact, non-disaggregated adipose tissue to form a composition, and administering the composition to the patient from which the adipose tissue was removed.
摘要翻译：描述了治疗患者的症状如隆胸，软组织缺损和尿失禁的方法。所述方法包括从患者中去除脂肪组织，加工脂肪组织的一部分以获得包含解聚的脂肪来源的干细胞的基本上分离的细胞群，将包含解聚的脂肪来源的细胞的浓缩的脂肪来源的细胞与未处理的，未分解的脂肪组织的部分以形成组合物，并将组合物施用于除去脂肪组织的患者。

3. 发明申请

US20120058093A1 METHODS OF USING REGENERATIVE CELLS IN THE TREATMENT OF PERIPHERAL VASCULAR DISEASE AND RELATED DISORDERS 审中-公开
公开(公告)号：US20120058093A1
公开(公告)日：2012-03-08
申请号：US13296075
申请日：2011-11-14
申请人： John K. Fraser , Marc H. Hedrick , Eric Daniels
发明人： John K. Fraser , Marc H. Hedrick , Eric Daniels
IPC分类号： A61K35/12 , A61P37/06 , A61P29/00 , A61P9/00 , A61P9/10
CPC分类号： A61K35/28 , A61K9/0019 , A61K35/44 , A61K45/06 , A61L27/3834 , A61L27/3886 , A61L2300/64 , A61L2430/00 , A61L2430/36 , C12N5/0667 , C12N5/069 , C12N2506/1384
摘要： Cells present in adipose tissue are used to treat patients, including patients with PVD and related diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic benefit.

4. 发明申请

US20110318833A1 ADIPOSE-DERIVED STEM CELLS AND LATICCES 审中-公开
公开(公告)号：US20110318833A1
公开(公告)日：2011-12-29
申请号：US13226338
申请日：2011-09-06
申请人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu
发明人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu
IPC分类号： C12N5/0775
CPC分类号： C12N5/0667 , A61K35/12 , A61K48/00 , C12N5/0068 , C12N5/06 , C12N5/0647 , C12N5/0654 , C12N5/0655 , C12N5/0658 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/01 , C12N2501/33 , C12N2501/39 , C12N2502/1305 , C12N2506/1384 , C12N2510/00 , C12N2533/90
摘要： The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.
摘要翻译：本发明提供脂肪来源的干细胞和晶格。一方面，本发明提供了一种基本上不含脂肪细胞和结缔组织干细胞的红细胞和克隆群的脂衍生的干细胞。细胞可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。此外，细胞可以扩增和培养以产生激素，并提供条件培养基以支持其他细胞群的生长和扩增。另一方面，本发明提供了一种基本上不含细胞的脂衍生晶格，其包括来自脂肪组织的细胞外基质材料。晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

5. 发明申请

US20110158968A1 METHODS OF MAKING ENHANCED, AUTOLOGOUS FAT GRAFTS 有权
公开(公告)号：US20110158968A1
公开(公告)日：2011-06-30
申请号：US13042334
申请日：2011-03-07
申请人： John K. Fraser , Marc H. Hedrick
发明人： John K. Fraser , Marc H. Hedrick
IPC分类号： A61K35/12 , A61P19/00 , A61P9/00 , A61P1/16
CPC分类号： A61K35/28 , A61B10/0283 , A61K9/0019 , A61K35/35 , A61M1/0039 , A61M2202/08 , C12M47/04 , C12N5/0667 , C12N5/069 , C12N2506/1384 , G06F19/00
摘要： Cells present in processed lipoaspirate tissue are used to treat patients. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Compositions that are administered to a patient include a mixture of adipose tissue and stem cells so that the composition has a higher concentration of stem cells than when the adipose tissue was removed from the patient.

6. 发明申请

US20110027879A1 Adipose-derived stem cells and lattices 审中-公开
标题翻译：脂肪来源的干细胞和晶格
公开(公告)号：US20110027879A1
公开(公告)日：2011-02-03
申请号：US12657722
申请日：2010-01-26
申请人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu , Patricia Zuk , Peter H. Ashjian
发明人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu , Patricia Zuk , Peter H. Ashjian
IPC分类号： C12N5/0775
CPC分类号： C12N5/0653 , A61K35/12 , A61K48/00 , C12N5/0068 , C12N5/0607 , C12N5/0647 , C12N5/0654 , C12N5/0655 , C12N5/0658 , C12N5/0667 , C12N9/1276 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/01 , C12N2501/15 , C12N2501/33 , C12N2501/39 , C12N2510/00 , C12N2533/90 , C12Y207/07049
摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.
摘要翻译：本发明单独提供脂肪来源的干细胞（ADSCs），脂肪来源的干细胞富含级分（ADSC-EF）和脂肪衍生的格子，并与本发明的ADSC组合。一方面，本发明提供了基本上不含结缔组织干细胞的脂肪细胞和红细胞和克隆群体的ADSC。 ADSC可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。另外，可以扩增和培养ADSC以产生分子如激素，并提供条件培养基以支持其它细胞群的生长和扩增。另一方面，本发明提供了一种基本上不含细胞的脂肪衍生的晶格，其包括来自脂肪组织的细胞外基质材料。晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

7. 发明申请

US20100303774A1 METHODS OF USING REGENERATIVE CELLS IN THE TREATMENT OF MUSCULOSKELETAL DISORDERS 有权
标题翻译：使用再生细胞治疗肌肉松弛症的方法
公开(公告)号：US20100303774A1
公开(公告)日：2010-12-02
申请号：US12853110
申请日：2010-08-09
申请人： Marc H. Hedrick , John K. Fraser , Susan Lynn Riley , Ronda Elizabeth Schreiber
发明人： Marc H. Hedrick , John K. Fraser , Susan Lynn Riley , Ronda Elizabeth Schreiber
IPC分类号： A61K35/12 , A61P19/02 , A61P19/04 , A61P19/08
CPC分类号： A61K35/28 , A61L27/18 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/3691 , A61L27/3834 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/40 , A61L2300/412 , A61L2300/64 , A61L2400/06 , A61L2430/02 , A61L2430/06 , A61L2430/40 , C12N5/0667
摘要： Regenerative cells present in adipose tissue are used to treat patients, including patients with musculoskeletal diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, regenerative cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic musculoskeletal benefit.
摘要翻译：存在于脂肪组织中的再生细胞用于治疗患者，包括肌肉骨骼疾病或病症的患者。治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的再生细胞输送给患者。所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。因此，在优选的方法中，存在于脂肪组织中的再生细胞与用于促进，产生或支持治疗性肌肉骨骼益处所必需的这种添加剂一起直接放置在受体中。

8. 发明授权

US07585670B2 Automated methods for isolating and using clinically safe adipose derived regenerative cells 有权
标题翻译：用于分离和使用临床安全的脂肪来源的再生细胞的自动化方法
公开(公告)号：US07585670B2
公开(公告)日：2009-09-08
申请号：US10884638
申请日：2004-07-02
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
IPC分类号： C12N5/00
CPC分类号： C12M47/04 , A61B17/00 , A61K35/28 , A61M1/00 , C12M29/04 , C12M45/00 , C12N5/0667
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译：描述了用于从多种组织分离细胞的系统和方法。特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。

9. 发明申请

US20090181456A1 Adipose-derived stem cells and lattices 审中-公开
标题翻译：脂肪来源的干细胞和晶格
公开(公告)号：US20090181456A1
公开(公告)日：2009-07-16
申请号：US12315967
申请日：2008-12-08
申请人： Marc H. Hedrick , Adam J. Katz , Ramon Lluil , J. William Futrell , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu
发明人： Marc H. Hedrick , Adam J. Katz , Ramon Lluil , J. William Futrell , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu
IPC分类号： C12N5/08
CPC分类号： C12N5/0667 , A61K35/12 , A61K48/00 , C12N5/0068 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/01 , C12N2501/15 , C12N2501/33 , C12N2501/39 , C12N2510/00 , C12N2533/90
摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.
摘要翻译：本发明单独提供脂肪来源的干细胞（ADSCs），脂肪来源的干细胞富含级分（ADSC-EF）和脂肪衍生的格子，并与本发明的ADSC组合。一方面，本发明提供了基本上不含结缔组织干细胞的脂肪细胞和红细胞和克隆群体的ADSC。 ADSC可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。另外，可以扩增和培养ADSC以产生分子如激素，并提供条件培养基以支持其它细胞群的生长和扩增。在另一方面，本发明提供了一种基本上不含细胞的脂肪衍生的晶格，其包括来自脂肪组织的细胞外基质材料。晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

10. 发明授权

US06316247B1 System and method for refining liposuctioned adipose tissue 失效
标题翻译：脂肪抽吸脂肪组织的系统和方法
公开(公告)号：US06316247B1
公开(公告)日：2001-11-13
申请号：US09333532
申请日：1999-06-15
申请人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Frank R. Walters
发明人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Frank R. Walters
IPC分类号： C07G1700
CPC分类号： A61L27/3604 , A61L27/3683
摘要： A device and method for producing refined adipose tissue for use in autologous adipose transplantation or research wherein a sterile environment is maintained. More particularly, a system for refining tissue comprising a first flexible container, a second flexible container having a plurality of pores providing for fluid communication between the interior of the first flexible container and the interior of the first enveloping flexible container, a first port that provides communication between the exterior environment and the interior of the first flexible container and thereby provides a means for introducing fluids into the interior of the first flexible container and allowing waste effluent to exit the first container, a second flexible container, a second port for inserting tissue into the second container and expressing refined tissue out of the container, and a means for controlling the opening and closing of the first and second ports. The method comprises introducing a tissue sample into the system and subjecting it to a washing phase wherein the tissue is agitated, the waste effluent is allowed to exit the system through the first port, and the refined tissue is expressed out the second port for further refinement or transplantation.
摘要翻译：用于生产用于自体脂肪移植或研究的精制脂肪组织的装置和方法，其中保持无菌环境。更具体地，涉及一种用于精制组织的系统，包括第一柔性容器，具有多个孔的第二柔性容器，所述第二柔性容器提供用于在第一柔性容器的内部与第一包封柔性容器的内部之间的流体连通;第一端口，外部环境和第一柔性容器的内部之间的连通，从而提供用于将流体引入第一柔性容器的内部并允许废物流出物离开第一容器，第二柔性容器，用于插入组织的第二端口进入第二容器并从容器中表达精制的组织，以及用于控制第一和第二端口的打开和关闭的装置。该方法包括将组织样品引入系统并使其进行洗涤阶段，其中组织被搅动，允许废物流出物通过第一端口离开系统，并且精制组织被表达出第二端口用于进一步细化或移植。

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