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1. 发明授权

US08883499B2 Systems and methods for isolating and using clinically safe adipose derived regenerative cells 有权
标题翻译：用于分离和使用临床安全的脂肪来源的再生细胞的系统和方法
公开(公告)号：US08883499B2
公开(公告)日：2014-11-11
申请号：US13452349
申请日：2012-04-20
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
IPC分类号： C12N5/00 , A61K35/28 , A61B17/00 , A61M1/00 , C12M1/00 , C12N5/0775
CPC分类号： C12M47/04 , A61B17/00 , A61K35/28 , A61M1/00 , C12M29/04 , C12M45/00 , C12N5/0667
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译：描述了用于从多种组织分离细胞的系统和方法。特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。

2. 发明授权

US07585670B2 Automated methods for isolating and using clinically safe adipose derived regenerative cells 有权
标题翻译：用于分离和使用临床安全的脂肪来源的再生细胞的自动化方法
公开(公告)号：US07585670B2
公开(公告)日：2009-09-08
申请号：US10884638
申请日：2004-07-02
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
IPC分类号： C12N5/00
CPC分类号： C12M47/04 , A61B17/00 , A61K35/28 , A61M1/00 , C12M29/04 , C12M45/00 , C12N5/0667
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译：描述了用于从多种组织分离细胞的系统和方法。特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。

3. 发明授权

US6007581A Asymmetric hip stem 失效
公开(公告)号：US6007581A
公开(公告)日：1999-12-28
申请号：US108698
申请日：1998-07-01
申请人： Philip C. Noble , Anthony K. Hedley , Michael J. Schulzki , William J. Kelly, Jr.
发明人： Philip C. Noble , Anthony K. Hedley , Michael J. Schulzki , William J. Kelly, Jr.
IPC分类号： A61F2/00 , A61F2/30 , A61F2/36 , A61F2/32
CPC分类号： A61F2/30942 , A61F2/36 , A61F2/30767 , A61F2/367 , A61F2/3672 , A61F2/3676 , A61F2002/30014 , A61F2002/30018 , A61F2002/30112 , A61F2002/30113 , A61F2002/30125 , A61F2002/30133 , A61F2002/30138 , A61F2002/30332 , A61F2002/30682 , A61F2002/30708 , A61F2002/3082 , A61F2002/30945 , A61F2002/30957 , A61F2002/3611 , A61F2002/3625 , A61F2002/365 , A61F2002/3696 , A61F2002/3698 , A61F2220/0033 , A61F2230/0004 , A61F2230/0006 , A61F2230/0008 , A61F2230/0015 , A61F2230/0017 , A61F2250/0018 , A61F2250/0029 , A61F2250/0084 , A61F2310/00029
摘要： An improved asymmetric femoral hip stem component for use in cementless hip replacement procedures is described. The stem comprises a proximal region having a novel three-dimensional configuration to allow for better fit and stability of the stem within the femoral intramedullary canal with minimal removal of strong bone therefrom. The stem further includes a twist isolated in the mid-stem region to improve fit while minimizing enlargement of the femoral canal. A distal end comprising a rotated internal slot is also described, wherein the slot reduces bending stiffness of the stem in both the coronal and sagittal planes.

4. 发明授权

US06629978B2 Valgus adapter 有权
标题翻译：高贵适配器
公开(公告)号：US06629978B2
公开(公告)日：2003-10-07
申请号：US09841548
申请日：2001-04-23
申请人： Michael J. Schulzki , Carlos E. Collazo , Kenneth Trimmer , Emilio Sanchez
发明人： Michael J. Schulzki , Carlos E. Collazo , Kenneth Trimmer , Emilio Sanchez
IPC分类号： A61F500
CPC分类号： A61B17/155
摘要： IM revision tools include a cutting guide having a coupling (preferably a male dovetail coupling), and a plurality of valgus adapters each having a mating (for example, female dovetail) coupling. According to a preferred embodiment of the invention, ten valgus adapters are provided: left and right with offsets of 0 mm, 2 mm, 4 mm, 6 mm, and 8 mm. All but the 0 mm valgus adapters are provided with dual rotational joints which allow a cutting guide to be positioned in both the anterior-posterior direction as well as in the medial-lateral direction. All but the 0 mm valgus adapters are provided with a reverse clock face below the female dovetail coupling. The methods include selecting the appropriate valgus adapter, attaching the valgus adapter to an IM stem and to the cutting guide, and inserting the IM stem into the femoral canal. If 0 mm offset adapter is not chosen, the cutting guide can be orbited 360° to position the cutting guide correctly. When the cutting guide is in position the degree of rotation can be determined by reading the reverse clock face on the valgus adapter. The reverse clock face reading can then be used to adjust the offset of the implant by setting the implant offset to the same setting.
摘要翻译： IM修订工具包括具有联接器（优选地是公头燕尾形联接件）的切割引导件和每个都具有配合（例如，雌性燕尾形）联接件的多个外翻适配器。根据本发明的优选实施例，提供了十个外翻适配器：左右偏移为0mm，2mm，4mm，6mm和8mm。除了0mm外翻适配器之外，所有外部均设置有双转动接头，允许切割引导件位于前后方向以及内侧方向上。除了0毫米外翻适配器之外，除了母型燕尾联轴器之外，还有一个反向钟表面。所述方法包括选择合适的外翻适配器，将外翻适配器连接到IM杆和切割引导件，以及将IM杆插入股管。如果没有选择0 mm偏移适配器，切割导轨可以360°摆动，以便正确定位切割导轨。当切割导轨处于适当位置时，可以通过读取外翻适配器上的反向时钟面来确定旋转度。然后可以通过将植入物偏置设置为相同的设置来使用反向时钟面部读数来调整植入物的偏移。

5. 发明授权

US5776204A Asymmetric hip stem 失效
公开(公告)号：US5776204A
公开(公告)日：1998-07-07
申请号：US653295
申请日：1996-05-24
申请人： Philip C. Noble , Anthony K. Hedley , Michael J. Schulzki , William J. Kelly, Jr.
发明人： Philip C. Noble , Anthony K. Hedley , Michael J. Schulzki , William J. Kelly, Jr.
IPC分类号： A61F2/00 , A61F2/30 , A61F2/36 , A61F2/32
CPC分类号： A61F2/30942 , A61F2/36 , A61F2/30767 , A61F2/367 , A61F2/3672 , A61F2/3676 , A61F2002/30014 , A61F2002/30018 , A61F2002/30112 , A61F2002/30113 , A61F2002/30125 , A61F2002/30133 , A61F2002/30138 , A61F2002/30332 , A61F2002/30682 , A61F2002/30708 , A61F2002/3082 , A61F2002/30945 , A61F2002/30957 , A61F2002/3611 , A61F2002/3625 , A61F2002/365 , A61F2002/3696 , A61F2002/3698 , A61F2220/0033 , A61F2230/0004 , A61F2230/0006 , A61F2230/0008 , A61F2230/0015 , A61F2230/0017 , A61F2250/0018 , A61F2250/0029 , A61F2250/0084 , A61F2310/00029
摘要： An improved asymmetric femoral hip stem component for use in cementless hip replacement procedures is described. The stem comprises a proximal region having a novel three-dimensional configuration to allow for better fit and stability of the stem within the femoral intramedullary canal with minimal removal of strong bone therefrom. The stem further includes a twist isolated in the mid-stem region to improve fit while minimizing enlargement of the femoral canal. A distal end comprising a rotated internal slot is also described, wherein the slot reduces bending stiffness of the stem in both the coronal and sagittal planes.

6. 发明申请

US20100136668A1 SYSTEMS AND METHODS FOR ISOLATING AND USING CLINICALLY SAFE ADIPOSE DERIVED REGENERATIVE CELLS 有权
标题翻译：用于分离和使用临床安全性ADIPOSE衍生的再生细胞的系统和方法
公开(公告)号：US20100136668A1
公开(公告)日：2010-06-03
申请号：US12554755
申请日：2009-09-04
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
IPC分类号： C12M1/00
CPC分类号： C12M47/04 , A61B17/00 , A61K35/28 , A61M1/00 , C12M29/04 , C12M45/00 , C12N5/0667
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译：描述了用于从多种组织分离细胞的系统和方法。特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。

7. 发明授权

US07514075B2 Systems and methods for separating and concentrating adipose derived stem cells from tissue 有权
标题翻译：从组织中分离和浓缩脂肪来源的干细胞的系统和方法
公开(公告)号：US07514075B2
公开(公告)日：2009-04-07
申请号：US10877822
申请日：2004-06-25
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Robert K. Shanahan
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Robert K. Shanahan
IPC分类号： A01N63/00
CPC分类号： A61K35/28
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译：描述了用于从多种组织分离细胞的系统和方法。特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。

8. 发明授权

US6102957A Asymmetric hip stem 失效
标题翻译：不对称髋干
公开(公告)号：US6102957A
公开(公告)日：2000-08-15
申请号：US108637
申请日：1998-07-01
申请人： Philip C. Noble , Anthony K. Hedley , Michael J. Schulzki , William J. Kelly, Jr.
发明人： Philip C. Noble , Anthony K. Hedley , Michael J. Schulzki , William J. Kelly, Jr.
IPC分类号： A61F2/00 , A61F2/30 , A61F2/36 , A61F2/32
CPC分类号： A61F2/30942 , A61F2/36 , A61F2/30767 , A61F2/367 , A61F2/3672 , A61F2/3676 , A61F2002/30014 , A61F2002/30018 , A61F2002/30112 , A61F2002/30113 , A61F2002/30125 , A61F2002/30133 , A61F2002/30138 , A61F2002/30332 , A61F2002/30682 , A61F2002/30708 , A61F2002/3082 , A61F2002/30945 , A61F2002/30957 , A61F2002/3611 , A61F2002/3625 , A61F2002/365 , A61F2002/3696 , A61F2002/3698 , A61F2220/0033 , A61F2230/0004 , A61F2230/0006 , A61F2230/0008 , A61F2230/0015 , A61F2230/0017 , A61F2250/0018 , A61F2250/0029 , A61F2250/0084 , A61F2310/00029
摘要： An improved asymmetric femoral hip stem component for use in cementless hip replacement procedures is described. The stem comprises a proximal region having a novel three-dimensional configuration to allow for better fit and stability of the stem within the femoral intramedullary canal with minimal removal of strong bone therefrom. The stem further includes a twist isolated in the mid-stem region to improve fit while minimizing enlargement of the femoral canal. A distal end comprising a rotated internal slot is also described, wherein the slot reduces bending stiffness of the stem in both the coronal and sagittal planes.
摘要翻译：描述了一种用于无骨水泥髋关节置换手术的改进的不对称股骨髋部骨干组件。茎包括具有新颖的三维构型的近端区域，以允许杆在股骨髓内管内的更好的拟合和稳定性，同时最小程度地移除强骨。茎进一步包括在中部茎区域中分离的扭曲以改善适应性，同时最小化股骨管的扩大。还描述了包括旋转的内部狭槽的远端，其中所述狭槽减小所述冠部在冠状面和矢状面中的弯曲刚度。

9. 发明授权

US5607431A Prosthetic hip implantation method and apparatus 失效
标题翻译：假体髋关节植入法及装置
公开(公告)号：US5607431A
公开(公告)日：1997-03-04
申请号：US386046
申请日：1995-02-09
申请人： Michael W. Dudasik , Matthew P. Poggie , Michael J. Schulzki
发明人： Michael W. Dudasik , Matthew P. Poggie , Michael J. Schulzki
IPC分类号： A61B17/15 , A61B17/16 , A61B17/17 , A61F2/36 , A61F2/46 , A61B17/56
CPC分类号： A61B17/164 , A61B17/15 , A61B17/1668 , A61B17/175 , A61F2/4684 , A61B17/1604 , A61F2/3662 , A61F2002/3611 , A61F2002/3625
摘要： A surgical instrument system for preparing the medullary canal of the femur for implanting a prosthetic femoral component includes a template to be used in determining osteotomy position from an x-ray. A gauge is provided to locate and mark this position on the anterior femur. A distal reamer having an elongated drive shaft is used to form the canal to receive the distal stem of the femoral component. A metaphyseal template is used to determine the proper anteversion/retroversion and a chisel is used to cut the lateral area of the femur, both of which are guided by the elongated reamer shaft. A proximal broach also guided by the reamer shaft is used to shape the proximal medullary canal.
摘要翻译：用于准备用于植入假体股骨部件的股骨髓质管的手术器械系统包括用于确定X射线截骨位置的模板。提供一个量规来定位和标记前股骨上的这个位置。使用具有细长驱动轴的远端扩孔器来形成用于接收股骨部件的远端柄的管道。干al端模板用于确定正确的前倾/逆转，并且使用凿子切割股骨的横向区域，两者均由细长的铰刀轴引导。用铰刀轴引导的近侧拉刀也用来塑造近端髓质管。

10. 发明申请

US20120264200A1 SYSTEMS AND METHODS FOR ISOLATING AND USING CLINICALLY SAFE ADIPOSE DERIVED REGENERATIVE CELLS 有权
标题翻译：用于分离和使用临床安全性ADIPOSE衍生的再生细胞的系统和方法
公开(公告)号：US20120264200A1
公开(公告)日：2012-10-18
申请号：US13452349
申请日：2012-04-20
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Rhonda Elizabeth Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Rhonda Elizabeth Schreiber , Isabella Wulur
IPC分类号： C12M1/12
CPC分类号： C12M47/04 , A61B17/00 , A61K35/28 , A61M1/00 , C12M29/04 , C12M45/00 , C12N5/0667
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译：描述了用于从多种组织分离细胞的系统和方法。特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。

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