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1. 发明授权

US6146899A Height referencing biochemical cassette 失效
标题翻译：高度参考生化胶带
公开(公告)号：US6146899A
公开(公告)日：2000-11-14
申请号：US258559
申请日：1999-02-26
申请人： Marc D. Porter , Vivian W. Jones , Curtis L. Mosher , Eric Henderson
发明人： Marc D. Porter , Vivian W. Jones , Curtis L. Mosher , Eric Henderson
IPC分类号： C40B40/06 , C40B40/10 , G01N33/543 , C12Q1/68 , G01N33/00
CPC分类号： B82Y30/00 , G01N33/54373 , B01J2219/00497 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , Y10T436/143333
摘要： A height referencing biochemical cassette comprising of a surface suitable to act as a coupling agent, a height referencing indicator, and molecules bonded to the surface. This cassette is a capable of use to test for bonding to these molecules through measuring the height difference between the indicator and the surface. This invention provides an efficient means to quickly and easily test for bonding of molecules to other molecules.
摘要翻译：包括生物化学盒的高度，其包括适合作为偶联剂的表面，高度参考指示剂和结合到表面的分子。该盒能够用于通过测量指示器和表面之间的高度差来测试与这些分子的结合。本发明提供了快速且容易地测试分子与其它分子结合的有效手段。

2. 发明授权

US5763768A Analytical method using modified scanning probes 失效
标题翻译：使用修改扫描探针的分析方法
公开(公告)号：US5763768A
公开(公告)日：1998-06-09
申请号：US819667
申请日：1997-03-17
申请人： Eric R. Henderson , Curtis L. Mosher , Vivian Wynne Jones , John-Bruce D. Green , Marc D. Porter
发明人： Eric R. Henderson , Curtis L. Mosher , Vivian Wynne Jones , John-Bruce D. Green , Marc D. Porter
IPC分类号： G01B21/30 , G01N33/543 , G01Q60/42 , G01B5/28 , G01N33/50
CPC分类号： G01Q60/42 , B82Y35/00 , G01N33/54373 , Y10S977/853
摘要： The present invention provides a method of analyzing for a specific material in a sample using a sensor including a resonating member having resonating properties. The resonating member has a probe and a known material is disposed on or forms the probe. The method includes the steps of positioning the sensor proximate to the sample, detecting a force dependent change in the resonance properties of the sensor, and confirming the presence of the specific material based on the identity of the known material and the detection of a resonance change.
摘要翻译：本发明提供一种使用包括具有谐振特性的谐振构件的传感器来分析样品中的特定材料的方法。谐振构件具有探针，已知材料设置在探针上或形成探针。该方法包括以下步骤：将传感器定位在样品附近，检测传感器的共振性质中的力相关变化，以及基于已知材料的身份和谐振变化的检测来确认特定材料的存在。

3. 发明授权

US07690325B2 Method and apparatus for depositing material onto a surface 失效
标题翻译：用于将材料沉积到表面上的方法和设备
公开(公告)号：US07690325B2
公开(公告)日：2010-04-06
申请号：US11120042
申请日：2005-04-29
申请人： Eric R. Henderson , Juntao Xu , Michael P. Lynch , Curtis L. Mosher , Janice Lillian Huff , Saju Rappai Nettikadan
发明人： Eric R. Henderson , Juntao Xu , Michael P. Lynch , Curtis L. Mosher , Janice Lillian Huff , Saju Rappai Nettikadan
IPC分类号： B05C5/00 , B05B7/06 , B05C3/00
CPC分类号： B01L3/0244 , B01J2219/00387 , B01J2219/00659 , B01L3/0248 , B01L2200/12 , B01L2200/143 , B01L2300/0816 , B01L2300/0838 , B01L2300/10 , B01L2400/02 , B01L2400/0406
摘要： Some embodiments of the present invention provide an apparatus and method in which material is deposited upon a surface from an elongated beam having an aperture defined therein through which the material is moved by passive adsorption. The elongated beam can be substantially planar along substantially its entire length, can be oriented at an acute angle with respect to the surface during deposition processes, and can have a length no greater than about 2 mm. In some embodiments, the aperture can be elongated, can extend from a material reservoir to a location short of the terminal end of the elongated beam or through the terminal end of the elongated beam, and can have a portion extending through the thickness of the elongated beam.
摘要翻译：本发明的一些实施例提供了一种装置和方法，其中材料从具有限定在其中的孔的细长梁沉积在表面上，通过该孔通过被动吸附来移动材料。细长梁基本上可以在其整个长度上基本上是平面的，在沉积过程中可以相对于表面以锐角定向，并且可以具有不大于约2mm的长度。在一些实施例中，孔可以是细长的，可以从材料储存器延伸到短于细长梁的终端的位置或者通过细长梁的终端，并且可以具有延伸穿过细长梁的厚度的部分光束。

4. 发明申请

US20090074966A1 SYSTEM AND METHOD FOR CREATING A SURFACE PATTERN 审中-公开
标题翻译：用于创建表面图案的系统和方法
公开(公告)号：US20090074966A1
公开(公告)日：2009-03-19
申请号：US11813592
申请日：2006-01-10
申请人： Eric R. Henderson , Curtis L. Mosher
发明人： Eric R. Henderson , Curtis L. Mosher
IPC分类号： B05D5/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00
摘要： Some embodiments of the disclosed surface patterning systems and methods utilize a surface patterning tool coupled to a support and adapted to deposit material onto a substrate, a controller, and first, second, and third actuators electrically coupled to and controlled by the controller. In some embodiments, the first, second, and third actuators are operable to move the substrate in X, Y, and Z directions, respectively, with respect to the surface patterning tool, wherein the substrate is movable by the first, second, and third actuators to different positions with respect to the surface patterning tool, and wherein material is transferable from the surface patterning tool to the substrate in each of the different positions to define the desired surface pattern. One or more of the actuators in some of the disclosed embodiments are piezoelectric actuators.
摘要翻译：所公开的表面图案形成系统和方法的一些实施例利用耦合到支撑件并适于将材料沉积到基板，控制器以及电耦合到控制器并由控制器控制的第一，第二和第三致动器的表面图案形成工具。在一些实施例中，第一，第二和第三致动器可操作以分别相对于表面图案形成工具在X，Y和Z方向上移动衬底，其中衬底可通过第一，第二和第三致动器相对于表面图案形成工具到不同的位置，并且其中材料可以从表面图案形成工具转移到每个不同位置中的衬底以限定所需的表面图案。一些所公开的实施例中的一个或多个致动器是压电致动器。

5. 发明授权

US06897015B2 Device and method of use for detection and characterization of pathogens and biological materials 失效
标题翻译：用于检测和表征病原体和生物材料的装置和方法
公开(公告)号：US06897015B2
公开(公告)日：2005-05-24
申请号：US10160372
申请日：2002-05-30
申请人： Eric R. Henderson , Saju R. Nettikadan , Curtis L. Mosher
发明人： Eric R. Henderson , Saju R. Nettikadan , Curtis L. Mosher
IPC分类号： B05D3/00 , C12Q1/02 , C12Q1/68 , C12Q1/70 , G01N33/552 , G01N33/553 , G01N33/554 , G01N33/569 , G01Q10/00 , G01Q30/20 , G01Q60/34 , G02B26/10
CPC分类号： G01N33/553 , G01N33/56983 , G01N2333/07 , Y10S977/853
摘要： The present invention includes a method and apparatus for the detection of a target material. The method and apparatus includes providing a substrate with a surface and forming a domains of deposited materials thereon. The deposited material can be placed on the surface and bound directly and non-specifically to the surface, or it may be specifically or non-specifically bound to the surface. The deposited material has an affinity for a specific target material. The domains thus created are termed affinity domains or deposition domains. Multiple affinity domains of deposited materials can be deposited on a single surface, creating a plurality of specific binding affinity domains for a plurality of target materials. Target materials may include, for example, pathogens or pathogenic markers such as viruses, bacteria, bacterial spores, parasites, prions, fungi, mold or pollen spores. The device thus created is incubated with a test solution, gas or other supporting environment suspected of containing one or more of the target materials. Specific binding interactions between the target materials and a particular affinity domain occurs and is detected by various methods.
摘要翻译：本发明包括用于检测目标材料的方法和装置。该方法和装置包括提供具有表面的基底并在其上形成沉积材料的区域。沉积的材料可以放置在表面上并且非特异性地结合到表面上，或者可以特异性地或非特异性地结合到表面上。沉积材料对特定靶材料具有亲和力。由此产生的结构域称为亲和结构域或沉积域。沉积材料的多个亲和性结构域可以沉积在单个表面上，为多个目标材料产生多个特异性结合亲和结构域。靶物质可包括例如病原体或致病性标志物，例如病毒，细菌，细菌孢子，寄生虫，朊病毒，真菌，霉菌或花粉孢子。将如此产生的装置与怀疑含有一种或多种目标材料的测试溶液，气体或其它支持环境一起温育。目标材料与特定亲和力域之间的特异性结合相互作用发生并通过各种方法检测。

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