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1. 发明授权

US07893177B1 Redox polymer nanoparticles 失效
标题翻译：氧化还原聚合物纳米粒子
公开(公告)号：US07893177B1
公开(公告)日：2011-02-22
申请号：US11930885
申请日：2007-10-31
申请人： Marc D. Porter , Jennifer H. Granger
发明人： Marc D. Porter , Jennifer H. Granger
IPC分类号： C08F30/04 , G01N33/547
CPC分类号： G01N33/54346 , C08G63/68 , C08J3/12 , Y10T436/13
摘要： The invention provides nanoparticles and nanoparticle conjugates comprising one or more redox-active species, methods of making nanoparticles and nanoparticle conjugates, and methods for using nanoparticles and nanoparticle conjugates, for example, as diagnostic agents for the detection of various analytes.
摘要翻译：本发明提供包含一种或多种氧化还原活性种类的纳米颗粒和纳米颗粒缀合物，制备纳米颗粒和纳米颗粒缀合物的方法，以及使用纳米颗粒和纳米颗粒缀合物的方法，例如用作检测各种分析物的诊断剂。

2. 发明授权

US07604953B2 Bioamplification for microbial sensor signal transduction 失效
标题翻译：生物扩增微生物传感器信号转导
公开(公告)号：US07604953B2
公开(公告)日：2009-10-20
申请号：US12130528
申请日：2008-05-30
申请人： Marc D. Porter , Betsy Jean Yakes , Robert J. Lipert , John P. Bannantine
发明人： Marc D. Porter , Betsy Jean Yakes , Robert J. Lipert , John P. Bannantine
IPC分类号： G01N33/53 , C12Q1/00 , A61K39/04
CPC分类号： G01N33/5695 , G01N2333/35
摘要： A process of detection of the causative agent of Johne's disease (Mycobacterium avium subsp. paratuberculosis) (MAP) by detecting shedding of surface protein of MAP. A preferred way is use of surface enhanced Raman Spectroscopy. The system of detecting MAP shedding of protein provides early detection and diagnosis, and therefore allows early treatment for Johne's disease in ruminant animals.
摘要翻译：通过检测MAP表面蛋白的脱落，检测约氏病（Mycobacterium avium subsp。paratuberculosis）（MAP）的病原体的过程。优选的方法是使用表面增强拉曼光谱。检测蛋白质的MAP脱落系统提供早期检测和诊断，因此可以在反刍动物中早期治疗约翰氏病。

3. 发明申请

US20090017562A1 RAMAN-ACTIVE REAGENTS 审中-公开
标题翻译：拉曼活性试剂
公开(公告)号：US20090017562A1
公开(公告)日：2009-01-15
申请号：US12044551
申请日：2008-03-07
申请人： Marc D. Porter , Hye-Young Park , Robert J. Lipert
发明人： Marc D. Porter , Hye-Young Park , Robert J. Lipert
IPC分类号： G01N33/544 , G01N33/543
CPC分类号： G01N33/587 , G01N33/54346
摘要： Raman Active Reagents (ERLs) are developed which use a nanoparticle substrate substantially covered with a mixed monolayer derived from a Raman active reporter molecule and an analyte binding molecule that both bind to the surface of the nanoparticle and thereby avoid the necessity for separate synthesis of a bifunctional linker molecule in making the ERL.
摘要翻译：开发拉曼活性试剂（ERL），其使用基本上覆盖有衍生自拉曼活性报道分子和分析物结合分子的混合单层的纳米颗粒底物，其均与纳米颗粒的表面结合，从而避免了单独合成双功能连接分子在制备ERL。

4. 发明授权

US06736978B1 Method and apparatus for magnetoresistive monitoring of analytes in flow streams 失效
标题翻译：流量分析物磁阻监测方法及装置
公开(公告)号：US06736978B1
公开(公告)日：2004-05-18
申请号：US10017467
申请日：2001-12-13
申请人： Marc D. Porter , Jing Ni , G. Brent Dawson , Ruth Shinar , Robert J. Lipert , Michael C. Granger , Mark Tondra
发明人： Marc D. Porter , Jing Ni , G. Brent Dawson , Ruth Shinar , Robert J. Lipert , Michael C. Granger , Mark Tondra
IPC分类号： G01N33553
CPC分类号： G01F1/708 , G01N33/54333 , Y10S436/806
摘要： Method and apparatus for manipulating and monitoring analyte flowing in fluid streams. A giant magnetoresistive sensor has an array of sensing elements that produce electrical output signals which vary in dependence on changes in the magnetic field proximate the sensing elements. The analyte is included in a stream, such that the stream has a magnetic property which is dependent on the concentration and distribution on the analyte therein. The stream is flowed past the giant magnetoresistive sensor and in sufficiently close proximity to cause the magnetic properties of the stream to produce electrical output signals. The electrical output signals are monitored as an indicator of analyte concentration or distribution in the stream flowing past the GMR sensor. Changes in the magnetic field produced by the background stream are introduced by analyte molecules, whose presence in the flow past the GMR will effect the output reading.
摘要翻译：用于操纵和监测在流体流中流动的分析物的方法和装置。巨磁阻传感器具有产生电输出信号的感测元件的阵列，该电输出信号根据感测元件附近的磁场的变化而变化。分析物被包含在流中，使得流具有取决于其上的分析物的浓度和分布的磁性。流流过巨磁电阻传感器并且足够靠近以使流的磁特性产生电输出信号。监测电输出信号作为流过GMR传感器的流中分析物浓度或分布的指标。由背景流产生的磁场的变化由分析物分子引入，其在流过GMR的流中的存在将影响输出读数。

5. 发明授权

US6146899A Height referencing biochemical cassette 失效
标题翻译：高度参考生化胶带
公开(公告)号：US6146899A
公开(公告)日：2000-11-14
申请号：US258559
申请日：1999-02-26
申请人： Marc D. Porter , Vivian W. Jones , Curtis L. Mosher , Eric Henderson
发明人： Marc D. Porter , Vivian W. Jones , Curtis L. Mosher , Eric Henderson
IPC分类号： C40B40/06 , C40B40/10 , G01N33/543 , C12Q1/68 , G01N33/00
CPC分类号： B82Y30/00 , G01N33/54373 , B01J2219/00497 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , Y10T436/143333
摘要： A height referencing biochemical cassette comprising of a surface suitable to act as a coupling agent, a height referencing indicator, and molecules bonded to the surface. This cassette is a capable of use to test for bonding to these molecules through measuring the height difference between the indicator and the surface. This invention provides an efficient means to quickly and easily test for bonding of molecules to other molecules.
摘要翻译：包括生物化学盒的高度，其包括适合作为偶联剂的表面，高度参考指示剂和结合到表面的分子。该盒能够用于通过测量指示器和表面之间的高度差来测试与这些分子的结合。本发明提供了快速且容易地测试分子与其它分子结合的有效手段。

6. 发明授权

US5763768A Analytical method using modified scanning probes 失效
标题翻译：使用修改扫描探针的分析方法
公开(公告)号：US5763768A
公开(公告)日：1998-06-09
申请号：US819667
申请日：1997-03-17
申请人： Eric R. Henderson , Curtis L. Mosher , Vivian Wynne Jones , John-Bruce D. Green , Marc D. Porter
发明人： Eric R. Henderson , Curtis L. Mosher , Vivian Wynne Jones , John-Bruce D. Green , Marc D. Porter
IPC分类号： G01B21/30 , G01N33/543 , G01Q60/42 , G01B5/28 , G01N33/50
CPC分类号： G01Q60/42 , B82Y35/00 , G01N33/54373 , Y10S977/853
摘要： The present invention provides a method of analyzing for a specific material in a sample using a sensor including a resonating member having resonating properties. The resonating member has a probe and a known material is disposed on or forms the probe. The method includes the steps of positioning the sensor proximate to the sample, detecting a force dependent change in the resonance properties of the sensor, and confirming the presence of the specific material based on the identity of the known material and the detection of a resonance change.
摘要翻译：本发明提供一种使用包括具有谐振特性的谐振构件的传感器来分析样品中的特定材料的方法。谐振构件具有探针，已知材料设置在探针上或形成探针。该方法包括以下步骤：将传感器定位在样品附近，检测传感器的共振性质中的力相关变化，以及基于已知材料的身份和谐振变化的检测来确认特定材料的存在。

7. 发明授权

US4992382A Porous polymer film calcium ion chemical sensor and method of using the same 失效
标题翻译：多孔聚合物膜钙离子化学传感器及其使用方法
公开(公告)号：US4992382A
公开(公告)日：1991-02-12
申请号：US396446
申请日：1989-08-21
申请人： Marc D. Porter , Lai-Kwan Chau
发明人： Marc D. Porter , Lai-Kwan Chau
IPC分类号： G01N31/00 , G01N31/22 , G01N33/84
CPC分类号： G01N33/84 , G01N31/22
摘要： A method of measuring calcium ions is disclosed wherein a calcium sensitive reagent, calcichrome, is immobilized on a porour polymer film. The reaction of the calcium sensitive reagent to the Ca(II) is then measured and concentration determined as a function of the reaction.
摘要翻译：公开了一种测量钙离子的方法，其中将钙敏感试剂，钙色素固定在多孔聚合物膜上。然后测量钙敏感试剂与Ca（II）的反应，并根据反应确定浓度。

8. 发明授权

US07473529B1 System and method for detecting cells or components thereof 失效
标题翻译：用于检测细胞或其组分的系统和方法
公开(公告)号：US07473529B1
公开(公告)日：2009-01-06
申请号：US11095098
申请日：2005-03-31
申请人： Marc D. Porter , Robert J. Lipert , Robert T. Doyle , Desiree S. Grubisha , Salma Rahman
发明人： Marc D. Porter , Robert J. Lipert , Robert T. Doyle , Desiree S. Grubisha , Salma Rahman
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837
摘要： A system and method for detecting a detectably labeled cell or component thereof in a sample comprising one or more cells or components thereof, at least one cell or component thereof of which is detectably labeled with at least two detectable labels. In one embodiment, the method comprises: (i) introducing the sample into one or more flow cells of a flow cytometer, (ii) irradiating the sample with one or more light sources that are absorbed by the at least two detectable labels, the absorption of which is to be detected, and (iii) detecting simultaneously the absorption of light by the at least two detectable labels on the detectably labeled cell or component thereof with an array of photomultiplier tubes, which are operably linked to two or more filters that selectively transmit detectable emissions from the at least two detectable labels.
摘要翻译：一种用于检测样品中可检测标记的细胞或其组分的系统和方法，所述样品包含一种或多种细胞或其组分，其至少一种细胞或其组分可检测地用至少两种可检测标记物标记。在一个实施方案中，该方法包括：（i）将样品引入流式细胞计数器的一个或多个流动池中，（ii）用被至少两个可检测标记吸收的一个或多个光源照射样品，将被检测到，并且（iii）同时检测由可检测标记的细胞或其组分上的至少两个可检测标记对光的吸收，其中光学倍增管阵列可操作地连接到选择性地与两个或更多个过滤器从所述至少两个可检测标记传输可检测的排放物。

9. 发明授权

US06432362B1 Chemical sensor and coating for same 失效
标题翻译：化学传感器和涂层相同
公开(公告)号：US06432362B1
公开(公告)日：2002-08-13
申请号：US09413401
申请日：1999-10-06
申请人： Ruth Shinar , Guojun Liu , Marc D. Porter
发明人： Ruth Shinar , Guojun Liu , Marc D. Porter
IPC分类号： G01N2700
CPC分类号： G01N29/022 , G01N2291/014 , G01N2291/0212 , G01N2291/0222 , G01N2291/0256 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427
摘要： An acoustic wave based-chemical sensor utilizing a crystal substrate and a coating of at least two blended materials is disclosed. The blended materials comprise a combination of (a) a high glass transition temperature polymer or a material of high melting point, and (b) a low glass transition temperature polymer or a material having a low melting point. Transducers are connected to the crystal substrate to generate an alternating potential across the crystal substrate, which in turn causes the crystal to resonate due to the converse piezoelectric effect. The blended coating absorbs the analyte, thus changing the mass of the chemical sensor, and accordingly changing its resonant frequency. The transducers detect this change in resonant frequency to indicate that the analyte is present. The use of blended materials results in a thicker coating combining the preferred properties of the blend constituents, such as improved detection sensitivities, faster response times, less acoustic wave damping, and higher operational temperature ranges.
摘要翻译：公开了一种使用晶体基底的基于声波的化学传感器和至少两种混合材料的涂层。混合材料包括（a）高玻璃化转变温度聚合物或高熔点材料的组合，和（b）低玻璃化转变温度聚合物或具有低熔点的材料。传感器连接到晶体衬底以在晶体衬底之间产生交替电位，这又导致晶体由于相反的压电效应而谐振。混合涂层吸收分析物，从而改变化学传感器的质量，从而改变其共振频率。传感器检测谐振频率的这种变化，以表明分析物存在。混合材料的使用导致较厚的涂层结合混合物组分的优选性能，例如改进的检测灵敏度，更快的响应时间，更少的声波阻尼和更高的操作温度范围。

10. 发明申请

US20110070662A1 RAMAN-ACTIVE REAGENTS AND THE USE THEREOF 审中-公开
标题翻译：拉曼活性试剂及其用途
公开(公告)号：US20110070662A1
公开(公告)日：2011-03-24
申请号：US12894810
申请日：2010-09-30
申请人： Marc D. Porter , Jing Ni , Robert J. Lipert , G. Brent Dawson
发明人： Marc D. Porter , Jing Ni , Robert J. Lipert , G. Brent Dawson
IPC分类号： G01N33/53 , G01N21/00
CPC分类号： C07H21/02 , G01N21/658 , G01N33/532 , G01N33/54373 , G01N33/553 , G01N33/58 , G01N33/587
摘要： The present invention provides a new class of Raman-active reagents for use in biological and other applications, as well as methods and kits for their use and manufacture. Each reagent includes a Raman-active reporter molecule, a binding molecule, and a surface enhancing particle capable of causing surface enhanced Raman scattering (SERS). The Raman-active reporter molecule and the binding molecule are affixed to the particle to give both a strong SERS signal and to provide biological functionality, i.e. antigen or drug recognition. The Raman-active reagents can function as an alternative to fluorescence-labeled reagents, with advantages in detection including signal stability, sensitivity, and the ability to simultaneously detect several biological materials. The Raman-active reagents also have a wide range of applications, especially in clinical fields (e.g., immunoassays, imaging, and drug screening).
摘要翻译：本发明提供用于生物和其它应用的新类型的拉曼活性试剂，以及用于其使用和制造的方法和试剂盒。每种试剂包括拉曼活性报道分子，结合分子和能够引起表面增强拉曼散射（SERS）的表面增强颗粒。拉曼活性报道分子和结合分子固定在颗粒上，以产生强的SERS信号并提供生物功能，即抗原或药物识别。拉曼活性试剂可以作为荧光标记试剂的替代品，具有检测的优点，包括信号稳定性，灵敏度和同时检测几种生物材料的能力。拉曼活性试剂也具有广泛的应用，特别是在临床领域（例如免疫测定，成像和药物筛选）中。

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