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1. 发明授权

US06897015B2 Device and method of use for detection and characterization of pathogens and biological materials 失效
标题翻译：用于检测和表征病原体和生物材料的装置和方法
公开(公告)号：US06897015B2
公开(公告)日：2005-05-24
申请号：US10160372
申请日：2002-05-30
申请人： Eric R. Henderson , Saju R. Nettikadan , Curtis L. Mosher
发明人： Eric R. Henderson , Saju R. Nettikadan , Curtis L. Mosher
IPC分类号： B05D3/00 , C12Q1/02 , C12Q1/68 , C12Q1/70 , G01N33/552 , G01N33/553 , G01N33/554 , G01N33/569 , G01Q10/00 , G01Q30/20 , G01Q60/34 , G02B26/10
CPC分类号： G01N33/553 , G01N33/56983 , G01N2333/07 , Y10S977/853
摘要： The present invention includes a method and apparatus for the detection of a target material. The method and apparatus includes providing a substrate with a surface and forming a domains of deposited materials thereon. The deposited material can be placed on the surface and bound directly and non-specifically to the surface, or it may be specifically or non-specifically bound to the surface. The deposited material has an affinity for a specific target material. The domains thus created are termed affinity domains or deposition domains. Multiple affinity domains of deposited materials can be deposited on a single surface, creating a plurality of specific binding affinity domains for a plurality of target materials. Target materials may include, for example, pathogens or pathogenic markers such as viruses, bacteria, bacterial spores, parasites, prions, fungi, mold or pollen spores. The device thus created is incubated with a test solution, gas or other supporting environment suspected of containing one or more of the target materials. Specific binding interactions between the target materials and a particular affinity domain occurs and is detected by various methods.
摘要翻译：本发明包括用于检测目标材料的方法和装置。该方法和装置包括提供具有表面的基底并在其上形成沉积材料的区域。沉积的材料可以放置在表面上并且非特异性地结合到表面上，或者可以特异性地或非特异性地结合到表面上。沉积材料对特定靶材料具有亲和力。由此产生的结构域称为亲和结构域或沉积域。沉积材料的多个亲和性结构域可以沉积在单个表面上，为多个目标材料产生多个特异性结合亲和结构域。靶物质可包括例如病原体或致病性标志物，例如病毒，细菌，细菌孢子，寄生虫，朊病毒，真菌，霉菌或花粉孢子。将如此产生的装置与怀疑含有一种或多种目标材料的测试溶液，气体或其它支持环境一起温育。目标材料与特定亲和力域之间的特异性结合相互作用发生并通过各种方法检测。

2. 发明申请

US20120309647A1 PATTERNING AND CELLULAR CO-CULTURE 审中-公开
标题翻译：文化与细胞文化
公开(公告)号：US20120309647A1
公开(公告)日：2012-12-06
申请号：US13483915
申请日：2012-05-30
申请人： John M. Collins , Saju R. Nettikadan
发明人： John M. Collins , Saju R. Nettikadan
IPC分类号： C40B50/14 , C40B40/00 , C40B30/06 , C12N5/07
CPC分类号： C12N5/0068 , C12N2502/00 , C12N2533/12 , C12N2533/52 , C12N2535/10 , G01N2500/10
摘要： Cell co-culturing methods and arrays providing versatility and high resolution. A method comprising: providing at least one substrate; providing at least one first tip with at least one first cell-adhesion material disposed thereon, and at least one second tip with at least one second cell-adhesion material disposed thereon, wherein the first cell-adhesion material is different from the second cell-adhesion material; depositing the first cell-adhesion material from the first tip to the substrate to form at least one first deposit, and depositing the second cell-adhesion material from the second tip to the substrate to form at least one second deposit; and wherein the first and second deposits are capable of providing selective binding to at least one first cell so that the first cell selectively binds to the first deposit, and wherein the second deposit is capable of binding to at least one second cell.
摘要翻译：细胞共培养方法和阵列提供多功能性和高分辨率。一种方法，包括：提供至少一个基底; 提供至少一个第一尖端，其上设置有至少一个第一细胞粘附材料，以及至少一个第二尖端，其上设置有至少一个第二细胞粘附材料，其中所述第一细胞粘附材料与所述第二细胞粘附材料不同，粘合材料; 将第一细胞粘附材料从第一末端沉积到基底以形成至少一个第一沉积物，以及将第二细胞粘附材料从第二末端沉积到基底以形成至少一个第二沉积物; 并且其中所述第一和第二沉积物能够提供与至少一个第一细胞的选择性结合，使得所述第一细胞选择性地结合所述第一沉积物，并且其中所述第二沉积物能够结合至少一个第二细胞。

3. 发明申请

US20110277193A1 SENSORS AND BIOSENSORS 审中-公开
标题翻译：传感器和生物传感器
公开(公告)号：US20110277193A1
公开(公告)日：2011-11-10
申请号：US13090827
申请日：2011-04-20
申请人： Alexander B. SMETANA , Saju R. Nettikadan
发明人： Alexander B. SMETANA , Saju R. Nettikadan
IPC分类号： G01Q70/18 , G01Q70/08
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , G01N2291/0257
摘要： Multiplexed printing and sensors for biological applications. Sensors can be made with high sensitivity and by high throughput methods. Multiple capture molecules can be applied to the same or different sensor elements such as cantilevers. The sensor element can be a microcantilever. Direct write lithography from nanoscopic tips can be used to make the sensor. Proteins and hydrogels can be printed. Specific binding can be detected.
摘要翻译：用于生物应用的多路复印和传感器。传感器可以高灵敏度和高通量方法制造。多个捕获分子可以应用于相同或不同的传感器元件，如悬臂梁。传感器元件可以是微型悬臂梁。可以使用纳米尖端的直接写入光刻来制作传感器。蛋白质和水凝胶可以印刷。可以检测到特异性结合。

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