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1. 发明授权

US07604953B2 Bioamplification for microbial sensor signal transduction 失效
标题翻译：生物扩增微生物传感器信号转导
公开(公告)号：US07604953B2
公开(公告)日：2009-10-20
申请号：US12130528
申请日：2008-05-30
申请人： Marc D. Porter , Betsy Jean Yakes , Robert J. Lipert , John P. Bannantine
发明人： Marc D. Porter , Betsy Jean Yakes , Robert J. Lipert , John P. Bannantine
IPC分类号： G01N33/53 , C12Q1/00 , A61K39/04
CPC分类号： G01N33/5695 , G01N2333/35
摘要： A process of detection of the causative agent of Johne's disease (Mycobacterium avium subsp. paratuberculosis) (MAP) by detecting shedding of surface protein of MAP. A preferred way is use of surface enhanced Raman Spectroscopy. The system of detecting MAP shedding of protein provides early detection and diagnosis, and therefore allows early treatment for Johne's disease in ruminant animals.
摘要翻译：通过检测MAP表面蛋白的脱落，检测约氏病（Mycobacterium avium subsp。paratuberculosis）（MAP）的病原体的过程。优选的方法是使用表面增强拉曼光谱。检测蛋白质的MAP脱落系统提供早期检测和诊断，因此可以在反刍动物中早期治疗约翰氏病。

2. 发明授权

US07829348B2 Raman-active reagents and the use thereof 有权
标题翻译：拉曼活性试剂及其用途
公开(公告)号：US07829348B2
公开(公告)日：2010-11-09
申请号：US10931142
申请日：2004-08-31
申请人： Marc D. Porter , Jing Ni , Robert J. Lipert , G. Brent Dawson
发明人： Marc D. Porter , Jing Ni , Robert J. Lipert , G. Brent Dawson
IPC分类号： G01N33/553
CPC分类号： C07H21/02 , G01N21/658 , G01N33/532 , G01N33/54373 , G01N33/553 , G01N33/58 , G01N33/587
摘要： The present invention provides a new class of Raman-active reagents for use in biological and other applications, as well as methods and kits for their use and manufacture. Each reagent includes a Raman-active reporter molecule, a binding molecule, and a surface enhancing particle capable of causing surface enhanced Raman scattering (SERS). The Raman-active reporter molecule and the binding molecule are affixed to the particle to give both a strong SERS signal and to provide biological functionality, i.e. antigen or drug recognition. The Raman-active reagents can function as an alternative to fluorescence-labeled reagents, with advantages in detection including signal stability, sensitivity, and the ability to simultaneously detect several biological materials. The Raman-active reagents also have a wide range of applications, especially in clinical fields (e.g., immunoassays, imaging, and drug screening).
摘要翻译：本发明提供用于生物和其它应用的新类型的拉曼活性试剂，以及用于其使用和制造的方法和试剂盒。每种试剂包括拉曼活性报道分子，结合分子和能够引起表面增强拉曼散射（SERS）的表面增强颗粒。拉曼活性报道分子和结合分子固定在颗粒上，以产生强的SERS信号并提供生物功能，即抗原或药物识别。拉曼活性试剂可以作为荧光标记试剂的替代品，具有检测的优点，包括信号稳定性，灵敏度和同时检测几种生物材料的能力。拉曼活性试剂也具有广泛的应用，特别是在临床领域（例如免疫测定，成像和药物筛选）中。

3. 发明授权

US07473529B1 System and method for detecting cells or components thereof 失效
标题翻译：用于检测细胞或其组分的系统和方法
公开(公告)号：US07473529B1
公开(公告)日：2009-01-06
申请号：US11095098
申请日：2005-03-31
申请人： Marc D. Porter , Robert J. Lipert , Robert T. Doyle , Desiree S. Grubisha , Salma Rahman
发明人： Marc D. Porter , Robert J. Lipert , Robert T. Doyle , Desiree S. Grubisha , Salma Rahman
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837
摘要： A system and method for detecting a detectably labeled cell or component thereof in a sample comprising one or more cells or components thereof, at least one cell or component thereof of which is detectably labeled with at least two detectable labels. In one embodiment, the method comprises: (i) introducing the sample into one or more flow cells of a flow cytometer, (ii) irradiating the sample with one or more light sources that are absorbed by the at least two detectable labels, the absorption of which is to be detected, and (iii) detecting simultaneously the absorption of light by the at least two detectable labels on the detectably labeled cell or component thereof with an array of photomultiplier tubes, which are operably linked to two or more filters that selectively transmit detectable emissions from the at least two detectable labels.
摘要翻译：一种用于检测样品中可检测标记的细胞或其组分的系统和方法，所述样品包含一种或多种细胞或其组分，其至少一种细胞或其组分可检测地用至少两种可检测标记物标记。在一个实施方案中，该方法包括：（i）将样品引入流式细胞计数器的一个或多个流动池中，（ii）用被至少两个可检测标记吸收的一个或多个光源照射样品，将被检测到，并且（iii）同时检测由可检测标记的细胞或其组分上的至少两个可检测标记对光的吸收，其中光学倍增管阵列可操作地连接到选择性地与两个或更多个过滤器从所述至少两个可检测标记传输可检测的排放物。

4. 发明申请

US20090017562A1 RAMAN-ACTIVE REAGENTS 审中-公开
标题翻译：拉曼活性试剂
公开(公告)号：US20090017562A1
公开(公告)日：2009-01-15
申请号：US12044551
申请日：2008-03-07
申请人： Marc D. Porter , Hye-Young Park , Robert J. Lipert
发明人： Marc D. Porter , Hye-Young Park , Robert J. Lipert
IPC分类号： G01N33/544 , G01N33/543
CPC分类号： G01N33/587 , G01N33/54346
摘要： Raman Active Reagents (ERLs) are developed which use a nanoparticle substrate substantially covered with a mixed monolayer derived from a Raman active reporter molecule and an analyte binding molecule that both bind to the surface of the nanoparticle and thereby avoid the necessity for separate synthesis of a bifunctional linker molecule in making the ERL.
摘要翻译：开发拉曼活性试剂（ERL），其使用基本上覆盖有衍生自拉曼活性报道分子和分析物结合分子的混合单层的纳米颗粒底物，其均与纳米颗粒的表面结合，从而避免了单独合成双功能连接分子在制备ERL。

5. 发明授权

US06736978B1 Method and apparatus for magnetoresistive monitoring of analytes in flow streams 失效
标题翻译：流量分析物磁阻监测方法及装置
公开(公告)号：US06736978B1
公开(公告)日：2004-05-18
申请号：US10017467
申请日：2001-12-13
申请人： Marc D. Porter , Jing Ni , G. Brent Dawson , Ruth Shinar , Robert J. Lipert , Michael C. Granger , Mark Tondra
发明人： Marc D. Porter , Jing Ni , G. Brent Dawson , Ruth Shinar , Robert J. Lipert , Michael C. Granger , Mark Tondra
IPC分类号： G01N33553
CPC分类号： G01F1/708 , G01N33/54333 , Y10S436/806
摘要： Method and apparatus for manipulating and monitoring analyte flowing in fluid streams. A giant magnetoresistive sensor has an array of sensing elements that produce electrical output signals which vary in dependence on changes in the magnetic field proximate the sensing elements. The analyte is included in a stream, such that the stream has a magnetic property which is dependent on the concentration and distribution on the analyte therein. The stream is flowed past the giant magnetoresistive sensor and in sufficiently close proximity to cause the magnetic properties of the stream to produce electrical output signals. The electrical output signals are monitored as an indicator of analyte concentration or distribution in the stream flowing past the GMR sensor. Changes in the magnetic field produced by the background stream are introduced by analyte molecules, whose presence in the flow past the GMR will effect the output reading.
摘要翻译：用于操纵和监测在流体流中流动的分析物的方法和装置。巨磁阻传感器具有产生电输出信号的感测元件的阵列，该电输出信号根据感测元件附近的磁场的变化而变化。分析物被包含在流中，使得流具有取决于其上的分析物的浓度和分布的磁性。流流过巨磁电阻传感器并且足够靠近以使流的磁特性产生电输出信号。监测电输出信号作为流过GMR传感器的流中分析物浓度或分布的指标。由背景流产生的磁场的变化由分析物分子引入，其在流过GMR的流中的存在将影响输出读数。

6. 发明申请

US20110070662A1 RAMAN-ACTIVE REAGENTS AND THE USE THEREOF 审中-公开
标题翻译：拉曼活性试剂及其用途
公开(公告)号：US20110070662A1
公开(公告)日：2011-03-24
申请号：US12894810
申请日：2010-09-30
申请人： Marc D. Porter , Jing Ni , Robert J. Lipert , G. Brent Dawson
发明人： Marc D. Porter , Jing Ni , Robert J. Lipert , G. Brent Dawson
IPC分类号： G01N33/53 , G01N21/00
CPC分类号： C07H21/02 , G01N21/658 , G01N33/532 , G01N33/54373 , G01N33/553 , G01N33/58 , G01N33/587
摘要： The present invention provides a new class of Raman-active reagents for use in biological and other applications, as well as methods and kits for their use and manufacture. Each reagent includes a Raman-active reporter molecule, a binding molecule, and a surface enhancing particle capable of causing surface enhanced Raman scattering (SERS). The Raman-active reporter molecule and the binding molecule are affixed to the particle to give both a strong SERS signal and to provide biological functionality, i.e. antigen or drug recognition. The Raman-active reagents can function as an alternative to fluorescence-labeled reagents, with advantages in detection including signal stability, sensitivity, and the ability to simultaneously detect several biological materials. The Raman-active reagents also have a wide range of applications, especially in clinical fields (e.g., immunoassays, imaging, and drug screening).
摘要翻译：本发明提供用于生物和其它应用的新类型的拉曼活性试剂，以及用于其使用和制造的方法和试剂盒。每种试剂包括拉曼活性报道分子，结合分子和能够引起表面增强拉曼散射（SERS）的表面增强颗粒。拉曼活性报道分子和结合分子固定在颗粒上，以产生强的SERS信号并提供生物功能，即抗原或药物识别。拉曼活性试剂可以作为荧光标记试剂的替代品，具有检测的优点，包括信号稳定性，灵敏度和同时检测几种生物材料的能力。拉曼活性试剂也具有广泛的应用，特别是在临床领域（例如免疫测定，成像和药物筛选）中。

7. 发明授权

US07824926B1 Raman-active reagents and the use thereof 失效
公开(公告)号：US07824926B1
公开(公告)日：2010-11-02
申请号：US09961628
申请日：2001-09-24
申请人： Marc D. Porter , Jing Ni , Robert J. Lipert , G. Brent Dawson
发明人： Marc D. Porter , Jing Ni , Robert J. Lipert , G. Brent Dawson
IPC分类号： G01N33/553
CPC分类号： G01N33/553 , G01N21/658 , G01N33/54373 , G01N33/587 , Y10T436/24
摘要： The present invention provides a new class of Raman-active reagents for use in biological and other applications, as well as methods and kits for their use and manufacture. Each reagent includes a Raman-active reporter molecule, a binding molecule, and a surface enhancing particle capable of causing surface enhanced Raman scattering (SERS). The Raman-active reporter molecule and the binding molecule are affixed to the particle to give both a strong SERS signal and to provide biological functionality, i.e. antigen or drug recognition. The Raman-active reagents can function as an alternative to fluorescence-labeled reagents, with advantages in detection including signal stability, sensitivity, and the ability to simultaneously detect several biological materials. The Raman-active reagents also have a wide range of applications, especially in clinical fields (e.g., immunoassays, imaging, and drug screening).

8. 发明授权

US5307146A Dual-wavelength photometer and fiber optic sensor probe 失效
标题翻译：双波长光度计和光纤传感器探头
公开(公告)号：US5307146A
公开(公告)日：1994-04-26
申请号：US962394
申请日：1992-10-16
申请人： Marc D. Porter , Thomas P. Jones , Shelley J. Coldiron
发明人： Marc D. Porter , Thomas P. Jones , Shelley J. Coldiron
IPC分类号： G01N21/27 , G01J1/16 , G01N21/31 , G01N21/77 , G01N21/80 , G01J3/427
CPC分类号： G01N21/7703 , G01J2001/1636 , G01N2021/3181 , G01N2021/772 , G01N21/80 , G01N2201/062 , G01N2201/084 , G01N2201/0866
摘要： A dual wavelength optical sensor for measuring chemical properties of a particular quantity, the optical sensor including a sensor probe having a thin sensing film whose optical characteristics are responsive to the chemical properties of the measured quantityThe United States Government has certain rights in this invention pursuant to Contract No. ITA87-02 between the U.S. Department of Commerce and Iowa State University.
摘要翻译：一种用于测量特定量的化学性质的双波长光学传感器，所述光学传感器包括具有薄的感测膜的传感器探针，所述传感器探针的光学特性响应于所述测量量在至少两个不同波长的光的化学特性当对至少两个不同波长的响应进行组合时，提供了测量的化学性质的自校准测量。光源产生至少两个不同波长的光，并且单个光纤将来自光源的光传送到传感器探针。样品检测器在传感器探头经过薄膜感测膜并从薄膜传感器接收来自传感器探针的光，并产生至少两个不同波长的光的光强度读数。光学传感器还包括用于组合来自样本检测器的光强度读数的信号处理系统，以产生自校准的测量，其考虑到薄传感膜的光学特性的变化，否则这将有助于传感器响应中的不稳定性。

9. 发明授权

US06432362B1 Chemical sensor and coating for same 失效
标题翻译：化学传感器和涂层相同
公开(公告)号：US06432362B1
公开(公告)日：2002-08-13
申请号：US09413401
申请日：1999-10-06
申请人： Ruth Shinar , Guojun Liu , Marc D. Porter
发明人： Ruth Shinar , Guojun Liu , Marc D. Porter
IPC分类号： G01N2700
CPC分类号： G01N29/022 , G01N2291/014 , G01N2291/0212 , G01N2291/0222 , G01N2291/0256 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427
摘要： An acoustic wave based-chemical sensor utilizing a crystal substrate and a coating of at least two blended materials is disclosed. The blended materials comprise a combination of (a) a high glass transition temperature polymer or a material of high melting point, and (b) a low glass transition temperature polymer or a material having a low melting point. Transducers are connected to the crystal substrate to generate an alternating potential across the crystal substrate, which in turn causes the crystal to resonate due to the converse piezoelectric effect. The blended coating absorbs the analyte, thus changing the mass of the chemical sensor, and accordingly changing its resonant frequency. The transducers detect this change in resonant frequency to indicate that the analyte is present. The use of blended materials results in a thicker coating combining the preferred properties of the blend constituents, such as improved detection sensitivities, faster response times, less acoustic wave damping, and higher operational temperature ranges.
摘要翻译：公开了一种使用晶体基底的基于声波的化学传感器和至少两种混合材料的涂层。混合材料包括（a）高玻璃化转变温度聚合物或高熔点材料的组合，和（b）低玻璃化转变温度聚合物或具有低熔点的材料。传感器连接到晶体衬底以在晶体衬底之间产生交替电位，这又导致晶体由于相反的压电效应而谐振。混合涂层吸收分析物，从而改变化学传感器的质量，从而改变其共振频率。传感器检测谐振频率的这种变化，以表明分析物存在。混合材料的使用导致较厚的涂层结合混合物组分的优选性能，例如改进的检测灵敏度，更快的响应时间，更少的声波阻尼和更高的操作温度范围。

10. 发明授权

US06237397B1 Chemical sensor and coating for same 失效
标题翻译：化学传感器和涂层相同
公开(公告)号：US06237397B1
公开(公告)日：2001-05-29
申请号：US09413628
申请日：1999-10-06
申请人： Ruth Shinar , Guojun Liu , Marc D. Porter
发明人： Ruth Shinar , Guojun Liu , Marc D. Porter
IPC分类号： G01N2902
CPC分类号： G01N29/022 , G01N2291/014 , G01N2291/0256 , G01N2291/02863 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427
摘要： An acoustic wave based-chemical sensor containing a crystal substrate and a coating of small particulate matter is disclosed. The small particulate matter can be graphite particles. Transducers are connected to the crystal substrate to generate an alternating potential across the crystal substrate, which in turn causes the crystal to resonate due to the converse piezoelectric effect. The coating absorbs the analyte, thus changing the mass of the sensor, and accordingly changing its resonant frequency. The transducers detect this change in resonant frequency to indicate that the analyte is present. The use of small particulate matter results in a coating having a large surface area which facilitates mass uptake of large amounts of VOCs, improved acoustic properties even with relatively thick coatings, and a high operational temperature range.
摘要翻译：公开了一种包含晶体衬底和小颗粒物质涂层的基于声波的化学传感器。小颗粒物可以是石墨颗粒。传感器连接到晶体衬底以在晶体衬底之间产生交替电位，这又导致晶体由于相反的压电效应而谐振。涂层吸收分析物，从而改变传感器的质量，从而改变其共振频率。传感器检测谐振频率的这种变化，以表明分析物存在。使用小的颗粒物质可形成具有大表面积的涂层，其有利于大量挥发性有机物的吸收，甚至在相对较厚的涂层和较高的操作温度范围内也改善了声学性能。

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