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1. 发明授权

US06558940B2 Streptomyces strain with potential anti-microbial activity against phytopathogenic fungi 失效
标题翻译：链霉菌菌株对植物病原真菌具有潜在的抗微生物活性
公开(公告)号：US06558940B2
公开(公告)日：2003-05-06
申请号：US09538456
申请日：2000-03-30
申请人： Mansoor Alam , Abdul Sattar , Sushil Kumar , Abdul Samad , Om Prakash Dhawan , Suman Preet Singh Khanuja , Ajit Kumar Shasany , Seema Singh , Poovappallivadakethil Viswanathan Nair Ajaya Kumar , Abdul Khaliq , Mohammad Zaim , Saba Shahabuddin , Mala Trivedi
发明人： Mansoor Alam , Abdul Sattar , Sushil Kumar , Abdul Samad , Om Prakash Dhawan , Suman Preet Singh Khanuja , Ajit Kumar Shasany , Seema Singh , Poovappallivadakethil Viswanathan Nair Ajaya Kumar , Abdul Khaliq , Mohammad Zaim , Saba Shahabuddin , Mala Trivedi
IPC分类号： C12N100
CPC分类号： C12R1/465 , C12N1/20
摘要： The present invention relates to a new strain of Streptomyces sp., called CIMAP A1 isolated from the soil of geranium (Pelargonium graveolens) planted in the experimental fields of CIMAP and having the accession No. ATCC PTA-4131 and capable of inhibiting the growth of phytopathogenic fungi.
摘要翻译：本发明涉及从CIMAP的实验领域种植的具有登录号ATCC PTA-4131并能够抑制生长的天竺葵（Pelargonium graveolens）土壤中分离出的称为CIMAP A1的新型链霉菌属菌株植物病原真菌

2. 发明申请

US20190062293A1 METAL-ORGANIC FRAMEWORKS FOR THE CONVERSION OF LIGNOCELLULOSIC DERIVATIVES TO RENEWABLE PLATFORM CHEMICALS 审中-公开
公开(公告)号：US20190062293A1
公开(公告)日：2019-02-28
申请号：US15539122
申请日：2015-12-17
申请人： Noppadon Sathitsuksanoh , Mark D. Allendorf , Anthe George , Robert Jansen , Kirsty Leong , Blake A. Simmons , Seema Singh , Philip Travisano, III
发明人： Noppadon Sathitsuksanoh , Mark D. Allendorf , Anthe George , Robert Jansen , Kirsty Leong , Blake A. Simmons , Seema Singh , Philip Travisano, III
IPC分类号： C07D307/50 , B01J31/16
摘要： Methods of processing lignocellulose using metal-organic frameworks (MOFs) to form renewable platform chemicals that may be used as initial feedstock are provided. Metal-organic frameworks react with Provide lignocellulosic derivative lignocellulosic derivatives such as glucose and fructose to form 5-hydroxymethyl furfural (HMF) with high yield and high selectivity for FIMF production.

3. 发明申请

US20130183739A1 Mixed Feedstocks Processing Using an Ionic Liquid 审中-公开
标题翻译：使用离子液体加工的混合原料
公开(公告)号：US20130183739A1
公开(公告)日：2013-07-18
申请号：US13550437
申请日：2012-07-16
申请人： Seema Singh , Rohit Arora , Chenlin Li , Ian P. Mathews , Blake A. Simmons
发明人： Seema Singh , Rohit Arora , Chenlin Li , Ian P. Mathews , Blake A. Simmons
IPC分类号： C08B37/00
CPC分类号： C08B37/0003 , C08L97/02 , C12P19/02 , C12P2201/00 , C12P2203/00 , C13K1/02 , C13K13/002 , C13K13/007
摘要： The present invention provides for a composition comprising two or more feedstocks and an ionic liquid (IL). The present invention also provides for a method for treating feedstocks, comprising providing a composition of the present invention comprising two or more feedstocks and an ionic liquid (IL).
摘要翻译：本发明提供包含两种或多种原料和离子液体（IL）的组合物。本发明还提供了一种用于处理原料的方法，其包括提供包含两种或多种原料和离子液体（IL）的本发明组合物。

4. 发明申请

US20140045920A1 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS, CLASSIFICATION, AND TREATMENT OF CANCER 有权
标题翻译：癌症诊断，分类和治疗的方法和组成
公开(公告)号：US20140045920A1
公开(公告)日：2014-02-13
申请号：US14007938
申请日：2012-03-30
申请人： Ajay Pratap Singh , Sanjeev Srivastava , Seema Singh
发明人： Ajay Pratap Singh , Sanjeev Srivastava , Seema Singh
IPC分类号： C12N15/113 , G01N33/50 , C12Q1/68
CPC分类号： C12N15/1135 , A61K31/337 , A61K31/713 , C12N15/113 , C12N2310/11 , C12N2310/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/31 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/5011 , G01N33/57434 , G01N33/57438 , G01N33/5748 , G01N2333/47
摘要： Some embodiments of the present technology relate to methods and compositions for the diagnosis and treatment of cancer. Some embodiments include methods and compositions for the diagnosis and treatment of castration-resistant prostate cancer. Some embodiments include methods and compositions for the diagnosis and treatment of pancreatic cancer.
摘要翻译：本技术的一些实施方案涉及用于诊断和治疗癌症的方法和组合物。一些实施方案包括用于诊断和治疗去势抗性前列腺癌的方法和组合物。一些实施方案包括用于诊断和治疗胰腺癌的方法和组合物。

5. 发明申请

US20130281423A1 METHODS AND COMPOSITIONS FOR AMELIORATING PANCREATIC CANCER 有权
标题翻译：用于治疗胰腺癌的方法和组合物
公开(公告)号：US20130281423A1
公开(公告)日：2013-10-24
申请号：US13881695
申请日：2011-10-25
申请人： Seema Singh , Ajay P. Singh
发明人： Seema Singh , Ajay P. Singh
IPC分类号： G01N33/50 , A61K31/395
CPC分类号： A61K31/395 , A61K31/7088 , A61K31/7105 , C12N15/1138 , C12N2310/14 , G01N33/502
摘要： Embodiments of the present invention include methods and compositions for ameliorating cancer. Some embodiments include methods and compositions for ameliorating pancreatic cancer targeting the CXCR4 receptor and the CXCL12 ligand.
摘要翻译：本发明的实施方案包括用于改善癌症的方法和组合物。一些实施方案包括用于改善靶向CXCR4受体和CXCL12配体的胰腺癌的方法和组合物。

6. 发明申请

US20120225797A1 MULTIPLEXED SCREENING OF ENZYME ACTIVITIES USING NANOSTRUCTURE-INITIATOR MASS SPECTROMETRY 审中-公开
标题翻译：使用纳米结构发射体质谱测定酶活性的多重筛选
公开(公告)号：US20120225797A1
公开(公告)日：2012-09-06
申请号：US13363695
申请日：2012-02-01
申请人： Trent R. Northen , Wolfgang E. Reindl , Kai Deng , Seema Singh , Anup K. Singh
发明人： Trent R. Northen , Wolfgang E. Reindl , Kai Deng , Seema Singh , Anup K. Singh
IPC分类号： C40B30/08 , C40B40/04
CPC分类号： C12Q1/00 , B82Y30/00 , G01N2560/00
摘要： Disclosed herein are methods, compositions and systems for analyzing and detecting enzyme activity. For examples, methods, compositions and systems for parallel detection and analysis of enzymatic activities of enzymes in complex biological mixtures are provided.
摘要翻译：本文公开了用于分析和检测酶活性的方法，组合物和系统。例如，提供了用于平行检测和分析复杂生物混合物中的酶的酶活性的方法，组合物和系统。

7. 发明授权

US10240180B2 Multiplexed screening of enzyme activities using nanostructure-initiator mass spectrometry 有权
公开(公告)号：US10240180B2
公开(公告)日：2019-03-26
申请号：US13363695
申请日：2012-02-01
申请人： Trent R. Northen , Wolfgang E. Reindl , Kai Deng , Seema Singh , Anup K. Singh , Xiaoliang Cheng
发明人： Trent R. Northen , Wolfgang E. Reindl , Kai Deng , Seema Singh , Anup K. Singh , Xiaoliang Cheng
IPC分类号： C40B30/10 , C40B20/04 , C40B20/08 , C12Q1/00 , B82Y30/00 , C40B40/04
摘要： Disclosed herein are methods, compositions and systems for analyzing and detecting enzyme activity. For examples, methods, compositions and systems for parallel detection and analysis of enzymatic activities of enzymes in complex biological mixtures are provided.

8. 发明授权

US09267934B2 Methods and compositions for ameliorating pancreatic cancer 有权
标题翻译：改善胰腺癌的方法和组合物
公开(公告)号：US09267934B2
公开(公告)日：2016-02-23
申请号：US13881695
申请日：2011-10-25
申请人： Seema Singh , Ajay P. Singh
发明人： Seema Singh , Ajay P. Singh
IPC分类号： A61K31/395 , G01N33/50 , A61K31/7088 , A61K31/7105
CPC分类号： A61K31/395 , A61K31/7088 , A61K31/7105 , C12N15/1138 , C12N2310/14 , G01N33/502
摘要： Embodiments of the present invention include methods and compositions for ameliorating cancer. Some embodiments include methods and compositions for ameliorating pancreatic cancer targeting the CXCR4 receptor and the CXCL12 ligand.
摘要翻译：本发明的实施方案包括用于改善癌症的方法和组合物。一些实施方案包括用于改善靶向CXCR4受体和CXCL12配体的胰腺癌的方法和组合物。

9. 发明授权

US09458456B2 Methods and compositions for the diagnosis, classification, and treatment of cancer 有权
标题翻译：用于诊断，分类和治疗癌症的方法和组合物
公开(公告)号：US09458456B2
公开(公告)日：2016-10-04
申请号：US14007938
申请日：2012-03-30
申请人： Ajay Pratap Singh , Sanjeev Srivastava , Seema Singh
发明人： Ajay Pratap Singh , Sanjeev Srivastava , Seema Singh
IPC分类号： C12N15/113 , C12Q1/68 , G01N33/574 , G01N33/50
CPC分类号： C12N15/1135 , A61K31/337 , A61K31/713 , C12N15/113 , C12N2310/11 , C12N2310/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/31 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/5011 , G01N33/57434 , G01N33/57438 , G01N33/5748 , G01N2333/47
摘要： Some embodiments of the present technology relate to methods and compositions for the diagnosis and treatment of cancer. Some embodiments include methods and compositions for the diagnosis and treatment of castration-resistant prostate cancer. Some embodiments include methods and compositions for the diagnosis and treatment of pancreatic cancer.
摘要翻译：本技术的一些实施方案涉及用于诊断和治疗癌症的方法和组合物。一些实施方案包括用于诊断和治疗去势抗性前列腺癌的方法和组合物。一些实施方案包括用于诊断和治疗胰腺癌的方法和组合物。

10. 发明授权

US08481974B1 Apparatus and method for measuring single cell and sub-cellular photosynthetic efficiency 有权
标题翻译：用于测量单细胞和亚细胞光合效率的装置和方法
公开(公告)号：US08481974B1
公开(公告)日：2013-07-09
申请号：US13233343
申请日：2011-09-15
申请人： Ryan Wesley Davis , Seema Singh , Huawen Wu
发明人： Ryan Wesley Davis , Seema Singh , Huawen Wu
IPC分类号： G01J1/58 , G01N21/64
CPC分类号： G01N21/6428 , G01J1/58 , G01N21/6408 , G01N2021/635 , G01N2021/6419 , G01N2021/6421
摘要： Devices for measuring single cell changes in photosynthetic efficiency in algal aquaculture are disclosed that include a combination of modulated LED trans-illumination of different intensities with synchronized through objective laser illumination and confocal detection. Synchronization and intensity modulation of a dual illumination scheme were provided using a custom microcontroller for a laser beam block and constant current LED driver. Therefore, single whole cell photosynthetic efficiency, and subcellular (diffraction limited) photosynthetic efficiency measurement modes are permitted. Wide field rapid light scanning actinic illumination is provided for both by an intensity modulated 470 nm LED. For the whole cell photosynthetic efficiency measurement, the same LED provides saturating pulses for generating photosynthetic induction curves. For the subcellular photosynthetic efficiency measurement, a switched through objective 488 nm laser provides saturating pulses for generating photosynthetic induction curves. A second near IR LED is employed to generate dark adapted states in the system under study.
摘要翻译：公开了用于测量藻类水产养殖光合效率的单细胞变化的装置，其包括具有同步通过目标激光照明和共聚焦检测的不同强度的调制LED反照相的组合。使用用于激光束块和恒流LED驱动器的定制微控制器提供双照明方案的同步和强度调制。因此，允许单个全细胞光合效率和亚细胞（衍射限制）光合效率测量模式。通过强度调制的470nm LED为两者提供宽场快速光扫描光化照明。对于整个细胞光合效率测量，相同的LED提供饱和脉冲以产生光合诱导曲线。对于亚细胞光合效率测量，切换目标488nm激光器提供用于产生光合诱导曲线的饱和脉冲。第二个近红外LED用于在被研究的系统中产生暗适应状态。

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