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1. 发明申请

US20120225797A1 MULTIPLEXED SCREENING OF ENZYME ACTIVITIES USING NANOSTRUCTURE-INITIATOR MASS SPECTROMETRY 审中-公开
标题翻译：使用纳米结构发射体质谱测定酶活性的多重筛选
公开(公告)号：US20120225797A1
公开(公告)日：2012-09-06
申请号：US13363695
申请日：2012-02-01
申请人： Trent R. Northen , Wolfgang E. Reindl , Kai Deng , Seema Singh , Anup K. Singh
发明人： Trent R. Northen , Wolfgang E. Reindl , Kai Deng , Seema Singh , Anup K. Singh
IPC分类号： C40B30/08 , C40B40/04
CPC分类号： C12Q1/00 , B82Y30/00 , G01N2560/00
摘要： Disclosed herein are methods, compositions and systems for analyzing and detecting enzyme activity. For examples, methods, compositions and systems for parallel detection and analysis of enzymatic activities of enzymes in complex biological mixtures are provided.
摘要翻译：本文公开了用于分析和检测酶活性的方法，组合物和系统。例如，提供了用于平行检测和分析复杂生物混合物中的酶的酶活性的方法，组合物和系统。

2. 外观设计

USD435084S Water filter 失效
公开(公告)号：USD435084S
公开(公告)日：2000-12-12
申请号：US115027
申请日：1999-12-06
申请人： Trent R. Northen , Robert W. Flagler , Alan D. Ball , George H. F. Schnakenberg, III
设计人： Trent R. Northen , Robert W. Flagler , Alan D. Ball , George H. F. Schnakenberg, III

3. 发明授权

US10386371B2 Metabolic flux measurement, imaging and microscopy 有权
公开(公告)号：US10386371B2
公开(公告)日：2019-08-20
申请号：US14343334
申请日：2012-09-07
申请人： Benjamin P. Bowen , Katherine B. Louie , Trent R. Northen , Marc K. Hellerstein
发明人： Benjamin P. Bowen , Katherine B. Louie , Trent R. Northen , Marc K. Hellerstein
IPC分类号： G01N33/58 , G16B20/00 , G01N33/68
摘要： Provided herein are methods for measuring molecular flux rates of molecules of interest in a tissue sample in spatially-organized manner and generating output (e.g., an image, a heat map, a contour map, a table or a database) representing the molecular flux rates of each spatially-defined location of the sample. Provided herein are also the output, as well as systems and computer-readable medium with computer-executable instructions for determining molecular flux rates of molecules of interest in the sample.

4. 发明授权

US10240180B2 Multiplexed screening of enzyme activities using nanostructure-initiator mass spectrometry 有权
公开(公告)号：US10240180B2
公开(公告)日：2019-03-26
申请号：US13363695
申请日：2012-02-01
申请人： Trent R. Northen , Wolfgang E. Reindl , Kai Deng , Seema Singh , Anup K. Singh , Xiaoliang Cheng
发明人： Trent R. Northen , Wolfgang E. Reindl , Kai Deng , Seema Singh , Anup K. Singh , Xiaoliang Cheng
IPC分类号： C40B30/10 , C40B20/04 , C40B20/08 , C12Q1/00 , B82Y30/00 , C40B40/04
摘要： Disclosed herein are methods, compositions and systems for analyzing and detecting enzyme activity. For examples, methods, compositions and systems for parallel detection and analysis of enzymatic activities of enzymes in complex biological mixtures are provided.

5. 发明授权

US09082600B1 Mass spectrometry methods and apparatus 有权
标题翻译：质谱法和仪器
公开(公告)号：US09082600B1
公开(公告)日：2015-07-14
申请号：US14153078
申请日：2014-01-13
申请人： Matthew Paul Greving , Trent R. Northen
发明人： Matthew Paul Greving , Trent R. Northen
IPC分类号： H01J49/02 , B65B5/04 , B01L3/00 , H01J49/04
CPC分类号： H01J49/02 , B01J2219/00315 , B01J2219/00612 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01L3/5085 , B01L3/5088 , B01L9/523 , B01L2200/141 , B01L2200/185 , B01L2300/041 , B01L2300/0819 , B01L2300/105 , B65B5/04 , C40B60/12 , H01J49/0418
摘要： Methods, apparatus, compositions, systems, and articles of manufacture useful in connection with performing offsite mass spectrometric (MS) analysis of samples are disclosed. In embodiments, library samples are arrayed on MS substrates in a blinded fashion and stability-packaged for transport to an off-site location where the MS substrate is de-packaged and MS analysis is performed, enabling off-site MS analysis without requiring transport of the sample library and without compromising the confidentiality of the library contents.
摘要翻译：公开了与进行样品的异地质谱（MS）分析有关的方法，装置，组合物，系统和制品。在实施方案中，将文库样品以无限制的方式排列在MS底物上，并稳定包装以便运输到MS基底被去包装和进行MS分析的非现场位置，从而实现异地MS分析，而不需要运输样本库，不影响图书馆内容的保密性。

6. 外观设计

USD437027S1 Water filter reservoir 失效
标题翻译：滤水池
公开(公告)号：USD437027S1
公开(公告)日：2001-01-30
申请号：US29115026
申请日：1999-12-06
申请人： Robert W. Flagler , Trent R. Northen , Alan D. Ball , George H. F. Schnakenberg, III
设计人： Robert W. Flagler , Trent R. Northen , Alan D. Ball , George H. F. Schnakenberg, III

7. 发明授权

US09460904B1 Methods, apparatus, and compositions for mass spectrometry 有权
标题翻译：用于质谱的方法，装置和组合物
公开(公告)号：US09460904B1
公开(公告)日：2016-10-04
申请号：US14628287
申请日：2015-02-22
申请人： Matthew Paul Greving , Trent R. Northen
发明人： Matthew Paul Greving , Trent R. Northen
IPC分类号： H01J49/00 , H01J49/04
CPC分类号： H01J49/0409 , B01J2219/00315 , B01J2219/00612 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01L3/5085 , B01L3/5088 , B01L9/523 , B01L2200/141 , B01L2200/185 , B01L2300/041 , B01L2300/0819 , B01L2300/105 , C40B60/12 , H01J49/0418
摘要： Methods, apparatus, compositions, systems, and articles of manufacture useful in connection with performing offsite mass spectrometric (MS) analysis of samples are disclosed. In embodiments, library samples are arrayed on MS substrates in a blinded fashion and stability-packaged for transport to an off-site location where the MS substrate is de-packaged and MS analysis is performed, enabling off-site MS analysis without requiring transport of the sample library and without compromising the confidentiality of the library contents. Also disclosed are embodiments relating to substrates for desorbing and ionizing analytes, including kits and methods of use thereof.
摘要翻译：公开了与进行样品的异地质谱（MS）分析有关的方法，装置，组合物，系统和制品。在实施方案中，将文库样品以无限制的方式排列在MS底物上，并稳定包装以便运输到MS基底被去包装和进行MS分析的非现场位置，从而实现异地MS分析，而不需要运输样本库，不影响图书馆内容的保密性。还公开了涉及用于解吸和离子化分析物的底物的实施方案，包括试剂盒及其使用方法。

8. 发明申请

US20140329274A1 METABOLIC FLUX MEASUREMENT, IMAGING AND MICROSCOPY 审中-公开
标题翻译：代用通量测量，成像和显微镜
公开(公告)号：US20140329274A1
公开(公告)日：2014-11-06
申请号：US14343334
申请日：2012-09-07
申请人： Benjamin P. Bowen , Katherine B. Louie , Trent R. Northen , Marc K. Hellerstein
发明人： Benjamin P. Bowen , Katherine B. Louie , Trent R. Northen , Marc K. Hellerstein
IPC分类号： G01N33/58
CPC分类号： G01N33/58 , G01N33/6848 , G01N2458/15 , G01N2570/00 , G01N2800/7028 , G16B20/00 , Y10T436/24
摘要： Provided herein are methods for measuring molecular flux rates of molecules of interest in a tissue sample in spatially-organized manner and generating output (e.g., an image, a heat map, a contour map, a table or a database) representing the molecular flux rates of each spatially-defined location of the sample. Provided herein are also the output, as well as systems and computer-readable medium with computer-executable instructions for determining molecular flux rates of molecules of interest in the sample.
摘要翻译：本文提供了以空间有组织的方式测量组织样品中感兴趣的分子的分子通量速率并产生代表分子通量速率的输出（例如，图像，热图，轮廓图，表或数据库）的方法的样品的每个空间定义的位置。本文还提供了输出以及具有用于确定样品中感兴趣的分子的分子通量速率的计算机可执行指令的系统和计算机可读介质。

9. 发明申请

US20100056392A1 MICROSTRUCTURE AND MICRODOMAIN MICROARRAYS, METHODS OF MAKING SAME AND USES THEREOF 审中-公开
标题翻译：微结构和微结构微阵列，其制备方法及其用途
公开(公告)号：US20100056392A1
公开(公告)日：2010-03-04
申请号：US11917406
申请日：2006-06-15
申请人： Matthew Greving , Neal Woodbury , Trent R. Northen
发明人： Matthew Greving , Neal Woodbury , Trent R. Northen
IPC分类号： C40B30/10 , C40B40/00 , C40B50/00 , C40B30/00 , C40B50/18 , C08F118/02
CPC分类号： G01N33/6851 , B01J2219/00644 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , G01N33/6845
摘要： Disclosed are methods for direct characterization of microdomains and/or three-dimensional microstructure arrays bearing high densities of reactive sites using Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectrometery (MALDI-MS) and other analytical techniques. The high site density of the arrays can provide sufficient sample of each array element and/or materials bound to each element to obtain directly using common analytical techniques such as MALDI-MS. Spatially directed synthesis of heteropolymers is done through the use of pliotolabile, electrically labile, and chemically labile protecting group(s).
摘要翻译：公开了使用矩阵辅助激光解吸电离飞行时间质谱（MALDI-MS）和其他分析技术直接表征具有高密度反应位点的微畴和/或三维微结构阵列的方法。阵列的高位点密度可以提供每个阵列元素和/或与每个元件结合的材料的足够的样品，以直接使用常见的分析技术如MALDI-MS。异源聚合物的空间定向合成是通过使用不溶性的，电不稳定的和化学上不稳定的保护基进行的。

10. 发明申请

US20090042741A1 MICROARRAY OF THREE-DIMENSIONAL HETEROPOLYMER MICROSTRUCTURES AND METHOD THEREFOR 审中-公开
标题翻译：三维异构体微结构微观结构及其方法
公开(公告)号：US20090042741A1
公开(公告)日：2009-02-12
申请号：US10599770
申请日：2005-05-06
申请人： Trent R. Northen , Neal W. Woodbury
发明人： Trent R. Northen , Neal W. Woodbury
IPC分类号： C40B40/14 , C40B50/14
CPC分类号： G01N33/54386 , B01J19/0046 , B01J2219/00387 , B01J2219/00527 , B01J2219/00596 , B01J2219/00644 , B01J2219/00722 , B01J2219/00725
摘要： A microarray has a substrate and a plurality of three-dimensional microstructures formed on the substrate. Each of the three-dimensional microstructures is made with polymer material and has a plurality of reactive sites formed on its surface and interior pores. The polymer material is polymer gel or other porous polymer. The combination of three-dimensional microstructure and porous polymer material increases the surface area of the microstructure and density of the reactive sites on the surface of the microstructures. The higher density of reactive sites increases the luminescence, visibility or instrument detectability of the interaction between analytes and reactive microstructure sites on the microarray. A plurality of chemical groups are respectively attached to the reactive sites. The chemical groups each include at least one monomer. The chemical groups may have different chemical structures. A plurality of microchannels can be formed around the microstructures for isolation.
摘要翻译：微阵列具有在基板上形成的基板和多个三维微结构。每个三维微结构由聚合物材料制成，并且在其表面和内部孔上形成多个反应性位点。聚合物材料是聚合物凝胶或其它多孔聚合物。三维微结构和多孔聚合物材料的组合增加了微观结构的表面积和微结构表面上的反应位点的密度。反应性位点的较高密度增加了微阵列上分析物和反应性微结构位点之间的相互作用的发光，可见性或仪器可检测性。多个化学基团分别连接到反应性位点。化学基团各自包含至少一种单体。化学基团可能具有不同的化学结构。可以在微结构周围形成多个微通道用于隔离。

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