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    • 1. 发明申请
    • Roller with weakened excitation behaviour
    • 滚子疲劳激发行为
    • US20080251626A1
    • 2008-10-16
    • US12077138
    • 2008-03-17
    • Manfred JungMichael SchebitzMatthias Zacker
    • Manfred JungMichael SchebitzMatthias Zacker
    • B65H77/00
    • F16H7/12F16H2007/0865
    • A roller for belt tensioning systems or wrap drives having a hollow hub and a cylindrical running ring. The hollow hub and the running ring are connected to one another by an annular web and wherein, on both sides of the annular web, the hollow hub and the running ring are supported relative to one another by circumferentially distributed radially arranged ribs. The number of ribs on both sides of the annular web can be a prime number. In addition, or in the alternative, the ribs on both sides of the annular web can be arranged so as to be non-centrically circumferentially offset. In addition, or in the alternative, the number of ribs on both sides of the annular web can deviate from one another. In addition, or in the alternative, the rib assembly can be provided with variable pitch angles around the circumference.
    • 一种用于带张紧系统或具有中空轮毂和圆柱形运行环的卷绕驱动器的辊。 中空轮毂和行驶环通过环形腹板彼此连接,并且其中在环形腹板的两侧上,中空轮毂和跑步环通过周向分布的径向布置的肋被相对于彼此支撑。 环形网的两侧的肋骨数可以是素数。 此外,或者在替代方案中,环形腹板的两侧上的肋可以被布置成非中心周向偏移。 此外,或者在替代方案中,环形网的两侧上的肋的数量彼此偏离。 另外,或者替代地,肋组件可以围绕圆周设置有可变的俯仰角。
    • 5. 发明申请
    • Belt tensioning device with external damping sleeve
    • 皮带张紧装置带外部阻尼套筒
    • US20070010361A1
    • 2007-01-11
    • US11474597
    • 2006-06-26
    • Vladimir KobelevManfred JungRudolf Berger
    • Vladimir KobelevManfred JungRudolf Berger
    • F16H7/14F16H7/22
    • F16H7/1218F16H7/1281F16H2007/081
    • A belt tensioning device has a torsion spring assembly and a damping assembly with a housing with a longitudinal axis A. A torsion spring is positioned in the housing so as to extend coaxially relative to the longitudinal axis A and which, by means of one of its ends, is secured in the housing in a rotationally fixed way. A tensioning arm is supported relative to the housing so as to be oscillatingly rotatable around the longitudinal axis A and is connected to the other end of the torsion spring in a rotationally fixed way. A tensioning roller is supported at a free end of the tensioning arm so as to be rotatable around an axis of rotation B and extending parallel relative to the longitudinal axis A. The damping assembly surrounds the housing coaxially relative to the longitudinal axis A and comprises cylindrical friction face pairs.
    • 带张紧装置具有扭转弹簧组件和具有带纵向轴线A的壳体的阻尼组件。扭力弹簧定位在壳体中,以便相对于纵向轴线A同轴地延伸,并且借助其中的一个 端部以旋转固定的方式固定在壳体中。 张紧臂相对于壳体被支撑,以便围绕纵向轴线A可旋转地旋转,并以旋转固定的方式连接到扭转弹簧的另一端。 张紧辊被支撑在张紧臂的自由端处,以便能够围绕旋转轴线B旋转并相对于纵向轴线A平行地延伸。阻尼组件相对于纵向轴线A同轴地包围壳体,并且包括圆柱形 摩擦面对。
    • 6. 发明申请
    • Compositions and methods for modulating sirtuin activity
    • 调节sirtuin活性的组合物和方法
    • US20050287597A1
    • 2005-12-29
    • US11022192
    • 2004-12-22
    • Melanie OttEric VerdinManfred Jung
    • Melanie OttEric VerdinManfred Jung
    • C12Q1/26C12Q1/34C12Q1/70G01N33/53
    • C12Q1/34C12Q1/26G01N2333/16G01N2333/918G01N2333/98G01N2500/02
    • The present invention provides treatment methods involving modulating a sirtuin activity and/or a sirtuin mRNA and/or a sirtuin polypeptide level. In some embodiments, the present invention provides treatment methods involving modulating SIRT1 activity and/or SIRT mRNA and/or polypeptide level. The present invention provides methods of inhibiting SIRT1 Tat deacetylase activity. Methods of inhibiting SIRT1 Tat deacetylase activity are useful for treating immunodeficiency virus infections, particularly human immunodeficiency virus (HIV) infection. Thus, the present invention provides methods of treating an immunodeficiency virus infection, generally involving inhibiting SIRT1 Tat deacetylase activity. The present invention further provides methods of identifying agents that modulate sirtuin activity (e.g., SIRT1 activity), particularly ability of sirtuins to interact with (e.g., bind and/or deacetylate) a substrate, e.g., a viral substrate such as a Tat polypeptide. The present invention further provides active agents that modulate sirtuin activity or expression; and compositions, including pharmaceutical compositions, comprising the active agents.
    • 本发明提供了涉及调节沉默调节蛋白的活性和/或sirtuin mRNA和/或sirtuin多肽水平的治疗方法。 在一些实施方案中,本发明提供了涉及调节SIRT1活性和/或SIRT mRNA和/或多肽水平的治疗方法。 本发明提供抑制SIRT1 Tat脱乙酰酶活性的方法。 抑制SIRT1 Tat脱乙酰酶活性的方法可用于治疗免疫缺陷病毒感染,特别是人类免疫缺陷病毒(HIV)感染。 因此,本发明提供了治疗免疫缺陷病毒感染的方法,通常涉及抑制SIRT1 Tat脱乙酰酶的活性。 本发明进一步提供了鉴定调节沉默调节蛋白的活性(例如,SIRT1活性)的药剂的方法,特别是sirtuins与底物(例如,结合和/或脱乙酰化)例如病毒底物如Tat多肽的能力。 本发明还提供调节沉默调节蛋白的活性或表达的活性剂; 和包含活性剂的组合物,包括药物组合物。
    • 8. 发明授权
    • Belt tensioning device for a belt drive and apparatus with a belt tensioning device
    • 用于皮带传动带的皮带张紧装置和带张紧装置的装置
    • US09523415B2
    • 2016-12-20
    • US13614466
    • 2012-09-13
    • Stefan SchauerteJoachim JudSimon PfeiferManfred Jung
    • Stefan SchauerteJoachim JudSimon PfeiferManfred Jung
    • F16H7/12F16H7/08
    • F16H7/1281F16H2007/081F16H2007/0893
    • A belt tensioning device for a belt drive having at least one apparatus with a housing, a driveshaft and a belt pulley, as well as an infinite belt for driving the belt pulley. The belt tensioning device includes a base that can be or is firmly connected to the apparatus, exactly one tensioning arm that, relative to the base, is supported so as to be pivotable around a pivot axis and that, via a torsion spring, is supported in the circumferential direction against the base. The belt tensioning device also includes a tensioning roller that, at the tensioning arm, is supported so as to be rotatable around an axis of rotation and serves to tension the belt. When the belt tensioning device is mounted at the apparatus, the pivot axis of the tensioning arm is arranged inside the outer diameter of the belt pulley of the apparatus.
    • 用于带驱动器的带张紧装置具有至少一个具有壳体,驱动轴和皮带轮的装置,以及用于驱动皮带轮的无限带。 带张紧装置包括可以或者牢固地连接到设备的基座,正好一个张紧臂,相对于基座被支撑,以便围绕枢转轴线枢转,并且经由扭转弹簧被支撑 在圆周方向上抵靠基座。 皮带张紧装置还包括张紧辊,其在张紧臂处被支撑成可围绕旋转轴线旋转并且用于张紧皮带。 当带张紧装置安装在装置上时,张紧臂的枢转轴线布置在装置的带轮的外径的内侧。