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1. 发明申请

US20050287597A1 Compositions and methods for modulating sirtuin activity 有权
标题翻译：调节sirtuin活性的组合物和方法
公开(公告)号：US20050287597A1
公开(公告)日：2005-12-29
申请号：US11022192
申请日：2004-12-22
申请人： Melanie Ott , Eric Verdin , Manfred Jung
发明人： Melanie Ott , Eric Verdin , Manfred Jung
IPC分类号： C12Q1/26 , C12Q1/34 , C12Q1/70 , G01N33/53
CPC分类号： C12Q1/34 , C12Q1/26 , G01N2333/16 , G01N2333/918 , G01N2333/98 , G01N2500/02
摘要： The present invention provides treatment methods involving modulating a sirtuin activity and/or a sirtuin mRNA and/or a sirtuin polypeptide level. In some embodiments, the present invention provides treatment methods involving modulating SIRT1 activity and/or SIRT mRNA and/or polypeptide level. The present invention provides methods of inhibiting SIRT1 Tat deacetylase activity. Methods of inhibiting SIRT1 Tat deacetylase activity are useful for treating immunodeficiency virus infections, particularly human immunodeficiency virus (HIV) infection. Thus, the present invention provides methods of treating an immunodeficiency virus infection, generally involving inhibiting SIRT1 Tat deacetylase activity. The present invention further provides methods of identifying agents that modulate sirtuin activity (e.g., SIRT1 activity), particularly ability of sirtuins to interact with (e.g., bind and/or deacetylate) a substrate, e.g., a viral substrate such as a Tat polypeptide. The present invention further provides active agents that modulate sirtuin activity or expression; and compositions, including pharmaceutical compositions, comprising the active agents.
摘要翻译：本发明提供了涉及调节沉默调节蛋白的活性和/或sirtuin mRNA和/或sirtuin多肽水平的治疗方法。在一些实施方案中，本发明提供了涉及调节SIRT1活性和/或SIRT mRNA和/或多肽水平的治疗方法。本发明提供抑制SIRT1 Tat脱乙酰酶活性的方法。抑制SIRT1 Tat脱乙酰酶活性的方法可用于治疗免疫缺陷病毒感染，特别是人类免疫缺陷病毒（HIV）感染。因此，本发明提供了治疗免疫缺陷病毒感染的方法，通常涉及抑制SIRT1 Tat脱乙酰酶的活性。本发明进一步提供了鉴定调节沉默调节蛋白的活性（例如，SIRT1活性）的药剂的方法，特别是sirtuins与底物（例如，结合和/或脱乙酰化）例如病毒底物如Tat多肽的能力。本发明还提供调节沉默调节蛋白的活性或表达的活性剂; 和包含活性剂的组合物，包括药物组合物。

2. 发明申请

US20100160262A1 COMPOSITIONS AND METHODS FOR MODULATING SIRTUIN ACTIVITY 审中-公开
标题翻译：用于调节SIRTUIN活性的组合物和方法
公开(公告)号：US20100160262A1
公开(公告)日：2010-06-24
申请号：US12343177
申请日：2008-12-23
申请人： Melanie Ott , Eric M. Verdin , Manfred Jung
发明人： Melanie Ott , Eric M. Verdin , Manfred Jung
IPC分类号： A61K31/655 , G01N33/573 , A61K31/538 , A61K31/551 , A61K31/497 , A61K31/506 , A61K31/52 , A61K31/4725
CPC分类号： A61K31/4725 , A61K31/497 , A61K31/506 , A61K31/52 , A61K31/538 , A61K31/551 , A61K31/655
摘要： The present invention provides treatment methods involving modulating a sirtuin activity and/or a sirtuin mRNA and/or a sirtuin polypeptide level. In some embodiments, the present invention provides treatment methods involving modulating SIRT1 activity and/or SIRT mRNA and/or polypeptide level. The present invention provides methods of inhibiting SIRT1 Tat deacetylase activity. Methods of inhibiting SIRT1 Tat deacetylase activity are useful for treating immunodeficiency virus infections, particularly human immunodeficiency virus (HIV) infection. Thus, the present invention provides methods of treating an immunodeficiency virus infection, generally involving inhibiting SIRT1 Tat deacetylase activity. The present invention further provides methods of identifying agents that modulate sirtuin activity (e.g., SIRT1 activity), particularly ability of sirtuins to interact with (e.g., bind and/or deacetylate) a substrate, e.g., a viral substrate such as a Tat polypeptide. The present invention further provides active agents that modulate sirtuin activity or expression; and compositions, including pharmaceutical compositions, comprising the active agents.
摘要翻译：本发明提供了涉及调节沉默调节蛋白的活性和/或sirtuin mRNA和/或sirtuin多肽水平的治疗方法。在一些实施方案中，本发明提供了涉及调节SIRT1活性和/或SIRT mRNA和/或多肽水平的治疗方法。本发明提供抑制SIRT1 Tat脱乙酰酶活性的方法。抑制SIRT1 Tat脱乙酰酶活性的方法可用于治疗免疫缺陷病毒感染，特别是人类免疫缺陷病毒（HIV）感染。因此，本发明提供了治疗免疫缺陷病毒感染的方法，通常涉及抑制SIRT1 Tat脱乙酰酶的活性。本发明进一步提供了鉴定调节沉默调节蛋白的活性（例如，SIRT1活性）的药剂的方法，特别是sirtuins与底物（例如，结合和/或脱乙酰化）例如病毒底物如Tat多肽的能力。本发明还提供调节沉默调节蛋白的活性或表达的活性剂; 和包含活性剂的组合物，包括药物组合物。

3. 发明授权

US07485416B2 Screening methods for the identification of agents that inhibit SIRT1 Tat deacetylase activity 有权
标题翻译：用于鉴定抑制SIRT1 Tat脱乙酰酶活性的试剂的筛选方法
公开(公告)号：US07485416B2
公开(公告)日：2009-02-03
申请号：US11022192
申请日：2004-12-22
申请人： Melanie Ott , Eric M. Verdin , Manfred Jung
发明人： Melanie Ott , Eric M. Verdin , Manfred Jung
IPC分类号： C12Q1/70 , A61K39/21
CPC分类号： C12Q1/34 , C12Q1/26 , G01N2333/16 , G01N2333/918 , G01N2333/98 , G01N2500/02
摘要： The present invention provides treatment methods involving modulating a sirtuin activity and/or a sirtuin mRNA and/or a sirtuin polypeptide level. In some embodiments, the present invention provides treatment methods involving modulating SIRT1 activity and/or SIRT mRNA and/or polypeptide level. The present invention provides methods of inhibiting SIRT1 Tat deacetylase activity. Methods of inhibiting SIRT1 Tat deacetylase activity are useful for treating immunodeficiency virus infections, particularly human immunodeficiency virus (HIV) infection. Thus, the present invention provides methods of treating an immunodeficiency virus infection, generally involving inhibiting SIRT1 Tat deacetylase activity. The present invention further provides methods of identifying agents that modulate sirtuin activity (e.g., SIRT1 activity), particularly ability of sirtuins to interact with (e.g., bind and/or deacetylate) a substrate, e.g., a viral substrate such as a Tat polypeptide. The present invention further provides active agents that modulate sirtuin activity or expression; and compositions, including pharmaceutical compositions, comprising the active agents.
摘要翻译：本发明提供了涉及调节沉默调节蛋白的活性和/或sirtuin mRNA和/或sirtuin多肽水平的治疗方法。在一些实施方案中，本发明提供了涉及调节SIRT1活性和/或SIRT mRNA和/或多肽水平的治疗方法。本发明提供抑制SIRT1 Tat脱乙酰酶活性的方法。抑制SIRT1 Tat脱乙酰酶活性的方法可用于治疗免疫缺陷病毒感染，特别是人类免疫缺陷病毒（HIV）感染。因此，本发明提供了治疗免疫缺陷病毒感染的方法，通常涉及抑制SIRT1 Tat脱乙酰酶的活性。本发明进一步提供了鉴定调节沉默调节蛋白的活性（例如，SIRT1活性）的药剂的方法，特别是sirtuins与底物（例如，结合和/或脱乙酰化）例如病毒底物如Tat多肽的能力。本发明还提供调节沉默调节蛋白的活性或表达的活性剂; 和包含活性剂的组合物，包括药物组合物。

4. 发明申请

US20130079185A1 Belt Tensioning Device For A Belt Drive And Apparatus With A Belt Tensioning Device 有权
标题翻译：带式拉紧装置用于皮带传动和带式张紧装置的装置
公开(公告)号：US20130079185A1
公开(公告)日：2013-03-28
申请号：US13614466
申请日：2012-09-13
申请人： Stefan Schauerte , Joachim Jud , Simon Pfeifer , Manfred Jung
发明人： Stefan Schauerte , Joachim Jud , Simon Pfeifer , Manfred Jung
IPC分类号： F16H7/12
CPC分类号： F16H7/1281 , F16H2007/081 , F16H2007/0893
摘要： A belt tensioning device for a belt drive having at least one apparatus with a housing, a driveshaft and a belt pulley, as well as an infinite belt for driving the belt pulley. The belt tensioning device includes a base that can be or is firmly connected to the apparatus, exactly one tensioning arm that, relative to the base, is supported so as to be pivotable around a pivot axis and that, via a torsion spring, is supported in the circumferential direction against the base. The belt tensioning device also includes a tensioning roller that, at the tensioning arm, is supported so as to be rotatable around an axis of rotation and serves to tension the belt. When the belt tensioning device is mounted at the apparatus, the pivot axis of the tensioning arm is arranged inside the outer diameter of the belt pulley of the apparatus.
摘要翻译：用于带驱动器的带张紧装置具有至少一个具有壳体，驱动轴和皮带轮的装置，以及用于驱动皮带轮的无限带。带张紧装置包括可以或者牢固地连接到设备的基座，正好一个张紧臂，相对于基座被支撑，以便围绕枢转轴线枢转，并且经由扭转弹簧被支撑在圆周方向上抵靠基座。皮带张紧装置还包括张紧辊，其在张紧臂处被支撑成可围绕旋转轴线旋转并且用于张紧皮带。当带张紧装置安装在装置上时，张紧臂的枢转轴线布置在装置的带轮的外径的内侧。

5. 发明授权

US07492554B2 Magnetic sensor with tilted magnetoresistive structures 失效
标题翻译：具有倾斜磁阻结构的磁传感器
公开(公告)号：US07492554B2
公开(公告)日：2009-02-17
申请号：US11335965
申请日：2006-01-20
申请人： Marcus Breuer , Guenther Crolly , Michael Haag , Manfred Jung , Thorsten Muehge , Johannes Paul , Joerg Sauerwein , Rolf Schaefer , Alexandra Welzel
发明人： Marcus Breuer , Guenther Crolly , Michael Haag , Manfred Jung , Thorsten Muehge , Johannes Paul , Joerg Sauerwein , Rolf Schaefer , Alexandra Welzel
IPC分类号： G11B5/33
CPC分类号： G01R33/0206 , G11B5/3909 , G11B5/3951 , G11B2005/3996
摘要： A magnetic field sensor device comprising a substrate having at least a first tilted planar section having a surface normal at a first angle with respect to a surface normal of the substrate, and at least a first magnetoresistive layered structure positioned at the at least first tilted section. Methods for manufacturing magnetic field sensor devices are also presented.
摘要翻译：一种磁场传感器装置，包括具有至少第一倾斜平面部分的基板，所述第一倾斜平面部分具有相对于所述基板的表面法线呈第一角度的法线，以及至少第一磁阻分层结构，其位于所述至少第一倾斜部分。还介绍了制造磁场传感器装置的方法。

6. 发明申请

US20060079360A1 Belt tensioning device with high damping rate 审中-公开
标题翻译：皮带张紧装置，阻尼率高
公开(公告)号：US20060079360A1
公开(公告)日：2006-04-13
申请号：US11237123
申请日：2005-09-28
申请人： Manfred Jung , Simon Pfeifer , Joachim Jud , Thomas Berndt , Jochen Asbeck , Rudolf Berger
发明人： Manfred Jung , Simon Pfeifer , Joachim Jud , Thomas Berndt , Jochen Asbeck , Rudolf Berger
IPC分类号： F16H7/12
CPC分类号： F16H7/1218 , F16H2007/081 , F16H2007/084
摘要： A belt tensioning device having a substantially cylindrical receiving housing and a hub coaxially arranged therein. The receiving housing and the hub are supported so as to be rotatable relative to one another as well as supported by a helical torsion spring so as to be pretensioned relative to one another. A damping device is provided which comprises a circumferentially slotted damping bush and a strip spring adapted to the damping bush, wherein the damping bush rests against the inside of the receiving housing. The strip spring is arranged between the damping bush and the torsion spring. The strip spring and the torsion spring are connected in series, wherein one of the two is supported on the receiving housing and the other one of the two on the hub.
摘要翻译：一种带张紧装置，其具有基本上圆柱形的容纳壳体和同轴地布置在其中的轮毂。所述接收壳体和所述轮毂被支撑成能够相对于彼此旋转并且由螺旋扭转弹簧支撑以相对于彼此预张紧。提供了一种阻尼装置，其包括周向开槽的阻尼衬套和适于阻尼衬套的带状弹簧，其中阻尼衬套靠在接收壳体的内部。带状弹簧布置在阻尼衬套和扭转弹簧之间。带状弹簧和扭转弹簧串联连接，其中两个之一支撑在接收壳体上，另一个支撑在轮毂上。

7. 发明申请

US20070010361A1 Belt tensioning device with external damping sleeve 审中-公开
标题翻译：皮带张紧装置带外部阻尼套筒
公开(公告)号：US20070010361A1
公开(公告)日：2007-01-11
申请号：US11474597
申请日：2006-06-26
申请人： Vladimir Kobelev , Manfred Jung , Rudolf Berger
发明人： Vladimir Kobelev , Manfred Jung , Rudolf Berger
IPC分类号： F16H7/14 , F16H7/22
CPC分类号： F16H7/1218 , F16H7/1281 , F16H2007/081
摘要： A belt tensioning device has a torsion spring assembly and a damping assembly with a housing with a longitudinal axis A. A torsion spring is positioned in the housing so as to extend coaxially relative to the longitudinal axis A and which, by means of one of its ends, is secured in the housing in a rotationally fixed way. A tensioning arm is supported relative to the housing so as to be oscillatingly rotatable around the longitudinal axis A and is connected to the other end of the torsion spring in a rotationally fixed way. A tensioning roller is supported at a free end of the tensioning arm so as to be rotatable around an axis of rotation B and extending parallel relative to the longitudinal axis A. The damping assembly surrounds the housing coaxially relative to the longitudinal axis A and comprises cylindrical friction face pairs.
摘要翻译：带张紧装置具有扭转弹簧组件和具有带纵向轴线A的壳体的阻尼组件。扭力弹簧定位在壳体中，以便相对于纵向轴线A同轴地延伸，并且借助其中的一个端部以旋转固定的方式固定在壳体中。张紧臂相对于壳体被支撑，以便围绕纵向轴线A可旋转地旋转，并以旋转固定的方式连接到扭转弹簧的另一端。张紧辊被支撑在张紧臂的自由端处，以便能够围绕旋转轴线B旋转并相对于纵向轴线A平行地延伸。阻尼组件相对于纵向轴线A同轴地包围壳体，并且包括圆柱形摩擦面对。

8. 发明授权

US5798525A X-ray enhanced SEM critical dimension measurement 失效
标题翻译： X射线增强SEM临界尺寸测量
公开(公告)号：US5798525A
公开(公告)日：1998-08-25
申请号：US670484
申请日：1996-06-26
申请人： Peter Benizri-Carl , Wolfgang Egert , Manfred Jung , Theodore Gerard van Kessel
发明人： Peter Benizri-Carl , Wolfgang Egert , Manfred Jung , Theodore Gerard van Kessel
IPC分类号： G01B15/00 , G01N23/225 , H01J37/28 , H01J37/252
CPC分类号： G01N23/2252 , G01B15/00 , H01J37/28 , H01J2237/2445 , H01J2237/2807 , H01J2237/2814
摘要： Structures having high height to width ratios may be measured using X-ray techniques, where the surrounding base and the structure are composed of different substances. The technique combines X-ray detection with scanning electron microscope (SEM) beam scanning. The X-ray emission is set to detect the presence of a specific substance which is either in the structure or surrounding the structure.
摘要翻译：可以使用X射线技术测量具有高的高宽比的结构，其中周围的基底和结构由不同的物质组成。该技术将X射线检测与扫描电子显微镜（SEM）光束扫描相结合。设置X射线发射以检测结构中或围绕结构的特定物质的存在。

9. 发明授权

US09523415B2 Belt tensioning device for a belt drive and apparatus with a belt tensioning device 有权
标题翻译：用于皮带传动带的皮带张紧装置和带张紧装置的装置
公开(公告)号：US09523415B2
公开(公告)日：2016-12-20
申请号：US13614466
申请日：2012-09-13
申请人： Stefan Schauerte , Joachim Jud , Simon Pfeifer , Manfred Jung
发明人： Stefan Schauerte , Joachim Jud , Simon Pfeifer , Manfred Jung
IPC分类号： F16H7/12 , F16H7/08
CPC分类号： F16H7/1281 , F16H2007/081 , F16H2007/0893
摘要： A belt tensioning device for a belt drive having at least one apparatus with a housing, a driveshaft and a belt pulley, as well as an infinite belt for driving the belt pulley. The belt tensioning device includes a base that can be or is firmly connected to the apparatus, exactly one tensioning arm that, relative to the base, is supported so as to be pivotable around a pivot axis and that, via a torsion spring, is supported in the circumferential direction against the base. The belt tensioning device also includes a tensioning roller that, at the tensioning arm, is supported so as to be rotatable around an axis of rotation and serves to tension the belt. When the belt tensioning device is mounted at the apparatus, the pivot axis of the tensioning arm is arranged inside the outer diameter of the belt pulley of the apparatus.
摘要翻译：用于带驱动器的带张紧装置具有至少一个具有壳体，驱动轴和皮带轮的装置，以及用于驱动皮带轮的无限带。带张紧装置包括可以或者牢固地连接到设备的基座，正好一个张紧臂，相对于基座被支撑，以便围绕枢转轴线枢转，并且经由扭转弹簧被支撑在圆周方向上抵靠基座。皮带张紧装置还包括张紧辊，其在张紧臂处被支撑成可围绕旋转轴线旋转并且用于张紧皮带。当带张紧装置安装在装置上时，张紧臂的枢转轴线布置在装置的带轮的外径的内侧。

10. 发明申请

US20060171081A1 Magnetic sensor with tilted magnetoresistive structures 失效
公开(公告)号：US20060171081A1
公开(公告)日：2006-08-03
申请号：US11335965
申请日：2006-01-20
申请人： Marcus Brcuer , Guenther Crolly , Michael Haag , Manfred Jung , Thorsten Muehge , Johannes Paul , Joerg Sauerwein , Rolf Schaefer , Alexandra Welzel
发明人： Marcus Brcuer , Guenther Crolly , Michael Haag , Manfred Jung , Thorsten Muehge , Johannes Paul , Joerg Sauerwein , Rolf Schaefer , Alexandra Welzel
IPC分类号： G11B5/33 , G11B5/127
CPC分类号： G01R33/0206 , G11B5/3909 , G11B5/3951 , G11B2005/3996
摘要： A magnetic field sensor device comprising a substrate having at least a first tilted planar section having a surface normal at a first angle with respect to a surface normal of the substrate, and at least a first magnetoresistive layered structure positioned at the at least first tilted section. Methods for manufacturing magnetic field sensor devices are also presented.

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