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1. 发明授权

US5340924A Method for heat treatment of lactoferrin without losing physiological activities thereof 失效
标题翻译：乳铁蛋白的热处理方法，而不会失去其生理活性
公开(公告)号：US5340924A
公开(公告)日：1994-08-23
申请号：US860224
申请日：1992-03-27
申请人： Mamoru Tomita , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Hiroaki Abe , Eiji Nagao
发明人： Mamoru Tomita , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Hiroaki Abe , Eiji Nagao
IPC分类号： A23J1/20 , A23J3/08 , C07K14/79 , C07K3/12 , C07K15/00 , C07K15/14 , C07K15/22
CPC分类号： A23J1/20 , A23J3/08 , C07K14/79 , Y10S530/832
摘要： A method for treatment of a matter which contains moisturized or liquified lactoferrin which has been isolated from mammalian milk, processed mammalian milk and by-products in mammalian milk-processing, without losing the physiological activities of lactoferrin, which comprises adjusting pH of said moisturized or liquefied lactoferrin contained in said matter within an acidic range between 2.0 and 6.0 both inclusive by adding acid or aqueous solution of acid when the pH of said moisturized or liquefied lactoferrin is out of said pH range, and heating said matter in the range from 60.degree. C. to 130.degree. C. for a span of time which may assure 60% or more of undenaturization rate of lactoferrin.
摘要翻译：一种处理含有保湿或液化的乳铁蛋白的物质的方法，其已从哺乳动物乳，加工的哺乳动物乳和哺乳动物乳加工中的副产物中分离出来，而不损失乳铁蛋白的生理活性，其包括调节所述保湿或当所述保湿或液化的乳铁蛋白的pH在所述pH范围之外时，通过加入酸或酸的水溶液，在所述物质中含有的液化乳铁蛋白在2.0至6.0之间的酸性范围内，并且将所述物质加热到60℃ 在130℃下，可以确保乳铁蛋白的未饱和化率达到60％以上。

2. 发明授权

US5389611A Lactoferrin hydrolyzate for use as an antibacterial agent and as a tyrosinase inhibition agent 失效
标题翻译：乳铁蛋白水解物用作抗菌剂和酪氨酸酶抑制剂
公开(公告)号：US5389611A
公开(公告)日：1995-02-14
申请号：US803955
申请日：1991-12-09
申请人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
发明人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
IPC分类号： A01N63/02 , A23J3/32 , A23J3/34 , A23L3/3526 , A61K8/64 , A61K38/01 , A61Q19/02 , C07K3/10 , C07K1/12
CPC分类号： A61Q17/005 , A01N63/02 , A23J3/32 , A23J3/343 , A23L3/3526 , A61K38/40 , A61K8/64 , A61Q19/02 , A61K2800/782
摘要： Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent, and which have remarkably more potent activity than unhydrolyzed lactoferrin; and lactoferrin hydrolyzates, having a decomposition rate between 4-50% as measured by formol titration, for use as a tyrosinase inhibition agent, are obtainable by conventional methods for hydrolysis with acids or enzymes, and are stable to heating.
摘要翻译：乳铁蛋白水解物，通过甲酸滴定测定的分解率为6％-20％，用作抗菌剂，并且具有比未水解的乳铁蛋白显着更强的活性; 和通过甲酸滴定测定的分解率为4-50％的乳铁蛋白水解物，用作酪氨酸酶抑制剂，可通过用酸或酶水解的常规方法获得，并且对加热稳定。

3. 发明授权

US5214028A Lactoferrin hydrolyzate for use as an antibacterial agent and as a tyrosinase inhibition agent 失效
标题翻译：用作抗菌剂和作为酪氨酸酶抑制剂的LACTOFERRIN水解产物
公开(公告)号：US5214028A
公开(公告)日：1993-05-25
申请号：US634763
申请日：1990-12-27
申请人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
发明人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
IPC分类号： A01N63/02 , A23J3/32 , A23J3/34 , A23L3/3526 , A61K8/64 , A61K38/01 , A61Q19/02
CPC分类号： A61Q17/005 , A01N63/02 , A23J3/32 , A23J3/343 , A23L3/3526 , A61K38/40 , A61K8/64 , A61Q19/02 , A61K2800/782
摘要： Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent and which have remarkly more potent activity than unhydrolyzed lactoferrin; and lactoferrin hydrolyzates, having a decomposition rate between 4-50% as measured by formol titration, for use as a tyrosinase inhibition agent, are obtainable by conventional methods for hydrolysis with acids or enzymes, and are stable to heating.

4. 发明授权

US5322836A Bioactive agents, compositions and materials comprising said bioactive agents 失效
标题翻译：包含所述生物活性剂的生物活性剂，组合物和材料
公开(公告)号：US5322836A
公开(公告)日：1994-06-21
申请号：US917693
申请日：1991-03-06
申请人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
发明人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
IPC分类号： A61K38/16 , A23C9/123 , A23K1/16 , A23L1/30 , A61K38/00 , A61P1/12 , C07K14/79 , C12N1/20 , C12N1/38 , C12R1/01 , A61K37/14 , A23C9/12 , A23C17/00
CPC分类号： C12N1/38 , A23C9/1234 , A23K20/147 , C07K14/79 , A61K38/00 , Y10S530/832
摘要： Bioactive agents, having growth-promoting activity upon Bifidobacteria, consisting of one or more lactoferrin-compounds selected from the group consisting of bovine lactoferrin, bovine apolactoferrin and bovine Fe-lactoferrin, which can be used as it is as agents to promote proliferation of Bifidobacteria both in vivo and in vitro, and as additives to prepare compositions, materials and products to afford growth-promoting activity thereto, and to improve survivability of Bifidobacteria, if contained therein.
摘要翻译：由双歧杆菌生长促进活性的生物活性剂，由一种或多种选自牛乳铁蛋白，牛非球蛋白铁和牛铁铁乳蛋白的乳铁蛋白化合物组成，可作为促进双歧杆菌增殖的药剂以及用作制备组合物，材料和产品以提供生长促进活性的添加剂，以及如果其中包含双歧杆菌的生存能力的添加剂。

5. 发明授权

US5296464A Bioactive agents and compositions for materials comprising the bioactive agent and a method for treating materials therewith 失效
标题翻译：用于包含生物活性剂的材料的生物活性剂和组合物以及用于处理材料的方法
公开(公告)号：US5296464A
公开(公告)日：1994-03-22
申请号：US780535
申请日：1991-10-21
申请人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
发明人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
IPC分类号： A01N63/02 , A23C9/152 , A23J1/20 , A23K1/16 , A23K1/175 , A23L3/3463 , A23L3/3526 , A61K38/00 , C07K14/79 , A61K37/14 , C07K15/22 , C12N1/38
CPC分类号： C07K14/79 , A01N63/02 , A23C9/1522 , A23J1/20 , A23K20/147 , A23K20/30 , A23L3/3463 , A23L3/3526 , A61K38/00
摘要： Bioactive agents consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin and having selective biological activities, i.e. growth-inhibitory activity against certain harmful microorganisms on one hand and growth-promoting activity upon certain useful microorganisms on the other hand; as well as compositions, products or materials therefor comprising the bioactive agents consisting of one or more lactoferrin-compounds selected from the group; and a method for treating materials, which are edible for human beings or animals or which are applicable to a portion of body of human beings or animals, with the bioactive agents consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin or the compositions comprising the bioactive agent consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin as an effective component.
摘要翻译：由选自Zn-，Cu-和Mn-乳铁蛋白的一种或多种乳铁蛋白化合物组成并具有选择性生物活性的生物活性剂，即一方面对某些有害微生物的生长抑制活性，以及一定程度上的生长促进活性另一方面有用的微生物; 以及其组合物，产品或材料，其包含由选自该组的一种或多种乳铁蛋白化合物组成的生物活性剂; 以及用于处理可用于人类或动物或适用于人或动物的一部分身体的材料的方法，所述生物活性剂由一种或多种选自以下的乳铁蛋白化合物组成：Zn- ，Cu-和Mn-乳铁蛋白或包含由一种或多种选自Zn-，Cu-和Mn-乳铁蛋白作为有效成分的乳铁蛋白化合物组成的生物活性剂的组合物。

6. 发明授权

US5266202A Reverse osmosis treatment process 失效
标题翻译：反渗透处理工艺
公开(公告)号：US5266202A
公开(公告)日：1993-11-30
申请号：US655199
申请日：1991-02-14
申请人： Shigeo Okonogi , Mamoru Tomita , Yasuo Fukuwatari , Koichi Matsumoto , Yoshitaka Tamura , Teruhiko Mizota , Atsushi Nakajima , Haruo Endo , Norio Sato , Koji Inagaki
发明人： Shigeo Okonogi , Mamoru Tomita , Yasuo Fukuwatari , Koichi Matsumoto , Yoshitaka Tamura , Teruhiko Mizota , Atsushi Nakajima , Haruo Endo , Norio Sato , Koji Inagaki
IPC分类号： A23C9/142 , B01D61/02 , B01D61/12 , B21D61/12
CPC分类号： B01D61/12 , A23C9/1427 , B01D61/022
摘要： This invention relates to a reverse osmosis treatment process, particularly a stable reverse osmosis treatment process which prevents a lowering in throughput capacity by carrying out treatment while keeping the permeate flux of a reverse osmosis membrane constant through the time of use of a module. The process of this invention can keep the throughput capacity constant, can prevent adhesion and pollution onto membrane surfaces and fouling thereon, and moreover can maintain stable operation in a continuous run.
摘要翻译：本发明涉及一种反渗透处理方法，特别是一种稳定的反渗透处理方法，其通过在使用模块时保持反渗透膜的渗透通量不变的同时进行处理，防止通过量下降。本发明的方法可以保持生产能力恒定，可以防止膜表面的粘附和污染，并在其上污染，而且可以在连续运行中保持稳定的操作。

7. 发明授权

US4791193A Process for producing bovine lactoferrin in high purity 失效
标题翻译：制备高纯度牛乳铁蛋白的方法
公开(公告)号：US4791193A
公开(公告)日：1988-12-13
申请号：US74034
申请日：1987-07-16
申请人： Shigeo Okonogi , Mamoru Tomita , Toshio Tomimura , Yoshitaka Tamura , Teruhiko Mizota
发明人： Shigeo Okonogi , Mamoru Tomita , Toshio Tomimura , Yoshitaka Tamura , Teruhiko Mizota
IPC分类号： C07K14/00 , A23J1/20
CPC分类号： A23J1/20 , Y10S530/832 , Y10S530/833
摘要： A process for producing bovine lactoferrin in high purity form raw milk-materials containing skim milk or whey originated form cow's milk which comprises: adsoption step wherein said raw materials are contacted, at a temperature between 0.degree.-60.degree. C., with weakly acidic cation-exchanger which includes carboxymethyl groups as ion exchanging groups and has haemoglobin adsorption property more than 3.5 g/100 ml; rinsing step wherein said exchanger is washed with water to remove substances other than those adsorbed to said exchanger; and desorption step wherein the substances adsorbed to said exchanger are desorbed therefrom with a solution of one or more of salts to thereby yield highly purified bovine lactoferrin without deterirating raw milk materials. Said desorption step can be carried out in a single stage to produce lactoferrin more than 80% purity to total proteins recovered, and in two stage to attain more than 98% purity.

8. 发明授权

US4985246A Composition of feedstuff 失效
标题翻译：饲料组成
公开(公告)号：US4985246A
公开(公告)日：1991-01-15
申请号：US924763
申请日：1986-10-30
申请人： Shigeo Okonogi , Mamoru Tomita , Seiichi Shimamura , Toshio Tomimura , Norio Ishibashi , Hiroshi Miyakawa , Koichi Sugawara
发明人： Shigeo Okonogi , Mamoru Tomita , Seiichi Shimamura , Toshio Tomimura , Norio Ishibashi , Hiroshi Miyakawa , Koichi Sugawara
IPC分类号： A23K1/16 , A23K1/00 , A61K35/74
CPC分类号： A23K10/10
摘要： A composition of feedstuff containing at least 0.5 wt. %, in solid content, of residual liquid of incubated culture broth of Bifido-bacteria and/or lactic acid bacteria which residual liquid is obtainable as the waste by-product of mass production of living or viable cell mass of the microorganisms by substantially excluding microbial cell mass from the incubated culture broth thereof.
摘要翻译：饲料的组合物含有至少0.5wt。％的固体含量的双歧杆菌和/或乳酸菌的培养培养液的残留液体，残留的液体作为大量生产微生物的活细胞或活细胞块的废弃副产物，通过基本排除微生物来自其培养的培养液的细胞质量。

9. 发明授权

US5304251A Crystalline lactulose trihydrate and a method for its manufacture 失效
标题翻译：结晶乳果糖三水合物及其制造方法
公开(公告)号：US5304251A
公开(公告)日：1994-04-19
申请号：US926308
申请日：1992-08-10
申请人： Mamoru Tomita , Seiichi Shimamura , Yoshitaka Tamura , Teruhiko Mizota , Satoshi Nakano , Itsuko Suzawa
发明人： Mamoru Tomita , Seiichi Shimamura , Yoshitaka Tamura , Teruhiko Mizota , Satoshi Nakano , Itsuko Suzawa
IPC分类号： A23L27/30 , C07H1/00 , C07H3/04 , C13B30/02 , C13K13/00 , C13F3/00 , C07H3/00 , C08B37/00
CPC分类号： C07H3/04 , A23L27/33 , C07H1/00 , C13K13/002
摘要： A crystalline lactulose trihydrate having molecular formula of C.sub.12 H.sub.22 O.sub.11.3H.sub.2 O and a method for its manufacture, which comprises crystallization from a lactulose syrup at a temperature of 2.degree.-20.degree. C., the starting lactulose syrup having a lactulose content of 70-90% of a total solid matters by weight, and having been concentrated to the total solid matters of 65-75% by weight and a ratio of lactose to water of less than 10% by weight.
摘要翻译：分子式为C12H22O11.3H2O的结晶乳果糖三水合物及其制造方法，其包括在2℃-20℃的温度下从乳果糖糖浆中结晶，所述起始乳果糖糖浆的乳果糖含量为70-90％的总固体重量，并且已经浓缩至总固体物质的65-75重量％，乳糖与水的比例小于10重量％。

10. 发明授权

US4015020A Tartar removal by electrodialysis and potassium level control in wine 失效
标题翻译：通过电渗析去除鞑靼葡萄酒中的钾水平控制
公开(公告)号：US4015020A
公开(公告)日：1977-03-29
申请号：US572726
申请日：1975-04-29
申请人： Taro Nagasawa , Mamoru Tomita , Yoshitaka Tamura , Teruhiko Mizota
发明人： Taro Nagasawa , Mamoru Tomita , Yoshitaka Tamura , Teruhiko Mizota
IPC分类号： C12G3/08
CPC分类号： C12G3/085
摘要： A method of treating wine, comprising introducing crude wine to both the dilution and concentration chambers of an electrodialysis apparatus; operating said apparatus so that the potassium concentration of the wine in the dilution chamber falls to below 500 mg/liter and the potassium content of the wine in the concentration chamber is increased into the range 1000 to 2000 mg/liters; cooling the wine from the concentration chamber to below 10.degree. C and adding tartaric acid crystals to said wine in order to adjust the pH into the range of 2.8 to 3.2 thereby precipitating tartar; separating the tartar from the wine and admixing said wine with wine emerging from the dilution chamber of the electrodialysis apparatus in a ratio such that the potassium content of the resulting mixture is below 500 mg/liter.
摘要翻译：一种处理葡萄酒的方法，包括将粗酒引入电渗析装置的稀释和浓缩室; 操作所述装置，使得稀释室中的葡萄酒的钾浓度降至500mg /升以下，浓缩室中酒的钾含量增加到1000-2000mg /升; 将葡萄酒从浓缩室冷却至10℃以下，并将酒石酸晶体加入到所述葡萄酒中，以将pH调节至2.8至3.2的范围，从而沉淀出牙垢; 将酒石与葡萄酒分离，并将所述葡萄酒与电渗析装置的稀释室中出现的葡萄酒混合，使得所得混合物的钾含量低于500mg /升。

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