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1. 发明授权

US08003666B2 Hydrate for medical purposes 有权
标题翻译：水合物用于医疗用途
公开(公告)号：US08003666B2
公开(公告)日：2011-08-23
申请号：US12293827
申请日：2007-03-27
申请人： Makoto Ono , Shoko Yoshida
发明人： Makoto Ono , Shoko Yoshida
IPC分类号： C07D215/38 , A61K31/04
CPC分类号： C07D401/04
摘要： The present invention relates to [7-[(7S)-7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hemihydrate. This hemihydrate is stable and easy to prepare, and has excellent properties for a pharmaceutical bulk powder.
摘要翻译：本发明涉及[7 - [（7S）-7-氨基-7-甲基-5-氮杂螺[2.4]庚-5-基] -6-氟-1 - [（1R，2S）-2-氟环丙基 ] -8-甲氧基-1,4-二氢-4-氧代喹啉-3-羧酸半水合物。该半水合物稳定且易于制备，并且对于药物散装粉末具有优异的性能。

2. 发明申请

US20100234410A1 HYDRATE FOR MEDICAL PURPOSES 有权
标题翻译：医用水剂
公开(公告)号：US20100234410A1
公开(公告)日：2010-09-16
申请号：US12293827
申请日：2007-03-27
申请人： Makoto Ono , Shoko Yoshida
发明人： Makoto Ono , Shoko Yoshida
IPC分类号： A61K31/4709 , C07D401/10 , A61P31/04 , A61P31/06 , A61P31/08
CPC分类号： C07D401/04
摘要： The present invention relates to [7-[(7S)-7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hemihydrate. This hemihydrate is stable and easy to prepare, and has excellent properties for a pharmaceutical bulk powder.
摘要翻译：本发明涉及[7 - [（7S）-7-氨基-7-甲基-5-氮杂螺[2.4]庚-5-基] -6-氟-1 - [（1R，2S）-2-氟环丙基 ] -8-甲氧基-1,4-二氢-4-氧代喹啉-3-羧酸半水合物。该半水合物稳定且易于制备，并且对于药物散装粉末具有优异的性能。

3. 发明申请

US20130338189A9 CRYSTAL OF ANTI-BACTERIAL COMPOUND 失效
标题翻译：抗菌化合物的晶体
公开(公告)号：US20130338189A9
公开(公告)日：2013-12-19
申请号：US13814534
申请日：2011-08-05
申请人： Makoto Ono
发明人： Makoto Ono
IPC分类号： A61K31/4709 , C07D401/02
CPC分类号： A61K31/4709 , C07D401/04
摘要： It is intended to provide a salt of a compound and crystals thereof useful as a therapeutic and/or preventive agent for infectious diseases which has wide and excellent antibacterial activity and has excellent safety.[Solution]The present invention provides the hydrochloride of 7-[(1R,5S)-1-amino-5-fluoro-3-azabicyclo[3.3.0]octan-3-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acid and crystals thereof, as a novel salt form of the compound and crystals thereof.
摘要翻译：旨在提供具有广泛和优异的抗菌活性并具有优异安全性的用作感染性疾病的治疗和/或预防剂的化合物及其晶体的盐。 [溶液]本发明提供7 - [（1R，5S）-1-氨基-5-氟-3-氮杂双环[3.3.0]辛-3-基] -6-氟-1 - [（ 1R，2S）-2-氟环丙烷-1-基] -1,4-二氢-8-甲基-4-氧代喹啉-3-羧酸及其晶体，作为化合物的新型盐及其晶体。

4. 发明授权

US08552716B2 Testing methods for magnetic heads and magnetic storage devices assembled with the magnetic heads 失效
标题翻译：用磁头组装的磁头和磁存储装置的测试方法
公开(公告)号：US08552716B2
公开(公告)日：2013-10-08
申请号：US12963551
申请日：2010-12-08
申请人： Fumiomi Ueda , Makoto Ono
发明人： Fumiomi Ueda , Makoto Ono
IPC分类号： G01R33/12
CPC分类号： G11B5/455
摘要： In one embodiment, a manufacturing method for magnetic heads includes classifying magnetic heads into one of: a first tested head class, and a non-test-candidate head class, determining characteristic values of the magnetic heads classified in the first tested head class, estimating characteristic values of the magnetic heads classified in the non-test-candidate head class, wherein the estimating is based on the characteristic values of the magnetic heads classified in the first tested head class, classifying each of the magnetic heads classified in the non-test-candidate head class into one of: a second tested head class, and a non-test head class based on the estimated characteristic values, determining characteristic values of the magnetic heads classified in the second tested head class, and screening magnetic heads in the second tested head class based on the determined characteristic values of the magnetic heads classified in the second tested head class.
摘要翻译：在一个实施例中，一种用于磁头的制造方法包括将磁头分类成以下之一：第一测试头类和非测试候选头类，确定分类在第一测试头类中的磁头的特征值，估计分类在非测试候选头类中的磁头的特征值，其中估计基于分类在第一测试头类中的磁头的特征值，将分类在非测试中的每个磁头分类根据估计的特征值，确定分类在第二测试头类别中的磁头的特征值，以及在第二测试头类别中筛选磁头，将头等级分为以下之一：第二测试头类和非测试头类基于分类在第二测试头类中的磁头的确定的特征值来测试头等级。

5. 发明申请

US20130230501A9 Cycloalkyl-Substituted Imidazole Derivative 有权
标题翻译：环烷基取代咪唑衍生物
公开(公告)号：US20130230501A9
公开(公告)日：2013-09-05
申请号：US13550366
申请日：2012-07-16
申请人： Tsutomu Nagata , Masahiro Inoue , Yuka Ashida , Kengo Noguchi , Makoto Ono
发明人： Tsutomu Nagata , Masahiro Inoue , Yuka Ashida , Kengo Noguchi , Makoto Ono
IPC分类号： A61K31/4172 , C07D405/12 , C07D403/06 , C07D401/12 , A61K31/4178 , A61K31/4439 , A61K38/43 , C07D233/90 , C07C271/22 , A61P7/02 , A61P9/10 , A61P3/10 , A61P35/00 , A61P11/00 , A61P1/16 , A61P27/02 , A61P35/04 , C07D233/64
CPC分类号： C07D405/12 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K9/08 , A61K9/10 , A61K9/2054 , A61K9/2059 , A61K9/4866 , A61K9/4875 , A61K31/417 , A61K31/4172 , A61K31/4178 , A61K31/4439 , A61K45/06 , A61K47/38 , C07D233/64 , C07D233/90 , C07D401/12 , C07D403/06 , C07D413/06
摘要： A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein A represents a C3 to C12 cycloalkyl group which may be substituted by one to three selected from a fluoro group, a hydroxy group, a C1 to C6 alkyl group, etc; R1, R2, and R3 each independently represent a hydrogen atom, a fluoro group, or a C1 to C6 alkyl group; R4 represents a hydrogen atom or a prodrug group; and Y represents —CH2—CHR5—CH2—NHR6 (wherein R5 represents a hydrogen atom, a C1 to C6 alkyl group, or a C1 to C6 alkoxy group, and R6 represents a hydrogen atom or a prodrug group), or the like exhibits excellent TAFIa inhibitory activity and is useful as a therapeutic drug for myocardial infarction, angina pectoris, acute coronary syndrome, cerebral infarction, deep vein thrombosis, pulmonary embolism, and the like.
摘要翻译：由以下通式（I）表示的化合物或其药理学上可接受的盐，其中A表示可以被1-3个选自氟基，羟基，C 1至C 6烷基中的1至3个取代的C 3至C 12环烷基集团等; R 1，R 2和R 3各自独立地表示氢原子，氟基或C 1至C 6烷基; R4表示氢原子或前药基团; Y表示-CH 2 -CHR 5 -CH 2 -NHR 6（其中，R5表示氢原子，C1〜C6烷基或C1〜C6烷氧基，R6表示氢原子或前药基）等表现出优良的TAFIa抑制活性，可用作心肌梗塞，心绞痛，急性冠状动脉综合征，脑梗死，深静脉血栓形成，肺栓塞等治疗药物。

6. 发明授权

US08290241B2 Analyzing apparatus, program, defect inspection apparatus, defect review apparatus, analysis system, and analysis method 有权
标题翻译：分析仪器，程序，缺陷检查装置，缺陷检查装置，分析系统和分析方法
公开(公告)号：US08290241B2
公开(公告)日：2012-10-16
申请号：US12039255
申请日：2008-02-28
申请人： Makoto Ono , Junko Konishi , Tomohiro Funakoshi
发明人： Makoto Ono , Junko Konishi , Tomohiro Funakoshi
IPC分类号： G06K9/00
CPC分类号： G06K9/6215 , G06K2209/19 , G06T7/0004 , G06T2207/30148
摘要： In order to allow to easily specify inspection recipe with which defects desired to be detected can be detected efficiently, a defect inspection apparatus performs defect inspection of a substrate in accordance with a plurality of inspection recipes and produces defect information associated with position of defect in the substrate and attribute data of the defect for each of the inspection recipes and a defect review apparatus produces review result information specifying a kind of defect selected from defects contained in the defect information. An analyzing apparatus obtains defect information and review result information and totalizes the number of defects having attribute data similar to attribute data possessed in defects corresponding to kind of defects to be analyzed for each inspection recipe.
摘要翻译：为了能够容易地指定能够有效地检测出希望的缺陷的检查配方，缺陷检查装置根据多个检查配方进行基板的缺陷检查，并且生成与缺陷的位置有关的缺陷信息每个检查配方的缺陷的基板和属性数据以及缺陷检查装置产生指定从缺陷信息中包含的缺陷中选择的缺陷的种类的检查结果信息。分析装置获取缺陷信息并查看结果信息，并且将具有属性数据的缺陷的数量的总和与每个检查配方的要分析的缺陷的种类相对应的缺陷中具有的属性数据相似。

7. 发明申请

US20110134559A1 METHODS FOR PRODUCING AND/OR TESTING MAGNETIC HEADS USING CLASSIFICATIONS 失效
标题翻译：使用分类生产和/或测试磁头的方法
公开(公告)号：US20110134559A1
公开(公告)日：2011-06-09
申请号：US12963551
申请日：2010-12-08
申请人： Fumiomi Ueda , Makoto Ono
发明人： Fumiomi Ueda , Makoto Ono
IPC分类号： G11B27/36 , G11B5/127
CPC分类号： G11B5/455
摘要： In one embodiment, a manufacturing method for magnetic heads includes classifying magnetic heads into one of a first tested head class, and a non-test-candidate head class, determining characteristic values of the magnetic heads classified in the first tested head class, estimating characteristic values of the magnetic heads classified in the non-test-candidate head class, wherein the estimating is based on the characteristic values of the magnetic heads classified in the first tested head class, classifying each of the magnetic heads classified in the non-test-candidate head class into one of: a second tested head class, and a non-test head class based on the estimated characteristic values, determining characteristic values of the magnetic heads classified in the second tested head class, and screening magnetic heads in the second tested head class based on the determined characteristic values of the magnetic heads classified in the second tested head class.
摘要翻译：在一个实施例中，一种用于磁头的制造方法包括将磁头分类为第一测试头类和非测试候选头类中的一个，确定分类在第一测试头类中的磁头的特性值，估计特性分类在非测试候选头类中的磁头的值，其中估计是基于分类在第一测试头类中的磁头的特性值，对分类在非测试头类中的每个磁头进行分类，将候选头类分为以下之一：第二测试头类，以及基于估计特征值的非测试头类，确定分类在第二测试头类中的磁头的特征值，以及在第二测试中筛选磁头基于分类在第二测试头类中的磁头的确定的特征值的头等级。

8. 发明授权

US07785079B2 Compressor and method of using compressor 失效
标题翻译：压缩机及压缩机使用方法
公开(公告)号：US07785079B2
公开(公告)日：2010-08-31
申请号：US11312589
申请日：2005-12-21
申请人： Makoto Ono , Wataru Sakuma
发明人： Makoto Ono , Wataru Sakuma
IPC分类号： F04B49/00
CPC分类号： F04B27/1036 , F04B27/0895 , F04B27/1054 , F04B27/1081 , F04B49/103 , F04B2201/1206
摘要： A compressor of the present invention is provided with a plurality of housing members (a front housing, a cylinder block, and a rear housing) that forms a body, a fastener (a bolt member) for coupling the plurality of the housing members to one another, a drive shaft inserted through the body and coupled to a power source via an electromagnetic clutch, a movable member (a piston) that moves in association with the drive shaft to compress a fluid, a detection body that moves in association with the drive shaft, and a detection part for detecting a rotational state of the drive shaft by means of the detection body. A magnetic sensor having a magnetic impedance element constitutes the detection part. The magnetic sensor is provided on an outer lateral face side of the body and in proximity to the fastener.
摘要翻译：本发明的压缩机设置有形成主体的多个壳体构件（前壳体，气缸体和后壳体），用于将多个壳体构件连接到一个壳体的紧固件（螺栓构件）另一种是驱动轴，其插入穿过主体并通过电磁离合器联接到动力源;可移动部件（活塞），其与驱动轴相关联地移动以压缩流体;检测体，其与驱动器相关联地移动; 以及用于通过检测体检测驱动轴的旋转状态的检测部。具有磁阻抗元件的磁传感器构成检测部。磁传感器设置在主体的外侧面上并且靠近紧固件。

9. 发明授权

US07629139B2 Extraction methods and assays for feed enzymes 有权
标题翻译：饲料酶的提取方法和测定
公开(公告)号：US07629139B2
公开(公告)日：2009-12-08
申请号：US11455954
申请日：2006-06-20
申请人： Shib Sankar Basu , Stephanie Winslow , Andrea Nelson , Makoto Ono , Scott Betts
发明人： Shib Sankar Basu , Stephanie Winslow , Andrea Nelson , Makoto Ono , Scott Betts
IPC分类号： C12Q1/34 , G01N1/18
CPC分类号： C12Q1/40 , C12Q1/34 , C12Q1/42 , Y10T436/255
摘要： This invention relates to methods of the detection of enzymatically active enzymes in feed added in the pre-pelleting stage. Further, this invention relates to the field of detecting thermotolerant enzymes added to feed in the pre-pelleting stage. In particular, the invention relates to the detection of a phytase enzyme, in particular an E. coli phytase or an E. coli derived phytase in feed, such as Quantum™ Phytase.
摘要翻译：本发明涉及在预颗粒阶段加入的饲料中检测酶活性酶的方法。此外，本发明涉及检测在预制粒阶段中加入饲料中的耐热酶的领域。特别地，本发明涉及植酸酶，特别是饲料中的大肠杆菌植酸酶或大肠杆菌衍生的植酸酶的检测，例如Quantum TM植酸酶。

10. 发明申请

US20090281074A1 DRUG COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING THROMBOSIS OR EMBOLISM 审中-公开
标题翻译：药物组合物和预防和治疗血栓形成或栓塞的方法
公开(公告)号：US20090281074A1
公开(公告)日：2009-11-12
申请号：US12250586
申请日：2008-10-14
申请人： Toshiharu OHTA , Satoshi Komoriya , Toshiharu Yoshino , Kouichi Outo , Yumi Nakamoto , Hiroyuki Naito , Akiyoshi Mochizuki , Tsutomu Nagata , Hideyuki Kanno , Noriyasu Haginoya , Kenji Yoshikawa , Masatoshi Nagamochi , Syozo Kobayashi , Makoto Ono
发明人： Toshiharu OHTA , Satoshi Komoriya , Toshiharu Yoshino , Kouichi Outo , Yumi Nakamoto , Hiroyuki Naito , Akiyoshi Mochizuki , Tsutomu Nagata , Hideyuki Kanno , Noriyasu Haginoya , Kenji Yoshikawa , Masatoshi Nagamochi , Syozo Kobayashi , Makoto Ono
IPC分类号： A61K31/397 , A61K31/437 , A61K31/502 , A61K31/5377 , A61K31/55
CPC分类号： C07D498/04 , C07D213/75 , C07D401/12 , C07D401/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/14 , C07D519/00
摘要： Drug compositions containing a substituted diamine compound represented by formula (1): Q1-Q2-r-N(R1)-Q3-N(R2) (1) wherein Q3 represents the following group wherein Q5 represents an alkylene group having 4 carbon atoms, R3 represents a hydrogen atom, and R4 represents a 3-6 membered heterocyclic group which may be substituted; are useful for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after artificial valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.
摘要翻译：含有式（1）表示的取代二胺化合物的药物组合物：Q1-Q2-rN（R1）-Q3-N（R2）（1）其中Q3表示以下基团，其中Q5表示具有4个碳原子的亚烷基，R3 表示氢原子，R4表示可以被取代的3-6元杂环基; 可用于预防和/或治疗脑梗死，脑栓塞，心肌梗死，心绞痛，肺梗塞，肺栓塞，Buerger病，深静脉血栓形成，弥散性血管内凝血综合征，人工瓣膜或关节置换后血栓形成，血栓形成和血管成形术后再闭塞，全身炎症反应综合征（SIRS），多器官功能障碍综合征（MODS），体外循环期间的血栓形成或血液抽血时的凝血。

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