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1. 发明申请

WO2008042331A2 FILM EMBEDDED PACKAGING AND METHOD OF MAKING SAME 审中-公开
标题翻译：薄膜嵌入式包装及其制造方法
公开(公告)号：WO2008042331A2
公开(公告)日：2008-04-10
申请号：PCT/US2007/021076
申请日：2007-09-28
申请人： MONOSOL RX LLC , SANGHVI, Pradeep , FUISZ, Richard, C.
发明人： SANGHVI, Pradeep , FUISZ, Richard, C.
IPC分类号： A61K9/24
CPC分类号： A61K9/009 , A61K9/006
摘要： The present invention relates to packaging in the form of a pouch, which may contain active substances, such as food products, pharmaceutical agents, nutraceuticals and cosmetic agents, or the like. More specifically, in some embodiments, the present invention provides a pouch, which includes at least one porous substrate encompassing a closed volume and at least one water-soluble film at least partially embedded in the at least one porous substrate. The pouch may contain an active substance within the closed volume, as well as an active substance in the water-soluble film. The present invention also relates to methods of making and using the pouches.
摘要翻译：本发明涉及可以含有活性物质（例如食品，药剂，营养制品和美容剂等）的小袋形式的包装。更具体地，在一些实施方案中，本发明提供了一种袋，其包括至少一个包含封闭体积的多孔基材和至少一个至少部分嵌入至少一个多孔基材中的水溶性膜。该袋可以包含封闭容积内的活性物质以及水溶性膜中的活性物质。本发明还涉及制造和使用袋的方法。

2. 发明申请

WO2008039737A3 A METHOD OF ADMINISTERING A FILM PRODUCT CONTAINING A DRUG 审中-公开
公开(公告)号：WO2008039737A3
公开(公告)日：2008-04-03
申请号：PCT/US2007/079357
申请日：2007-09-25
申请人： MONOSOL RX, LLC , MYERS, Garry, L. , FUISZ, Richard, C.
发明人： MYERS, Garry, L. , FUISZ, Richard, C.
IPC分类号： A61K9/70 , A61K9/00
摘要： The invention relates to a fast-dissolving film product containing at least one drug; and a water soluble polymer composition. The invention further relates to methods of administering the film product. The method includes administering the film to the oral cavity of a subject in need of the drug; and administering a fluid in the oral cavity while the film is present therein to substantially dissolve the film and form a solution or dispersion thereof to be ingested by the subject. Desirably, ingestion of the thus-formed solution or dispersion provides increased blood levels of the drug as compared to the film taken without the fluid.

3. 发明申请

WO2011028824A1 UNIT ASSEMBLY AND METHOD OF MAKING SAME 审中-公开
标题翻译：单元组件及其制造方法
公开(公告)号：WO2011028824A1
公开(公告)日：2011-03-10
申请号：PCT/US2010/047561
申请日：2010-09-01
申请人： MONOSOL RX, LLC , FUISZ, Richard, C.
发明人： FUISZ, Richard, C.
IPC分类号： B65D75/06 , B65D75/12 , B65D75/20
CPC分类号： B65D75/06 , B65D75/12 , B65D75/20 , B65D2575/586
摘要： The present invention provides a unit assembly (10) for storing and dispensing a film strip (50). The unit assembly includes a first and second panel (14,16) each having a perimetrical edge (24, 26); wherein the first and second panels are substantially opposed to each other; and at least one gusseted side panel (18) disposed between at least a portion of the panels along a common side thereof, the gusseted side panel configured to facilitate access to at least one film strip which is stored in a perimetrically sealed, substantially planar cavity within the unit assembly.
摘要翻译：本发明提供一种用于存储和分配胶片条（50）的单元组件（10）。单元组件包括每个具有周边（24,26）的第一和第二面板（14,16）。其中所述第一和第二面板基本上彼此相对; 以及至少一个角撑板侧板（18），其沿着公共侧设置在所述面板的至少一部分之间，所述角撑板侧板被配置为便于接近至少一个胶片带，所述至少一个胶片条被存储在周边密封的基本上平坦的空腔在单元组件内。

4. 发明申请

WO2008121951A2 PACKAGED FILM DOSAGE UNIT CONTAINING A COMPLEXATE 审中-公开
标题翻译：包装胶囊剂量单位包含复合物
公开(公告)号：WO2008121951A2
公开(公告)日：2008-10-09
申请号：PCT/US2008/058877
申请日：2008-03-31
申请人： MONOSOL RX, LLC , FUISZ, Richard, C.
发明人： FUISZ, Richard, C.
IPC分类号： A61K47/02
CPC分类号： B65D79/00 , A61K9/0056 , A61K47/10 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/6951 , B82Y5/00 , G06F19/00 , G06Q30/0283 , G06Q50/22 , Y02A90/22
摘要： The present invention relates to packaged orally consumable film dosage units for delivery of actives into the oral cavity. In particular, the packaged pharmaceutical product contains a complexate including a complexing agent and an active, an orally consumable film for delivery of the complexate and a package for containing the orally consumable filrn. The package includes indicia associated therewith, The indicia identifies the eomplexate as the active ingredient contained in the film, which is as a regulatory approvable chemical entity, The present invention aSso relates to methods of labeling, pricing, marketing and satisfying governmental regulations for such packaged pharmaceutical products.
摘要翻译：本发明涉及用于将活性物质输送到口腔中的包装的口服消耗膜剂量单位。特别地，包装的药物包含络合剂，包括络合剂和活性物质，用于递送络合物的口腔消耗性膜和用于容纳口腔消毒品的包装。该包装包括与之相关的标记。该标记将该复合物鉴定为该膜中包含的活性成分，其作为可监管的可批准化学实体。本发明涉及标签，定价，销售和满足用于这种包装的政府法规的方法药品。

5. 发明申请

WO2011143424A1 FILM COMPOSITIONS FOR DELIVERY OF ACTIVES 审中-公开
标题翻译：用于交付活动的胶片组合物
公开(公告)号：WO2011143424A1
公开(公告)日：2011-11-17
申请号：PCT/US2011/036244
申请日：2011-05-12
申请人： MONOSOL RX, LLC , MYERS, Garry, L. , FUISZ, Richard, C.
发明人： MYERS, Garry, L. , FUISZ, Richard, C.
IPC分类号： A61K9/70
CPC分类号： A61K9/7007 , A61K8/0204 , A61K8/0208 , A61K8/0216 , A61K8/0291 , A61K8/0295 , A61K8/355 , A61K8/731 , A61K8/86 , A61K31/74 , A61K47/10 , A61K47/38 , A61K2800/413 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q9/02 , A61Q15/00 , A61Q17/005 , A61Q17/02 , A61Q17/04 , A61Q19/00 , A61Q19/10 , B29C41/28 , B29K2001/00 , B29K2001/12 , B29K2003/00 , B29K2005/00 , B82Y5/00
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films contain at least one active agent, which may be administered to a user topically, transmucosally, vaginally, ocularly, aurally, nasally, transdermally or orally.
摘要翻译：本发明涉及其制备的薄膜产品及其制备方法，其表现出非自聚集均匀的异质性。期望地，膜在水中分解并且可以通过受控的干燥过程或保持膜所需的均匀性的其它方法形成。期望地，膜包含至少一种活性剂，其可以局部，经粘膜，阴道，眼睛，耳朵，鼻腔，经皮或口服施用于使用者。

6. 发明申请

WO2011150302A1 ORAL FILM DOSAGE FORM HAVING INDICIA THEREON 审中-公开
标题翻译：具有INDICIA THEREON的ORAL FILM剂型
公开(公告)号：WO2011150302A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/038282
申请日：2011-05-27
申请人： MONOSOL RX, LLC , FUISZ, Richard, C. , HARIHARAN, Madhu
发明人： FUISZ, Richard, C. , HARIHARAN, Madhu
IPC分类号： A61J3/00 , G09F3/02 , A61K9/70 , B65B11/50
CPC分类号： A61K9/7007 , A61J3/00 , A61J3/007 , A61K9/0056 , A61K9/2072 , G09F3/02 , G09F3/0297
摘要： The present invention relates to rapidly dissolving edible film dosage form incorporating indicia. The indicia may correspond to an active ingredient that may be evenly distributed throughout the film. The indicia may be associated with at least one surface of the film composition and provide information to the consumer that is relevant to the edible film dosage form.
摘要翻译：本发明涉及快速溶解含有标记的可食用膜剂型。标记可以对应于可以均匀分布在整个膜中的活性成分。标记可以与膜组合物的至少一个表面相关联，并且向消费者提供与可食用膜剂型相关的信息。

7. 发明申请

WO2010083183A1 UNIT ASSEMBLY FOR MULTIPLE FILM DOSAGES, APPARATUS, AND METHODS 审中-公开
标题翻译：单位大会用于多个片剂，装置和方法
公开(公告)号：WO2010083183A1
公开(公告)日：2010-07-22
申请号：PCT/US2010/020844
申请日：2010-01-13
申请人： MONOSOL RX LLC , HARIHARAN, Madhusudan , FUISZ, Richard, C.
发明人： HARIHARAN, Madhusudan , FUISZ, Richard, C.
IPC分类号： A61K9/20 , A61K9/70
CPC分类号： A23P20/20 , A61K9/0056 , A61K9/7007 , Y10T83/0448 , Y10T83/0524 , Y10T83/889
摘要： A unit assembly including a plurality of individual film strips, each film strip having an active within a polymer matrix, the film strips having respective perimetrical edges, the plurality of individual film strips being alternatingly positioned next to one another such that a film strip perimetrical edge is at least partially offset from a subsequent film strip perimetrical edge, wherein the respective perimetrical edges of the film strips are directly adjacent to each other.
摘要翻译：一种单元组件，包括多个单独的薄膜条，每个薄膜带在聚合物基质内具有活性物质，所述薄膜带具有相应的周边边缘，所述多个单独薄膜条交替地彼此相邻地定位，使得薄膜带周边至少部分地偏离随后的胶片条周边边缘，其中胶片条的各个周边边缘彼此直接相邻。

8. 发明申请

WO2008147772A1 FILM SHREDS AND DELIVERY SYSTEMS INCORPORATING SAME 审中-公开
标题翻译：电影胶卷和交付系统
公开(公告)号：WO2008147772A1
公开(公告)日：2008-12-04
申请号：PCT/US2008/064245
申请日：2008-05-20
申请人： MONOSOL RX, LLC , SANGHVI, Pradeep , FUISZ, Richard, C.
发明人： SANGHVI, Pradeep , FUISZ, Richard, C.
IPC分类号： A61K9/00
CPC分类号： A61K31/465 , A61K9/006 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/1664 , A61K9/7007
摘要： Compositions are provided that include water soluble or water dispersible film shreds, a carrier and an active, such as, but not limited to a drug, flavoring agent or coloring agent. Also provided are methods of use of the film shreds, such as in improving the dissolution, stability, aesthetics, or taste of a composition or its components, and in reducing a disease risk associated with an active.
摘要翻译：提供的组合物包括水溶性或水分散性薄膜碎片，载体和活性剂，例如但不限于药物，调味剂或着色剂。还提供了使用薄膜碎片的方法，例如改善组合物或其组分的溶解，稳定性，美观性或味道，以及降低与活性相关的疾病风险。

9. 发明申请

WO2008108969A1 PACKET STRUCTURE, SUCH AS FOR A FILM STRIP 审中-公开
标题翻译：包装结构，如电影条
公开(公告)号：WO2008108969A1
公开(公告)日：2008-09-12
申请号：PCT/US2008/002651
申请日：2008-02-28
申请人： MONOSOL RX, LLC , FUISZ, Richard, C. , DETWILER, Bruce, D.
发明人： FUISZ, Richard, C. , DETWILER, Bruce, D.
IPC分类号： B65D75/58
CPC分类号： B65D75/5805 , B65D75/66 , Y10T225/10
摘要： The packet structure includes an envelope structure and a tear structure therein. The tear structure provides for tearing of a specific section of the envelope structure to gain access to a film strip which is stored within an internal cavity in the envelope structure. The tear structure has a reduced resistance to tearing relative to an adjoining portion of the envelope structure. The reduced resistance to tearing directs the tearing of the envelope structure to a specific section thereof. The tear structure may alternatively have a pull-string attached within the envelope structure and extending through an aperture therein to a location outside of the envelope structure. The location of the aperture and attachment of the pull-string within the envelope structure directs the tearing of the envelope structure to a specific section thereof.
摘要翻译：分组结构包括其中的包络结构和撕裂结构。撕裂结构提供了包封结构的特定部分的撕裂以获得存储在包络结构内的内部空腔内的胶片条。撕裂结构相对于包络结构的相邻部分具有降低的撕裂阻力。降低的撕裂阻力将包封结构的撕裂引导到其特定部分。泪液结构可以可选地具有附接在包封结构内的拉弦，并且延伸通过其中的孔到包络结构外部的位置。孔的位置和拉弦在包络结构内的附着将包络结构的撕裂引导到其特定部分。

10. 发明申请

WO2008100375A3 POLYMER-BASED FILMS AND DRUG DELIVERY SYSTEMS MADE THEREFROM 审中-公开
公开(公告)号：WO2008100375A3
公开(公告)日：2008-08-21
申请号：PCT/US2008/000973
申请日：2008-01-25
申请人： MONOSOL RX LLC , FUISZ, Richard, C. , FUISZ, Joseph, M. , MYERS, Garry, L. , YANG, Robert, K. , SANGHVI, Pradeep, P.
发明人： FUISZ, Richard, C. , FUISZ, Joseph, M. , MYERS, Garry, L. , YANG, Robert, K. , SANGHVI, Pradeep, P.
IPC分类号： A61K9/70
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component which includes polyethylene oxide, optionally blended with at least one additional polymer. The films may alternatively contain a polymer component which includes polyvinyl alcohol, optionally blended with at least one additional polymer. The films also may contain a pharmaceutical and/or cosmetic active agent.

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