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1. 发明申请

WO2004009445A2 PACKAGING AND DISPENSING OF RAPID DISSOLVE DOSAGE FORM 审中-公开
标题翻译：包装和分配快速溶解剂量形式
公开(公告)号：WO2004009445A2
公开(公告)日：2004-01-29
申请号：PCT/US2003/022882
申请日：2003-07-22
申请人： KOSMOS PHARMA , YANG, Robert, K. , FUISZ, Richard, C. , MYERS, Gary, L. , FUISZ, Joseph, M.
发明人： YANG, Robert, K. , FUISZ, Richard, C. , MYERS, Gary, L. , FUISZ, Joseph, M.
IPC分类号： B65B
CPC分类号： A61K9/7007 , A61J1/03 , A61J3/078 , A61K8/02 , A61K31/4545 , A61K2800/87 , A61Q11/00 , B65B5/06 , B65B11/50 , B65B25/06
摘要： An oral dosage delivery vehicle comprising an edible film including a uniformly distributed active ingredient, wherein said film comprises dosage units releasably joined by one or more weakened sections, which permit said dosage units to be detached from said film.
摘要翻译：一种口服剂量递送载体，其包含包含均匀分布的活性成分的可食用膜，其中所述膜包含通过一个或多个弱化部分可释放地连接的剂量单位，其允许所述剂量单元从所述膜分离。

2. 发明申请

WO2002041838A3 STABILIZATION METHOD AND COMPOSITION UTILIZING AN AMPHOTERIC POLYMER 审中-公开
公开(公告)号：WO2002041838A3
公开(公告)日：2002-05-30
申请号：PCT/US2001/044417
申请日：2001-11-27
申请人： CONAGRA FOODS, INC. , YANG, Robert, K.
发明人： YANG, Robert, K.
IPC分类号： A23L1/222
摘要： A method for increasing the stability of a food-grade or pharmaceutical-grade liquid, such as an extracted oil, herbal extract, flavor, color, or volatile chemical component used in the flavor industry, is provided. The method comprises mixing the liquid with an amphoteric polymer, preferably polyvinylpyrrolidone, to thereby infuse the liquid into the amphoteric polymer matrix and form a generally-solid, stabilized product. Optionally, bulking agents, absorbents, and flowing agents can be mixed with the liquid and amphoteric polymer to enhance the properties of the stabilized product. The inventive method is particularly useful for entrapping liquids that are highly volatile, heat sensitive and/or easily oxidizable.

3. 发明申请

WO2004066986A9 THIN FILM WITH NON-SELF-AGGREGATING UNIFORM HETEROGENEITY AND DRUG DELIVERY SYSTEMS MADE THEREFROM 审中-公开
标题翻译：具有非自我聚集均匀异质性和药物输送系统的薄膜
公开(公告)号：WO2004066986A9
公开(公告)日：2004-09-30
申请号：PCT/US2004002602
申请日：2004-01-30
申请人： MONOSOLRX LLC , YANG ROBERT K , FUISZ RICHARD C , MYERS GARY L , FUISZ JOSEPH M
发明人： YANG ROBERT K , FUISZ RICHARD C , MYERS GARY L , FUISZ JOSEPH M
IPC分类号： A61K9/00 , A61K9/70 , F26B13/20
CPC分类号： A61K9/006 , A61K9/7015 , F26B13/104
摘要： The invention relates to film products containing desired levels of active components and methods of their preparation. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films may be exposed to temperatures above that at which the active components typically degrade without concern for loss of the desired activity.
摘要翻译：本发明涉及含有所需水平的活性成分的薄膜产品及其制备方法。期望地，膜在水中分解并且可以通过受控的干燥过程或保持膜所需的均匀性的其它方法形成。期望地，膜可以暴露于高于活性组分通常降解的温度，而不考虑所需活性的损失。

4. 发明申请

WO2003030882A1 THIN FILM WITH NON-SELF-AGGREGATING UNIFORM HETEROGENEITY, PROCESS FOR THEIR PRODUCTION AND DRUG DELIVERY SYSTEMS MADE THEREFORM 审中-公开
标题翻译：具有非自我聚集均匀异质性的薄膜，其生产和药物输送系统的过程由其制成
公开(公告)号：WO2003030882A1
公开(公告)日：2003-04-17
申请号：PCT/US2002/032575
申请日：2002-10-11
申请人： KOSMOS PHARMA , YANG, Robert, K. , FUISZ, Richard, C. , MYERS, Gary, L. , FUISZ, Joseph, M.
发明人： YANG, Robert, K. , FUISZ, Richard, C. , MYERS, Gary, L. , FUISZ, Joseph, M.
IPC分类号： A61K9/70
CPC分类号： A61K9/7015 , A61K9/006 , A61K9/1635 , A61K9/1652 , A61K9/7007
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film.
摘要翻译：本发明涉及其制备的薄膜产品及其制备方法，其表现出非自聚集均匀的异质性。期望地，膜在水中分解并且可以通过受控的干燥过程或保持膜所需均匀性的其它方法形成。期望地，膜含有每单位面积膜的活性剂药物和/或化妆品活性剂不超过10％变化的药物和/或化妆品活性剂。

5. 发明申请

WO2003030881A1 GLUCAN BASED FILM DELIVERY SYSTEMS 审中-公开
标题翻译：基于GLUCAN的胶片传送系统
公开(公告)号：WO2003030881A1
公开(公告)日：2003-04-17
申请号：PCT/US2002/032542
申请日：2002-10-11
申请人： KOSMOS PHARMA , YANG, Robert, K. , FUISZ, Richard, C.
发明人： YANG, Robert, K. , FUISZ, Richard, C.
IPC分类号： A61K9/70
CPC分类号： A61K9/7015 , A61K9/006 , A61K9/1635 , A61K9/1652 , A61K9/7007 , F26B13/104
摘要： An ingestible water-soluble delivery system in the form of a film composition comprising a glucan and a water-soluble polymer, wherein the ratio of glucan to water soluble polymer is about 40:1 to about 0.1:5. Delivery system films of the present invention include a low content of pullulan and can include a relatively high content of a pharmaceutical, cosmetic, or biologically-active agent.
摘要翻译：包含葡聚糖和水溶性聚合物的薄膜组合物形式的可摄取的水溶性递送系统，其中葡聚糖与水溶性聚合物的比例为约40:1至约0.1:5。本发明的递送系统膜包括低含量的支链淀粉，并且可以包括相对高含量的药物，化妆品或生物活性剂。

6. 发明申请

WO2004009445A3 PACKAGING AND DISPENSING OF RAPID DISSOLVE DOSAGE FORM 审中-公开
标题翻译：包装和分发快速溶解剂型
公开(公告)号：WO2004009445A3
公开(公告)日：2004-06-10
申请号：PCT/US0322882
申请日：2003-07-22
申请人： KOSMOS PHARMA , YANG ROBERT K , FUISZ RICHARD C , MYERS GARY L , FUISZ JOSEPH M
发明人： YANG ROBERT K , FUISZ RICHARD C , MYERS GARY L , FUISZ JOSEPH M
IPC分类号： A61J3/07 , A61K8/02 , A61K9/70 , A61Q11/00 , A61Q19/00 , B65B11/50 , B65D65/46 , B65D75/42 , A01N25/34 , A61K47/00
CPC分类号： A61K9/7007 , A61J1/03 , A61J3/078 , A61K8/02 , A61K31/4545 , A61K2800/87 , A61Q11/00 , B65B5/06 , B65B11/50 , B65B25/06
摘要： An oral dosage delivery vehicle comprising an edible film including a uniformly distributed active ingredient, wherein said film comprises dosage units releasably joined by one or more weakened sections, which permit said dosage units to be detached from said film.
摘要翻译：包含可食性膜的口服剂量递送载体，所述可食性膜包含均匀分布的活性成分，其中所述膜包含通过一个或多个弱化部分可释放地连接的剂量单元，其允许所述剂量单元与所述膜分离。

7. 发明申请

WO0241838A2 STABILIZATION METHOD AND COMPOSITION UTILIZING AN AMPHOTERIC POLYMER 审中-公开
标题翻译：稳定化方法和组合物利用AMPHOTERIC聚合物
公开(公告)号：WO0241838A2
公开(公告)日：2002-05-30
申请号：PCT/US0144417
申请日：2001-11-27
申请人： CONAGRA FOODS INC , YANG ROBERT K
发明人： YANG ROBERT K
IPC分类号： A23L1/22 , A23L1/275 , A61K
CPC分类号： A23L5/42 , A23L27/70 , A23L27/74
摘要： A method for increasing the stability of a food-grade or pharmaceutical-grade liquid, such as an extracted oil, herbal extract, flavor, color, or volatile chemical component used in the flavor industry, is provided. The method comprises mixing the liquid with an amphoteric polymer, preferably polyvinylpyrrolidone, to thereby infuse the liquid into the amphoteric polymer matrix and form a generally-solid, stabilized product. Optionally, bulking agents, absorbents, and flowing agents can be mixed with the liquid and amphoteric polymer to enhance the properties of the stabilized product. The inventive method is particularly useful for entrapping liquids that are highly volatile, heat sensitive and/or easily oxidizable.
摘要翻译：提供了用于提高食品级或药用级液体如风味工业中使用的提取油，草药提取物，风味剂，颜色或挥发性化学成分的稳定性的方法。该方法包括将液体与两性聚合物（优选聚乙烯吡咯烷酮）混合，从而将液体注入两性聚合物基质中并形成通常为固体的稳定化产物。任选地，填充剂，吸收剂和流动剂可以与液体和两性聚合物混合以增强稳定化产物的性质。本发明的方法特别适用于捕获高挥发性，热敏性和/或易于氧化的液体。

8. 发明申请

WO2008100375A3 POLYMER-BASED FILMS AND DRUG DELIVERY SYSTEMS MADE THEREFROM 审中-公开
公开(公告)号：WO2008100375A3
公开(公告)日：2008-08-21
申请号：PCT/US2008/000973
申请日：2008-01-25
申请人： MONOSOL RX LLC , FUISZ, Richard, C. , FUISZ, Joseph, M. , MYERS, Garry, L. , YANG, Robert, K. , SANGHVI, Pradeep, P.
发明人： FUISZ, Richard, C. , FUISZ, Joseph, M. , MYERS, Garry, L. , YANG, Robert, K. , SANGHVI, Pradeep, P.
IPC分类号： A61K9/70
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component which includes polyethylene oxide, optionally blended with at least one additional polymer. The films may alternatively contain a polymer component which includes polyvinyl alcohol, optionally blended with at least one additional polymer. The films also may contain a pharmaceutical and/or cosmetic active agent.

9. 发明申请

WO2008100375A2 POLYMER-BASED FILMS AND DRUG DELIVERY SYSTEMS MADE THEREFROM 审中-公开
标题翻译：基于聚合物的薄膜和由其制造的药物递送系统
公开(公告)号：WO2008100375A2
公开(公告)日：2008-08-21
申请号：PCT/US2008000973
申请日：2008-01-25
申请人： MONOSOL RX LLC , FUISZ RICHARD C , FUISZ JOSEPH M , MYERS GARRY L , YANG ROBERT K , SANGHVI PRADEEP P
发明人： FUISZ RICHARD C , FUISZ JOSEPH M , MYERS GARRY L , YANG ROBERT K , SANGHVI PRADEEP P
IPC分类号： A61K9/70
CPC分类号： B29C39/003 , A61J3/00 , A61J2200/20 , A61K9/006 , A61K9/7007 , B29C39/14 , B29C71/02 , F26B13/104
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component which includes polyethylene oxide, optionally blended with at least one additional polymer. The films may alternatively contain a polymer component which includes polyvinyl alcohol, optionally blended with at least one additional polymer. The films also may contain a pharmaceutical and/or cosmetic active agent.
摘要翻译：本发明涉及显示非自聚集均匀异质性的膜产品及其制备方法。理想的是，这些薄膜在水中崩解并且可以通过受控的干燥过程或维持薄膜所需的均匀性的其他过程形成。该膜包含聚合物组分，其包含聚环氧乙烷，任选地与至少一种另外的聚合物共混。或者可以包含聚合物组分，其包含聚乙烯醇，任选地与至少一种另外的聚合物共混。该膜也可以含有药物和/或美容活性剂。

10. 发明申请

WO2003030883A1 UNIFORM FILMS FOR RAPID DISSOLVE DOSAGE FORM INCORPORATING TASTE-MASKING COMPOSITIONS 审中-公开
标题翻译：用于快速溶解剂用量的复合膜
公开(公告)号：WO2003030883A1
公开(公告)日：2003-04-17
申请号：PCT/US2002/032594
申请日：2002-10-11
申请人： KOSMOS PHARMA , FUISZ, Richard, C. , YANG, Robert, K. , MYERS, Gary, L.
发明人： FUISZ, Richard, C. , YANG, Robert, K. , MYERS, Gary, L.
IPC分类号： A61K9/70
CPC分类号： A61K9/7007 , A61K9/006 , A61K9/1635 , A61K9/1652
摘要： A thin film drug delivery composition includes (i) a flowable water-soluble film forming matrix; (ii) a particulate bioeffecting agent uniformly stationed therein; and (iii) a taste-masking agent coated or intimately associated with the particulate to provide taste-masking of the bioeffecting agent. The combined particulate and taste-masking agent have a particle size of 200 microns or less and the flowable water-soluble film forming matrix is capable of being dried without loss of uniformity in the stationing of the particulate bioeffecting agent therein. The combined particulate and taste-masking agent have a particle size of 150 microns or less, for example 100 microns or less. Moreover, the flowable water-soluble film forming matrix is formable into a dry film of less than about 380 microns in thickness, for example less than about 250 microns in thickness.
摘要翻译：薄膜药物递送组合物包括（i）可流动的水溶性成膜基质; （ii）均匀地置于其中的颗粒状生物影响剂; 和（iii）与微粒涂覆或密切相关的掩味剂，以提供生物影响剂的掩味。组合的颗粒和掩味剂具有200微米或更小的粒度，并且可流动的水溶性成膜基质能够在其中颗粒生物效应剂的驻留中不损失均匀性而被干燥。组合的颗粒和掩味剂的粒度为150微米或更小，例如100微米或更小。此外，可流动的水溶性成膜基质可以形成为厚度小于约380微米，例如小于约250微米厚的干膜。

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