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1. 发明申请

WO2006052763A2 COMPRESSION AND COLD WELD SEALING METHODS AND DEVICES 审中-公开
标题翻译：压缩和冷焊密封方法和装置
公开(公告)号：WO2006052763A2
公开(公告)日：2006-05-18
申请号：PCT/US2005040049
申请日：2005-11-04
申请人： MICROCHIPS INC , COPPETA JONATHAN R , SHELTON KURT , SHEPPARD NORMAN F JR , SNELL DOUGLAS B
发明人： COPPETA JONATHAN R , SHELTON KURT , SHEPPARD NORMAN F JR , SNELL DOUGLAS B
IPC分类号： B81B7/00 , A61K9/00 , A61K9/20 , B23K20/02
CPC分类号： B81C1/00269 , A61K9/0097 , A61M5/14276 , A61M2205/0244 , A61M2207/00 , B23K20/02 , B33Y80/00 , B81B2201/06 , B81C1/00047 , B81C1/00095 , B81C2203/0109 , B81C2203/019 , B81C2203/038 , F16B4/004 , F16B5/08 , F16B11/004 , H01L23/10 , H01L23/3142 , H01L2224/05001 , H01L2224/05023 , H01L2224/051 , H01L2224/05568 , H01L2224/056 , H01L2224/16237 , H01L2224/81193 , H01L2924/01322 , H01L2924/10253 , H01L2924/1461 , Y10T403/477 , H01L2924/00 , H01L2924/00014
摘要： Compression cold welding methods, joint structures, and hermetically sealed containment devices are provided. The method includes providing a first substrate having at least one first joint structure which comprises a first joining surface, which surface comprises a first metal; providing a second substrate having at least one second joint structure which comprises a second joining surface, which surface comprises a second metal; and compressing together the at least one first joint structure and the at least one second joint structure to locally deform and shear the joining surfaces at one or more interfaces in an amount effective to form a metal-to-metal bond between the first metal and second metal of the joining surfaces. Overlaps at the joining surfaces are effective to displace surface contaminants and facilitate intimate contact between the joining surfaces without heat input. Hermetically sealed devices can contain drug formulations, biosensors, or MEMS devices.
摘要翻译：提供了压缩冷焊方法，接头结构和密封的密封装置。该方法包括提供具有至少一个第一接合结构的第一基板，该第一接合结构包括第一接合表面，该表面包括第一金属; 提供具有至少一个第二接合结构的第二基板，所述第二接合结构包括第二接合表面，所述表面包括第二金属; 以及将所述至少一个第一接头结构和所述至少一个第二接头结构压缩在一起以在一个或多个界面处局部地变形和剪切所述接合表面，其量有效地形成所述第一金属与所述第二金属之间的金属 - 金属结合接合表面的金属。在接合表面处的交叠有效地置换表面污染物并有助于在没有热量输入的情况下接合表面之间的紧密接触。密封装置可以包含药物制剂，生物传感器或MEMS装置。

2. 发明申请

WO2005010240A2 LOW TEMPERATURE METHODS FOR HERMETICALLY SEALING RESERVOIR DEVICES 审中-公开
标题翻译：用于人造密封储存器件的低温方法
公开(公告)号：WO2005010240A2
公开(公告)日：2005-02-03
申请号：PCT/US2004023137
申请日：2004-07-19
申请人： MICROCHIPS INC , COPPETA JONATHAN R , UHLAND SCOTT A , POLITO BENJAMIN F , SHEPPARD NORMAN F JR , FEAKES CHRISTINA M , SNELL DOUGLAS , SANTINI JOHN T JR
发明人： COPPETA JONATHAN R , UHLAND SCOTT A , POLITO BENJAMIN F , SHEPPARD NORMAN F JR , FEAKES CHRISTINA M , SNELL DOUGLAS , SANTINI JOHN T JR
IPC分类号： A61K9/00 , B01L3/00 , B65B7/28 , H01L21/50 , C25D5/10 , A61M5/14 , C25D5/54 , G02B6/38 , G02B6/42 , H01L23/06 , H01L23/10
CPC分类号： B01L3/5085 , A61K9/0009 , A61K9/0097 , B01L3/5027 , B01L2400/0677 , B81B2201/058 , B81C1/00269 , B81C2203/0145 , H01L21/50
摘要： Methods are provided for hermetically sealing an opening in a reservoir of a containment device. The method comprises applying a polymeric material to an opening in a reservoir of a containment device, the reservoir comprising reservoir contents (such as a drug or a sensor) to be hermetically isolated within the reservoir, the applied polymeric material closing off the opening and forming a temporary seal; and adhering a hermetic sealing material onto the polymeric material to hermetically seal the opening. The reservoir can be a micro-reservoir. The containment device can comprises an array of two or more of reservoirs, and the method comprises hermetically sealing each of the two or more reservoirs.
摘要翻译：提供了用于气密地密封容纳装置的储存器中的开口的方法。该方法包括将聚合物材料施加到容纳装置的储存器中的开口，所述储存器包括要在储存器内气密隔离的储存器内容物（例如药物或传感器），所施加的聚合物材料封闭开口并形成临时印章并将气密密封材料粘附到聚合物材料上以气密地密封开口。储层可以是微储层。容纳装置可以包括两个或更多个储存器的阵列，并且该方法包括气密地密封两个或更多储存器中的每一个。

3. 发明申请

WO2008154416A2 ELECTROCHEMICAL BIOSENSORS AND ARRAYS 审中-公开
标题翻译：电化学生物传感器和阵列
公开(公告)号：WO2008154416A2
公开(公告)日：2008-12-18
申请号：PCT/US2008066172
申请日：2008-06-06
申请人： MICROCHIPS INC , SHEPPARD NORMAN F JR , SANTINI JOHN T JR
发明人： SHEPPARD NORMAN F JR , SANTINI JOHN T JR
IPC分类号： A61B5/00 , C12Q1/00 , G01N27/49 , G01N33/487
CPC分类号： A61B5/14865 , A61B5/14532 , C12Q1/004 , G01N27/3272
摘要： Electrochemical sensor devices are provided, in various amperometric, potentiometric, and conductometric sensor device configurations. An amperometric sensor device may include a structural body which has at least one reservoir that has at least one opening; a working electrode located within the reservoir; analyte sensor chemistry located within the reservoir and deposited on at least the working electrode; an auxiliary electrode located outside of the reservoir; a reference electrode; at least one reservoir cap closing the opening to isolate the working electrode and analyte sensor chemistry within the reservoir and to prevent an analyte outside of the reservoir from contacting the analyte sensor chemistry; and means for rupturing or displacing the reservoir cap to permit the analyte from outside of the reservoir to contact the analyte sensor chemistry.
摘要翻译：以各种电流，电位和电导率传感器装置配置提供电化学传感器装置。电流传感器装置可以包括具有至少一个具有至少一个开口的储存器的结构体; 位于储存器内的工作电极; 分析物传感器化学位于储层内并沉积在至少工作电极上; 位于储存器外部的辅助电极; 参考电极; 至少一个储存器盖封闭所述开口以将所述工作电极和所述分析物传感器化学物质隔离在所述储存器内并防止所述储存器外的分析物接触所述分析物传感器化学物质; 以及用于破裂或移动储存器盖以允许来自储存器外部的分析物接触分析物传感器化学物质的装置。

4. 发明申请

WO2006055593A3 FABRICATION METHODS AND STRUCTURES FOR MICRO-RESERVOIR DEVICES 审中-公开
标题翻译：微型储存装置的制造方法和结构
公开(公告)号：WO2006055593A3
公开(公告)日：2007-04-19
申请号：PCT/US2005041453
申请日：2005-11-15
申请人： MICROCHIPS INC , MALONEY JOHN M , SBIAA ZOUHAIR , SANTINI JOHN T JR , SHEPPARD NORMAN F JR , UHLAND SCOTT A
发明人： MALONEY JOHN M , SBIAA ZOUHAIR , SANTINI JOHN T JR , SHEPPARD NORMAN F JR , UHLAND SCOTT A
IPC分类号： B01L3/00
CPC分类号： B01L3/50853 , A61K9/0024 , A61K9/0097 , B01L2200/12 , B01L2300/0819 , B01L2400/0677
摘要： Methods are provided for making a multi-reservoir device comprising (i) patterning one or more photoresist layers on a substrate; (ii) depositing onto the substrate at least one metal layer by a sputtering process to form a plurality of reservoir caps and conductive traces; (iii) removing the photoresist layers using a liftoff process; (iv) forming a plurality of reservoirs in the substrate; (v) loading each reservoir with reservoir contents (such as a drug or sensor); and (vi) sealing each reservoir. Optionally, the reservoir cap comprises a first conductive metal layer coated with one or more protective noble metal films. To enhance the resistance of the substrate (e.g., a silicon substrate) to etching in vivo, the interior sidewalls of the reservoirs optionally can include a protective coating (e.g., gold, platinum, carbon, silicon carbide, silicon dioxide, and platinum silicide), or sidewalls comprising silicon can be doped with boron or another impurity.
摘要翻译：提供了用于制造多贮存器器件的方法，包括（i）在衬底上图案化一个或多个光致抗蚀剂层; （ii）通过溅射工艺在衬底上沉积至少一个金属层，以形成多个储存器盖和导电迹线; （iii）使用剥离工艺除去光致抗蚀剂层; （iv）在所述基板中形成多个储存器; （v）向每个储存器装载储存器内容物（例如药物或传感器）; 和（vi）密封每个储存器。可选地，储存器盖包括涂覆有一个或多个保护性贵金属膜的第一导电金属层。为了增强衬底（例如，硅衬底）在体内蚀刻的电阻，存储器的内侧壁任选地可以包括保护涂层（例如金，铂，碳，碳化硅，二氧化硅和硅化铂），或者包含硅的侧壁可以掺杂硼或另一种杂质。

5. 发明申请

WO0187486A3 MICROFLUIDICS DEVICES AND METHODS FOR PERFORMING CELL BASED ASSAYS 审中-公开
标题翻译：微流控装置和方法，用于执行基于细胞的测定
公开(公告)号：WO0187486A3
公开(公告)日：2002-10-24
申请号：PCT/US0115823
申请日：2001-05-15
申请人： TECAN TRADING AG , CARVALHO BRUCE , SHEPPARD NORMAN F JR , FEAKES CHRISTINA , KELLOGG GREG
发明人： CARVALHO BRUCE , SHEPPARD NORMAN F JR , FEAKES CHRISTINA , KELLOGG GREG
IPC分类号： G01N21/78 , A63B63/08 , B01J19/00 , B01L3/00 , F21S2/00 , F21V15/04 , F21V33/00 , G01N21/05 , G01N21/76 , G01N35/00 , G01N37/00 , B01F13/00 , G01N21/07 , G01N27/447
CPC分类号： B01L3/50273 , A63B63/083 , B01L3/5025 , B01L3/5027 , B01L7/00 , B01L2300/0806 , B01L2300/0864 , B01L2300/0874 , B01L2300/10 , B01L2300/1805 , B01L2400/0409 , B01L2400/0688
摘要： This invention provides methods and apparatus for performing microanalytic analyses and procedures, particularly miniaturized cell based assays. These methods are useful for performing a variety of cell-based assays, including drug candidate screening, life sciences research, and clinical and molecular diagnostics.
摘要翻译：本发明提供了用于进行微量分析分析和程序，特别是基于小型化的基于细胞的测定的方法和装置。这些方法对于进行各种基于细胞的测定是有用的，包括药物候选筛选，生命科学研究以及临床和分子诊断。

6. 发明申请

WO0187768A3 USE OF VAPOR-DEPOSITED CONFORMAL COATINGS IN MICROFLUIDIC STRUCTURES 审中-公开
标题翻译：在微流体结构中使用蒸气沉积的合适涂层
公开(公告)号：WO0187768A3
公开(公告)日：2002-04-18
申请号：PCT/US0115805
申请日：2001-05-15
申请人： TECAN TRADING AG , SHEPPARD NORMAN F JR , CARVALHO BRUCE
发明人： SHEPPARD NORMAN F JR , CARVALHO BRUCE
IPC分类号： B81B1/00 , B01L3/00 , C12Q1/68 , B81C1/00 , B01J19/00 , B32B31/00
CPC分类号： B01L3/502707 , B01L2200/12 , B01L2300/0806 , B01L2300/163 , C12Q1/686 , C12Q2565/629
摘要： This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention particularly provides microsystem platforms comprising microfluidics components wherein the interior surfaces of the components comprise a conformal coating of parylene.
摘要翻译：本发明涉及用于进行微量分析和微合成分析和方法的方法和装置。本发明特别提供了包含微流体组分的微系统平台，其中组分的内表面包含聚对二甲苯的保形涂层。

7. 发明专利

JP2007248470A Microfabricated device for storing chemical substance and device to be selectively exposed 审中-公开
标题翻译：用于储存化学物质的微生物装置和被选择性暴露的装置
公开(公告)号：JP2007248470A
公开(公告)日：2007-09-27
申请号：JP2007094383
申请日：2007-03-30
申请人： Microchips Inc , マイクロチップス・インコーポレーテッド
发明人： SANTINI JOHN T JR , SHEPPARD NORMAN F JR , YOUNG CHUNG CHANG , LANGER ROBERT S
IPC分类号： G01N21/64 , G01N37/00 , A61K9/00 , A61K38/28 , A61P3/10 , B01J19/00 , B01L3/00 , B01L99/00 , B81B1/00 , B81C3/00 , C40B60/14 , G01N21/27 , G01N21/41 , G01N27/12 , G01N27/28 , G01N27/327 , G01N27/416 , G01N33/66 , G01N35/00
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： PROBLEM TO BE SOLVED: To provide a microchip device for controlling the exposure of a secondary device. SOLUTION: The microchip device includes a substrate. The substrate has a plurality of reservoirs. The plurality of reservoirs contains the secondary device, and reactive components or a combination thereof. At least one barrier layer covers the each reservoir to protect a content of the each reservoir from one or more environmental components existing in an outside of the reservoir. The barrier layer can be selectively decomposed or permeable, and a separated contents is thereby exposed to the one or more environmental components. The secondary device preferably includes a sensor or sensing component (for example, a biosensor, or a photodetecting or image generating device (for example, optical fiber)). A catalysts and a reagent are mentioned as preferable reactive components, and may be immobilized in the reservoir. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于控制次级装置的曝光的微芯片装置。解决方案：微芯片器件包括衬底。衬底具有多个储存器。多个储存器包含次级装置和反应性组件或其组合。至少一个阻挡层覆盖每个储存器以保护每个储存器的内容物不存在存在于储存器外部的一个或多个环境成分。阻挡层可以选择性地分解或渗透，并且分离的内容物因此暴露于一种或多种环境组分。次要装置优选地包括传感器或感测部件（例如，生物传感器，或光电检测或图像生成装置（例如，光纤））。提及催化剂和试剂作为优选的反应性组分，并且可以固定在储存器中。版权所有（C）2007，JPO＆INPIT

8. 发明专利

JP2012148342A Compression and cold weld sealing method and device 有权
标题翻译：压缩和冷焊密封方法和装置
公开(公告)号：JP2012148342A
公开(公告)日：2012-08-09
申请号：JP2012045363
申请日：2012-03-01
申请人： Microchips Inc , マイクロチップス・インコーポレーテッド
发明人： COPPETA JONATHAN R , SHELTON KURT , SHEPPARD NORMAN F JR , SNELL DOUGLAS B , SANTINI CATHERINE M B
IPC分类号： B23K20/00 , A61L31/00 , A61M37/00 , B23K1/00 , B23K1/14 , B81B7/02 , B81C3/00
CPC分类号： B81C1/00269 , A61K9/0097 , A61M5/14276 , A61M2205/0244 , A61M2207/00 , B23K20/02 , B33Y80/00 , B81B2201/06 , B81C1/00047 , B81C1/00095 , B81C2203/0109 , B81C2203/019 , B81C2203/038 , F16B4/004 , F16B5/08 , F16B11/004 , H01L23/10 , H01L23/3142 , H01L2224/05001 , H01L2224/05023 , H01L2224/051 , H01L2224/05568 , H01L2224/056 , H01L2224/16237 , H01L2224/81193 , H01L2924/01322 , H01L2924/10253 , H01L2924/1461 , Y10T403/477 , H01L2924/00 , H01L2924/00014
摘要： PROBLEM TO BE SOLVED: To provide compression cold welding methods for sealing parts together, joint structures, and hermetically sealed containment devices.SOLUTION: The method includes: providing a first substrate 12 having at least one first joint structure 16 which comprises a first joining surface 18, which surface comprises a first metal; providing a second substrate 14 having at least one second joint structure which comprises a second joining surface 22, which surface comprises a second metal; and compressing together the at least one first joint structure and the at least one second joint structure to locally deform and shear the joining surfaces at one or more interfaces in an amount effective to form a metal-to-metal bond between the first metal and second metal of the joining surfaces. Overlaps at the joining surfaces are effective to displace surface contaminants and facilitate intimate contact between the joining surfaces without heat input. Hermetically sealed devices can contain drug formulations, biosensors, or MEMS devices.
摘要翻译：要解决的问题：提供用于将部件密封在一起的压缩冷焊接方法，接头结构和密封的密封装置。解决方案：该方法包括：提供具有至少一个第一接头结构16的第一基底12，其包括第一接合表面18，该第一接合表面18包括第一金属; 提供具有至少一个第二接头结构的第二基底14，该第二接合结构包括第二接合表面22，该表面包括第二金属; 以及将所述至少一个第一接合结构和所述至少一个第二接头结构压在一起，以在一个或多个界面上局部变形和剪切所述接合表面，所述接合面有效地在所述第一金属和所述第二接头结构之间形成金属与金属之间的接合金属的接合面。在接合表面上的重叠有效地移动表面污染物并促进接合表面之间的紧密接触而不需要热量输入。密封装置可以包含药物制剂，生物传感器或MEMS装置。版权所有（C）2012，JPO＆INPIT

9. 发明专利

JP2010099483A Flexible microchip device for ophthalmic and other applications 审中-公开
标题翻译：柔性微型手术用于眼科和其他应用
公开(公告)号：JP2010099483A
公开(公告)日：2010-05-06
申请号：JP2009277085
申请日：2009-12-04
申请人： Microchips Inc , マイクロチップス・インコーポレーテッド
发明人： SANTINI JOHN T JR , CIMA MICHAEL J , LANGER ROBERT S , AUSIELLO DENNIS , SHEPPARD NORMAN F JR , HERMAN STEPHEN J
IPC分类号： A61F2/14 , A61F9/007 , A61K9/00 , A61M37/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： PROBLEM TO BE SOLVED: To provide microchip device arrays that can conform to a curved surface for the controlled release or exposure of reservoir contents. SOLUTION: The arrays 50 comprise two or more microchip device elements 54, each of the two or more microchip device elements includes a plurality of reservoirs 62 that contain molecules for controlled release or components for selective exposure, and a means for flexibly connecting the device elements. The reservoirs can contain one or more drugs and/or one or more secondary devices (for example, sensors or elements thereof). Preferably, these microchip devices contain and controllably release therapeutic, prophylactic, and diagnostic molecules on and into the eye of a patient in need thereof. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供可以符合弯曲表面的微芯片器件阵列，用于控制释放或暴露储层内容物。阵列50包括两个或多个微芯片器件元件54，两个或多个微芯片器件元件中的每一个包括多个储存器62，其包含用于受控释放的分子或用于选择性曝光的部件，以及用于柔性连接的装置设备元素。储存器可以包含一种或多种药物和/或一个或多个次要装置（例如，传感器或其元件）。优选地，这些微芯片装置在有需要的患者的眼睛上含有并可控制地释放治疗，预防和诊断分子。版权所有（C）2010，JPO＆INPIT

10. 发明专利

JP2009195721A Release controlling device and method 有权
标题翻译：释放控制装置和方法
公开(公告)号：JP2009195721A
公开(公告)日：2009-09-03
申请号：JP2009103479
申请日：2009-04-21
申请人： Microchips Inc , マイクロチップス・インコーポレーテッド
发明人： UHLAND SCOTT A , POLITO BENJAMIN F , MALONEY JOHN M , SHEPPARD NORMAN F JR , HERMAN STEPHEN J , YOMTOV BARRY M
IPC分类号： A61M37/00 , A61B5/00 , A61B5/0215 , A61B5/042 , A61K9/00 , A61M5/14 , A61M5/142 , A61M31/00 , A61N1/32
CPC分类号： A61M25/0082 , A61B5/0215 , A61B5/042 , A61B5/1459 , A61B5/1473 , A61B5/4839 , A61M5/14276 , A61M25/0069 , A61M37/00 , A61M2005/1726 , A61M2205/0244 , A61M2205/123 , A61M2205/3653 , A61N1/32 , Y10T436/25
摘要： PROBLEM TO BE SOLVED: To provide a device which can control a reservoir content to be released and exposed, and a method. SOLUTION: The device 50 comprises electric input and electric output wires 62a which are connected to reservoir caps 58a, 58b, 58c, and 58d made of an electroconductive material to prevent a reservoir content 56 from being released out of the device 50 and exposed to a molecule outside the device 50, so that the reservoir caps are broken down by loading them when an electric current is impressed via the electric input and electric output wires 62a to release and expose the reservoir content 56: the reservoir content 56 can comprise a releasing system containing a drug molecule to release or can comprise a secondary device (such as a sensor). COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够控制要释放和暴露的储存器内容物的装置，以及一种方法。解决方案：装置50包括电输入和电输出线62a，其连接到由导电材料制成的储存器盖58a，58b，58c和58d，以防止储存器部件56从装置50中释放出来，以及暴露于器件50外部的分子，使得当通过电输入和电输出线62a施加电流时，通过加载它们来使储存器盖分解，以释放和暴露储存器内容物56：储存器内容物56可以包括包含释放药物分子的释放系统或可以包括次级装置（例如传感器）。版权所有（C）2009，JPO＆INPIT

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