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1. 发明专利

JP2007248470A Microfabricated device for storing chemical substance and device to be selectively exposed 审中-公开
标题翻译：用于储存化学物质的微生物装置和被选择性暴露的装置
公开(公告)号：JP2007248470A
公开(公告)日：2007-09-27
申请号：JP2007094383
申请日：2007-03-30
申请人： Microchips Inc , マイクロチップス・インコーポレーテッド
发明人： SANTINI JOHN T JR , SHEPPARD NORMAN F JR , YOUNG CHUNG CHANG , LANGER ROBERT S
IPC分类号： G01N21/64 , G01N37/00 , A61K9/00 , A61K38/28 , A61P3/10 , B01J19/00 , B01L3/00 , B01L99/00 , B81B1/00 , B81C3/00 , C40B60/14 , G01N21/27 , G01N21/41 , G01N27/12 , G01N27/28 , G01N27/327 , G01N27/416 , G01N33/66 , G01N35/00
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： PROBLEM TO BE SOLVED: To provide a microchip device for controlling the exposure of a secondary device. SOLUTION: The microchip device includes a substrate. The substrate has a plurality of reservoirs. The plurality of reservoirs contains the secondary device, and reactive components or a combination thereof. At least one barrier layer covers the each reservoir to protect a content of the each reservoir from one or more environmental components existing in an outside of the reservoir. The barrier layer can be selectively decomposed or permeable, and a separated contents is thereby exposed to the one or more environmental components. The secondary device preferably includes a sensor or sensing component (for example, a biosensor, or a photodetecting or image generating device (for example, optical fiber)). A catalysts and a reagent are mentioned as preferable reactive components, and may be immobilized in the reservoir. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于控制次级装置的曝光的微芯片装置。解决方案：微芯片器件包括衬底。衬底具有多个储存器。多个储存器包含次级装置和反应性组件或其组合。至少一个阻挡层覆盖每个储存器以保护每个储存器的内容物不存在存在于储存器外部的一个或多个环境成分。阻挡层可以选择性地分解或渗透，并且分离的内容物因此暴露于一种或多种环境组分。次要装置优选地包括传感器或感测部件（例如，生物传感器，或光电检测或图像生成装置（例如，光纤））。提及催化剂和试剂作为优选的反应性组分，并且可以固定在储存器中。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2012148342A Compression and cold weld sealing method and device 有权
标题翻译：压缩和冷焊密封方法和装置
公开(公告)号：JP2012148342A
公开(公告)日：2012-08-09
申请号：JP2012045363
申请日：2012-03-01
申请人： Microchips Inc , マイクロチップス・インコーポレーテッド
发明人： COPPETA JONATHAN R , SHELTON KURT , SHEPPARD NORMAN F JR , SNELL DOUGLAS B , SANTINI CATHERINE M B
IPC分类号： B23K20/00 , A61L31/00 , A61M37/00 , B23K1/00 , B23K1/14 , B81B7/02 , B81C3/00
CPC分类号： B81C1/00269 , A61K9/0097 , A61M5/14276 , A61M2205/0244 , A61M2207/00 , B23K20/02 , B33Y80/00 , B81B2201/06 , B81C1/00047 , B81C1/00095 , B81C2203/0109 , B81C2203/019 , B81C2203/038 , F16B4/004 , F16B5/08 , F16B11/004 , H01L23/10 , H01L23/3142 , H01L2224/05001 , H01L2224/05023 , H01L2224/051 , H01L2224/05568 , H01L2224/056 , H01L2224/16237 , H01L2224/81193 , H01L2924/01322 , H01L2924/10253 , H01L2924/1461 , Y10T403/477 , H01L2924/00 , H01L2924/00014
摘要： PROBLEM TO BE SOLVED: To provide compression cold welding methods for sealing parts together, joint structures, and hermetically sealed containment devices.SOLUTION: The method includes: providing a first substrate 12 having at least one first joint structure 16 which comprises a first joining surface 18, which surface comprises a first metal; providing a second substrate 14 having at least one second joint structure which comprises a second joining surface 22, which surface comprises a second metal; and compressing together the at least one first joint structure and the at least one second joint structure to locally deform and shear the joining surfaces at one or more interfaces in an amount effective to form a metal-to-metal bond between the first metal and second metal of the joining surfaces. Overlaps at the joining surfaces are effective to displace surface contaminants and facilitate intimate contact between the joining surfaces without heat input. Hermetically sealed devices can contain drug formulations, biosensors, or MEMS devices.
摘要翻译：要解决的问题：提供用于将部件密封在一起的压缩冷焊接方法，接头结构和密封的密封装置。解决方案：该方法包括：提供具有至少一个第一接头结构16的第一基底12，其包括第一接合表面18，该第一接合表面18包括第一金属; 提供具有至少一个第二接头结构的第二基底14，该第二接合结构包括第二接合表面22，该表面包括第二金属; 以及将所述至少一个第一接合结构和所述至少一个第二接头结构压在一起，以在一个或多个界面上局部变形和剪切所述接合表面，所述接合面有效地在所述第一金属和所述第二接头结构之间形成金属与金属之间的接合金属的接合面。在接合表面上的重叠有效地移动表面污染物并促进接合表面之间的紧密接触而不需要热量输入。密封装置可以包含药物制剂，生物传感器或MEMS装置。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2010099483A Flexible microchip device for ophthalmic and other applications 审中-公开
标题翻译：柔性微型手术用于眼科和其他应用
公开(公告)号：JP2010099483A
公开(公告)日：2010-05-06
申请号：JP2009277085
申请日：2009-12-04
申请人： Microchips Inc , マイクロチップス・インコーポレーテッド
发明人： SANTINI JOHN T JR , CIMA MICHAEL J , LANGER ROBERT S , AUSIELLO DENNIS , SHEPPARD NORMAN F JR , HERMAN STEPHEN J
IPC分类号： A61F2/14 , A61F9/007 , A61K9/00 , A61M37/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： PROBLEM TO BE SOLVED: To provide microchip device arrays that can conform to a curved surface for the controlled release or exposure of reservoir contents. SOLUTION: The arrays 50 comprise two or more microchip device elements 54, each of the two or more microchip device elements includes a plurality of reservoirs 62 that contain molecules for controlled release or components for selective exposure, and a means for flexibly connecting the device elements. The reservoirs can contain one or more drugs and/or one or more secondary devices (for example, sensors or elements thereof). Preferably, these microchip devices contain and controllably release therapeutic, prophylactic, and diagnostic molecules on and into the eye of a patient in need thereof. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供可以符合弯曲表面的微芯片器件阵列，用于控制释放或暴露储层内容物。阵列50包括两个或多个微芯片器件元件54，两个或多个微芯片器件元件中的每一个包括多个储存器62，其包含用于受控释放的分子或用于选择性曝光的部件，以及用于柔性连接的装置设备元素。储存器可以包含一种或多种药物和/或一个或多个次要装置（例如，传感器或其元件）。优选地，这些微芯片装置在有需要的患者的眼睛上含有并可控制地释放治疗，预防和诊断分子。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2009195721A Release controlling device and method 有权
标题翻译：释放控制装置和方法
公开(公告)号：JP2009195721A
公开(公告)日：2009-09-03
申请号：JP2009103479
申请日：2009-04-21
申请人： Microchips Inc , マイクロチップス・インコーポレーテッド
发明人： UHLAND SCOTT A , POLITO BENJAMIN F , MALONEY JOHN M , SHEPPARD NORMAN F JR , HERMAN STEPHEN J , YOMTOV BARRY M
IPC分类号： A61M37/00 , A61B5/00 , A61B5/0215 , A61B5/042 , A61K9/00 , A61M5/14 , A61M5/142 , A61M31/00 , A61N1/32
CPC分类号： A61M25/0082 , A61B5/0215 , A61B5/042 , A61B5/1459 , A61B5/1473 , A61B5/4839 , A61M5/14276 , A61M25/0069 , A61M37/00 , A61M2005/1726 , A61M2205/0244 , A61M2205/123 , A61M2205/3653 , A61N1/32 , Y10T436/25
摘要： PROBLEM TO BE SOLVED: To provide a device which can control a reservoir content to be released and exposed, and a method. SOLUTION: The device 50 comprises electric input and electric output wires 62a which are connected to reservoir caps 58a, 58b, 58c, and 58d made of an electroconductive material to prevent a reservoir content 56 from being released out of the device 50 and exposed to a molecule outside the device 50, so that the reservoir caps are broken down by loading them when an electric current is impressed via the electric input and electric output wires 62a to release and expose the reservoir content 56: the reservoir content 56 can comprise a releasing system containing a drug molecule to release or can comprise a secondary device (such as a sensor). COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够控制要释放和暴露的储存器内容物的装置，以及一种方法。解决方案：装置50包括电输入和电输出线62a，其连接到由导电材料制成的储存器盖58a，58b，58c和58d，以防止储存器部件56从装置50中释放出来，以及暴露于器件50外部的分子，使得当通过电输入和电输出线62a施加电流时，通过加载它们来使储存器盖分解，以释放和暴露储存器内容物56：储存器内容物56可以包括包含释放药物分子的释放系统或可以包括次级装置（例如传感器）。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2009142661A Flexible microchip device for ophthalmic and other applications 有权
标题翻译：柔性微型手术用于眼科和其他应用
公开(公告)号：JP2009142661A
公开(公告)日：2009-07-02
申请号：JP2009000222
申请日：2009-01-05
申请人： Microchips Inc , マイクロチップス・インコーポレーテッド
发明人： SANTINI JOHN T JR , CIMA MICHAEL J , LANGER ROBERT S , AUSIELLO DENNIS , SHEPPARD NORMAN F JR , HERMAN STEPHEN J
IPC分类号： A61F9/007 , A61K9/00 , A61K9/70 , A61M31/00 , A61M37/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： PROBLEM TO BE SOLVED: To provide microchip device arrays that can conform to a curved surface for the controlled release or exposure of reservoir contents. SOLUTION: The arrays comprise two or more microchip device elements 54, each of the two or more microchip device elements includes a plurality of reservoirs 62 that contain molecules for controlled release or components for selective exposure, and a means for flexibly connecting the device elements. The reservoirs can contain one or more drugs and/or one or more secondary devices (for example, sensors or elements thereof). Preferably, this microchip devices contain and controllably release therapeutic, prophylactic, and diagnostic molecules on and into the eye of a patient in need thereof. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供可以符合弯曲表面的微芯片器件阵列，用于控制释放或暴露储层内容物。阵列包括两个或多个微芯片器件元件54，两个或更多个微芯片器件元件中的每一个包括多个储存器62，其包含用于控制释放的分子或用于选择性曝光的部件，以及用于灵活地连接设备元素。储存器可以包含一种或多种药物和/或一个或多个次要装置（例如，传感器或其元件）。优选地，该微芯片装置在有需要的患者眼中含有并可控地释放治疗，预防和诊断分子。版权所有（C）2009，JPO＆INPIT

6. 发明申请

WO0230401A3 MICROCHIP RESERVOIR DEVICES AND FACILITATED CORROSION OF ELECTRODES 审中-公开
标题翻译：微电极储存器件和电极的腐蚀性腐蚀
公开(公告)号：WO0230401A3
公开(公告)日：2003-01-16
申请号：PCT/US0142698
申请日：2001-10-11
申请人： MICROCHIPS INC
发明人： SHEPPARD NORMAN F JR , FEAKES CHRISTINA M , SANTINI JOHN T JR
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0024 , A61K9/0009 , A61K9/0097 , A61M5/14276 , A61M2205/0244
摘要： Methods and devices are provided for enhancing corrosion of an electrode in a biocompatible fluid. The method comprises (1) placing a primary electrode and a counter electrode in an electroconductive biocompatible fluid to form an electrochemical cell; and (2) applying a time-varying potential, through the electrochemical cell, to the primary electrode. In a preferred embodiment, the primary electrode is metal and comprises a reservoir cap of a microchip device for the release of molecules or exposure of device reservoir contents. The potential preferably is characterized by a waveform having a maximum potential effectively anodic to meet or exceed the corrosion potential of the primary electrode. Also, the minimum potential preferably is effectively cathodic to be below the value where redeposition of metal ions on the metal electrode can substantially occur, thereby corroding the metal electrode.
摘要翻译：提供了用于增强生物相容性流体中的电极腐蚀的方法和装置。该方法包括（1）将主电极和对电极放置在导电生物相容性流体中以形成电化学电池; 和（2）通过电化学电池将时变电位施加到初级电极。在优选实施例中，主电极是金属并且包括用于释放分子的微芯片装置的储存器盖或装置储存器内容物的暴露。该电位优选的特征在于具有有效地阳极以满足或超过初级电极的腐蚀电位的最大电位的波形。此外，最小电位优选有效地为阴极，低于金属电极上的金属离子可以基本上发生再沉积，从而腐蚀金属电极的值。

7. 发明专利

CA2577709C MULTI-CAP RESERVOIR DEVICES FOR CONTROLLED RELEASE OR EXPOSURE OF RESERVOIR CONTENTS 未知
公开(公告)号：CA2577709C
公开(公告)日：2013-04-16
申请号：CA2577709
申请日：2005-09-01
申请人： MICROCHIPS INC
发明人： SANTINI JOHN T JR , SBIAA ZOUHAIR , COPPETA JONATHAN R , UHLAND SCOTT A , SHEPPARD NORMAN F JR
IPC分类号： B01L3/00 , A61K9/00 , A61M37/00
摘要： Reservoir-based devices are provided in which an individual reservoir has at least two openings with a support structure therebetween and closed by reservoir caps covering the openings to control release or exposure of reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor. The device includes a substrate; at least one reservoir disposed in the substrate, the reservoir having two or more openings; reservoir contents located in the reservoir; two or more discrete reservoir caps, each reservoir cap sealingly covering at least one of the reservoir openings; and control means for selectively disintegrating or permeabilizing the reservoir caps.

8. 发明专利

DE602005013253D1 未知
公开(公告)号：DE602005013253D1
公开(公告)日：2009-04-23
申请号：DE602005013253
申请日：2005-09-01
申请人： MICROCHIPS INC
发明人： SANTINI JOHN T , SBIAA ZOUHAIR , COPPETA JONATHAN R , UHLAND SCOTT , SHEPPARD NORMAN F JR
IPC分类号： B01L3/00 , A61K9/00 , A61M37/00
摘要： Devices, such as medical devices, are provided which include a body portion having at least one reservoir which has two or more openings, the two or more openings being defined in part by a reservoir cap support; reservoir contents, such as a drug formulation or sensor, disposed inside the reservoir; and a reservoir cap which closes off the two or more reservoir openings. The reservoir cap, which can be ruptured, controls release or exposure of the reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor.

9. 发明专利

AU2007200736A1 Controlled release device and method 未知
公开(公告)号：AU2007200736A1
公开(公告)日：2007-03-08
申请号：AU2007200736
申请日：2007-02-20
申请人： MICROCHIPS INC
发明人： SHEPPARD NORMAN F JR , HERMAN STEPHEN J , MALONEY JOHN M , UHLAND SCOTT A , POLITO BENJAMIN F , YOMTOV BARRY M
IPC分类号： A61K9/00 , A61M5/14

10. 发明专利

AU2003303288A1 CONTROLLED RELEASE DEVICE AND METHOD USING ELECTROTHERMAL ABLATION 未知
公开(公告)号：AU2003303288A1
公开(公告)日：2004-09-06
申请号：AU2003303288
申请日：2003-08-15
申请人： MICROCHIPS INC
发明人： HERMAN STEPHEN J , YOMTOV BARRY M , UHLAND SCOTT A , POLITO BENJAMIN F , MALONEY JOHN M , SHEPPARD NORMAN F JR
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/042 , A61K9/00 , A61M5/14 , A61M5/142 , A61M37/00 , A61N1/32
摘要： Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a substrate, a plurality of reservoirs in the substrate, reservoir contents disposed in the reservoirs, discrete reservoir caps covering each reservoir to seal the reservoir contents in the reservoirs, and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo. At least one of the reservoir caps comprises a first electrically conductive layer coated with one or more protective layers. In one embodiment, the control circuitry comprises an electrical input lead and an electrical output lead connected to and directly contacting each of said reservoir caps and a source of electric power for applying an electrical current through each reservoir cap in an amount effective to rupture each of the reservoir caps.

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