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1. 发明申请

WO2006055593A3 FABRICATION METHODS AND STRUCTURES FOR MICRO-RESERVOIR DEVICES 审中-公开
标题翻译：微型储存装置的制造方法和结构
公开(公告)号：WO2006055593A3
公开(公告)日：2007-04-19
申请号：PCT/US2005041453
申请日：2005-11-15
申请人： MICROCHIPS INC , MALONEY JOHN M , SBIAA ZOUHAIR , SANTINI JOHN T JR , SHEPPARD NORMAN F JR , UHLAND SCOTT A
发明人： MALONEY JOHN M , SBIAA ZOUHAIR , SANTINI JOHN T JR , SHEPPARD NORMAN F JR , UHLAND SCOTT A
IPC分类号： B01L3/00
CPC分类号： B01L3/50853 , A61K9/0024 , A61K9/0097 , B01L2200/12 , B01L2300/0819 , B01L2400/0677
摘要： Methods are provided for making a multi-reservoir device comprising (i) patterning one or more photoresist layers on a substrate; (ii) depositing onto the substrate at least one metal layer by a sputtering process to form a plurality of reservoir caps and conductive traces; (iii) removing the photoresist layers using a liftoff process; (iv) forming a plurality of reservoirs in the substrate; (v) loading each reservoir with reservoir contents (such as a drug or sensor); and (vi) sealing each reservoir. Optionally, the reservoir cap comprises a first conductive metal layer coated with one or more protective noble metal films. To enhance the resistance of the substrate (e.g., a silicon substrate) to etching in vivo, the interior sidewalls of the reservoirs optionally can include a protective coating (e.g., gold, platinum, carbon, silicon carbide, silicon dioxide, and platinum silicide), or sidewalls comprising silicon can be doped with boron or another impurity.
摘要翻译：提供了用于制造多贮存器器件的方法，包括（i）在衬底上图案化一个或多个光致抗蚀剂层; （ii）通过溅射工艺在衬底上沉积至少一个金属层，以形成多个储存器盖和导电迹线; （iii）使用剥离工艺除去光致抗蚀剂层; （iv）在所述基板中形成多个储存器; （v）向每个储存器装载储存器内容物（例如药物或传感器）; 和（vi）密封每个储存器。可选地，储存器盖包括涂覆有一个或多个保护性贵金属膜的第一导电金属层。为了增强衬底（例如，硅衬底）在体内蚀刻的电阻，存储器的内侧壁任选地可以包括保护涂层（例如金，铂，碳，碳化硅，二氧化硅和硅化铂），或者包含硅的侧壁可以掺杂硼或另一种杂质。

2. 发明申请

WO2008008845A3 MULTI-RESERVOIR PUMP DEVICE FOR DIALYSIS, BIOSENSING, OR DELIVERY OF SUBSTANCES 审中-公开
标题翻译：用于透析，生物传感或输送物质的多储层泵装置
公开(公告)号：WO2008008845A3
公开(公告)日：2008-04-10
申请号：PCT/US2007073271
申请日：2007-07-11
申请人： MICROCHIPS INC , SANTINI JOHN T , CIMA MICHAEL F , COPPETA JONATHAN R , PRESCOTT JAMES H , SBIAA ZOUHAIR , STAPLES MARK A
发明人： SANTINI JOHN T , CIMA MICHAEL F , COPPETA JONATHAN R , PRESCOTT JAMES H , SBIAA ZOUHAIR , STAPLES MARK A
IPC分类号： A61M37/00 , A61M5/14
CPC分类号： A61M37/0015 , A61M5/1409 , A61M5/14248 , A61M5/1452 , A61M5/14526 , A61M2005/14204 , A61M2005/14268 , A61M2037/0023
摘要： A pump patch device is provided for drug delivery. The device may include a substrate having a plurality of discrete reservoirs, each reservoir having a reservoir opening; a drug disposed in the reservoirs; a pump for delivering a carrier fluid through or adjacent to the reservoir openings; a flow channel for receiving and combining the carrier fluid from the pump with the drug from the reservoirs to form a fluidized drug; and a needle for delivering the fluidized drug into the skin or another biological tissue of a patient. A device is provided for use in dialysis that includes a non-disposable module including a pump or pressure generator; and a disposable cassette operably connected to the pump or pressure generator and including a plurality of discrete reservoirs containing drug and sensors. A fluidics connection device is provided that includes a compression cold weld seal for a microfluidic via.
摘要翻译：提供泵补丁装置用于药物递送。该装置可以包括具有多个分立储存器的基板，每个储存器具有储存器开口; 贮存在药物中的药物; 用于将载体流体输送通过或邻近储存器开口的泵; 流动通道，用于接收和组合来自泵的载体流体与来自储存器的药物以形成流化药物; 以及用于将流化药物输送到患者的皮肤或另一生物组织中的针。提供用于透析的装置，其包括非一次性模块，其包括泵或压力发生器; 以及可操作地连接到泵或压力发生器并且包括多个包含药物和传感器的离散储存器的一次性盒。提供一种流体连接装置，其包括用于微流体通孔的压缩冷焊缝。

3. 发明专利

CA2577709C MULTI-CAP RESERVOIR DEVICES FOR CONTROLLED RELEASE OR EXPOSURE OF RESERVOIR CONTENTS 未知
公开(公告)号：CA2577709C
公开(公告)日：2013-04-16
申请号：CA2577709
申请日：2005-09-01
申请人： MICROCHIPS INC
发明人： SANTINI JOHN T JR , SBIAA ZOUHAIR , COPPETA JONATHAN R , UHLAND SCOTT A , SHEPPARD NORMAN F JR
IPC分类号： B01L3/00 , A61K9/00 , A61M37/00
摘要： Reservoir-based devices are provided in which an individual reservoir has at least two openings with a support structure therebetween and closed by reservoir caps covering the openings to control release or exposure of reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor. The device includes a substrate; at least one reservoir disposed in the substrate, the reservoir having two or more openings; reservoir contents located in the reservoir; two or more discrete reservoir caps, each reservoir cap sealingly covering at least one of the reservoir openings; and control means for selectively disintegrating or permeabilizing the reservoir caps.

4. 发明专利

DE602005013253D1 未知
公开(公告)号：DE602005013253D1
公开(公告)日：2009-04-23
申请号：DE602005013253
申请日：2005-09-01
申请人： MICROCHIPS INC
发明人： SANTINI JOHN T , SBIAA ZOUHAIR , COPPETA JONATHAN R , UHLAND SCOTT , SHEPPARD NORMAN F JR
IPC分类号： B01L3/00 , A61K9/00 , A61M37/00
摘要： Devices, such as medical devices, are provided which include a body portion having at least one reservoir which has two or more openings, the two or more openings being defined in part by a reservoir cap support; reservoir contents, such as a drug formulation or sensor, disposed inside the reservoir; and a reservoir cap which closes off the two or more reservoir openings. The reservoir cap, which can be ruptured, controls release or exposure of the reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor.

5. 发明专利

AT424928T 未知
公开(公告)号：AT424928T
公开(公告)日：2009-03-15
申请号：AT05805709
申请日：2005-09-01
申请人： MICROCHIPS INC
发明人： SANTINI JOHN , SBIAA ZOUHAIR , COPPETA JONATHAN , UHLAND SCOTT , SHEPPARD NORMAN F JR
IPC分类号： B01L3/00 , A61K9/00 , A61M37/00
摘要： Devices, such as medical devices, are provided which include a body portion having at least one reservoir which has two or more openings, the two or more openings being defined in part by a reservoir cap support; reservoir contents, such as a drug formulation or sensor, disposed inside the reservoir; and a reservoir cap which closes off the two or more reservoir openings. The reservoir cap, which can be ruptured, controls release or exposure of the reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor.

6. 发明专利

AU2005279729B2 Multi-cap reservoir devices for controlled release or exposure of reservoir contents 未知
公开(公告)号：AU2005279729B2
公开(公告)日：2010-12-02
申请号：AU2005279729
申请日：2005-09-01
申请人： MICROCHIPS INC
发明人： SANTINI JOHN T JR , UHLAND SCOTT , SBIAA ZOUHAIR , SHEPPARD NORMAN F JR , COPPETA JONATHAN R
IPC分类号： B01L3/00 , A61K9/00 , A61M37/00
摘要： Devices, such as medical devices, are provided which include a body portion having at least one reservoir which has two or more openings, the two or more openings being defined in part by a reservoir cap support; reservoir contents, such as a drug formulation or sensor, disposed inside the reservoir; and a reservoir cap which closes off the two or more reservoir openings. The reservoir cap, which can be ruptured, controls release or exposure of the reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor.

7. 发明专利

CA2577709A1 MULTI-CAP RESERVOIR DEVICES FOR CONTROLLED RELEASE OR EXPOSURE OF RESERVOIR CONTENTS 未知
公开(公告)号：CA2577709A1
公开(公告)日：2006-03-09
申请号：CA2577709
申请日：2005-09-01
申请人： MICROCHIPS INC
发明人： SBIAA ZOUHAIR , COPPETA JONATHAN R , SANTINI JOHN T JR , SHEPPARD NORMAN F JR , UHLAND SCOTT
IPC分类号： B01L3/00 , A61K9/00 , A61M37/00
摘要： Devices, such as medical devices, are provided which include a body portion having at least one reservoir which has two or more openings, the two or more openings being defined in part by a reservoir cap support; reservoir contents, such as a drug formulation or sensor, disposed inside the reservoir; and a reservoir cap which closes off the two or more reservoir openings. The reservoir cap, which can be ruptured, controls release or exposure of the reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor.

8. 发明专利

AU2005279729A1 Multi-cap reservoir devices for controlled release or exposure of reservoir contents 未知
公开(公告)号：AU2005279729A1
公开(公告)日：2006-03-09
申请号：AU2005279729
申请日：2005-09-01
申请人： MICROCHIPS INC
发明人： SANTINI JOHN T JR , UHLAND SCOTT , SBIAA ZOUHAIR , COPPETA JONATHAN R
IPC分类号： B01L3/00 , A61K9/00 , A61M37/00
摘要： Devices, such as medical devices, are provided which include a body portion having at least one reservoir which has two or more openings, the two or more openings being defined in part by a reservoir cap support; reservoir contents, such as a drug formulation or sensor, disposed inside the reservoir; and a reservoir cap which closes off the two or more reservoir openings. The reservoir cap, which can be ruptured, controls release or exposure of the reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor.

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