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1. 发明专利

JP2008284379A Method for hermetically sealing microchip reservoir devices 审中-公开
标题翻译：用于密封微孔储存器件的方法
公开(公告)号：JP2008284379A
公开(公告)日：2008-11-27
申请号：JP2008157288
申请日：2008-06-16
申请人： Microchips Inc , マイクロチップス・インコーポレーテッド
发明人： UHLAND SCOTT A , POLITO BENJAMIN F , HERMAN STEPHEN J , SANTINI JOHN T JR , MALONEY JOHN M
IPC分类号： A61J3/07 , B81C3/00 , A61K9/00 , A61K9/22 , B23K1/06 , B23K26/00 , B81B1/00 , H01L27/14
CPC分类号： A61K9/0097
摘要： PROBLEM TO BE SOLVED: To provide methods for hermetically sealing reservoirs of microchip devices, and hermetically sealing the substrate assemblies in a hermetic packaging structure. SOLUTION: The method comprises: (1) the step of providing a primary substrate 12 having a front side and a back side, the substrates comprising a plurality of reservoirs positioned between the front side and the back side, each reservoir being loaded with molecules or a secondary device for controlled release or exposure, the reservoirs having at least one opening in need of sealing, the primary substrate including one or more hermetic sealing materials; and (2) the step of providing a hermetic sealing substrate 18 having a surface composed of one or more hermetic sealing materials. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供用于密封微芯片装置的储存器的方法，并将密封基板组件气密地密封在密封包装结构中。解决方案：该方法包括：（1）提供具有前侧和后侧的主基板12的步骤，该基板包括位于前侧和后侧之间的多个储存器，每个储存器被加载具有用于控制释放或暴露的分子或二次装置，所述储存器具有至少一个需要密封的开口，所述主基底包括一个或多个密封材料; 和（2）提供具有由一种或多种密封材料构成的表面的气密密封基材18的步骤。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2010099483A Flexible microchip device for ophthalmic and other applications 审中-公开
标题翻译：柔性微型手术用于眼科和其他应用
公开(公告)号：JP2010099483A
公开(公告)日：2010-05-06
申请号：JP2009277085
申请日：2009-12-04
申请人： Microchips Inc , マイクロチップス・インコーポレーテッド
发明人： SANTINI JOHN T JR , CIMA MICHAEL J , LANGER ROBERT S , AUSIELLO DENNIS , SHEPPARD NORMAN F JR , HERMAN STEPHEN J
IPC分类号： A61F2/14 , A61F9/007 , A61K9/00 , A61M37/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： PROBLEM TO BE SOLVED: To provide microchip device arrays that can conform to a curved surface for the controlled release or exposure of reservoir contents. SOLUTION: The arrays 50 comprise two or more microchip device elements 54, each of the two or more microchip device elements includes a plurality of reservoirs 62 that contain molecules for controlled release or components for selective exposure, and a means for flexibly connecting the device elements. The reservoirs can contain one or more drugs and/or one or more secondary devices (for example, sensors or elements thereof). Preferably, these microchip devices contain and controllably release therapeutic, prophylactic, and diagnostic molecules on and into the eye of a patient in need thereof. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供可以符合弯曲表面的微芯片器件阵列，用于控制释放或暴露储层内容物。阵列50包括两个或多个微芯片器件元件54，两个或多个微芯片器件元件中的每一个包括多个储存器62，其包含用于受控释放的分子或用于选择性曝光的部件，以及用于柔性连接的装置设备元素。储存器可以包含一种或多种药物和/或一个或多个次要装置（例如，传感器或其元件）。优选地，这些微芯片装置在有需要的患者的眼睛上含有并可控制地释放治疗，预防和诊断分子。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2009195721A Release controlling device and method 有权
标题翻译：释放控制装置和方法
公开(公告)号：JP2009195721A
公开(公告)日：2009-09-03
申请号：JP2009103479
申请日：2009-04-21
申请人： Microchips Inc , マイクロチップス・インコーポレーテッド
发明人： UHLAND SCOTT A , POLITO BENJAMIN F , MALONEY JOHN M , SHEPPARD NORMAN F JR , HERMAN STEPHEN J , YOMTOV BARRY M
IPC分类号： A61M37/00 , A61B5/00 , A61B5/0215 , A61B5/042 , A61K9/00 , A61M5/14 , A61M5/142 , A61M31/00 , A61N1/32
CPC分类号： A61M25/0082 , A61B5/0215 , A61B5/042 , A61B5/1459 , A61B5/1473 , A61B5/4839 , A61M5/14276 , A61M25/0069 , A61M37/00 , A61M2005/1726 , A61M2205/0244 , A61M2205/123 , A61M2205/3653 , A61N1/32 , Y10T436/25
摘要： PROBLEM TO BE SOLVED: To provide a device which can control a reservoir content to be released and exposed, and a method. SOLUTION: The device 50 comprises electric input and electric output wires 62a which are connected to reservoir caps 58a, 58b, 58c, and 58d made of an electroconductive material to prevent a reservoir content 56 from being released out of the device 50 and exposed to a molecule outside the device 50, so that the reservoir caps are broken down by loading them when an electric current is impressed via the electric input and electric output wires 62a to release and expose the reservoir content 56: the reservoir content 56 can comprise a releasing system containing a drug molecule to release or can comprise a secondary device (such as a sensor). COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够控制要释放和暴露的储存器内容物的装置，以及一种方法。解决方案：装置50包括电输入和电输出线62a，其连接到由导电材料制成的储存器盖58a，58b，58c和58d，以防止储存器部件56从装置50中释放出来，以及暴露于器件50外部的分子，使得当通过电输入和电输出线62a施加电流时，通过加载它们来使储存器盖分解，以释放和暴露储存器内容物56：储存器内容物56可以包括包含释放药物分子的释放系统或可以包括次级装置（例如传感器）。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2009142661A Flexible microchip device for ophthalmic and other applications 有权
标题翻译：柔性微型手术用于眼科和其他应用
公开(公告)号：JP2009142661A
公开(公告)日：2009-07-02
申请号：JP2009000222
申请日：2009-01-05
申请人： Microchips Inc , マイクロチップス・インコーポレーテッド
发明人： SANTINI JOHN T JR , CIMA MICHAEL J , LANGER ROBERT S , AUSIELLO DENNIS , SHEPPARD NORMAN F JR , HERMAN STEPHEN J
IPC分类号： A61F9/007 , A61K9/00 , A61K9/70 , A61M31/00 , A61M37/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： PROBLEM TO BE SOLVED: To provide microchip device arrays that can conform to a curved surface for the controlled release or exposure of reservoir contents. SOLUTION: The arrays comprise two or more microchip device elements 54, each of the two or more microchip device elements includes a plurality of reservoirs 62 that contain molecules for controlled release or components for selective exposure, and a means for flexibly connecting the device elements. The reservoirs can contain one or more drugs and/or one or more secondary devices (for example, sensors or elements thereof). Preferably, this microchip devices contain and controllably release therapeutic, prophylactic, and diagnostic molecules on and into the eye of a patient in need thereof. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供可以符合弯曲表面的微芯片器件阵列，用于控制释放或暴露储层内容物。阵列包括两个或多个微芯片器件元件54，两个或更多个微芯片器件元件中的每一个包括多个储存器62，其包含用于控制释放的分子或用于选择性曝光的部件，以及用于灵活地连接设备元素。储存器可以包含一种或多种药物和/或一个或多个次要装置（例如，传感器或其元件）。优选地，该微芯片装置在有需要的患者眼中含有并可控地释放治疗，预防和诊断分子。版权所有（C）2009，JPO＆INPIT

5. 发明申请

WO03032957A9 METHODS FOR HERMETICALLY SEALING MICROCHIP RESERVOIR DEVICES 审中-公开
标题翻译：用于密封微孔储存器件的方法
公开(公告)号：WO03032957A9
公开(公告)日：2004-05-06
申请号：PCT/US0220490
申请日：2002-06-28
申请人： MICROCHIPS INC
发明人： UHLAND SCOTT A , POLITO BENJAMIN F , HERMAN STEPHEN J , SANTINI JOHN T JR , MALONEY JOHN M
IPC分类号： B81C3/00 , A61K9/00 , A61K9/22 , B23K1/06 , B23K26/00 , B81B1/00 , H01L27/14
CPC分类号： A61K9/0097
摘要： Methods are provided for hermetically sealing the reservoirs of microchip devices and for hermetically sealing the substrate assemblies in a hermetic packaging structure. In one embodiment, the method comprises (1) providing a primary substrate having a front side and a back side, the substrate comprising a plurality of reservoirs positioned between the front side and the back side, each reservoir being loaded with molecules or a secondary device for controlled release or exposure, the reservoirs having at least one opening in need of sealing, the primary substrate including one or more hermetic sealing materials; (2) providing a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; (3) positioning the hermetic sealing substrate over the reservoir openings and contacting said hermetic sealing materials of the primary substrate with said hermetic sealing materials of the hermetic sealing substrate; and (4) applying energy or a mechanical force to the contacted sealing materials effective to form a hermetic seal between the hermetic sealing substrate and the primary substrate to hermetically seal the reservoir openings.
摘要翻译：提供了用于气密地密封微芯片装置的储存器的方法，以及用于密封密封封装结构中的基板组件。在一个实施例中，该方法包括（1）提供具有前侧和后侧的主基底，所述基底包括位于前侧和后侧之间的多个储存器，每个储存器装载有分子或辅助装置为了控制释放或暴露，储存器具有至少一个需要密封的开口，主基底包括一个或多个气密密封材料; （2）提供具有由一种或多种密封材料构成的表面的气密密封基材; （3）将气密密封基板定位在储存器开口上，并使主基板的气密密封材料与气密密封基板的气密密封材料接触; 和（4）将能量或机械力施加到接触的密封材料上，以有效地在气密密封基底和初级基底之间形成气密密封，从而气密地密封储层开口。

6. 发明申请

WO0230264A3 MICROCHIP RESERVOIR DEVICES USING WIRELESS TRANSMISSION OF POWER AND DATA 审中-公开
标题翻译：使用无线传输功率和数据的MICROCHIP储存设备
公开(公告)号：WO0230264A3
公开(公告)日：2003-07-17
申请号：PCT/US0131767
申请日：2001-10-10
申请人： MICROCHIPS INC
发明人： SHEPPARD NORMAN F JR , SANTINI JOHN T JR , HERMAN STEPHEN J , CIMA MICHAEL J , LANGER ROBERT S , AUSIELLO DENNIS
IPC分类号： A61B5/0402 , A61B5/0476 , A61K9/00 , A61K9/22 , A61M5/14
CPC分类号： A61B1/041 , A61B5/0402 , A61B5/0476 , A61B5/14539 , A61K9/0009 , A61K9/0051 , A61K9/0097 , A61M5/14 , A61M5/14276 , A61M2205/0244 , A61M2205/3523 , A61M2210/0612 , A61M2210/1042
摘要： Devices, systems, and methods are provided for wirelessly powering and/or communicating with microchip devices used for the controlled exposure and release of reservoir contents, such as drugs, reagents, and sensors. In one embodiment, the system includes (1) a microchip device comprising a substrate having a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a rechargeable or on-demand power source comprising a local component which can wirelessly receive power from a remote transmitter wherein the received power can be used, directly or following transduction, to activate said release or exposure of the reservoir contents. In another embodiment, the system comprises (1) a microchip device comprising a substrate a plurality or reservoirs containing reservoir contents for release or exposure; and (2) a telemetry system for the wireless transfer of data between the microchip device and a remote controller.
摘要翻译：提供了设备，系统和方法，用于与用于受控地暴露和释放储存器内容物（例如药物，试剂和传感器）的微芯片装置的无线供电和/或通信。在一个实施例中，系统包括（1）微芯片装置，其包括具有多个储存器的基板，所述储存器包含用于释放或曝光的储存器内容物; 和（2）可充电或点播电源，其包括本地组件，其可以从远程发射器无线地接收电力，其中可以直接或继续使用所接收的功率来激活所述储存器内容物的释放或暴露。在另一个实施例中，该系统包括（1）微芯片装置，其包括基底，多个或储存器包含用于释放或暴露的储存器内容物; 和（2）用于在微芯片设备和遥控器之间无线传输数据的遥测系统。

7. 发明专利

DE602004029396D1 MEDIZINPRODUKT ZUM MESSEN VON GLUCOSE 未知
公开(公告)号：DE602004029396D1
公开(公告)日：2010-11-11
申请号：DE602004029396
申请日：2004-11-03
申请人： MICROCHIPS INC
发明人： SANTINI JOHN T JR , HERMAN STEPHEN J
IPC分类号： A61B5/00 , A61M31/00 , A61N1/00

8. 发明专利

AU2007200736A1 Controlled release device and method 未知
公开(公告)号：AU2007200736A1
公开(公告)日：2007-03-08
申请号：AU2007200736
申请日：2007-02-20
申请人： MICROCHIPS INC
发明人： SHEPPARD NORMAN F JR , HERMAN STEPHEN J , MALONEY JOHN M , UHLAND SCOTT A , POLITO BENJAMIN F , YOMTOV BARRY M
IPC分类号： A61K9/00 , A61M5/14

9. 发明专利

AU2003303288A1 CONTROLLED RELEASE DEVICE AND METHOD USING ELECTROTHERMAL ABLATION 未知
公开(公告)号：AU2003303288A1
公开(公告)日：2004-09-06
申请号：AU2003303288
申请日：2003-08-15
申请人： MICROCHIPS INC
发明人： HERMAN STEPHEN J , YOMTOV BARRY M , UHLAND SCOTT A , POLITO BENJAMIN F , MALONEY JOHN M , SHEPPARD NORMAN F JR
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/042 , A61K9/00 , A61M5/14 , A61M5/142 , A61M37/00 , A61N1/32
摘要： Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a substrate, a plurality of reservoirs in the substrate, reservoir contents disposed in the reservoirs, discrete reservoir caps covering each reservoir to seal the reservoir contents in the reservoirs, and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo. At least one of the reservoir caps comprises a first electrically conductive layer coated with one or more protective layers. In one embodiment, the control circuitry comprises an electrical input lead and an electrical output lead connected to and directly contacting each of said reservoir caps and a source of electric power for applying an electrical current through each reservoir cap in an amount effective to rupture each of the reservoir caps.

10. 发明申请

WO2006015299A9 Multi-reservoir device for transdermal drug delivery and sensing 审中-公开
标题翻译：用于透皮药物传递和感测的多储器装置
公开(公告)号：WO2006015299A9
公开(公告)日：2006-06-15
申请号：PCT/US2005027201
申请日：2005-08-01
申请人： MICROCHIPS INC , SANTINI JR JOHN T , STAPLES MARK ANDREW , HERMAN STEPHEN J
发明人： SANTINI JR JOHN T , STAPLES MARK ANDREW , HERMAN STEPHEN J
IPC分类号： A61K9/70 , A61M37/00
CPC分类号： A61K9/703 , A61F2013/00642 , A61K9/0009 , A61K9/0021 , A61K9/0097 , A61K9/7084 , A61K9/7092 , A61M37/0015 , A61M2037/0023 , A61N1/30
摘要： Devices and methods are provide for transdermal administration of a pharmaceutical agent to a patient in need thereof. In one aspect, the device includes a substrate; a plurality of discrete reservoirs in the substrate; one or more pharmaceutical agents stored in the reservoirs; discrete reservoir caps which prevent the pharmaceutical agent from passing out from the reservoirs; control means for actuating release of the one or more pharmaceutical agents from one or more of the reservoirs by disintegrating or permeabilizing the reservoir caps; means for securing the device to the skin of the patient; and means for transporting to the skin the one or more pharmaceutical agents following release from the one or more of the reservoir.
摘要翻译：提供了将药剂透皮施用于有需要的患者的装置和方法。一方面，该装置包括基板; 衬底中的多个离散储存器; 储存在储存器中的一种或多种药剂; 分离的储存器盖，其防止药剂从储存器中流出; 控制装置，用于通过使储存器盖分解或渗透来致动一个或多个药剂从一个或多个储存器释放; 用于将装置固定到患者皮肤的装置; 以及用于在一个或多个储存器释放之后将一种或多种药物运送到皮肤的装置。

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