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1. 发明申请

WO2009064879A3 ANTIMICROBIAL COATINGS FOR MEDICAL DEVICES AND METHODS FOR MAKING AND USING THEM 审中-公开
公开(公告)号：WO2009064879A3
公开(公告)日：2009-05-22
申请号：PCT/US2008/083395
申请日：2008-11-13
申请人： MEDTRONIC MINIMED, INC. , YANG, Zhongping , JIN, Eunjoo , CHRISTOFERSON, Laura , SHAH, Rajiv
发明人： YANG, Zhongping , JIN, Eunjoo , CHRISTOFERSON, Laura , SHAH, Rajiv
IPC分类号： A61L27/34 , A61L27/50
摘要： Embodiments of the invention provide methods for using compositions to inhibit microbial growth on a surface of a medical device having the composition applied thereto, to medical devices having the composition applied to a surface thereof and to methods for using the compositions to coat medical devices.

2. 发明公开

EP2854641A2 FOLDOVER SENSORS AND METHODS FOR MAKING AND USING THEM 有权
标题翻译： FALTSENSOREN UND VERFAHREN ZUR HERSTELLUNG UND VERWENDUNG DAVON
公开(公告)号：EP2854641A2
公开(公告)日：2015-04-08
申请号：EP13728608.4
申请日：2013-05-24
申请人： Medtronic MiniMed, Inc. , Little, Megan E. , Wolfe, Katherine T. , Raghavendhar, Gautham , Liang, Bradley Chi , Shah, Rajiv
发明人： LITTLE, Megan E. , WOLFE, Katherine T. , RAGHAVENDHAR, Gautham , LIANG, Bradley Chi , SHAH, Rajiv
IPC分类号： A61B5/1486
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2562/125 , A61B2562/166 , A61B2562/222 , C12Q1/001 , C12Q1/006 , G01N27/3272 , Y10T29/49204
摘要： The invention disclosed herein includes sensors having three dimensional configurations that allow expansive "360°" sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Embodiments of the invention provide analyte sensors having foldable substrates adapted to produce optimized configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.
摘要翻译：本文公开的发明包括具有三维配置的传感器，其允许在这些传感器被布置的环境中进行膨胀的“360°”感测（即感测来自多个方向的分析物）。本发明的实施例提供了分析物传感器，其具有适于产生电极元件的优化配置的可折叠基底以及用于制造和使用这种传感器的方法。本发明的典型实施方案包括用于治疗糖尿病的葡萄糖传感器。

3. 发明公开

EP2800778A1 STABILIZED POLYMERS FOR USE WITH ANALYTE SENSORS AND METHODS FOR MAKING AND USING THEM 有权转让
标题翻译：稳定化聚合物与用于生产和使用分析物传感器及使用方法
公开(公告)号：EP2800778A1
公开(公告)日：2014-11-12
申请号：EP13700597.1
申请日：2013-01-04
申请人： Medtronic MiniMed, Inc. , Wang, Jenn-Hann L. , Cochran, Brooks B. , Dang, Tri T. , Shah, Rajiv
发明人： WANG, Jenn-Hann, L. , COCHRAN, Brooks, B. , DANG, Tri, T. , SHAH, Rajiv
IPC分类号： C08G77/458 , C08G18/50 , C08G18/61 , C08K5/00 , C12Q1/00 , C08K5/13 , C08G18/28 , C08G18/32 , C08G18/75
CPC分类号： C08G77/458 , C08K5/13 , C12Q1/002 , C08L75/00
摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a linear polyurethane/polyurea polymer comprising one or more agents selected for their ability to stabilize the polymers against thermal and/or oxidative degradation.

4. 发明公开

EP2948057A1 MUTING GLUCOSE SENSOR OXYGEN RESPONSE AND REDUCING ELECTRODE EDGE GROWTH WITH PULSED CURRENT PLATING 有权转让
标题翻译：葡萄糖传感器氧代谢及排除用脉冲STROMPLATTIERUNG增长铅减少
公开(公告)号：EP2948057A1
公开(公告)日：2015-12-02
申请号：EP13729544.0
申请日：2013-05-24
申请人： Medtronic MiniMed, Inc. , Huang, Ting , Rao, Ashwin K. , Shah, Rajiv , Yang, Qingling
发明人： HUANG, Ting , RAO, Ashwin, K. , SHAH, Rajiv , YANG, Qingling
IPC分类号： A61B5/145 , A61B5/1486 , G01N33/573 , C25D5/18
摘要： The invention disclosed herein includes amperometric glucose sensors having electrodes formed from processes that electrodeposit platinum black in a manner that produces relatively smooth three dimensional metal architectures, ones that contribute to sensor reliability and stability. Embodiments of the invention provide analyte sensors having such uniform electrode architectures as well as methods for making and using these sensor electrodes. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.

5. 发明申请

WO2011115949A1 GLUCOSE SENSOR 审中-公开
标题翻译：葡萄糖传感器
公开(公告)号：WO2011115949A1
公开(公告)日：2011-09-22
申请号：PCT/US2011/028447
申请日：2011-03-15
申请人： MEDTRONIC MINIMED, INC. , WOLFE, Katherine T. , KANTAK, Ameya S. , LARSON, Eric Allan , PESANTEZ, Daniel E. , XI, Dongjuan , CHIU, Chia-Hung , SHAH, Rajiv
发明人： WOLFE, Katherine T. , KANTAK, Ameya S. , LARSON, Eric Allan , PESANTEZ, Daniel E. , XI, Dongjuan , CHIU, Chia-Hung , SHAH, Rajiv
IPC分类号： G01N27/403 , G01N27/49 , A61B5/1486
CPC分类号： A61B5/14546 , A61B5/14503 , A61B5/14532 , A61B5/14542 , A61B5/14865 , A61B5/6848
摘要： Embodiments of the invention provide analyte sensors having optimized elements and/or configurations of elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes, comprising : a plurality of sensor wires (301, 302, 303, 304) having a first end and second end and each arranged in a substanially common orientation, the plurality of sensor wires being electically conductive and including: a first sensor wire (303, 304) substantially covered by a first electically insulating cover (310), wherein a aperture in the first electrically insulating cover defines a working electrode area (313, 314); a second sensor wire (301) substantially covered by a second electrically insulating cover (310), wherein an aperture in the second electrically insulating cover defines a reference electrode area (311); and a third sensor wire (302) substantially covered by a third electrically insulating insulating cover (310), wherein an aperture in the third electrically insulating cover defines a counter electrode area (312).
摘要翻译：本发明的实施例提供了具有优化的元件和/或元件构造的分析物传感器以及用于制造和使用这种传感器的方法。本发明的典型实施例包括用于治疗糖尿病的葡萄糖传感器，包括：多个传感器线（301,302,303,304），其具有第一端和第二端，并且各自以基本共同的取向布置，传感器导线是导电的并且包括：基本上由第一电绝缘盖（310）覆盖的第一传感器线（303,304），其中所述第一电绝缘盖中的孔限定工作电极区域（313,314）; 基本上由第二电绝缘盖（310）覆盖的第二传感器线（301），其中所述第二电绝缘盖中的孔限定参考电极区域（311）; 以及基本上由第三电绝缘绝缘盖（310）覆盖的第三传感器线（302），其中所述第三电绝缘盖中的孔限定对电极区域（312）。

6. 发明申请

WO2009026236A1 METHOD AND SYSTEM FOR REMEDYING SENSOR MALFUNCTIONS DETECTED BY ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY 审中-公开
标题翻译：电化学阻抗光谱法检测传感器畸变的方法和系统
公开(公告)号：WO2009026236A1
公开(公告)日：2009-02-26
申请号：PCT/US2008/073493
申请日：2008-08-18
申请人： MEDTRONIC MINIMED, INC. , WANG, Lu , SHAH, Rajiv
发明人： WANG, Lu , SHAH, Rajiv
IPC分类号： G01N27/416 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1495 , A61M5/1723 , A61M2230/201
摘要： A method and system that enables a user to maintain a sensor in real time. The present invention involves performing a diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure to measure sensor impedance value in order to determine if the sensor is operating at an optimal level. If the sensor is not operating at an optimal level, the present invention may further involve performing a sensor remedial action. The sensor remedial action involves reversing the DC voltage being applied between the working electrode and the reference electrode. The reversed DC voltage may be coupled with an AC voltage to extend its reach.
摘要翻译：一种使用户实时维护传感器的方法和系统。本发明涉及执行诊断电化学阻抗谱（EIS）程序来测量传感器阻抗值，以便确定传感器是否以最佳水平操作。如果传感器不工作在最佳水平，本发明可进一步涉及执行传感器补救动作。传感器补救措施包括反转施加在工作电极和参比电极之间的直流电压。反向的直流电压可以与AC电压耦合以扩展其范围。

7. 发明申请

WO2007070486A2 BIOSENSORS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：生物传感器及其制备和使用方法
公开(公告)号：WO2007070486A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/047271
申请日：2006-12-12
申请人： MEDTRONIC MINIMED, INC. , SHAH, Rajiv , SOUNDARARAJAN, Gopikrishnan , GOTTLIEB, Rebecca, K. , HOSS, Udo , GROVENDER, Eric, A. , PENDO, Shaun
发明人： SHAH, Rajiv , SOUNDARARAJAN, Gopikrishnan , GOTTLIEB, Rebecca, K. , HOSS, Udo , GROVENDER, Eric, A. , PENDO, Shaun
IPC分类号： G01N27/327 , C12Q1/00 , C08G77/46 , C08L83/12 , G03F7/00
CPC分类号： C12Q1/006
摘要： Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having glucose oxidase coatings.
摘要翻译：本发明的实施例提供具有优化的选择渗透膜的分析物传感器以及用于制造和使用这种传感器的方法。本发明的实施例还提供分析物传感器，例如具有涂覆有分析物传感组合物的多孔基质的分析物传感器以及用于制造和使用这种传感器的方法。说明性实施例包括具有葡萄糖氧化酶涂层的电化学葡萄糖传感器。

8. 发明申请

WO2005065537A1 IMPLANTABLE APPARATUS FOR SENSING MULTIPLE PARAMETERS 审中-公开
标题翻译：用于感应多个参数的可植入装置
公开(公告)号：WO2005065537A1
公开(公告)日：2005-07-21
申请号：PCT/US2004/041932
申请日：2004-12-15
申请人： MEDTRONIC MINIMED, INC. , REGHABI, Bahar , GOTTLIEB, Rebecca , SHAH, Rajiv , ENEGREN, Bradley, J. , VAN ANTWERP, William, P.
发明人： REGHABI, Bahar , GOTTLIEB, Rebecca , SHAH, Rajiv , ENEGREN, Bradley, J. , VAN ANTWERP, William, P.
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/01 , A61B5/0215 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/14546 , A61B5/14551 , A61B5/1459 , A61B5/412 , A61B5/4839 , A61B5/6852 , A61B2562/063
摘要： An apparatus for sensing multiple parameters includes an implantable housing and a plurality of implantable sensors disposed within the implantable housing. The plurality of implantable sensors sense parameters in a patient, such as biological or physiological parameters, for example, and each responds to an analyte in the patient. The plurality of implantable sensors may include, but is not limited to, electrochemical, potentiometric, current and optical sensors.
摘要翻译：一种用于感测多个参数的装置包括可植入壳体和设置在可植入壳体内的多个可植入传感器。多个可植入传感器感测患者中的参数，例如生物或生理参数，并且每个对患者中的分析物进行响应。多个可植入传感器可以包括但不限于电化学，电位，电流和光学传感器。

9. 发明申请

WO2013036493A1 ORTHOGONALLY REDUNDANT SENSOR SYSTEMS AND METHODS 审中-公开
标题翻译：正交冗余传感器系统和方法
公开(公告)号：WO2013036493A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/053707
申请日：2012-09-04
申请人： MEDTRONIC MINIMED, INC. , SHAH, Rajiv , KRISTENSEN, Jesper Svenning , WOLFE, Katherine T. , AASMUL, Soren , BANSAL, Anubhuti
发明人： SHAH, Rajiv , KRISTENSEN, Jesper Svenning , WOLFE, Katherine T. , AASMUL, Soren , BANSAL, Anubhuti
IPC分类号： A61B5/00 , A61B5/1459 , A61B5/1473 , A61B5/1455 , G01N21/77
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/0004 , A61B5/14556 , A61B5/1459 , A61B5/1473 , A61B5/4839 , A61B5/6848 , A61B5/6849 , A61B5/742 , A61M5/1723 , A61M2230/201 , G01N21/6408 , G01N21/6428 , G01N21/7703 , G01N33/66 , G01N2021/6441 , G01N2021/6484 , G01N2021/772 , G01N2021/7733 , G01N2021/775 , G01N2021/7759 , G01N2021/7786 , G01N2333/4724
摘要： A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values. The sensors' distal portions may be inserted into a user's body via a single delivery needle and may be co-located inside the user's body.
摘要翻译：连续葡萄糖监测系统可以包括手持监视器，发射器，胰岛素泵和正交冗余葡萄糖传感器，其可以包括光学葡萄糖传感器和非光学葡萄糖传感器。前者可以是纤维光学传感器，其包括具有葡萄糖类似物和荧光团标记的葡萄糖受体的竞争性葡萄糖结合亲和力测定，其通过光学询问系统例如堆叠的平面集成光学系统进行询问。非光学传感器可以是具有沿其长度分布的多个电极的电化学传感器。光学和电化学传感器的近端部分可以容纳在发射器内部并且可操作地与仪器耦合，以便例如从传感器接收信号，转换成相应的葡萄糖值并传达葡萄糖值。传感器的远端部分可以经由单个输送针插入使用者的身体，并且可以位于使用者的身体内。

10. 发明申请

WO2012100133A2 ELECTRODE COMPOSITIONS FOR USE WITH ANALYTE SENSORS 审中-公开
标题翻译：用于分析传感器的电极组合物
公开(公告)号：WO2012100133A2
公开(公告)日：2012-07-26
申请号：PCT/US2012/021983
申请日：2012-01-20
申请人： MEDTRONIC MINIMED, INC. , YANG, Qingling , SHAH, Rajiv , LI, Xiaolong , PHAM, Barry Phong , LI, Yiwen
发明人： YANG, Qingling , SHAH, Rajiv , LI, Xiaolong , PHAM, Barry Phong , LI, Yiwen
IPC分类号： C12Q1/00
CPC分类号： C12Q1/001 , C12Q1/005
摘要： Embodiments of the invention provide amperometric analyte sensors having optimized elements such as electrodes formed from sputtered platinum compositions as well as layers of material selected to optimize the characteristics of a wide variety of sensor elements and sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.
摘要翻译：本发明的实施例提供具有优化元件的电流分析传感器，例如由溅射的铂组合物形成的电极以及被选择用于优化各种传感器元件和传感器的特性的材料层。尽管可以在多种情况下使用创新的实施例，但是本发明的典型实施例包括用于糖尿病管理的葡萄糖传感器。

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