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1. 发明申请

WO2009064879A3 ANTIMICROBIAL COATINGS FOR MEDICAL DEVICES AND METHODS FOR MAKING AND USING THEM 审中-公开
公开(公告)号：WO2009064879A3
公开(公告)日：2009-05-22
申请号：PCT/US2008/083395
申请日：2008-11-13
申请人： MEDTRONIC MINIMED, INC. , YANG, Zhongping , JIN, Eunjoo , CHRISTOFERSON, Laura , SHAH, Rajiv
发明人： YANG, Zhongping , JIN, Eunjoo , CHRISTOFERSON, Laura , SHAH, Rajiv
IPC分类号： A61L27/34 , A61L27/50
摘要： Embodiments of the invention provide methods for using compositions to inhibit microbial growth on a surface of a medical device having the composition applied thereto, to medical devices having the composition applied to a surface thereof and to methods for using the compositions to coat medical devices.

2. 发明申请

WO2010088698A2 ANTIMICROBIAL ACCESSORY FOR AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于可植入医疗装置的抗微生物附件
公开(公告)号：WO2010088698A2
公开(公告)日：2010-08-05
申请号：PCT/US2010/022944
申请日：2010-02-02
申请人： MEDTRONIC, INC. , COBIAN, Kenneth, E. , EICHENBERG GALLAGHER, Genevieve, Louise , SEILER, Peter, M. , DANG, Kiem, H. , HEMENWAY, Michael, S. , YANG, Zhongping , SCHULD, James, L. , BLUMENTHAL, Tico
发明人： COBIAN, Kenneth, E. , EICHENBERG GALLAGHER, Genevieve, Louise , SEILER, Peter, M. , DANG, Kiem, H. , HEMENWAY, Michael, S. , YANG, Zhongping , SCHULD, James, L. , BLUMENTHAL, Tico
IPC分类号： A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58
CPC分类号： A61L2/0082 , A61K31/496 , A61K31/65 , A61L2/24 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/208 , A61L2300/404 , A61L2300/406 , A61L2300/604 , A61L2300/608 , Y10T428/249953 , C08L89/06
摘要： An antimicrobial accessory may include a pressure sensitive adhesive and an antimicrobial mixed in the pressure sensitive adhesive. In some examples, an antimicrobial accessory may include at least one first domain comprising a pressure sensitive adhesive and a first antimicrobial and at least one second domain including a second polymer and a second antimicrobial. The antimicrobial accessory may be configured to be attached to a housing of an implantable medical device (IMD).
摘要翻译：抗微生物附件可以包括压敏粘合剂和混合在压敏粘合剂中的抗微生物剂。在一些实例中，抗微生物附件可包括至少一个包含压敏粘合剂和第一抗微生物剂的第一区域和至少一个包含第二聚合物和第二抗微生物剂的第二区域。抗微生物附件可以被配置成附着到可植入医疗设备（IMD）的外壳。

3. 发明申请

WO2004071291A2 IMPLANTABLE CHEMICAL SENSOR 审中-公开
标题翻译：可植入化学传感器
公开(公告)号：WO2004071291A2
公开(公告)日：2004-08-26
申请号：PCT/US2004/004210
申请日：2004-02-12
申请人： MEDTRONIC, INC. , YANG, Zhongping , MARTIN, Roy, C. , CARNEY, James, K.
发明人： YANG, Zhongping , MARTIN, Roy, C. , CARNEY, James, K.
IPC分类号： A61B5/00
CPC分类号： A61B5/0031 , G01N21/6428 , G01N21/77 , G01N2021/6419 , G01N2021/6421 , G01N2021/7759 , G01N2021/7786 , G01N2201/022 , G01N2201/0227
摘要： A method and apparatus is provided for determining a property of an analyte using a sensing layer whose optical response changes with the analyte. The apparatus includes a housing with an optically transparent window for receiving the sensing layer. The window passes optical stimulation to the sensing layer and the optical response from the sensing layer. A stimulating light emitter is coupled to a first face of an optical body monolithically coupled to the window and a light detector is coupled to a second face of the optical body for receiving the response. The optical response changes as the concentration of the analyte changes. Reference molecules included in the sensing layer can provide a calibration signal to a second light detector mounted on a third face of the optical body. The first, second and third faces of the optical body are different and not coplanar.
摘要翻译：提供了一种使用其光响应随分析物变化的感测层来确定分析物的性质的方法和装置。该装置包括具有用于接收感测层的光学透明窗口的壳体。窗口将光学刺激传递到感测层和来自感测层的光学响应。刺激光发射器耦合到单体耦合到窗口的光学体的第一面，并且光检测器耦合到光学体的第二面以接收响应。光学响应随分析物浓度的变化而变化。包括在感测层中的参考分子可以向安装在光学体的第三面上的第二光检测器提供校准信号。光学体的第一面，第二面和第三面不同，不共面。

4. 发明申请

WO2005011490A1 IMPLANTABLE BIOSENSOR 审中-公开
标题翻译：可植入生物传感器
公开(公告)号：WO2005011490A1
公开(公告)日：2005-02-10
申请号：PCT/US2004/024516
申请日：2004-07-29
申请人： MEDTRONIC, INC. , YANG, Zhongping
发明人： YANG, Zhongping
IPC分类号： A61B5/00
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/14532
摘要： An implantable sensor includes a biosensor, integrated circuitry to operate the biosensor and an antenna to transmit data collected from the biosensor. The sensor does not include an internal power source and instead receives power from an external source in the form of RF energy. The RF energy is received by the sensor, rectified, and used as a DC source. The sensor is implanted in a subcutaneous location to allow the biosensor to measure desired characteristics.
摘要翻译：植入式传感器包括生物传感器，用于操作生物传感器的集成电路和用于传送从生物传感器收集的数据的天线。传感器不包括内部电源，而是以RF能量的形式从外部电源接收电力。 RF能量由传感器接收，整流，并用作直流电源。将传感器植入皮下位置以允许生物传感器测量所需特征。

5. 发明申请

WO2004000471A1 MICROSTAMPING ACTIVATED POLYMER SURFACES 审中-公开
标题翻译：微量激活聚合物表面
公开(公告)号：WO2004000471A1
公开(公告)日：2003-12-31
申请号：PCT/US2003/018487
申请日：2003-06-12
申请人： DUKE UNIVERSITY , CHILKOTI, Ashutosh , YANG, Zhongping , HYUN, Jinho
发明人： CHILKOTI, Ashutosh , YANG, Zhongping , HYUN, Jinho
IPC分类号： B05D1/00
CPC分类号： B82Y30/00 , A61L27/34 , A61L27/50 , A61L27/54 , A61L2300/22 , A61L2300/23 , A61L2300/252 , A61L2300/258 , A61L2300/604 , B01J19/0046 , B01J2219/00382 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B05D1/185 , B05D1/283 , B82Y40/00 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/545 , Y10T156/19
摘要： Methods of attaching a ligand to a surface are described that include contacting a surface having an amphiphilic comb polymer present thereon and having a first reactive moiety attached thereto with a substrate having at least one ligand thereon. The ligand can include a second reactive moiety, wherein the second reactive moiety of the biological ligand and the first reactive moiety of the amphiphilic comb polymer form a covalent bond. The substrate can be separated from the surface, thereby leaving the biological ligand covalently bound to the amphiphilic comb polymer.
摘要翻译：描述了将配体连接到表面的方法，其包括使具有其上存在的两亲性梳状聚合物的表面与其上具有至少一个配体的底物接触，并具有与其连接的第一反应性部分。配体可以包括第二反应性部分，其中生物配体的第二反应性部分和两亲梳状聚合物的第一反应性部分形成共价键。底物可以与表面分离，从而使生物配体与两亲性梳状聚合物共价结合。

6. 发明申请

WO2009131880A1 PASSIVE FIXATION MEDICAL ELECTRICAL LEAD 审中-公开
标题翻译：被动固定医用电线
公开(公告)号：WO2009131880A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/040638
申请日：2009-04-15
申请人： MEDTRONIC, INC. , YANG, Zhongping , THOMPSON, Amy, E. , ADAMS, Paulus, G. , MICHELS, Koen
发明人： YANG, Zhongping , THOMPSON, Amy, E. , ADAMS, Paulus, G. , MICHELS, Koen
IPC分类号： A61N1/05
CPC分类号： A61N1/05
摘要： An implantable passive fixation lead is disclosed. The passive fixation lead comprises an elongate lead body having at least one elongate conductive element. The lead body includes a proximal end and a distal end. A support member has a first surface and a second surface. The second surface is coupled to the distal end of the lead body. A linking material is coupled to the first surface of the support member. A bioadhesive material is coupled to the linking material. A removable cover is placed over the bioadhesive material.
摘要翻译：公开了可植入的被动固定引线。被动固定引线包括具有至少一个细长导电元件的细长引线体。引线体包括近端和远端。支撑构件具有第一表面和第二表面。第二表面联接到引线主体的远端。连接材料联接到支撑构件的第一表面。生物粘附材料与连接材料连接。可移除的盖子放置在生物粘附材料上。

7. 发明申请

WO2007076383A3 SELF-ASSEMBLING CROSS-LINKING MOLECULAR NANO FILM 审中-公开
公开(公告)号：WO2007076383A3
公开(公告)日：2007-07-05
申请号：PCT/US2006/062356
申请日：2006-12-20
申请人： Medtronic, Inc. , YANG, Zhongping
发明人： YANG, Zhongping
IPC分类号： A61L27/34 , A61L31/10 , A61B5/00 , A61N1/00
摘要： The present invention is a molecular nano film formed on a surface of an implantable medical device to provide a barrier to tissue attachment. The film comprises self-assembling cross-linking molecules.

8. 发明申请

WO2006115777A1 METHOD AND APPARATUS FOR OPTIMIZING CARDIAC RESYNCHRONIZATION THERAPY 审中-公开
标题翻译：用于优化心脏再生治疗的方法和装置
公开(公告)号：WO2006115777A1
公开(公告)日：2006-11-02
申请号：PCT/US2006/013597
申请日：2006-04-11
申请人： MEDTRONIC, INC. , YANG, Zhongping , HJELLE, Mark, A. , HINE, Douglas, S.
发明人： YANG, Zhongping , HJELLE, Mark, A. , HINE, Douglas, S.
IPC分类号： A61N1/05 , A61B5/00 , A61N1/362
CPC分类号： A61N1/36557 , A61N1/056 , A61N1/3627 , A61N1/36564
摘要： In some embodiments, a method for optimizing cardiac resynchronization therapy (CRT) may include one or more of the following steps: (a) conducting a baseline measurement of a physical parameter of a patient before initiating CRT, (b) performing an implantation process including implanting a pacing device and pacing leads in the patient, the pacing device and pacing leads for providing the CRT, (c) initiating CRT on the patient, (d) measuring the physical parameter of the patient after initiation of the CRT, (e) comparing the measured physical parameter after initiation of the CRT to the baseline measure of the physical parameter to analyze the patient's response to the CRT, (f) adjusting the CRT during the implantation process to try and improve the patient's response to the CRT, and (g) repositioning at least one of the patient leads during the implantation process to try and improve the patient's response to the CRT.
摘要翻译：在一些实施例中，用于优化心脏再同步治疗（CRT）的方法可以包括以下步骤中的一个或多个：（a）在开始CRT之前对患者的物理参数进行基线测量，（b）执行植入过程，包括将起搏装置和起搏引线植入患者体内，起搏装置和起搏引线用于提供CRT，（c）在患者身上启动CRT，（d）在CRT开始后测量患者的物理参数，（e）将CRT开始后的测量物理参数与物理参数的基线测量进行比较，以分析患者对CRT的反应，（f）在植入过程中调整CRT以尝试改善患者对CRT的反应，和 g）在植入过程期间重新定位至少一个患者导线，以试图改善患者对CRT的反应。

9. 发明申请

WO2005020797A2 IMPLANTABLE BIOSENSOR DEVICES FOR MONITORING CARDIAC MARKER MOLECULES 审中-公开
标题翻译：用于监测心脏标记分子的可植入生物传感器装置
公开(公告)号：WO2005020797A2
公开(公告)日：2005-03-10
申请号：PCT/US2004/027958
申请日：2004-08-26
申请人： MEDTRONIC, INC. , MANDA, Ven , BENNETT, Tommy, D. , YANG, Zhongping
发明人： MANDA, Ven , BENNETT, Tommy, D. , YANG, Zhongping
IPC分类号： A61B
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61N1/36514
摘要： ABSTRACT: An implantable biosensor system is disclosed that is adapted to determine levels of cardiac markers in a patient to aid in the diagnosis, determination of the severity and management of cardiovascular diseases. The biosensor includes nanowire sensor elements having a biological recognition element attached to a nanowire transducer that specifically binds to the cardiac marker being measured. Each of the sensor elements is associated with a protective member that prevents the sensor element from interacting with the surrounding environment. At a selected time, the protective member may be disabled, thereby allowing the sensor element to begin sensing signals within a living body.
摘要翻译：摘要：公开了一种植入式生物传感器系统，其适于确定患者心脏标志物的水平，以帮助诊断，确定心血管疾病的严重性和管理。生物传感器包括纳米线传感器元件，其具有连接到纳米线转换器的生物识别元件，其特异性地结合正被测量的心脏标志物。每个传感器元件与防止传感器元件与周围环境相互作用的保护构件相关联。在选择的时间，保护构件可以被禁用，从而允许传感器元件开始感测活体内的信号。

10. 发明申请

WO2008002831A3 MEDICAL DEVICE 审中-公开
公开(公告)号：WO2008002831A3
公开(公告)日：2008-01-03
申请号：PCT/US2007/071856
申请日：2007-06-22
申请人： MEDTRONIC, INC , MCVENES, Rick D. , YANG, Zhongping
发明人： MCVENES, Rick D. , YANG, Zhongping
IPC分类号： C23C16/455 , A61N1/00 , A61L15/00
摘要： An implantable electrical medical device and method for manufacturing the same are provided. The method includes forming a conductive substrate, placing the conductive substrate in a deposition chamber; and forming a conformal coating over the conductive substrate using atomic layer deposition. In various embodiments, the conformal coating is a conductive coating and in other embodiments the conformal coating is a dielectric coating.

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