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1. 发明申请

WO2012100133A2 ELECTRODE COMPOSITIONS FOR USE WITH ANALYTE SENSORS 审中-公开
标题翻译：用于分析传感器的电极组合物
公开(公告)号：WO2012100133A2
公开(公告)日：2012-07-26
申请号：PCT/US2012/021983
申请日：2012-01-20
申请人： MEDTRONIC MINIMED, INC. , YANG, Qingling , SHAH, Rajiv , LI, Xiaolong , PHAM, Barry Phong , LI, Yiwen
发明人： YANG, Qingling , SHAH, Rajiv , LI, Xiaolong , PHAM, Barry Phong , LI, Yiwen
IPC分类号： C12Q1/00
CPC分类号： C12Q1/001 , C12Q1/005
摘要： Embodiments of the invention provide amperometric analyte sensors having optimized elements such as electrodes formed from sputtered platinum compositions as well as layers of material selected to optimize the characteristics of a wide variety of sensor elements and sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.
摘要翻译：本发明的实施例提供具有优化元件的电流分析传感器，例如由溅射的铂组合物形成的电极以及被选择用于优化各种传感器元件和传感器的特性的材料层。尽管可以在多种情况下使用创新的实施例，但是本发明的典型实施例包括用于糖尿病管理的葡萄糖传感器。

2. 发明申请

WO2012100130A1 LAYERED ENZYME COMPOSITIONS FOR USE WITH ANALYTE SENSORS 审中-公开
标题翻译：分层酶组合物与分析仪一起使用
公开(公告)号：WO2012100130A1
公开(公告)日：2012-07-26
申请号：PCT/US2012/021980
申请日：2012-01-20
申请人： MEDTRONIC MINIMED, INC. , LI, Xiaolong , SHAH, Rajiv , YANG, Qingling , LI, Yiwen , PHAM, Barry Phong
发明人： LI, Xiaolong , SHAH, Rajiv , YANG, Qingling , LI, Yiwen , PHAM, Barry Phong
IPC分类号： C12Q1/00
CPC分类号： C12Q1/00 , C12Q1/005 , C12Q1/006
摘要： Embodiments of the invention provide amperometric analyte sensors having optimized elements such as electrodes formed from sputtered platinum compositions as well as layers of material selected to optimize the characteristics of a wide variety of sensor elements and sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.
摘要翻译：本发明的实施例提供具有优化元件的电流分析传感器，例如由溅射的铂组合物形成的电极以及被选择用于优化各种传感器元件和传感器的特性的材料层。尽管可以在多种情况下使用创新的实施例，但是本发明的典型实施例包括用于糖尿病管理的葡萄糖传感器。

3. 发明公开

EP2948057A1 MUTING GLUCOSE SENSOR OXYGEN RESPONSE AND REDUCING ELECTRODE EDGE GROWTH WITH PULSED CURRENT PLATING 有权转让
标题翻译：葡萄糖传感器氧代谢及排除用脉冲STROMPLATTIERUNG增长铅减少
公开(公告)号：EP2948057A1
公开(公告)日：2015-12-02
申请号：EP13729544.0
申请日：2013-05-24
申请人： Medtronic MiniMed, Inc. , Huang, Ting , Rao, Ashwin K. , Shah, Rajiv , Yang, Qingling
发明人： HUANG, Ting , RAO, Ashwin, K. , SHAH, Rajiv , YANG, Qingling
IPC分类号： A61B5/145 , A61B5/1486 , G01N33/573 , C25D5/18
摘要： The invention disclosed herein includes amperometric glucose sensors having electrodes formed from processes that electrodeposit platinum black in a manner that produces relatively smooth three dimensional metal architectures, ones that contribute to sensor reliability and stability. Embodiments of the invention provide analyte sensors having such uniform electrode architectures as well as methods for making and using these sensor electrodes. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.

4. 发明申请

WO2014116293A1 MUTING GLUCOSE SENSOR OXYGEN RESPONSE AND REDUCING ELECTRODE EDGE GROWTH WITH PULSED CURRENT PLATING 审中-公开
标题翻译：静脉注射葡萄糖传感器氧气反应并减少电极边缘生长与脉冲电流
公开(公告)号：WO2014116293A1
公开(公告)日：2014-07-31
申请号：PCT/US2013/042754
申请日：2013-05-24
申请人： MEDTRONIC MINIMED, INC. , HUANG, Ting , RAO, Ashwin, K. , SHAH, Rajiv , YANG, Qingling
发明人： HUANG, Ting , RAO, Ashwin, K. , SHAH, Rajiv , YANG, Qingling
IPC分类号： A61B5/145 , A61B5/1486 , G01N33/573 , C25D5/18
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2562/125 , C12Q1/006 , C25D3/50 , C25D5/18 , G01N2333/902
摘要： The invention disclosed is an amperometric glucose sensor having electrodes formed from processes that electrodeposit platinum black by using a pulsed plating process. This can produce relatively smooth three dimensional metal architectures, ones that contribute to sensor reliability and stability. Embodiments of the invention provide analyte sensors having such uniform electrode architectures as well as methods for making (and using) these sensor electrodes. Such electrodes can be used in amperometric glucose sensors worn by diabetic individuals.
摘要翻译：本发明公开了一种电流葡萄糖传感器，其具有通过使用脉冲电镀方法电沉积铂黑的方法形成的电极。这可以产生相对平滑的三维金属结构，有助于传感器的可靠性和稳定性。本发明的实施例提供具有这种均匀电极结构的分析物传感器以及制造（和使用）这些传感器电极的方法。这种电极可用于由糖尿病患者佩戴的电流葡萄糖传感器。

5. 发明申请

WO2014008297A1 ANALYTE SENSORS AND PRODUCTION THEREOF 审中-公开
标题翻译：分析传感器及其生产
公开(公告)号：WO2014008297A1
公开(公告)日：2014-01-09
申请号：PCT/US2013/049138
申请日：2013-07-02
申请人： MEDTRONIC MINIMED, INC. , LI, Yiwen , WANG, Jenn-Hann, L. , SHAH, Rajiv
发明人： LI, Yiwen , WANG, Jenn-Hann, L. , SHAH, Rajiv
IPC分类号： C12Q1/54
CPC分类号： C12Q1/54 , C12Q1/006 , G01N27/307
摘要： Embodiments of the invention provide methods and materials for making analyte sensors having a plurality of layered elements such as amperometric glucose sensors that are used by diabetic individuals to monitor blood sugar concentrations. Embodiments of the invention utilize plasma deposition technologies to form thin films of adhesion promoting compositions useful in such sensors. Sensors that incorporate the thin film compositions formed by these processes exhibit a number of desirable characteristics.
摘要翻译：本发明的实施方案提供了用于制备分析物传感器的方法和材料，所述分析物传感器具有多个分层元件，例如由糖尿病个体用于监测血糖浓度的电流葡萄糖传感器。本发明的实施方案利用等离子体沉积技术形成用于这种传感器的粘合促进组合物的薄膜。结合由这些方法形成的薄膜组合物的传感器表现出许多期望的特征。

6. 发明公开

EP2854641A2 FOLDOVER SENSORS AND METHODS FOR MAKING AND USING THEM 有权
标题翻译： FALTSENSOREN UND VERFAHREN ZUR HERSTELLUNG UND VERWENDUNG DAVON
公开(公告)号：EP2854641A2
公开(公告)日：2015-04-08
申请号：EP13728608.4
申请日：2013-05-24
申请人： Medtronic MiniMed, Inc. , Little, Megan E. , Wolfe, Katherine T. , Raghavendhar, Gautham , Liang, Bradley Chi , Shah, Rajiv
发明人： LITTLE, Megan E. , WOLFE, Katherine T. , RAGHAVENDHAR, Gautham , LIANG, Bradley Chi , SHAH, Rajiv
IPC分类号： A61B5/1486
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2562/125 , A61B2562/166 , A61B2562/222 , C12Q1/001 , C12Q1/006 , G01N27/3272 , Y10T29/49204
摘要： The invention disclosed herein includes sensors having three dimensional configurations that allow expansive "360°" sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Embodiments of the invention provide analyte sensors having foldable substrates adapted to produce optimized configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.
摘要翻译：本文公开的发明包括具有三维配置的传感器，其允许在这些传感器被布置的环境中进行膨胀的“360°”感测（即感测来自多个方向的分析物）。本发明的实施例提供了分析物传感器，其具有适于产生电极元件的优化配置的可折叠基底以及用于制造和使用这种传感器的方法。本发明的典型实施方案包括用于治疗糖尿病的葡萄糖传感器。

7. 发明公开

EP2800778A1 STABILIZED POLYMERS FOR USE WITH ANALYTE SENSORS AND METHODS FOR MAKING AND USING THEM 有权转让
标题翻译：稳定化聚合物与用于生产和使用分析物传感器及使用方法
公开(公告)号：EP2800778A1
公开(公告)日：2014-11-12
申请号：EP13700597.1
申请日：2013-01-04
申请人： Medtronic MiniMed, Inc. , Wang, Jenn-Hann L. , Cochran, Brooks B. , Dang, Tri T. , Shah, Rajiv
发明人： WANG, Jenn-Hann, L. , COCHRAN, Brooks, B. , DANG, Tri, T. , SHAH, Rajiv
IPC分类号： C08G77/458 , C08G18/50 , C08G18/61 , C08K5/00 , C12Q1/00 , C08K5/13 , C08G18/28 , C08G18/32 , C08G18/75
CPC分类号： C08G77/458 , C08K5/13 , C12Q1/002 , C08L75/00
摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a linear polyurethane/polyurea polymer comprising one or more agents selected for their ability to stabilize the polymers against thermal and/or oxidative degradation.

8. 发明申请

WO2011115949A1 GLUCOSE SENSOR 审中-公开
标题翻译：葡萄糖传感器
公开(公告)号：WO2011115949A1
公开(公告)日：2011-09-22
申请号：PCT/US2011/028447
申请日：2011-03-15
申请人： MEDTRONIC MINIMED, INC. , WOLFE, Katherine T. , KANTAK, Ameya S. , LARSON, Eric Allan , PESANTEZ, Daniel E. , XI, Dongjuan , CHIU, Chia-Hung , SHAH, Rajiv
发明人： WOLFE, Katherine T. , KANTAK, Ameya S. , LARSON, Eric Allan , PESANTEZ, Daniel E. , XI, Dongjuan , CHIU, Chia-Hung , SHAH, Rajiv
IPC分类号： G01N27/403 , G01N27/49 , A61B5/1486
CPC分类号： A61B5/14546 , A61B5/14503 , A61B5/14532 , A61B5/14542 , A61B5/14865 , A61B5/6848
摘要： Embodiments of the invention provide analyte sensors having optimized elements and/or configurations of elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes, comprising : a plurality of sensor wires (301, 302, 303, 304) having a first end and second end and each arranged in a substanially common orientation, the plurality of sensor wires being electically conductive and including: a first sensor wire (303, 304) substantially covered by a first electically insulating cover (310), wherein a aperture in the first electrically insulating cover defines a working electrode area (313, 314); a second sensor wire (301) substantially covered by a second electrically insulating cover (310), wherein an aperture in the second electrically insulating cover defines a reference electrode area (311); and a third sensor wire (302) substantially covered by a third electrically insulating insulating cover (310), wherein an aperture in the third electrically insulating cover defines a counter electrode area (312).
摘要翻译：本发明的实施例提供了具有优化的元件和/或元件构造的分析物传感器以及用于制造和使用这种传感器的方法。本发明的典型实施例包括用于治疗糖尿病的葡萄糖传感器，包括：多个传感器线（301,302,303,304），其具有第一端和第二端，并且各自以基本共同的取向布置，传感器导线是导电的并且包括：基本上由第一电绝缘盖（310）覆盖的第一传感器线（303,304），其中所述第一电绝缘盖中的孔限定工作电极区域（313,314）; 基本上由第二电绝缘盖（310）覆盖的第二传感器线（301），其中所述第二电绝缘盖中的孔限定参考电极区域（311）; 以及基本上由第三电绝缘绝缘盖（310）覆盖的第三传感器线（302），其中所述第三电绝缘盖中的孔限定对电极区域（312）。

9. 发明申请

WO2009026236A1 METHOD AND SYSTEM FOR REMEDYING SENSOR MALFUNCTIONS DETECTED BY ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY 审中-公开
标题翻译：电化学阻抗光谱法检测传感器畸变的方法和系统
公开(公告)号：WO2009026236A1
公开(公告)日：2009-02-26
申请号：PCT/US2008/073493
申请日：2008-08-18
申请人： MEDTRONIC MINIMED, INC. , WANG, Lu , SHAH, Rajiv
发明人： WANG, Lu , SHAH, Rajiv
IPC分类号： G01N27/416 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1495 , A61M5/1723 , A61M2230/201
摘要： A method and system that enables a user to maintain a sensor in real time. The present invention involves performing a diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure to measure sensor impedance value in order to determine if the sensor is operating at an optimal level. If the sensor is not operating at an optimal level, the present invention may further involve performing a sensor remedial action. The sensor remedial action involves reversing the DC voltage being applied between the working electrode and the reference electrode. The reversed DC voltage may be coupled with an AC voltage to extend its reach.
摘要翻译：一种使用户实时维护传感器的方法和系统。本发明涉及执行诊断电化学阻抗谱（EIS）程序来测量传感器阻抗值，以便确定传感器是否以最佳水平操作。如果传感器不工作在最佳水平，本发明可进一步涉及执行传感器补救动作。传感器补救措施包括反转施加在工作电极和参比电极之间的直流电压。反向的直流电压可以与AC电压耦合以扩展其范围。

10. 发明申请

WO2007070486A2 BIOSENSORS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：生物传感器及其制备和使用方法
公开(公告)号：WO2007070486A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/047271
申请日：2006-12-12
申请人： MEDTRONIC MINIMED, INC. , SHAH, Rajiv , SOUNDARARAJAN, Gopikrishnan , GOTTLIEB, Rebecca, K. , HOSS, Udo , GROVENDER, Eric, A. , PENDO, Shaun
发明人： SHAH, Rajiv , SOUNDARARAJAN, Gopikrishnan , GOTTLIEB, Rebecca, K. , HOSS, Udo , GROVENDER, Eric, A. , PENDO, Shaun
IPC分类号： G01N27/327 , C12Q1/00 , C08G77/46 , C08L83/12 , G03F7/00
CPC分类号： C12Q1/006
摘要： Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having glucose oxidase coatings.
摘要翻译：本发明的实施例提供具有优化的选择渗透膜的分析物传感器以及用于制造和使用这种传感器的方法。本发明的实施例还提供分析物传感器，例如具有涂覆有分析物传感组合物的多孔基质的分析物传感器以及用于制造和使用这种传感器的方法。说明性实施例包括具有葡萄糖氧化酶涂层的电化学葡萄糖传感器。

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