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1. 发明申请

WO9957128A8 OPTIMIZATION OF PEST RESISTANCE GENES USING DNA SHUFFLING 审中-公开
标题翻译：使用DNA切片优化抗病基因
公开(公告)号：WO9957128A8
公开(公告)日：2001-02-15
申请号：PCT/US9908473
申请日：1999-04-22
申请人： MAXYGEN INC , STEMMER WILLEM P C , CASTLE LINDA , YAMAMOTO TAKASHI
发明人： STEMMER WILLEM P C , CASTLE LINDA , YAMAMOTO TAKASHI
IPC分类号： C12N15/09 , C07K14/325 , C12N5/00 , C12N15/82 , C12R1/07 , C07H21/04 , C12N5/14
CPC分类号： C12N15/8285 , C07K14/325 , C07K2319/00 , C12N15/8286 , Y02A40/162 , Y02A40/164
摘要： This invention provides methods of obtaining pest resistance genes that are improved over naturally occurring genes for use in conferring upon plants resistance to pests. The methods involve the use of DNA shuffling of pest resistance genes to produce libraries of recombinant pest resistance genes, which are then screened to identify those that exhibit the improved property or properties of interest.
摘要翻译：本发明提供了获得害虫抗性基因的方法，该基因比用于赋予植物抗病虫害性的天然存在的基因更好。该方法涉及使用有害动物抗性基因的DNA改组来产生重组害虫抗性基因的文库，然后对其进行筛选以鉴定那些显示改善的感兴趣的性质或性质的基因。

2. 发明申请

WO0004190A9 EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION 审中-公开
标题翻译：通过重新序列重组实现全细胞和有机体的发育
公开(公告)号：WO0004190A9
公开(公告)日：2000-08-10
申请号：PCT/US9915972
申请日：1999-07-15
申请人： MAXYGEN INC , DEL CARDAYRE STEPHEN , TOBIN MATTHEW , STEMMER WILLEM P C , NESS JON E , MINSHULL JEREMY , PATTEN PHILLIP A , SUBRAMANIAN VENKITESWATAN , CASTLE LINDA A , KREBBER CLAUS M , BASS STEVE , ZHANG YING XIN , COX TONY , HUISMAN GJALT , YUAN LING , AFFHOLTER JOSEPH A
发明人： DEL CARDAYRE STEPHEN , TOBIN MATTHEW , STEMMER WILLEM P C , NESS JON E , MINSHULL JEREMY , PATTEN PHILLIP A , SUBRAMANIAN VENKITESWATAN , CASTLE LINDA A , KREBBER CLAUS M , BASS STEVE , ZHANG YING-XIN , COX TONY , HUISMAN GJALT , YUAN LING , AFFHOLTER JOSEPH A
IPC分类号： A01H5/00 , A01K67/027 , C07K14/245 , C12N15/09 , C12N15/10 , C12N15/82 , C12P17/16 , C12Q1/68 , C12N15/00
CPC分类号： C12N15/102 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12P17/162 , C12Q1/68 , C12Q1/6811 , C12Q1/6827 , C12R1/465
摘要： The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
摘要翻译：本发明提供了采用迭代循环重组和选择/筛选全细胞和生物体以获得所需性质的方法的方法。这些性质的实例包括增加的重组原性，基因组拷贝数以及蛋白质和次级代谢物的表达和/或分泌能力。

3. 发明申请

WO0173000A3 METHODS FOR MODULATING CELLULAR AND ORGANISMAL PHENOTYPES 审中-公开
标题翻译：调节细胞和有机基因的方法
公开(公告)号：WO0173000A3
公开(公告)日：2002-06-27
申请号：PCT/US0109203
申请日：2001-03-23
申请人： MAXYGEN INC , STEMMER WILLEM P C , MINSHULL JEREMY , KEENAN ROBERT J
发明人： STEMMER WILLEM P C , MINSHULL JEREMY , KEENAN ROBERT J
IPC分类号： C12N15/10 , C12N15/113 , C12N15/66 , C12N15/11 , C12N15/63 , C12Q1/68
CPC分类号： C12N15/1079 , C07K2319/00 , C12N15/1027 , C12N15/1034 , C12N15/113 , C12N15/66 , C12N2310/111
摘要： Methods for identifying and controlling the genetic and metabolic pathways underlying complex phenotypes are provided. Conjoint polynucleotide segments that contribute to or disrupt elements of a multigenic phenotype are produced and expressed in cells of interest. Conjoint polynucleotide segments are recombined and/or mutated to give rise to libraries of recombinant concatamers which are expressed in cells of interest. Libraries of conjoint polynucleotide segments and recombinant concatamers are expressed episomally or integrated into the DNA of organelles or chromosomes. Cells are screened or selected to identify members of the population of cells exhibiting a desired phenotype. Libraries and vectors comprising conjoint polynucleotide segments and recombinant concatamers, as well as cells expressing such libraries and vectors or their components are provided. Kits containing conjoint polynucleotide segments, recombinant concatamers, vectors including such polynucleotides, and cells including such polynucleotides and vectors are provided.
摘要翻译：提供了鉴定和控制复杂表型下遗传和代谢途径的方法。有助于或破坏多基因表型的元件的连接多核苷酸片段在感兴趣的细胞中产生并表达。连接的多核苷酸片段被重组和/或突变以产生在感兴趣的细胞中表达的重组连接体的文库。联合多核苷酸片段和重组连接体的文库以附加方式表达或整合到细胞器或染色体的DNA中。筛选或选择细胞以鉴定呈现所需表型的细胞群体的成员。提供了包含组合多核苷酸片段和重组连接体的文库和载体，以及表达这些文库和载体或其组分的细胞。提供了含有联合多核苷酸片段，重组连接体，包含此类多核苷酸的载体和包含此类多核苷酸和载体的细胞的试剂盒。

4. 发明申请

WO0175087A3 SUBTILISIN VARIANTS 审中-公开
公开(公告)号：WO0175087A3
公开(公告)日：2002-12-19
申请号：PCT/US0110781
申请日：2001-04-02
申请人： MAXYGEN INC , NOVOZYMES AS , NESS JON E , WELCH MARK , GIVER LORRAINE J , CHERRY JOEL R , BORCHERT TORBEN V , STEMMER WILLEM P C , MINSHULL JEREMY
发明人： NESS JON E , WELCH MARK , GIVER LORRAINE J , CHERRY JOEL R , BORCHERT TORBEN V , STEMMER WILLEM P C , MINSHULL JEREMY
IPC分类号： C12N15/09 , C07K16/40 , C11D3/386 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/54 , C12N9/56 , C12N15/57 , G06F17/50
CPC分类号： C12N9/6408 , C12N9/54
摘要： New subtilisin homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, shuffling methods involving the new homologues, antibodies to the new homologues, and methods of using the homologues are also provided.
摘要翻译：提供了新的枯草杆菌蛋白酶同源物（核酸和蛋白质）。还提供了包括这些新蛋白质，重组细胞，涉及新同系物的洗牌方法，新同系物抗体以及使用同源物的方法的组合物。

5. 发明申请

WO0028008A9 MODIFIED RIBULOSE 1,5-BISPHOSPHATE CARBOXYLASE/OXYGENASE 审中-公开
标题翻译： 1,5-二磷酸羧化酶/氧化酶修饰的纤维素
公开(公告)号：WO0028008A9
公开(公告)日：2002-04-11
申请号：PCT/US9926772
申请日：1999-11-09
申请人： MAXYGEN INC , STEMMER WILLEM P C , SUBRAMANIAN VENKITSWARAN , ZHU GENHAI , LIU LI , SELIFONOV SERGEY A
发明人： STEMMER WILLEM P C , SUBRAMANIAN VENKITSWARAN , ZHU GENHAI , LIU LI , SELIFONOV SERGEY A
IPC分类号： A01H5/00 , C12N5/10 , C12N9/88 , C12N15/09 , C12N15/29 , C12N15/82 , C12Q1/02 , C12Q1/68 , C12N5/14 , C12P19/34
CPC分类号： C12N15/8245 , C12N9/88 , C12N15/8243
摘要： The invention relates to methods and compositions for generating, modifying, adapting, and optimizing polynucleotide sequences that encode proteins having Rubisco biosynthetic enzyme activities which are useful for introduction into plant species, agronomically-important microorganisms, and other hosts, and related aspects.
摘要翻译：本发明涉及用于产生，修饰，适应和优化编码具有Rubisco生物合成酶活性的蛋白质的多核苷酸序列的方法和组合物，其可用于引入植物物种，农艺学重要的微生物和其他宿主及相关方面。

6. 发明申请

WO0100234A3 METHODS AND COMPOSITIONS FOR ENGINEERING OF ATTENUATED VACCINES 审中-公开
标题翻译：减毒疫苗工程的方法和组合物
公开(公告)号：WO0100234A3
公开(公告)日：2001-08-02
申请号：PCT/US0016984
申请日：2000-06-20
申请人： MAXYGEN INC , PUNNONEN JUHA , HOWARD RUSSELL , STEMMER WILLEM P C , DELCARDAYRE STEPHEN , APT DORIS
发明人： PUNNONEN JUHA , HOWARD RUSSELL , STEMMER WILLEM P C , DELCARDAYRE STEPHEN , APT DORIS
IPC分类号： C12N15/09 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/21 , A61K39/255 , A61K39/265 , A61K39/29 , A61K39/295 , A61P31/00 , C12N7/04 , C12Q1/68 , C12N15/00 , C12N1/36
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/21 , A61K39/255 , A61K39/265 , A61K39/29 , A61K2039/5254 , A61K2039/53 , C12N2710/16034 , C12N2710/16334 , C12N2720/12334 , C12N2740/16034 , C12N2760/16134 , C12N2760/18534 , C12N2770/10034 , C12N2770/12034 , C12N2770/20034 , C12N2770/24134 , C12N2770/24161 , C12N2770/32434 , C12N2770/36034
摘要： This invention provides attenuated vaccines, and methods of obtaining attenuated vaccines. The vaccines of the invention include recombinant viral, bacterial, parasite, and other organisms that are evolved to exhibit increased attenuation without loss of effectiveness as a vaccine. The methods involve the creation of libraries of recombinant nucleic acids (e.g., whole or partial genomes, or particular nucleic acids) which are introduced into the vaccine viruses or other organisms, followed by screening and/or selection for those viruses or organisms that are attenuated.
摘要翻译：本发明提供了减毒疫苗和获得减毒疫苗的方法。本发明的疫苗包括重组病毒，细菌，寄生虫和其他生物，其演变为展现增加的减毒而不丧失作为疫苗的有效性。该方法包括产生引入疫苗病毒或其他生物体中的重组核酸（例如全部或部分基因组或特定核酸）的文库，然后筛选和/或选择那些减毒的病毒或生物体。

7. 发明申请

WO0018906A3 SHUFFLING OF CODON ALTERED GENES 审中-公开
公开(公告)号：WO0018906A3
公开(公告)日：2000-10-26
申请号：PCT/US9922588
申请日：1999-09-28
申请人： MAXYGEN INC , PATTEN PHILLIP A , LIU LU , STEMMER WILLEM P C
发明人： PATTEN PHILLIP A , LIU LU , STEMMER WILLEM P C
IPC分类号： C12N15/09 , A61K39/00 , C07K14/16 , C07K14/505 , C07K14/535 , C12N1/21 , C12N7/00 , C12N9/16 , C12N15/10 , G06F19/00 , A61K39/21 , B01J19/00 , C07B61/00 , C12N5/10 , C12N7/04 , C12N15/11
CPC分类号： C12N15/1027 , A61K39/00 , B01J2219/00689 , C07K14/005 , C07K14/505 , C07K14/535 , C12N9/16 , C12N2740/16122
摘要： Methods of recombining codon-altered libraries of nucleic acids are provided. The nucleic acids can include conservative or non-conservative modifications of coding sequences, in addition to codon alterations, as compared with wild-type sequences. In addition to making new proteins, methods of generation vectors with reduced rates of reversion to wild-type and attenuated viruses are also provided.

8. 发明申请

WO0222663A2 STRESS RESISTANT RETROVIRUSES 审中-公开
标题翻译：抗压抗逆转录病毒
公开(公告)号：WO0222663A2
公开(公告)日：2002-03-21
申请号：PCT/US0129036
申请日：2001-09-17
申请人： MAXYGEN INC , GENETIC THERAPY INC , SOONG NAY WEI , STEMMER WILLEM P C , POWELL SHARON K , OTTO EDWARD
发明人： SOONG NAY WEI , STEMMER WILLEM P C , POWELL SHARON K , OTTO EDWARD
IPC分类号： A61K38/00 , A61K48/00 , C07K14/15 , C12N7/01 , C12N15/867 , C07K14/005
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C07K14/005 , C12N2740/13022 , C12N2740/13043
摘要： Stress and/or shear resistant retrovirus envelope protein polypeptides and nucleic acids encoding such polypeptides, as well as fragments of such nucleic acids and polypeptides and compositions thereof, are provided. Retroviruses incorporating such polypeptides and methods of using stress resistant retrovirus envelope protein polypeptides and corresponding nucleic acids are also described.
摘要翻译：提供了抗应激和/或抗剪切逆转录病毒包膜蛋白多肽和编码这些多肽的核酸，以及这些核酸和多肽的片段及其组合物。还描述了并入此类多肽的逆转录病毒以及使用抗逆转录病毒包膜蛋白多肽和相应核酸的方法。

9. 发明申请

WO0052155A3 RECOMBINATION OF INSERTION MODIFIED NUCLEIC ACIDS 审中-公开
标题翻译：插入改性核酸的重组
公开(公告)号：WO0052155A3
公开(公告)日：2001-07-26
申请号：PCT/US0005573
申请日：2000-03-03
申请人： MAXYGEN INC , PATTEN PHILLIP A , HEINRICHS VOLKER , STEMMER WILLEM P C
发明人： PATTEN PHILLIP A , HEINRICHS VOLKER , STEMMER WILLEM P C
IPC分类号： C12N15/10 , C12N15/82 , C12P21/04 , C12N15/11 , C12N9/00 , C12N9/14 , C12N15/62
CPC分类号： C12N15/8274 , C12N15/10 , C12N15/1027 , C12N15/8216 , C12N15/8289 , Y10T436/143333
摘要： Methods of modulating, tuning and improving hybridization properties and recombination properties of molecules for use in nucleic acid shuffling procedures, relates recombination mixtures and methods of modulating, tuning, improving and evolving splicing of RNAs and proteins are provided.
摘要翻译：调节，调节和改进用于核酸洗牌过程的分子的杂交性质和重组性质的方法涉及重组混合物，并且提供调节，调节，改进和进化的RNA和蛋白质剪接的方法。

10. 发明申请

WO0151663A3 INTEGRATED SYSTEMS AND METHODS FOR DIVERSITY GENERATION AND SCREENING 审中-公开
标题翻译：用于多样性生成和筛选的集成系统和方法
公开(公告)号：WO0151663A3
公开(公告)日：2002-06-13
申请号：PCT/US0101056
申请日：2001-01-10
申请人： MAXYGEN INC , BASS STEVEN H , DAVIS S CHRISTOPHER , PATTEN PHILLIP A , TOBIN MATTHEW , MINSHULL JEREMY , WELCH MARK , GUSTAFSSON CLAES , CARR BRIAN , JENNE STEPHANE , RAILLARD SUN AI , CRAMERI ANDREAS , STEMMER WILLEM P C , EMIG ROBIN , LONGCHAMP PASCAL , GOLDMAN STANLEY , GIVER LORRAINE J , AFFHOLTER JOSEPH A
发明人： BASS STEVEN H , DAVIS S CHRISTOPHER , PATTEN PHILLIP A , TOBIN MATTHEW , MINSHULL JEREMY , WELCH MARK , GUSTAFSSON CLAES , CARR BRIAN , JENNE STEPHANE , RAILLARD SUN AI , CRAMERI ANDREAS , STEMMER WILLEM P C , EMIG ROBIN , LONGCHAMP PASCAL , GOLDMAN STANLEY , GIVER LORRAINE J , AFFHOLTER JOSEPH A
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , C12N15/10 , C12Q1/68 , G01N37/00 , G06F19/00
CPC分类号： C12N15/1031 , B01J19/0046 , B01J2219/00378 , B01J2219/00585 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/00722 , B82Y30/00 , C12N15/1027 , C40B60/04 , G06F19/18 , Y02A90/22
摘要： Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.
摘要翻译：提供了用于多样化生成和筛选的集成系统和方法。该系统使用普通液体和阵列处理组分来提供核酸多样化，转录，翻译，产物筛选和随后的多样化反应。

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