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1. 发明专利

CA69153A BRAKE 未知
公开(公告)号：CA69153A
公开(公告)日：1900-10-29
申请号：CA69153D
申请日：1900-04-09
申请人： OTTO EDWARD C F , OTTO EDWARD C F JR
发明人： OTTO EDWARD C F , OTTO EDWARD C F JR

2. 发明授权

US665971A Brake. 失效
公开(公告)号：US665971A
公开(公告)日：1901-01-15
申请号：US1900014302
申请日：1900-04-25
申请人： OTTO EDWARD CHARLES FREDERICK , OTTO EDWARD CHARLES FREDERICK JR
发明人： OTTO EDWARD CHARLES FREDERICK , OTTO EDWARD CHARLES FREDERICK JR
CPC分类号： B62L5/04

3. 发明授权

US653692A Brake. 失效
公开(公告)号：US653692A
公开(公告)日：1900-07-17
申请号：US1900006425
申请日：1900-02-24
申请人： OTTO EDWARD CHARLES FREDERICK , OTTO EDWARD CHARLES FREDERICK JR
发明人： OTTO EDWARD CHARLES FREDERICK , OTTO EDWARD CHARLES FREDERICK JR
CPC分类号： F16D65/22

4. 发明授权

US654411A Bicycle-brake. 失效
公开(公告)号：US654411A
公开(公告)日：1900-07-24
申请号：US1900006424
申请日：1900-02-24
申请人： OTTO EDWARD CHARLES FREDERICK , OTTO EDWARD CHARLES FREDERICK JR
发明人： OTTO EDWARD CHARLES FREDERICK , OTTO EDWARD CHARLES FREDERICK JR
CPC分类号： B62L5/04

5. 发明申请

WO2005070948A1 CORRECTION OF ALPHA-1-ANTITRYPSIN GENETIC DEFECTS USING SPLICEOSOME MEDIATED RNA TRANS SPLICING 审中-公开
标题翻译：使用SPLICEOSOME介导的RNA转移分离的ALPHA-1-抗体基因缺陷的修正
公开(公告)号：WO2005070948A1
公开(公告)日：2005-08-04
申请号：PCT/US2005/002549
申请日：2005-01-21
申请人： INTRONN, INC. , PUTTARAJU, Madaiah , OTTO, Edward , GARCIA-BLANCO, Mariano, A. , MCGARRITY, Gerard, J. , TEMPLE, Gary, F. , COTE, Collette , MITCHELL, Lloyd, G. , MANSFIELD, Gary, S.
发明人： PUTTARAJU, Madaiah , OTTO, Edward , GARCIA-BLANCO, Mariano, A. , MCGARRITY, Gerard, J. , TEMPLE, Gary, F. , COTE, Collette , MITCHELL, Lloyd, G. , MANSFIELD, Gary, S.
IPC分类号： C07H21/02
CPC分类号： C12N15/10 , C12N15/102 , C12P19/34
摘要： The present invention provides methods and compositions for generating novel nucleic acid molecules through targeted spliceosomal mediated RNA trans -splicing. The compositions of the invention include pre-trans -splicing molecules (PTMs) designed to interact with a SERPINAI target precursor messenger RNA molecule (target pre-mRNA) and mediate a trans -splicing reaction resulting in the generation of a novel chimeric RNA molecule (chimeric RNA). In particular, the PTMs of the present invention include those genetically engineered to interact with SERPINA1 target pre-mRNA so as to result in correction of SERPINAI genetic defects responsible for AAT deficiency. The PTMs of the invention may also comprise sequences that are processed out of the PTM to yield duplex siRNA molecules directed specifically to mutant SERPIN Al mRNAs. Such duplexed siRNAs are designed to reduce the accumulation of toxic AAT protein in liver cells. The methods and compositions of the present invention can be used in gene therapy for correction of SERPINAI disorders such as AAT deficiency.
摘要翻译：本发明提供了通过靶向剪接体介导的RNA转接产生新的核酸分子的方法和组合物。本发明的组合物包括设计为与SERPINAI靶前体信使RNA分子（靶前体mRNA）相互作用的转录前分子（PTM），并介导导致产生新型嵌合RNA分子的反式剪接反应（嵌合RNA）。特别地，本发明的PTM包括经遗传工程改造以与SERPINA1靶前体mRNA相互作用，从而导致对负责AAT缺陷的SERPINAI遗传缺陷的校正。本发明的PTM还可以包含从PTM中加工得到的特异性引导突变体SERPIN A1 mRNA的双链体siRNA分子的序列。这样的双链体siRNA被设计为减少肝细胞中有毒的AAT蛋白的积累。本发明的方法和组合物可用于基因治疗以纠正SERPINAI病症如AAT缺陷。

6. 发明申请

WO2005023990A2 TRANS-SPLICING MEDIATED PHOTODYNAMIC THERAPY 审中-公开
标题翻译：转移介导的光电疗法
公开(公告)号：WO2005023990A2
公开(公告)日：2005-03-17
申请号：PCT/US2004029022
申请日：2004-09-07
申请人： INTRONN INC , MITCHELL LLOYD G , OTTO EDWARD , MERRIL CARL R
发明人： MITCHELL LLOYD G , OTTO EDWARD , MERRIL CARL R
IPC分类号： C12N15/09 , A61K31/7105 , A61K31/711 , A61K48/00 , C07H21/02 , C07H21/04 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N15/10 , C12N15/113 , C12N15/62 , C12N15/63 , C12N15/64 , C12N15/85 , C12N15/86 , C12N15/861 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12N
CPC分类号： C12N15/10 , C12N15/1027 , C12N15/1086 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/111 , C12N2310/3519 , C12N2320/33 , C12N2840/445
摘要： The present invention provides methods and compositions for conferring selective death on cells expressing a specific target precursor messenger RNA (selective target pre-mRNA). The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRMA) expressed within a cell and mediate a trans-splicing reaction resulting in the generation of a novel chimeric mRNA molecule (chimeric mRNA) capable of encoding a light producing protein or enzyme. Cell death is further mediated by the presence of a photosensitizer which upon photoactivation produces cytotoxicity.
摘要翻译：本发明提供了赋予表达特异性靶标前体信使RNA（选择性靶前体mRNA）的细胞上选择性死亡的方法和组合物。本发明的组合物包括设计成与在细胞内表达的靶前体信使RNA分子（靶前mRMA）相互作用的转录前分子（PTM），并介导反剪接反应，导致产生新的嵌合能够编码产生光的蛋白质或酶的mRNA分子（嵌合mRNA）。细胞死亡进一步由光敏剂的存在介导，光敏剂在光活化时产生细胞毒性。

7. 发明申请

WO2009000030A1 SCALP POTENTIAL MEASURING METHOD AND APPARATUS 审中-公开
标题翻译： SCALP潜在测量方法和装置
公开(公告)号：WO2009000030A1
公开(公告)日：2008-12-31
申请号：PCT/AU2008/000919
申请日：2008-06-23
申请人： CMTE DEVELOPMENT LIMITED , OTTO, Edward, J. , BONGERS, Daniel, R.
发明人： OTTO, Edward, J. , BONGERS, Daniel, R.
IPC分类号： A61B5/0476 , A61B5/0478
CPC分类号： A61B5/0476 , A61B5/04004 , A61B5/6814 , A61B5/7225
摘要： An apparatus for measuring scalp potential is disclosed, which comprises a plurality of sensors and a pre-amplifier coupled to these sensors. The sensors are adapted to measure a raw scalp potential measurement though a hair and air interface, and may be considered as a difference, reference or common measurement. The interface presents a high and variable source impedance coupling to the scalp. The pre-amplifier is adapted to have an input impedance significantly higher than that presented by the source interface, and receives the raw scalp potential measurement to produce a pre-amplified scalp potential measurement.
摘要翻译：公开了一种用于测量头皮电位的装置，其包括耦合到这些传感器的多个传感器和前置放大器。这些传感器适用于通过头发和空气界面测量原始头皮电位测量，并且可以被认为是差异，参考或常见测量。该界面呈现与头皮耦合的高且可变的源阻抗。前置放大器适于具有显着高于源接口所呈现的输入阻抗，并且接收原始头皮电位测量以产生预放大的头皮电位测量。

8. 发明申请

WO2005070023A2 EXPRESSION OF APOA-1 AND VARIANTS THEREOF USING SPLICEOSOME MEDIATED RNA TRANS-SPLICING 审中-公开
标题翻译： APOA-1的表达及其使用SPLICEOSOME介导的RNA转移分离的变体
公开(公告)号：WO2005070023A2
公开(公告)日：2005-08-04
申请号：PCT/US2005002392
申请日：2005-01-21
申请人： INTRONN INC , PUTTARAJU MADAIAH , OTTO EDWARD , GARCIA-BLANCO MARIANO A , MCGARRITY GERARD J , TEMPLE GARY F , MITCHELL LLOYD G
发明人： PUTTARAJU MADAIAH , OTTO EDWARD , GARCIA-BLANCO MARIANO A , MCGARRITY GERARD J , TEMPLE GARY F , MITCHELL LLOYD G
IPC分类号： C07K14/775 , C12N15/11 , C12N15/113
CPC分类号： C07K14/775 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/3519 , C12N2320/33
摘要： The present invention provides methods and compositions for generating novel nucleic acid molecules through targeted spliceosome mediated RNA trans-splicing that result in expression of an apoA-1 variant, the preferred embodiment referred to herein as the apoA-1 Milano variant. The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) and mediate a trans-splicing reaction resulting in the generation of a novel chimeric RNA molecule (chimeric RNA) capable of encoding the apoA-1 Milano variant. The expression of this variant protein results in protection against vascular disorders resulting from plaque build up, i.e., strokes and heart attacks. In particular, the PTMs of the presént invention include those genetically engineered to interact with the apoA-1 target premRNA so as to result in expression of the apoA-1 Milano variant. In addition, the PTMs of the invention include those genetically engineered to interact with the apoB or albumin or other specific target pre-mRNAs so as to result in expression of an apoB/apoA-1 and/or alb/apoA-1 wild type or Milano fusion protein thereby reducing apoB expression and simultaneously produce ApoA-1 function.
摘要翻译：本发明提供了通过靶向剪接体介导的RNA转接产生新的核酸分子的方法和组合物，其导致apoA-1变体（本文中称为apoA-1 Milano变体）的优选实施方案的表达。本发明的组合物包括被设计成与靶前体信使RNA分子（靶前mRNA）相互作用并且介导导致产生新的嵌合RNA分子（嵌合体）的反式剪接反应的预转录分子（PTM） RNA）能够编码apoA-1 Milano变体。该变体蛋白质的表达导致保护免受斑块积聚引起的血管疾病，即中风和心脏病发作。特别地，预发明的PTM包括经遗传工程改造以与apoA-1靶preRNA相互作用以产生载脂蛋白-A 1米兰变体的表达的那些。此外，本发明的PTM包括经遗传工程改造以与载脂蛋白B或白蛋白或其它特异性靶前体mRNA相互作用以产生apoB / apoA-1和/或alb / apoA-1野生型或米诺融合蛋白从而降低apoB表达并同时产生ApoA-1功能。

9. 发明申请

WO2004038380A3 SCREENING METHODS FOR IDENTIFICATION OF EFFICIENT PRE-TRANS-SPLICING MOLECULES 审中-公开
公开(公告)号：WO2004038380A3
公开(公告)日：2004-05-06
申请号：PCT/US2003/034102
申请日：2003-10-23
申请人： INTRONN, INC. , MITCHELL, Lloyd, G. , PUTTARAJU, Madaiah , GARCIA-BLANCO, Mariano , OTTO, Edward , YANG, Yanping
发明人： MITCHELL, Lloyd, G. , PUTTARAJU, Madaiah , GARCIA-BLANCO, Mariano , OTTO, Edward , YANG, Yanping
IPC分类号： C12Q1/68
摘要： The present invention provides methods and compositions for rapid high capacity functional screening to identify optimal pre- trans -splicing molecules (PTMs). The compositions of the invention include PTM expression libraries capable of encoding candidate PTMs designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) and mediate a trans-splicing reaction resulting in the generation of a novel chimeric RNA molecule (chimeric RNA). The candidate PTMs of the invention encode a portion of a first reporter molecule and may encode one or more other reporter molecules, which can be used to select for cells expressing optimal PTMs (efficient and specific). The compositions of the invention also include cells that express a target pre-mRNA encoding the remaining portion of the first reporter molecule. The screening methods of the invention encompass (i) contacting a PTM expression library with cells expressing a target pre-mRNA under conditions in which a trans -splicing reaction will occur in the presence of an optimal PTM (expressed by the library vector) resulting in the formation of a chimeric repaired RNA molecule capable of encoding at least one reporter molecule; (ii) selecting for cells expressing the repaired reporter molecule wherein expression of the reporter molecule indicates the presence of an optimal PTM in the selected cell; and (iii) identifying the optimal PTM expressed in the selected cell(s). The additional reporter molecule(s) can be used to assess both specific and non-specific trans -splicing, as well direct PTM expression.

10. 发明申请

WO2005070023A3 EXPRESSION OF APOA-1 AND VARIANTS THEREOF USING SPLICEOSOME MEDIATED RNA TRANS-SPLICING 审中-公开
公开(公告)号：WO2005070023A3
公开(公告)日：2005-08-04
申请号：PCT/US2005/002392
申请日：2005-01-21
申请人： INTRONN, INC. , PUTTARAJU, Madaiah , OTTO, Edward , GARCIA-BLANCO, Mariano, A. , MCGARRITY, Gerard, J. , TEMPLE, Gary, F. , MITCHELL, Lloyd, G.
发明人： PUTTARAJU, Madaiah , OTTO, Edward , GARCIA-BLANCO, Mariano, A. , MCGARRITY, Gerard, J. , TEMPLE, Gary, F. , MITCHELL, Lloyd, G.
IPC分类号： C07H21/02
摘要： The present invention provides methods and compositions for generating novel nucleic acid molecules through targeted spliceosome mediated RNA trans -splicing that result in expression of an apoA-1 variant, the preferred embodiment referred to herein as the apoA-1 Milano variant. The compositions of the invention include pre- trans -splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) and mediate a trans- splicing reaction resulting in the generation of a novel chimeric RNA molecule (chimeric RNA) capable of encoding the apoA-1 Milano variant. The expression of this variant protein results in protection against vascular disorders resulting from plaque build up, i.e., strokes and heart attacks. In particular, the PTMs of the presént invention include those genetically engineered to interact with the apoA-1 target premRNA so as to result in expression of the apoA-1 Milano variant. In addition, the PTMs of the invention include those genetically engineered to interact with the apoB or albumin or other specific target pre-mRNAs so as to result in expression of an apoB/apoA-1 and/or alb/apoA-1 wild type or Milano fusion protein thereby reducing apoB expression and simultaneously produce ApoA-1 function.

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