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1. 发明申请

WO2015095185A1 FORTIFIED MICRONUTRIENT SALT FORMULATIONS 审中-公开
标题翻译：经过微生物的盐制剂
公开(公告)号：WO2015095185A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/070583
申请日：2014-12-16
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , TOKITAE LLC
发明人： JAKLENEC, Ana , XU, Xian , WOOD, Lowell, L., Jr. , ECKHOFF, Philip, A. , GATES, William , NIKOLIC, Boris , LANGER, Robert, S.
IPC分类号： A23L1/302 , A23L1/304 , A23L1/00 , A23L1/22
CPC分类号： A61K9/5026 , A23L27/72 , A23L27/74 , A23L33/10 , A23L33/15 , A23L33/155 , A23L33/16 , A23P10/30 , A23V2002/00 , A61K9/4866 , A61K9/501 , A61K9/5073 , A61K31/07 , A61K31/23 , A61K31/295 , A61K31/375 , A61K31/519 , A61K31/593 , A61K31/714 , A61K33/18 , A61K33/26 , A61K33/30 , A61K45/06 , A61K47/26 , A61K47/36
摘要： Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.
摘要翻译：本文描述了耐湿度和烹饪条件的盐制剂。该制剂提供包封在耐热pH值敏感的水不溶性聚合物中的微量营养素和维生素颗粒，其被包装在盐壳内。 pH敏感的水不溶性的热稳定材料稳定微量营养素，特别是在高温下，例如在食物制备和烹饪期间，并且在所需位置例如胃，小肠等释放微量营养素。优选的pH- 敏感的聚合物在低pH下释放，小于胃中存在的pH。颗粒可用于与盐同时递送每日推荐剂量的微量营养素，从而消除维生素丸的需要。这在遭受严重营养不良的人群中特别重要。

2. 发明申请

WO2015191925A1 SELF-ASSEMBLED RESIDENCE DEVICES AND RELATED METHODS 审中-公开
标题翻译：自组织住宅设备及相关方法
公开(公告)号：WO2015191925A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035429
申请日：2015-06-11
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC , TOKITAE LLC
发明人： BELLINGER, Andrew , ZHANG, Shiyi , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , MO, Stacy , LIN, Jiaqi , DICICCIO, Angela , GLETTIG, Dean, Liang , WOOD, Lowell, L., Jr. , ECKHOFF, Philip, A.
IPC分类号： A61M31/00 , A61M29/04
CPC分类号： A61K9/0065 , A61K9/0053 , A61K9/48 , A61K31/357 , A61K31/65 , A61K31/7048 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/40 , A61K47/42 , A61K47/58 , A61K47/6901 , A61M31/002 , C08G18/4277 , C08G18/73 , C08G63/08 , C08G83/006 , C08G2230/00 , C08L33/02 , C08L33/08 , C08L33/14 , C08L2203/02
摘要： Residence devices as well as their related methods of manufacture and use are generally provided. In some embodiments, a residence device includes a plurality of self-assembling structures that assemble in vivo to form an aggregate structure. Each structure of the plurality of structures includes a first side and a first attachment point that attaches to a second attachment point on another structure of the plurality of structures. The aggregate structure may be sized and shaped to maintain an in vivo position relative to an internal orifice of a subject. The attachment between the first and second attachment points may degrade after a period of time.
摘要翻译：通常提供住宅设备及其相关的制造和使用方法。在一些实施例中，居住装置包括在体内组装以形成聚集体结构的多个自组装结构。多个结构的每个结构包括附接到多个结构的另一结构上的第二附接点的第一侧和第一附接点。聚集体结构的尺寸和形状可以相对于受试者的内部孔口维持体内位置。在一段时间之后，第一和第二附着点之间的连接可能会降级。

3. 发明申请

WO2015191922A1 ENTERIC ELASTOMERS 审中-公开
标题翻译： ENTERIC弹性体
公开(公告)号：WO2015191922A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035425
申请日：2015-06-11
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , TOKITAE LLC
发明人： ZHANG, Shiyi , BELLINGER, Andrew , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , GLETTIG, Dean, Liang , WOOD, Lowell, L., Jr. , ECKHOFF, Philip, A.
IPC分类号： A61K31/78 , A61K31/197 , C07C57/04
CPC分类号： A61K9/0065 , A61K9/0053 , A61K9/48 , A61K31/357 , A61K31/65 , A61K31/7048 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/40 , A61K47/42 , A61K47/58 , A61K47/6901 , A61M31/002 , C08G18/4277 , C08G18/73 , C08G63/08 , C08G83/006 , C08G2230/00 , C08L33/02 , C08L33/08 , C08L33/14 , C08L2203/02
摘要： Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.
摘要翻译：通常提供肠道弹性体和相关方法。在一些实施方案中，肠溶弹性体是聚合物复合物。某些实施方案包括聚合物复合物，其中两个含羧基聚合物内的氢键与聚合物网络交联成弹性和pH响应聚合物复合材料。有利地，该聚合物复合物在酸性环境（例如胃）中具有稳定和弹性的能力，但可以溶解在诸如小肠和大肠的中性pH环境中。在一些实施方案中，本文所述的聚合物复合材料包含两种或更多种具有羧基官能团的聚合物的混合物，使得两种或更多种聚合物形成氢键。在某些实施方案中，聚合物复合材料具有肠溶性和弹性性质。

4. 发明授权

EP3154553B1 ENTERIC ELASTOMERS 有权
公开(公告)号：EP3154553B1
公开(公告)日：2020-08-05
申请号：EP15806483.2
申请日：2015-06-11
申请人： Massachusetts Institute Of Technology , The Brigham and Women's Hospital, Inc. , Tokitae LLC
发明人： ZHANG, Shiyi , BELLINGER, Andrew , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , GLETTIG, Dean, Liang , WOOD, Lowell, L., Jr. , ECKHOFF, Philip, A.
IPC分类号： A61M31/00 , A61M29/04 , A61K9/00

5. 发明公开

EP3154553A1 ENTERIC ELASTOMERS 有权
标题翻译： ENTERALE ELASTOMERE
公开(公告)号：EP3154553A1
公开(公告)日：2017-04-19
申请号：EP15806483.2
申请日：2015-06-11
申请人： Massachusetts Institute Of Technology , The Brigham and Women's Hospital, Inc. , Tokitae LLC
发明人： ZHANG, Shiyi , BELLINGER, Andrew , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , GLETTIG, Dean, Liang , WOOD, Lowell, L., Jr. , ECKHOFF, Philip, A.
IPC分类号： A61K31/78 , A61K31/197 , C07C57/04
摘要： Described are gastric residence structures that include an active substance. The gastric residence structures may include one or more arms that include a loadable polymeric component, an elastic polymeric component, and a separate linker component. The linker may connect the one or more arms with the elastic polymeric component. The gastric residence structures may be configured to be folded and physically constrained during administration and may be configured to assume an open retention shape upon removal of a constraint. The change between the folded shape and the open retention shape may be mediated by the elastic polymeric component that undergoes elastic deformation when the residence structure is in the folded shape and recoils when the gastric residence structure assumes the open retention shape.
摘要翻译：通常提供住宅结构，系统和相关方法。某些实施方案包括将住院结构施用（例如，口服）给对象（例如，患者），使得住宿结构保持在受试者内部某一时间（例如，至少约24小时）在被释放之前。在一些情况下，住院结构可以是胃停留结构。在一些实施方案中，本文所述的结构和系统包括一种或多种配置用于在酸性环境中高水平的活性物质（例如治疗剂）负载，高活性物质和/或结构稳定性，在内部的机械柔性和强度孔（例如，胃腔），容易通过胃肠道直到输送到期望的内部孔口（例如胃腔），和/或在生理环境（例如，肠环境）中快速溶解/降解）和/或对化学刺激剂的反应（例如，摄入引起快速溶解/降解的溶液）。在某些实施方案中，该结构具有模块化设计，将配置用于控制释放治疗剂，诊断和/或增强剂的材料与胃停留所必需的结构材料组合，但被配置用于控制和/或可调节的降解/溶解以确定保留形状完整性丧失并且结构从胃腔排出的时间。例如，在某些实施方案中，宿主结构包括第一弹性组分，被配置成释放活性物质（例如治疗剂）的第二组分和任选的连接体。在一些这样的实施方案中，接头可以被配置为降解，使得停留结构在预定量的时间之后分裂并且从受试者内部的位置释放。

7. 发明公开

EP3154622A1 SELF-ASSEMBLED RESIDENCE DEVICES AND RELATED METHODS 有权
标题翻译：谢尔顿·维尔芬
公开(公告)号：EP3154622A1
公开(公告)日：2017-04-19
申请号：EP15805932.9
申请日：2015-06-11
申请人： Massachusetts Institute Of Technology , The Brigham and Women's Hospital, Inc.
发明人： BELLINGER, Andrew , ZHANG, Shiyi , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , MO, Stacy , LIN, Jiaqi , DICICCIO, Angela , GLETTIG, Dean, Liang , WOOD, Lowell, L., Jr. , ECKHOFF, Philip, A.
IPC分类号： A61M31/00 , A61M29/04
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.
摘要翻译：通常提供住宅结构，系统和相关方法。某些实施方案包括将住院结构施用（例如，口服）给对象（例如，患者），使得住宿结构保持在受试者内部某一时间（例如，至少约24小时）在被释放之前。在一些情况下，住院结构可以是胃停留结构。在一些实施方案中，本文所述的结构和系统包括一种或多种配置用于在酸性环境中高水平的活性物质（例如治疗剂）负载，高活性物质和/或结构稳定性，在内部的机械柔性和强度孔（例如，胃腔），容易通过胃肠道直到输送到期望的内部孔口（例如胃腔），和/或在生理环境（例如，肠环境）中快速溶解/降解）和/或对化学刺激剂的反应（例如，摄入引起快速溶解/降解的溶液）。在某些实施方案中，该结构具有模块化设计，将配置用于控制释放治疗剂，诊断和/或增强剂的材料与胃停留所必需的结构材料组合，但被配置用于控制和/或可调节的降解/溶解以确定保留形状完整性丧失并且结构从胃腔排出的时间。例如，在某些实施方案中，宿主结构包括第一弹性组分，被配置成释放活性物质（例如治疗剂）的第二组分和任选的连接体。在一些这样的实施方案中，接头可以被配置为降解，使得停留结构在预定量的时间之后分裂并且从受试者内部的位置释放。

8. 发明申请

WO2016200771A1 MULTI-MONODOSE CONTAINERS 审中-公开
标题翻译：多单体容器
公开(公告)号：WO2016200771A1
公开(公告)日：2016-12-15
申请号：PCT/US2016/036151
申请日：2016-06-07
申请人： TOKITAE LLC
发明人： CHOU, Fong-Li , ECKHOFF, Philip, A. , FOWLER, Lawrence, Morgan , LIU, Shieng , NATARAJAN, Krishnan , PETERSON, Nels, R. , WOOD, Lowell, L., Jr.
IPC分类号： A61J1/06 , B65D77/22 , B65D1/09 , A61J1/14 , A61J3/00
CPC分类号： A61J1/16 , A61J1/1406 , A61J1/1412 , A61J1/18 , A61J2200/70 , A61J2200/72 , A61J2205/30
摘要： Multi-monodose containers are described including a row of at least two vials, a first vial connected to an adjacent second vial through an articulating joint, the articulating joint sufficiently flexible to reversibly mate a planar outer surface of the first vial with a planar outer surface of the adjacent second vial; wherein the row of the at least two vials is configured to form a first rectangular packing cross-sectional area in an expanded configuration and configured to form a second rectangular packing cross-sectional area in a folded configuration, the second rectangular packing cross-sectional area smaller than the first rectangular packing cross-sectional area.
摘要翻译：描述了包含一行至少两个小瓶的多单容器容器，通过铰接接头连接到相邻的第二小瓶的第一小瓶，所述铰接接头足够柔软以使第一小瓶的平面外表面与平面外表面的相邻第二小瓶; 其中所述至少两个小瓶的所述行被配置为形成膨胀构型中的第一矩形填充横截面积并且构造成在折叠构型中形成第二矩形填充横截面积，所述第二矩形填充横截面积小于第一矩形填料横截面积。

9. 发明申请

WO2015009800A1 MULTI-COMPARTMENT PHARMACEUTICAL VIALS 审中-公开
标题翻译：多层药水
公开(公告)号：WO2015009800A1
公开(公告)日：2015-01-22
申请号：PCT/US2014/046813
申请日：2014-07-16
申请人： TOKITAE LLC
发明人： ECKHOFF, Philip, A. , ISHIKAWA, Muriel, Y. , LEVINE, Orin , PETERSON, Nels, R. , WOOD, Lowell, L., Jr. , WOOD, Victoria Y., H.
IPC分类号： A61J1/06 , B65D1/09 , B65D25/06
CPC分类号： A61J1/1425 , A61J1/05 , A61J1/1406
摘要： Multi-compartment pharmaceutical vials are described. In some embodiments, a multi-compartment pharmaceutical vial includes: a multi-compartment pharmaceutical storage region including a bottom wall, at least one outer wall and at least one interior wall, the bottom wall, the at least one outer wall and the at least one interior wall forming a plurality of pharmaceutical storage compartments, each pharmaceutical storage compartment including an aperture positioned opposite to the bottom wall of the pharmaceutical storage region; and an access region attached to the pharmaceutical storage region, the access region including a plurality of conduits, each with a first end and a second end, wherein the first end of each conduit is connected to one aperture in a pharmaceutical storage compartment, and the second end of each conduit circumscribes an aperture positioned opposite to the bottom wall.
摘要翻译：描述了多室药物小瓶。在一些实施方案中，多隔室药物瓶包括：多室药物储存区域，包括底壁，至少一个外壁和至少一个内壁，底壁，至少一个外壁和至少一个内壁形成多个药物储存室，每个药物储存室包括与药物储存区域的底壁相对定位的孔口; 以及附接到所述药物储存区域的进入区域，所述进入区域包括多个导管，每个导管具有第一端和第二端，其中每个导管的第一端连接到药物储存室中的一个孔，并且每个导管的第二端围绕与底壁相对定位的孔。

10. 发明申请

WO2011097040A1 TEMPERATURE-STABILIZED STORAGE SYSTEMS 审中-公开
标题翻译：温度稳定的存储系统
公开(公告)号：WO2011097040A1
公开(公告)日：2011-08-11
申请号：PCT/US2011/000234
申请日：2011-02-08
申请人： TOKITAE LLC , CHOU, Fong-Li , DEANE, Geoffrey, F. , FOWLER, Lawrence Morgan , GATES, William , GUO, Zihong , HU, Jenny Ezu , HYDE, Roderick, A. , JUNG, Edward, K., Y. , KARE, Jordin, T. , MYHRVOLD, Nathan, P. , PEGRAM, Nathan , PETERSON, Nels, R. , TEGREENE, Clarence, T. , WHITMER, Charles , WOOD, Lowell, L., Jr.
发明人： CHOU, Fong-Li , DEANE, Geoffrey, F. , FOWLER, Lawrence Morgan , GATES, William , GUO, Zihong , HU, Jenny Ezu , HYDE, Roderick, A. , JUNG, Edward, K., Y. , KARE, Jordin, T. , MYHRVOLD, Nathan, P. , PEGRAM, Nathan , PETERSON, Nels, R. , TEGREENE, Clarence, T. , WHITMER, Charles , WOOD, Lowell, L., Jr.
IPC分类号： F25D3/08
CPC分类号： B65D81/3806 , A61J1/00 , A61J2200/40 , F28D20/02
摘要： A substantially thermally sealed storage container includes an outer assembly, including one or more sections of ultra efficient insulation material substantially defining at least one thermally sealed storage region, and an inner assembly, including at least one heat sink unit within the at least one thermally sealed storage region. The inner assembly may include at least one stored material dispenser unit, wherein the at least one stored material dispenser unit includes one or more interlocks. The inner assembly may include a storage structure configured for receiving and storing at least one heat sink module and at least one stored material module. Substantially thermally sealed containers including flexible connectors joining an aperture in the exterior of the container to an aperture in a substantially thermally sealed storage region within the container are described. Systems including at least one substantially thermally sealed storage container and an information system are also described.
摘要翻译：基本上热密封的存储容器包括外部组件，其包括基本上限定至少一个热密封存储区域的一个或多个超高效绝缘材料部分和内部组件，所述内部组件包括至少一个热密封的至少一个散热器单元存储区域。内部组件可以包括至少一个储存的材料分配器单元，其中至少一个储存的材料分配器单元包括一个或多个互锁。内部组件可以包括构造成用于接收和存储至少一个散热器模块和至少一个存储的材料模块的存储结构。描述了基本上热密封的容器，其包括将容器的外部中的孔与容器内基本上热密封的存储区中的孔接合的柔性连接器。还描述了包括至少一个基本上热密封的储存容器和信息系统的系统。

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