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1. 发明申请

WO2015191922A1 ENTERIC ELASTOMERS 审中-公开
标题翻译： ENTERIC弹性体
公开(公告)号：WO2015191922A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035425
申请日：2015-06-11
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , TOKITAE LLC
发明人： ZHANG, Shiyi , BELLINGER, Andrew , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , GLETTIG, Dean, Liang , WOOD, Lowell, L., Jr. , ECKHOFF, Philip, A.
IPC分类号： A61K31/78 , A61K31/197 , C07C57/04
CPC分类号： A61K9/0065 , A61K9/0053 , A61K9/48 , A61K31/357 , A61K31/65 , A61K31/7048 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/40 , A61K47/42 , A61K47/58 , A61K47/6901 , A61M31/002 , C08G18/4277 , C08G18/73 , C08G63/08 , C08G83/006 , C08G2230/00 , C08L33/02 , C08L33/08 , C08L33/14 , C08L2203/02
摘要： Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.
摘要翻译：通常提供肠道弹性体和相关方法。在一些实施方案中，肠溶弹性体是聚合物复合物。某些实施方案包括聚合物复合物，其中两个含羧基聚合物内的氢键与聚合物网络交联成弹性和pH响应聚合物复合材料。有利地，该聚合物复合物在酸性环境（例如胃）中具有稳定和弹性的能力，但可以溶解在诸如小肠和大肠的中性pH环境中。在一些实施方案中，本文所述的聚合物复合材料包含两种或更多种具有羧基官能团的聚合物的混合物，使得两种或更多种聚合物形成氢键。在某些实施方案中，聚合物复合材料具有肠溶性和弹性性质。

2. 发明申请

WO2015191920A1 RESIDENCE STRUCTURES AND RELATED METHODS 审中-公开
标题翻译：居住结构和相关方法
公开(公告)号：WO2015191920A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035423
申请日：2015-06-11
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , TOKITAE LLC
发明人： BELLINGER, Andrew , ZHANG, Shiyi , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , MO, Stacy , GRANT, Tyler , JAFARI, Mousa , GLETTIG, Dean, Liang , DICICCIO, Angela , WOOD, Lowell, L. , ECKHOFF, Philip, A.
IPC分类号： C08F8/00 , C08G63/682
CPC分类号： A61K9/0065 , A61K9/0053 , A61K9/48 , A61K31/357 , A61K31/65 , A61K31/7048 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/40 , A61K47/42 , A61K47/58 , A61K47/6901 , A61M31/002 , C08G18/4277 , C08G18/73 , C08G63/08 , C08G83/006 , C08G2230/00 , C08L33/02 , C08L33/08 , C08L33/14 , C08L2203/02
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.
摘要翻译：通常提供住宅结构，系统和相关方法。某些实施方案包括将住院结构施用（例如，口服）给对象（例如，患者），使得住院结构保持在受试者内部某一时间（例如至少约24小时）之前被释放。在一些情况下，住院结构可以是胃停留结构。在一些实施方案中，本文所述的结构和系统包含一种或多种配置用于在酸性环境中负载高活性物质（例如治疗剂），高活性物质和/或结构稳定性，内部机械柔性和强度的材料孔（例如胃腔），容易通过胃肠道直到输送到期望的内部孔（例如胃腔），和/或在生理环境（例如，肠环境）和/或对化学刺激剂的反应（例如，摄入引起快速溶解/降解的溶液）。在某些实施方案中，结构具有模块化设计，将配置用于治疗，诊断和/或增强剂的受控释放的材料与胃停留所必需的结构材料组合，但被配置用于受控和/或可调节的降解/溶解以确定保留形状完整性丧失并且结构从胃腔排出的时间。例如，在某些实施方案中，停留结构包括第一弹性组分，被配置成释放活性物质（例如治疗剂）的第二组分和任选的连接体。在一些这样的实施方案中，接头可以被配置为降解，使得停留结构在预定量的时间之后分离并且在对象内部的位置释放。

3. 发明申请

WO2015191925A1 SELF-ASSEMBLED RESIDENCE DEVICES AND RELATED METHODS 审中-公开
标题翻译：自组织住宅设备及相关方法
公开(公告)号：WO2015191925A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035429
申请日：2015-06-11
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC , TOKITAE LLC
发明人： BELLINGER, Andrew , ZHANG, Shiyi , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , MO, Stacy , LIN, Jiaqi , DICICCIO, Angela , GLETTIG, Dean, Liang , WOOD, Lowell, L., Jr. , ECKHOFF, Philip, A.
IPC分类号： A61M31/00 , A61M29/04
CPC分类号： A61K9/0065 , A61K9/0053 , A61K9/48 , A61K31/357 , A61K31/65 , A61K31/7048 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/40 , A61K47/42 , A61K47/58 , A61K47/6901 , A61M31/002 , C08G18/4277 , C08G18/73 , C08G63/08 , C08G83/006 , C08G2230/00 , C08L33/02 , C08L33/08 , C08L33/14 , C08L2203/02
摘要： Residence devices as well as their related methods of manufacture and use are generally provided. In some embodiments, a residence device includes a plurality of self-assembling structures that assemble in vivo to form an aggregate structure. Each structure of the plurality of structures includes a first side and a first attachment point that attaches to a second attachment point on another structure of the plurality of structures. The aggregate structure may be sized and shaped to maintain an in vivo position relative to an internal orifice of a subject. The attachment between the first and second attachment points may degrade after a period of time.
摘要翻译：通常提供住宅设备及其相关的制造和使用方法。在一些实施例中，居住装置包括在体内组装以形成聚集体结构的多个自组装结构。多个结构的每个结构包括附接到多个结构的另一结构上的第二附接点的第一侧和第一附接点。聚集体结构的尺寸和形状可以相对于受试者的内部孔口维持体内位置。在一段时间之后，第一和第二附着点之间的连接可能会降级。

4. 发明授权

EP3154553B1 ENTERIC ELASTOMERS 有权
公开(公告)号：EP3154553B1
公开(公告)日：2020-08-05
申请号：EP15806483.2
申请日：2015-06-11
申请人： Massachusetts Institute Of Technology , The Brigham and Women's Hospital, Inc. , Tokitae LLC
发明人： ZHANG, Shiyi , BELLINGER, Andrew , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , GLETTIG, Dean, Liang , WOOD, Lowell, L., Jr. , ECKHOFF, Philip, A.
IPC分类号： A61M31/00 , A61M29/04 , A61K9/00

5. 发明公开

EP3154553A1 ENTERIC ELASTOMERS 有权
标题翻译： ENTERALE ELASTOMERE
公开(公告)号：EP3154553A1
公开(公告)日：2017-04-19
申请号：EP15806483.2
申请日：2015-06-11
申请人： Massachusetts Institute Of Technology , The Brigham and Women's Hospital, Inc. , Tokitae LLC
发明人： ZHANG, Shiyi , BELLINGER, Andrew , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , GLETTIG, Dean, Liang , WOOD, Lowell, L., Jr. , ECKHOFF, Philip, A.
IPC分类号： A61K31/78 , A61K31/197 , C07C57/04
摘要： Described are gastric residence structures that include an active substance. The gastric residence structures may include one or more arms that include a loadable polymeric component, an elastic polymeric component, and a separate linker component. The linker may connect the one or more arms with the elastic polymeric component. The gastric residence structures may be configured to be folded and physically constrained during administration and may be configured to assume an open retention shape upon removal of a constraint. The change between the folded shape and the open retention shape may be mediated by the elastic polymeric component that undergoes elastic deformation when the residence structure is in the folded shape and recoils when the gastric residence structure assumes the open retention shape.
摘要翻译：通常提供住宅结构，系统和相关方法。某些实施方案包括将住院结构施用（例如，口服）给对象（例如，患者），使得住宿结构保持在受试者内部某一时间（例如，至少约24小时）在被释放之前。在一些情况下，住院结构可以是胃停留结构。在一些实施方案中，本文所述的结构和系统包括一种或多种配置用于在酸性环境中高水平的活性物质（例如治疗剂）负载，高活性物质和/或结构稳定性，在内部的机械柔性和强度孔（例如，胃腔），容易通过胃肠道直到输送到期望的内部孔口（例如胃腔），和/或在生理环境（例如，肠环境）中快速溶解/降解）和/或对化学刺激剂的反应（例如，摄入引起快速溶解/降解的溶液）。在某些实施方案中，该结构具有模块化设计，将配置用于控制释放治疗剂，诊断和/或增强剂的材料与胃停留所必需的结构材料组合，但被配置用于控制和/或可调节的降解/溶解以确定保留形状完整性丧失并且结构从胃腔排出的时间。例如，在某些实施方案中，宿主结构包括第一弹性组分，被配置成释放活性物质（例如治疗剂）的第二组分和任选的连接体。在一些这样的实施方案中，接头可以被配置为降解，使得停留结构在预定量的时间之后分裂并且从受试者内部的位置释放。

6. 发明申请

WO2020160399A1 SYSTEMS AND METHODS FOR LIQUID INJECTION 审中-公开
公开(公告)号：WO2020160399A1
公开(公告)日：2020-08-06
申请号：PCT/US2020/016087
申请日：2020-01-31
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , NOVO NORDISK A/S
发明人： LANGER, Robert, S. , TRAVERSO, Carlo, Giovanni , ABRAMSON, Alex, G. , JESPERSEN, Mikkel, Oliver , MOURIDSEN, Brian , WINDUM, Jesper , POULSEN, Mette , JENSEN, Brian , WATER, Jorrit, Jeroen , LEY, Mikkel Wennemoes, Hvitfeld , LU, Xiaoya , FREDERIKSEN, Morten, Revsgaard
IPC分类号： A61M5/20 , A61M5/28 , A61M5/32 , A61M31/00
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject) such as a liquid pharmaceutical agent. In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self- actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article.

7. 发明申请

WO2018175861A1 MACRO TISSUE EXPLANT, METHODS AND USES THEREFOR 审中-公开
公开(公告)号：WO2018175861A1
公开(公告)日：2018-09-27
申请号：PCT/US2018/023982
申请日：2018-03-23
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： TRAVERSO, Carlo, Giovanni , VON ERLACH, Thomas, Christian , LANGER, Robert, S. , SAXTON, Sarah , MINAHAN, Daniel
IPC分类号： C12N5/071 , G01N33/50
摘要： Tissue explants of the gastrointestinal tract are provided. Methods of making and using the tissue explants are also provided, along with substrates designed for the tissue explants described.

8. 发明申请

WO2018089684A1 TRIGGERABLE HYDROGEL COMPOSITIONS AND RELATED METHODS 审中-公开
标题翻译：可触发的水凝胶组合物和相关方法
公开(公告)号：WO2018089684A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/060932
申请日：2017-11-09
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： TRAVERSO, Carlo, Giovanni , LIU, Jinyao , LANGER, Robert, S.
IPC分类号： A61K47/69
CPC分类号： A61K49/0404 , A61K9/0063 , A61K9/0065 , A61K9/06 , A61K31/137 , A61K31/496 , A61K45/06 , A61K47/32 , A61K47/36 , A61K49/0409
摘要： Triggerable hydrogel compositions and related methods are generally disclosed. In some embodiments, the compositions and related methods may be used for medical- related or other applications. For example, the compositions and methods described herein may be useful, for example, in biomedical applications such as articles for (e.g., gastric) retention. In certain embodiments, the composition comprises a polymer network comprising two or more interpenetrating polymers. In some embodiments, methods for deploying and/or removing an article comprising the composition, such as an article for gastric retention, are provided. The article and/or composition may be removed internally from a subject by, for example, introducing at least one reagent (e.g., one reagent, two reagents) such that at least a portion of the composition disassociates. In some cases, the polymer network is configured (e.g., upon administration of the composition to a subject) such that the composition is retained at the location internal to the subject for greater than or equal to 24 hours.
摘要翻译：一般公开了可触发的水凝胶组合物和相关方法。在一些实施方案中，组合物和相关方法可以用于医学相关或其他应用。例如，本文描述的组合物和方法可用于例如生物医学应用，例如用于（例如，胃）保留的制品。在某些实施方案中，组合物包含含有两种或更多种互穿聚合物的聚合物网络。在一些实施方案中，提供了用于展开和/或移除包含组合物的制品（诸如用于胃潴留的制品）的方法。通过例如引入至少一种试剂（例如一种试剂，两种试剂）使得至少一部分组合物解离，可以从受试者内部去除制品和/或组合物。在一些情况下，配置聚合物网络（例如，在将组合物给予对象时），使得组合物保持在对象内部的位置大于或等于24小时。

9. 发明申请

WO2008147456A2 DRUG DELIVERY SYSTEMS USING FC FRAGMENTS 审中-公开
标题翻译：使用FC FRAGMENTS的药物输送系统
公开(公告)号：WO2008147456A2
公开(公告)日：2008-12-04
申请号：PCT/US2007/085318
申请日：2007-11-20
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , FAROKHZAD, Omid, C. , ALEXIS, Frank , KUO, Timothy, T. , PRIDGEN, Eric , RADOVIC-MORENO, Aleksandar, Filip , LANGER, Robert, S.
发明人： FAROKHZAD, Omid, C. , ALEXIS, Frank , KUO, Timothy, T. , PRIDGEN, Eric , RADOVIC-MORENO, Aleksandar, Filip , LANGER, Robert, S.
IPC分类号： A61K39/395
CPC分类号： A61K47/6937 , A61K47/68 , A61K47/6935 , C07K2319/035 , C07K2319/30 , C07K2319/33
摘要： The present invention provides drug delivery systems comprising FcRn binding partners (e.g., FcRn binding partner, Fc fragment) associated with a particle or an agent to be delivered. Inventive drug delivery systems allow for binding to the FcRn receptor and transcytosis into and/or through a cell or cell layer. Inventive systems are useful for delivering therapeutic agents across the endothelium of blood vessels or the epithelium of an organ.
摘要翻译：本发明提供包含与待递送的颗粒或试剂相关联的FcRn结合配偶体（例如，FcRn结合配偶体，Fc片段）的药物递送系统。本发明的药物递送系统允许与FcRn受体结合并进入细胞或细胞层和/或通过细胞或细胞层。本发明的系统可用于递送治疗剂穿过血管的内皮或器官的上皮。

10. 发明申请

WO2022103833A1 METAL-ORGANIC FRAMEWORK MEDIATED MACROMOLECULE DELIVERY SYSTEM 审中-公开
公开(公告)号：WO2022103833A1
公开(公告)日：2022-05-19
申请号：PCT/US2021/058774
申请日：2021-11-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： LANGER, Robert, S. , TRAVERSO, Carlo Giovanni , WENTWORTH, Adam , QI, Xiaoyue
IPC分类号： A61P43/00 , A61K39/00 , A61P35/00
摘要： Articles and methods related to the administration of biomolecules to subjects using metal-organic frameworks are generally described. In some embodiments, an article is described, the article comprising a substrate comprising an adhesive layer, a support layer disposed on at least a portion of the substrate, and an active material disposed on and/or in at least a portion of the support layer, wherein the active material comprises a composite comprising a metal-organic framework and a biomolecule. In certain embodiments, a method of treating a subject with a biomolecule is described, the method comprising administering an article to a subject.

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