专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2015191925A1 SELF-ASSEMBLED RESIDENCE DEVICES AND RELATED METHODS 审中-公开
标题翻译：自组织住宅设备及相关方法
公开(公告)号：WO2015191925A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035429
申请日：2015-06-11
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC , TOKITAE LLC
发明人： BELLINGER, Andrew , ZHANG, Shiyi , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , MO, Stacy , LIN, Jiaqi , DICICCIO, Angela , GLETTIG, Dean, Liang , WOOD, Lowell, L., Jr. , ECKHOFF, Philip, A.
IPC分类号： A61M31/00 , A61M29/04
CPC分类号： A61K9/0065 , A61K9/0053 , A61K9/48 , A61K31/357 , A61K31/65 , A61K31/7048 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/40 , A61K47/42 , A61K47/58 , A61K47/6901 , A61M31/002 , C08G18/4277 , C08G18/73 , C08G63/08 , C08G83/006 , C08G2230/00 , C08L33/02 , C08L33/08 , C08L33/14 , C08L2203/02
摘要： Residence devices as well as their related methods of manufacture and use are generally provided. In some embodiments, a residence device includes a plurality of self-assembling structures that assemble in vivo to form an aggregate structure. Each structure of the plurality of structures includes a first side and a first attachment point that attaches to a second attachment point on another structure of the plurality of structures. The aggregate structure may be sized and shaped to maintain an in vivo position relative to an internal orifice of a subject. The attachment between the first and second attachment points may degrade after a period of time.
摘要翻译：通常提供住宅设备及其相关的制造和使用方法。在一些实施例中，居住装置包括在体内组装以形成聚集体结构的多个自组装结构。多个结构的每个结构包括附接到多个结构的另一结构上的第二附接点的第一侧和第一附接点。聚集体结构的尺寸和形状可以相对于受试者的内部孔口维持体内位置。在一段时间之后，第一和第二附着点之间的连接可能会降级。

2. 发明申请

WO2015191922A1 ENTERIC ELASTOMERS 审中-公开
标题翻译： ENTERIC弹性体
公开(公告)号：WO2015191922A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035425
申请日：2015-06-11
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , TOKITAE LLC
发明人： ZHANG, Shiyi , BELLINGER, Andrew , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , GLETTIG, Dean, Liang , WOOD, Lowell, L., Jr. , ECKHOFF, Philip, A.
IPC分类号： A61K31/78 , A61K31/197 , C07C57/04
CPC分类号： A61K9/0065 , A61K9/0053 , A61K9/48 , A61K31/357 , A61K31/65 , A61K31/7048 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/40 , A61K47/42 , A61K47/58 , A61K47/6901 , A61M31/002 , C08G18/4277 , C08G18/73 , C08G63/08 , C08G83/006 , C08G2230/00 , C08L33/02 , C08L33/08 , C08L33/14 , C08L2203/02
摘要： Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.
摘要翻译：通常提供肠道弹性体和相关方法。在一些实施方案中，肠溶弹性体是聚合物复合物。某些实施方案包括聚合物复合物，其中两个含羧基聚合物内的氢键与聚合物网络交联成弹性和pH响应聚合物复合材料。有利地，该聚合物复合物在酸性环境（例如胃）中具有稳定和弹性的能力，但可以溶解在诸如小肠和大肠的中性pH环境中。在一些实施方案中，本文所述的聚合物复合材料包含两种或更多种具有羧基官能团的聚合物的混合物，使得两种或更多种聚合物形成氢键。在某些实施方案中，聚合物复合材料具有肠溶性和弹性性质。

3. 发明申请

WO2015191920A1 RESIDENCE STRUCTURES AND RELATED METHODS 审中-公开
标题翻译：居住结构和相关方法
公开(公告)号：WO2015191920A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035423
申请日：2015-06-11
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , TOKITAE LLC
发明人： BELLINGER, Andrew , ZHANG, Shiyi , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , MO, Stacy , GRANT, Tyler , JAFARI, Mousa , GLETTIG, Dean, Liang , DICICCIO, Angela , WOOD, Lowell, L. , ECKHOFF, Philip, A.
IPC分类号： C08F8/00 , C08G63/682
CPC分类号： A61K9/0065 , A61K9/0053 , A61K9/48 , A61K31/357 , A61K31/65 , A61K31/7048 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/40 , A61K47/42 , A61K47/58 , A61K47/6901 , A61M31/002 , C08G18/4277 , C08G18/73 , C08G63/08 , C08G83/006 , C08G2230/00 , C08L33/02 , C08L33/08 , C08L33/14 , C08L2203/02
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.
摘要翻译：通常提供住宅结构，系统和相关方法。某些实施方案包括将住院结构施用（例如，口服）给对象（例如，患者），使得住院结构保持在受试者内部某一时间（例如至少约24小时）之前被释放。在一些情况下，住院结构可以是胃停留结构。在一些实施方案中，本文所述的结构和系统包含一种或多种配置用于在酸性环境中负载高活性物质（例如治疗剂），高活性物质和/或结构稳定性，内部机械柔性和强度的材料孔（例如胃腔），容易通过胃肠道直到输送到期望的内部孔（例如胃腔），和/或在生理环境（例如，肠环境）和/或对化学刺激剂的反应（例如，摄入引起快速溶解/降解的溶液）。在某些实施方案中，结构具有模块化设计，将配置用于治疗，诊断和/或增强剂的受控释放的材料与胃停留所必需的结构材料组合，但被配置用于受控和/或可调节的降解/溶解以确定保留形状完整性丧失并且结构从胃腔排出的时间。例如，在某些实施方案中，停留结构包括第一弹性组分，被配置成释放活性物质（例如治疗剂）的第二组分和任选的连接体。在一些这样的实施方案中，接头可以被配置为降解，使得停留结构在预定量的时间之后分离并且在对象内部的位置释放。

4. 发明授权

EP3154553B1 ENTERIC ELASTOMERS 有权
公开(公告)号：EP3154553B1
公开(公告)日：2020-08-05
申请号：EP15806483.2
申请日：2015-06-11
申请人： Massachusetts Institute Of Technology , The Brigham and Women's Hospital, Inc. , Tokitae LLC
发明人： ZHANG, Shiyi , BELLINGER, Andrew , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , GLETTIG, Dean, Liang , WOOD, Lowell, L., Jr. , ECKHOFF, Philip, A.
IPC分类号： A61M31/00 , A61M29/04 , A61K9/00

5. 发明公开

EP3154553A1 ENTERIC ELASTOMERS 有权
标题翻译： ENTERALE ELASTOMERE
公开(公告)号：EP3154553A1
公开(公告)日：2017-04-19
申请号：EP15806483.2
申请日：2015-06-11
申请人： Massachusetts Institute Of Technology , The Brigham and Women's Hospital, Inc. , Tokitae LLC
发明人： ZHANG, Shiyi , BELLINGER, Andrew , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , GLETTIG, Dean, Liang , WOOD, Lowell, L., Jr. , ECKHOFF, Philip, A.
IPC分类号： A61K31/78 , A61K31/197 , C07C57/04
摘要： Described are gastric residence structures that include an active substance. The gastric residence structures may include one or more arms that include a loadable polymeric component, an elastic polymeric component, and a separate linker component. The linker may connect the one or more arms with the elastic polymeric component. The gastric residence structures may be configured to be folded and physically constrained during administration and may be configured to assume an open retention shape upon removal of a constraint. The change between the folded shape and the open retention shape may be mediated by the elastic polymeric component that undergoes elastic deformation when the residence structure is in the folded shape and recoils when the gastric residence structure assumes the open retention shape.
摘要翻译：通常提供住宅结构，系统和相关方法。某些实施方案包括将住院结构施用（例如，口服）给对象（例如，患者），使得住宿结构保持在受试者内部某一时间（例如，至少约24小时）在被释放之前。在一些情况下，住院结构可以是胃停留结构。在一些实施方案中，本文所述的结构和系统包括一种或多种配置用于在酸性环境中高水平的活性物质（例如治疗剂）负载，高活性物质和/或结构稳定性，在内部的机械柔性和强度孔（例如，胃腔），容易通过胃肠道直到输送到期望的内部孔口（例如胃腔），和/或在生理环境（例如，肠环境）中快速溶解/降解）和/或对化学刺激剂的反应（例如，摄入引起快速溶解/降解的溶液）。在某些实施方案中，该结构具有模块化设计，将配置用于控制释放治疗剂，诊断和/或增强剂的材料与胃停留所必需的结构材料组合，但被配置用于控制和/或可调节的降解/溶解以确定保留形状完整性丧失并且结构从胃腔排出的时间。例如，在某些实施方案中，宿主结构包括第一弹性组分，被配置成释放活性物质（例如治疗剂）的第二组分和任选的连接体。在一些这样的实施方案中，接头可以被配置为降解，使得停留结构在预定量的时间之后分裂并且从受试者内部的位置释放。

6. 发明申请

WO2015168297A1 POLYMERIC MATERIALS FOR BIO-APPLICATIONS 审中-公开
标题翻译：生物应用聚合材料
公开(公告)号：WO2015168297A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/028311
申请日：2015-04-29
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： DICICCIO, Angela , BELLINGER, Andrew , TRAVERSO, Carlo, Giovanni , GLETTIG, Dean, Liang , GRANT, Tyler , LANGER, Robert, S. , WALTON, Elizabeth
IPC分类号： C08G59/18 , C08L33/10
CPC分类号： C08G59/22 , A61K31/357 , A61K31/573 , A61K31/7048 , A61K47/34 , A61K47/48215 , A61K47/48784 , A61K47/60 , A61K47/6903 , C08G59/4207 , C08G59/686 , C08G63/664 , C08G63/87 , C08G2210/00 , C08G2230/00
摘要： A composition comprising a biodegradable polymeric material and therapeutic agent associated with the polymeric material that advantageously can provide controlled release of the therapeutic agent, while comprising little to no auxiliary materials. In some embodiments, the composition is formed by the reaction of one or more monomers in the presence of a food grade catalyst. In another embodiment, the composition comprises a polymeric material capable of undergoing thermal reconfiguration (i.e. a dynamic network). Advantageously, the compositions and materials described herein may comprise a reconfigurable polymeric material (e.g., a thermoset polymeric material) having the strength and integrity of epoxy resins, the biomedical applicability of hydrogels, and/or the moldability of vitrimers.
摘要翻译：包含可生物降解的聚合物材料和与聚合物材料相关联的治疗剂的组合物，其有利地可以提供治疗剂的受控释放，同时包含很少或没有辅助材料。在一些实施方案中，通过一种或多种单体在食品级催化剂存在下的反应形成组合物。在另一个实施方案中，组合物包含能够进行热重构（即动态网络）的聚合材料。有利地，本文所述的组合物和材料可以包含具有环氧树脂的强度和完整性，水凝胶的生物医学适用性和/或可成形性的可重构聚合材料（例如，热固性聚合物材料）。

7. 发明申请

WO2019232292A8 RESIDENT ARTICLES FOR GRAM-LEVEL DOSING 审中-公开
公开(公告)号：WO2019232292A8
公开(公告)日：2019-12-05
申请号：PCT/US2019/034792
申请日：2019-05-31
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , BELLINGER, Andrew , GRANT, Tyler , VERMA, Malvika , BENSEL, Taylor , MINAHAN, Daniel
IPC分类号： A61K9/00 , A61M31/00
摘要： Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the article includes dimensions configured for transesophageal retrieval. In some cases, the articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

8. 发明申请

WO2019232292A1 RESIDENT ARTICLES FOR GRAM-LEVEL DOSING 审中-公开
公开(公告)号：WO2019232292A1
公开(公告)日：2019-12-05
申请号：PCT/US2019/034792
申请日：2019-05-31
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL INC.
发明人： TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , BELLINGER, Andrew , GRANT, Tyler , VERMA, Malvika , BENSEL, Taylor , MINAHAN, Daniel
IPC分类号： A61K9/00 , A61M31/00
摘要： Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the article includes dimensions configured for transesophageal retrieval. In some cases, the articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

9. 发明授权

EP3155024B1 RESIDENCE STRUCTURES AND RELATED METHODS 有权
公开(公告)号：EP3155024B1
公开(公告)日：2020-09-16
申请号：EP15806017.8
申请日：2015-06-11
申请人： Massachusetts Institute Of Technology , The Brigham and Women's Hospital, Inc.
发明人： BELLINGER, Andrew , ZHANG, Shiyi , TRAVERSO, Carlo, Giovanni , LANGER, Robert, S. , MO, Stacy , GRANT, Tyler , JAFARI, Mousa , GLETTIG, Dean Liang , DICICCIO, Angela , WOOD, Lowell L. Jr. , ECKHOFF, Philip A.
IPC分类号： A61K9/00

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式