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1. 发明申请

WO2019108580A1 GASTRIC RESIDENT ELECTRONICS 审中-公开
公开(公告)号：WO2019108580A1
公开(公告)日：2019-06-06
申请号：PCT/US2018/062728
申请日：2018-11-28
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： LANGER, Robert S. , TRAVERSO, Carlo Giovanni , KONG, Yong Lin
IPC分类号： A61B5/07 , A61B5/00
CPC分类号： A61B5/6885 , A61B5/0031 , A61B5/073 , A61B5/4238 , A61B5/6861 , A61B5/6871 , A61B2560/0443 , A61B2562/0285 , A61B2562/162 , A61M31/002 , A61M2205/0216 , A61M2205/0272 , A61M2205/3523 , A61M2210/1053
摘要： Gastric resident electronics, devices, systems, and related methods are generally provided. Some embodiments comprise administering (e.g., orally) an (electronic) resident structure to a subject (e.g., a patient) such that the (electronic) resident structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before exiting said location internal to the subject. In some embodiments, the resident structure is a gastric resident electronic. That is to say, in some embodiments, the resident structure is configured for relatively long gastric residence and comprises an electronic component. In some embodiments, the structures and components described herein may comprise one or more components configured for the delivery of an active substance(s) (e.g., a pharmaceutical agent) to the subject. In some embodiments, the device has a modular design, combining an electronic component(s) with materials configured for controlled and/or tunable degradation/dissolution to determine the time at which (gastric) residence is lost and the device exits the location internal to the subject. For example, in some embodiments, the resident structure comprises an electronic component and one or more additional components associated with the electronic component such that the resident structure is configured to be retained at a location internal to a subject for greater than or equal to 24 hours.

2. 发明申请

WO2018213593A1 SELF-RIGHTING SYSTEMS, METHODS, AND RELATED COMPONENTS 审中-公开
公开(公告)号：WO2018213593A1
公开(公告)日：2018-11-22
申请号：PCT/US2018/033210
申请日：2018-05-17
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： TRAVERSO, Carlo Giovanni , ABRAMSON, Alex G. , SALVADOR, Ester Caffarel , ROXHED, Niclas , KHANG, Minsoo , BENSEL, Taylor , LANGER, Robert S.
IPC分类号： A61J3/07 , A61K9/00 , A61M5/00 , A61M5/14
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

3. 发明申请

WO2022034041A1 DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：WO2022034041A1
公开(公告)日：2022-02-17
申请号：PCT/EP2021/072199
申请日：2021-08-09
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , NOVO NORDISK A/S , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： ARRICK, Graham , BOHR, Adam , CLEVELAND, Cody , FRANDSEN, Kim , GHAZAL, Aghiad , GWYNNE, Declan , JEPSEN, Jacob Pyung Hwa , KOZHUHAROV, Bozhidar Nikolaev , LANGER, Robert , LAST, Torben Sebastian , LU, Yi , MOURIDSEN, Brian , ROXHED, Niclas , STICKER, Drago , TRAVERSO, Carlo Giovanni , WAINER, Jacob , WATER, Jorrit Jeroen , YOU, Siheng S
IPC分类号： A61M31/00
摘要： A drug delivery device for administration to a subject includes a reservoir containing an active pharmaceutical ingredient and a potential energy source. The drug delivery device also includes a trigger operatively associated with the potential energy source, where the trigger is configured to actuate at a predetermined location within the subject. The drug delivery device also includes a rupturable membrane disposed along a flow path extending between the reservoir and an outlet, where the membrane is configured to rupture when the trigger is actuated. Once the trigger is actuated, the potential energy from the potential energy source may be released to expel the active pharmaceutical ingredient in a jet through the outlet.

4. 发明申请

WO2021099608A1 METHODS FOR MANUFACTURING TISSUE INTERFACING COMPONENTS 审中-公开
公开(公告)号：WO2021099608A1
公开(公告)日：2021-05-27
申请号：PCT/EP2020/082967
申请日：2020-11-20
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , NOVO NORDISK A/S
发明人： TRAVERSO, Carlo Giovanni , FREDERIKSEN, Morten Revsgaard , WATER, Jorrit Jeroen
IPC分类号： A61K9/00
摘要： Methods of manufacturing tissue interfacing components, such as solid needles comprising one or more therapeutic agents, are disclosed. In some embodiments, a method for manufacturing a tissue interfacing component comprises compressing a granular therapeutic agent within a mold cavity of a mold to form a solid tissue interfacing component. The mold cavity may define an elongated shape extending along a longitudinal axis from an opening of the mold cavity to a distal end of the mold cavity, and the granular therapeutic agent may be compressed by moving a mold punch along the longitudinal axis towards the distal end. After compressing the granular therapeutic agent to form the solid tissue interfacing component, the tissue interfacing component may be removed from the mold and subsequently inserted into tissue to deliver the therapeutic agent to a subject.

5. 发明申请

WO2018213593A9 SELF-RIGHTING SYSTEMS, METHODS, AND RELATED COMPONENTS 审中-公开
公开(公告)号：WO2018213593A9
公开(公告)日：2018-11-22
申请号：PCT/US2018/033210
申请日：2018-05-17
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： TRAVERSO, Carlo Giovanni , ABRAMSON, Alex G. , CAFFAREL SALVADOR, Ester , ROXHED, Niclas , KHANG, Minsoo , BENSEL, Taylor , LANGER, Robert S.
IPC分类号： A61J3/07 , A61K9/00 , A61M5/00 , A61M5/14
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

6. 发明申请

WO2022103833A1 METAL-ORGANIC FRAMEWORK MEDIATED MACROMOLECULE DELIVERY SYSTEM 审中-公开
公开(公告)号：WO2022103833A1
公开(公告)日：2022-05-19
申请号：PCT/US2021/058774
申请日：2021-11-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： LANGER, Robert, S. , TRAVERSO, Carlo Giovanni , WENTWORTH, Adam , QI, Xiaoyue
IPC分类号： A61P43/00 , A61K39/00 , A61P35/00
摘要： Articles and methods related to the administration of biomolecules to subjects using metal-organic frameworks are generally described. In some embodiments, an article is described, the article comprising a substrate comprising an adhesive layer, a support layer disposed on at least a portion of the substrate, and an active material disposed on and/or in at least a portion of the support layer, wherein the active material comprises a composite comprising a metal-organic framework and a biomolecule. In certain embodiments, a method of treating a subject with a biomolecule is described, the method comprising administering an article to a subject.

7. 发明申请

WO2022055991A1 THERAPEUTIC CARBON MONOXIDE FORMULATIONS 审中-公开
公开(公告)号：WO2022055991A1
公开(公告)日：2022-03-17
申请号：PCT/US2021/049457
申请日：2021-09-08
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
发明人： TRAVERSO, Carlo Giovanni , BYRNE, James D. , BOYCE, Hannah , OTTERBEIN, Leo E. , GALLO, David J.
IPC分类号： A61K38/48 , A61K41/13 , A61K47/34
摘要： A pharmaceutical composition is described that includes a pharmaceutical carrier comprising gas pockets containing carbon monoxide gas, wherein the pharmaceutical carrier is a foam, a solid, or a hydrogel. Methods of using the pharmaceutical composition to treat an inflammatory disease or condition, and methods of making the pharmaceutical composition, are also described.

8. 发明申请

WO2021231847A1 OLEOGEL AND OLEOPASTE COMPOSITIONS AND USES THEREOF 审中-公开
公开(公告)号：WO2021231847A1
公开(公告)日：2021-11-18
申请号：PCT/US2021/032428
申请日：2021-05-14
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： LANGER, Robert S. , TRAVERSO, Carlo Giovanni , KIRTANE, Ameya R. , WAHANE, Aniket , KARAVASILI, Christina
IPC分类号： A61K9/00 , A61K9/06 , A61K31/00 , A61K47/44 , A61K47/36
摘要： The present disclosure provides oleogel and oleopaste compositions, as well as methods, kits, preparations, and methods of using the same. The oleogels and oleopastes presented herein include compositions comprising azithromycin, albendazole, lumefantrine, praziquantel, moxifloxacin, and ivermectin.

9. 发明申请

WO2018213579A1 SELF-ACTUATING ARTICLES 审中-公开
公开(公告)号：WO2018213579A1
公开(公告)日：2018-11-22
申请号：PCT/US2018/033187
申请日：2018-05-17
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： TRAVERSO, Carlo Giovanni , ABRAMSON, Alex G. , SALVADOR, Ester Caffarel , ROXHED, Niclas , KHANG, Minsoo , BENSEL, Taylor , LANGER, Robert S.
IPC分类号： A61M5/32 , A61M5/20
摘要： Self-actuating articles including, for example, self-actuating needles and/or self- actuating biopsy punches, are generally provided. Advantageously, the self-actuating articles described herein may be useful as a general platform for delivery of a wide variety of pharmaceutical drugs that are typically delivered via injection directly into tissue due to degradation in the GI tract. The self-actuating articles described herein may also be used to deliver sensors and/or take biopsies without the need for an endoscopy. In some embodiments, the article comprises a spring (e.g., a coil spring, a beam, a material having particular mechanical recovery characteristics). Those of ordinary skill in the art would understand that the term spring is not intended to be limited to coil springs, but generally encompass any reversibly compressive material and/or component which, after releasing an applied compressive force on the material/component, the material/component substantially returns to an uncompressed length of the material/component (e.g., the within 95% of the length of the material/component prior to compression).

10. 发明申请

WO2019108580A8 GASTRIC RESIDENT ELECTRONICS 审中-公开
公开(公告)号：WO2019108580A8
公开(公告)日：2019-06-06
申请号：PCT/US2018/062728
申请日：2018-11-28
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： LANGER, Robert S. , TRAVERSO, Carlo Giovanni , KONG, Yong Lin
IPC分类号： A61B5/07 , A61B5/00
摘要： Gastric resident electronics, devices, systems, and related methods are generally provided. Some embodiments comprise administering (e.g., orally) an (electronic) resident structure to a subject (e.g., a patient) such that the (electronic) resident structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before exiting said location internal to the subject. In some embodiments, the resident structure is a gastric resident electronic. That is to say, in some embodiments, the resident structure is configured for relatively long gastric residence and comprises an electronic component. In some embodiments, the structures and components described herein may comprise one or more components configured for the delivery of an active substance(s) (e.g., a pharmaceutical agent) to the subject. In some embodiments, the device has a modular design, combining an electronic component(s) with materials configured for controlled and/or tunable degradation/dissolution to determine the time at which (gastric) residence is lost and the device exits the location internal to the subject. For example, in some embodiments, the resident structure comprises an electronic component and one or more additional components associated with the electronic component such that the resident structure is configured to be retained at a location internal to a subject for greater than or equal to 24 hours.

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