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1. 发明申请

WO2004087283A1 FLUID SEPARATION 审中-公开
标题翻译：流体分离
公开(公告)号：WO2004087283A1
公开(公告)日：2004-10-14
申请号：PCT/US2004/009451
申请日：2004-03-25
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , GUENTHER, Axel , JENSEN, Klavs, F. , JHUNJHUNWALA, Manish , SCHMIDT, Martin, A.
发明人： GUENTHER, Axel , JENSEN, Klavs, F. , JHUNJHUNWALA, Manish , SCHMIDT, Martin, A.
IPC分类号： B01D11/00
CPC分类号： B01L3/502784 , B01D17/045 , B01D17/048 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F13/0222 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L2200/0673 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2300/161 , B01L2300/165 , B01L2400/0406 , B01L2400/0487 , B01L2400/0694 , F16K99/0001 , F16K99/0017 , F16K99/0057 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , Y10T436/25375
摘要： A method of separating a first fluid from a second fluid may include prewetting with the first fluid at least one channel defined by a separation device, the at least one channel thereby containing a column of the first fluid along its length. A combined flow of the first fluid and the second fluid may be presented to the separation device, so that the at least one channel is in fluid communication with the combined flow. Fluid pressure may be applied across the combined flow and the separation device, but the applied pressure should not exceed the capillary pressure in the at least one channel. Otherwise, the combined flow may be forced through the separation device. In this manner, the first fluid flows through the at least one channel, and the second fluid is excluded from the at least one channel, thereby separating at least a portion of the first fluid from the second fluid.
摘要翻译：从第二流体分离第一流体的方法可以包括用第一流体预润湿由分离装置限定的至少一个通道，因此至少一个通道沿其长度包含第一流体的柱。可以将第一流体和第二流体的组合流体提供给分离装置，使得至少一个通道与组合流体流体连通。流体压力可以跨过组合的流量和分离装置施加，但施加的压力不应超过至少一个通道中的毛细管压力。否则，组合的流动可能被迫通过分离装置。以这种方式，第一流体流过至少一个通道，并且第二流体从至少一个通道排除，从而将第一流体的至少一部分与第二流体分离。

2. 发明申请

WO2006137878A3 FLOW METHOD AND REACTOR FOR MANUFACTURING NANOCRYSTALS 审中-公开
公开(公告)号：WO2006137878A3
公开(公告)日：2006-12-28
申请号：PCT/US2005/033827
申请日：2005-09-23
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , YEN, Brian, K., H. , GUENTHER, Axel , JENSEN, Klavs, F. , SCHMIDT, Martin , BAWENDI, Moungi, G.
发明人： YEN, Brian, K., H. , GUENTHER, Axel , JENSEN, Klavs, F. , SCHMIDT, Martin , BAWENDI, Moungi, G.
IPC分类号： H01L21/20 , H01L21/36
摘要： A population of nanocrystals having a narrow and controllable size distribution and can be prepared by a segmented-flow method.

3. 发明申请

WO2003013729A2 THERMALLY EFFICIENT MICROMACHINED DEVICE 审中-公开
标题翻译：热效微机器装置
公开(公告)号：WO2003013729A2
公开(公告)日：2003-02-20
申请号：PCT/US2002/023305
申请日：2002-07-23
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ARANA, Leonel, R. , FRANZ, Aleksander, J. , JENSEN, Klavs, F. , SCHAEVITZ, Samuel, B. , SCHMIDT, Martin, A.
发明人： ARANA, Leonel, R. , FRANZ, Aleksander, J. , JENSEN, Klavs, F. , SCHAEVITZ, Samuel, B. , SCHMIDT, Martin, A.
IPC分类号： B01L
CPC分类号： B01F5/0618 , B01F13/0059 , B01F2005/0621 , B01F2005/0636 , B01J19/0093 , B01J23/468 , B01J35/04 , B01J2219/00783 , B01J2219/00828 , B01J2219/00835 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01L3/5027 , B01L2200/14 , B01L2300/1805 , B01L2300/1883 , C01B3/047 , C01B3/323 , C01B3/386 , C01B2203/0233 , C01B2203/0261 , C01B2203/066 , C01B2203/0811 , C01B2203/0822 , C01B2203/1223 , C01B2203/1247 , C01B2203/1282 , F28F3/12 , F28F2260/02 , H01M8/04097 , H01M8/04201 , H01M8/0606 , H01M2250/405 , Y02B90/16 , Y02E60/364 , Y02P20/128 , Y02P20/52
摘要： A micromachined device for efficient thermal processing at least one fluid stream includes at least one fluid conducting tube having at least a region with wall thickness of less than 50μ. The device optionally includes one or more thermally conductive structures in thermal communication with first and second thermally insulating portions of the fluid conducting tube. The device also may include a thermally conductive region, and at least a portion of the fluid conducting tube is disposed within the region. A plurality of structures may be provided projecting from a wall of the fluid conducting tube into an inner volume of the tube. The structures enhance thermal conduction between a fluid within the tube and a wall of the tube. A method for fabricating, from a substrate, a micromachined device for processing a fluid stream allows the selective removal of portions of the substrate to provide desired structures integrated within the device. As an example, the micromachined device may be adapted to efficiently react fluid reactants to produce fuel for a fuel cell associated with the device, resulting in a system capable of conversion of chemical to electrical energy.
摘要翻译：用于有效热处理至少一种流体流的微机械装置包括至少一个流体传导管，该流体传导管具有至少一个壁厚小于50μ的区域。该装置可选地包括与流体传导管的第一和第二热绝缘部分热连通的一个或多个导热结构。该装置还可以包括导热区域，并且流体传导管的至少一部分设置在该区域内。多个结构可以设置成从流体传导管的壁突出到管的内部容积中。该结构增强了管内流体和管壁之间的热传导。用于从基底制造用于处理流体流的微机械装置的方法允许选择性去除基底的部分以提供集成在装置内的期望的结构。作为示例，微机械装置可以适于有效地使流体反应物反应以产生与该装置相关的燃料电池的燃料，从而导致能够将化学物质转化为电能的系统。

4. 发明申请

WO2011056929A1 CONTINUOUS FLOW SYNTHESIS OF AMINO ALCOHOLS USING MICROREACTORS 审中-公开
标题翻译：使用微生物的氨基醇的连续流动合成
公开(公告)号：WO2011056929A1
公开(公告)日：2011-05-12
申请号：PCT/US2010/055386
申请日：2010-11-04
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BEDORE, Matthew, W. , ZABORENKO, Nikolay , JENSEN, Klavs, F. , JAMISON, Timothy, F.
发明人： BEDORE, Matthew, W. , ZABORENKO, Nikolay , JENSEN, Klavs, F. , JAMISON, Timothy, F.
IPC分类号： C07C213/04 , C07D209/00 , C07D211/00 , B01J19/00
CPC分类号： C07C213/04 , B01J19/0093 , B01J2219/00788 , B01J2219/0081 , B01J2219/00828 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00952 , C07C2601/14 , C07C2602/08 , C07D209/08 , C07D215/26 , C07C215/30 , C07C215/44 , C07C217/30 , C07C217/32
摘要： The present invention provides various methods for the synthesis of chemical species in a microreactor environment. In some cases, reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. For example, the method may involve the synthesis of amino alcohols within a microchannel. Embodiment described herein may allow for reactions with significantly shorter reaction times and increased efficiency.
摘要翻译：本发明提供了在微反应器环境中合成化学物质的各种方法。在某些情况下，本发明的反应产物可能作为药物和聚合物研究中的中间体和/或产品是有价值的。例如，该方法可以涉及在微通道内合成氨基醇。本文描述的实施方案可以允许具有显着更短的反应时间和提高效率的反应。

5. 发明申请

WO2013059343A1 INTRACELLULAR DELIVERY 审中-公开
标题翻译：细胞内递送
公开(公告)号：WO2013059343A1
公开(公告)日：2013-04-25
申请号：PCT/US2012/060646
申请日：2012-10-17
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SHAREI, Armon , ADAMO, Andrea , LANGER, Robert , JENSEN, Klavs, F.
发明人： SHAREI, Armon , ADAMO, Andrea , LANGER, Robert , JENSEN, Klavs, F.
IPC分类号： C12M3/00 , C12M3/02 , C12N15/89
CPC分类号： C12N5/0602 , B82Y5/00 , C12M23/16 , C12M35/02 , C12M35/04 , C12N15/87
摘要： A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.
摘要翻译：一种用于在细胞膜中引起扰动的微流体系统，所述系统包括限定内腔的微流体通道并且被配置为使得悬浮在缓冲液中的细胞可以穿过其中，其中所述微流体通道包括细胞变形收缩部，其中直径收缩是细胞直径的函数。

6. 发明申请

WO2007006033A2 MICROFLUIDIC SEPARATORS FOR MULTIPHASE FLUID-FLOW BASED ON MEMBRANES 审中-公开
标题翻译：基于膜的多相流体流动微流体分离器
公开(公告)号：WO2007006033A2
公开(公告)日：2007-01-11
申请号：PCT/US2006/026464
申请日：2006-07-05
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , JENSEN, Klavs, F. , KRALJ, Jason, G. , SAHOO, Hemantkumar, Ramesh
发明人： JENSEN, Klavs, F. , KRALJ, Jason, G. , SAHOO, Hemantkumar, Ramesh
IPC分类号： B01D69/12
CPC分类号： B01D63/087 , B01D63/088 , B01L3/502723 , B01L3/50273 , B01L3/502753 , B01L3/502769 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , Y10T29/49826
摘要： One aspect of the invention relates to fluid-phase separators and devices containing them. Another aspect of the invention relates to the use of said fluid-phase separators and devices containing them for separating individual phases from gas-liquid and liquid-liquid two-phase mixtures for a range of flow regimes. The present invention also relates to methods of making said fluid-phase separators and devices containing them.
摘要翻译：本发明的一个方面涉及含有它们的流体相分离器和装置。本发明的另一方面涉及使用所述流体相分离器和包含它们的装置用于在一系列流动状态下将气相和液 - 液两相混合物分离出各相。本发明还涉及制造所述流体相分离器和包含它们的装置的方法。

7. 发明申请

WO2006037022A2 MICROBIOREACTOR FOR CONTINUOUS CELL CULTURE 审中-公开
标题翻译：连续细胞培养微生物
公开(公告)号：WO2006037022A2
公开(公告)日：2006-04-06
申请号：PCT/US2005/034774
申请日：2005-09-26
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ZHANG, Zhiyu , BOCCAZZI, Paolo , CHOI, Hyun-Goo , JENSEN, Klavs, F. , SINSKEY, Anthony, J.
发明人： ZHANG, Zhiyu , BOCCAZZI, Paolo , CHOI, Hyun-Goo , JENSEN, Klavs, F. , SINSKEY, Anthony, J.
IPC分类号： C12M3/00
CPC分类号： C12M23/16 , B01L3/502707 , B01L3/502715 , B01L3/502723 , B01L2300/0654 , B01L2300/0816 , B01L2300/0877 , B01L2300/0887 , B01L2300/10 , B01L2300/185 , B01L2300/1883 , B01L2400/0466 , B01L2400/0487 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C12M29/04 , C12M29/10 , C12M37/00 , C12M41/26 , C12M41/34 , G01N21/03 , G01N2021/0346
摘要： The present invention microscale bioreactors (microfermentors) and microscale bioreactor arrays for use in culturing cells. The microfermentors include a vessel for culturing cells and means for providing oxygen to the interior of the vessel at a concentration sufficient to support cell growth, e.g., growth of bacterial cells. Depending on the embodiment, the microfermentor vessel may have various interior volumes of less than approximately 1 ml. The microfermentors may include an aeration membrane and optionally a variety of sensing devices. Methods of using the microfermentors, e.g., to select optimum cell strains or bioprocess parameters are provided. The microbioreactors having a variety of different designs, some of which incorporate active fluid mixing and/or have the capability to operate in batch, fed-batch, or continuous mode. In certain embodiments the microreactors operate as microchemostats. Methods for culturing cells under chemostat conditions in a microbioreactor are also provided.
摘要翻译：本发明的用于培养细胞的微生物生物反应器（微发酵器）和微生物生物反应器阵列。微发酵器包括用于培养细胞的容器和用于以足以支持细胞生长（例如细菌细胞生长）的浓度向容器内部提供氧气的装置。取决于实施方案，微发酵罐容器可以具有小于约1ml的各种内部体积。微发酵器可以包括曝气膜和任选的各种感测装置。提供了使用微发酵器的方法，例如选择最佳细胞株或生物过程参数。具有各种不同设计的微生物反应器，其中一些结合有活性流体混合和/或具有以批量，补料分批或连续模式操作的能力。在某些实施方案中，微反应器作为微量化学剂操作。还提供了在微生物反应器中在恒化器条件下培养细胞的方法。

8. 发明申请

WO2011091243A2 TRAPPING, RECYCLING, AND OTHER TECHNIQUES INVOLVING CATALYSTS 审中-公开
标题翻译：俘获，回收和其他涉及催化剂的技术
公开(公告)号：WO2011091243A2
公开(公告)日：2011-07-28
申请号：PCT/US2011/022047
申请日：2011-01-21
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , JENSEN, Klavs, F. , JOHANSEN, Lars , NAGY, Kevin
发明人： JENSEN, Klavs, F. , JOHANSEN, Lars , NAGY, Kevin
CPC分类号： B01J31/2243 , B01J8/0442 , B01J19/0093 , B01J21/08 , B01J31/006 , B01J31/0277 , B01J31/2265 , B01J31/2273 , B01J31/2278 , B01J31/2404 , B01J35/1019 , B01J35/1061 , B01J2208/00548 , B01J2208/00557 , B01J2219/00047 , B01J2219/00788 , B01J2219/00835 , B01J2219/00867 , B01J2219/00984 , B01J2231/48 , B01J2231/543 , B01J2531/0252 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/845 , B01J2540/225 , Y10T137/0318
摘要： Trapping, recycling, and other techniques involving catalysts are provided by this invention. The present invention provides for the retention of catalysts and other immobilized entities within a reaction region. In one aspect, the invention promotes such retention by incorporating support material regions including relatively little (or, in some cases, substantially no) catalyst (and thus, a relatively large number of catalyst adsorption sites) which can trap catalyst as it is transported through the downstream support material. In some cases, such arrangements can be achieved by using multiple beds arranged in series. In other instances, the amount of catalyst can be varied within a single bed to achieve the desired effect. The embodiments described herein can be used in systems in which the catalyst is covalently or non-covalently associated with the support surface.
摘要翻译：本发明提供了包括催化剂的捕集，回收和其他技术。本发明提供了在反应区域内保留催化剂和其他固定化实体。在一个方面，本发明通过引入包括相对较少（或者在一些情况下基本上不存在）的催化剂（并且因此相对大量的催化剂吸附位点）的载体材料区域来促进这种保持，当催化剂被传输通过下游支撑材料。在某些情况下，这种布置可以通过使用多个串联排列的床来实现。在其他情况下，催化剂的量可以在单床内变化以实现期望的效果。本文所述的实施方案可用于其中催化剂与载体表面共价或非共价缔合的体系中。

9. 发明申请

WO2007038572A2 MICROBIOREACTOR FOR CONTINUOUS CELL CULTURE 审中-公开
标题翻译：连续细胞培养微生物
公开(公告)号：WO2007038572A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/037612
申请日：2006-09-26
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ZHANG, Zhiyu , BOCCAZZI, Paolo , CHOI, Hyun-goo , JENSEN, Klavs, F. , SINSKEY, Anthony, J.
发明人： ZHANG, Zhiyu , BOCCAZZI, Paolo , CHOI, Hyun-goo , JENSEN, Klavs, F. , SINSKEY, Anthony, J.
IPC分类号： C12M3/00 , C12M1/12
CPC分类号： C12M23/16 , B01F13/0059 , B01F13/0827 , B01L3/502707 , B01L3/502715 , B01L3/502723 , B01L7/00 , B01L2300/0822 , B01L2300/0887 , B01L2300/10 , B82Y30/00 , C12M23/24 , C12M23/34 , C12M27/02 , C12M29/04 , C12M41/26 , C12M41/32
摘要： The present invention microscale bioreactors (microfermentors) and microscale bioreactor arrays for use in culturing cells. The microfermentors include a vessel for culturing cells and means for providing oxygen to the interior of the vessel at a concentration sufficient to support cell growth, e.g., growth of bacterial cells. Depending on the embodiment, the microfermentor vessel may have various interior volumes of less than approximately 1 ml. The microfermentors may include an aeration membrane and optionally a variety of sensing devices. Methods of using the microfermentors, e.g., to select optimum cell strains or bioprocess parameters are provided. The microbioreactors having a variety of different designs, some of which incorporate active fluid mixing and/or have the capability to operate in batch, fed- batch, or continuous mode. In certain embodiments the microreactors operate as microchemostats. Methods for culturing cells under chemostat conditions in a microbioreactor are also provided.
摘要翻译：本发明的用于培养细胞的微生物生物反应器（微发酵器）和微生物生物反应器阵列。微发酵器包括用于培养细胞的容器和用于以足以支持细胞生长（例如细菌细胞生长）的浓度向容器内部提供氧气的装置。取决于实施方案，微发酵罐容器可以具有小于约1ml的各种内部体积。微发酵器可以包括曝气膜和任选的各种感测装置。提供了使用微发酵器的方法，例如选择最佳细胞株或生物过程参数。具有各种不同设计的微生物反应器，其中一些包括主动流体混合和/或具有以批量，补料或连续模式操作的能力。在某些实施方案中，微反应器作为微量化学剂操作。还提供了在微生物反应器中在恒化器条件下培养细胞的方法。

10. 发明申请

WO2009002459A3 FREE FLOW ISOELECTRIC FOCUSING DEVICES AND METHODS 审中-公开
标题翻译：自由流动等电聚焦装置和方法
公开(公告)号：WO2009002459A3
公开(公告)日：2008-12-31
申请号：PCT/US2008/007743
申请日：2008-06-20
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ALBRECHT, Jacob , JENSEN, Klavs, F.
发明人： ALBRECHT, Jacob , JENSEN, Klavs, F.
IPC分类号： G01N27/447
摘要： The invention relates to devices and methods for the separation of species, including biological species and involves the use of free flow isolectric focusing (FF-IEF) devices capable of establishing a pH gradient in a gradient orientation that is perpendicular to the direction of fluid flow. In one embodiment a channel (224) constructed and arranged to receive a fluid flow, comprises non-parallel sidewalls (230, 240) and at least two electrodes (260,262). In a further embodiment the device comprises a first region comprising a first channel and a second region comprising at least two channels fluidly connected to the first channel. A method is also disclosed wherein a channel is provided, the channel comprising a first region and a second region, wherein the first region has a first pH gradient across the channel in a gradient orientation that is perpendicular to the direction of fluid flow and the second regin has a second pH gradient across the channel in a gradient orientation that is perpendicular to the direction of fluid flow.
摘要翻译：本发明涉及用于分离物种（包括生物物种）的装置和方法，并涉及使用能够建立梯度取向的pH梯度的自由流动等电聚焦（FF-IEF）装置，垂直于流体流动的方向。在一个实施例中，构造和布置成接收流体流的通道（224）包括不平行的侧壁（230,240）和至少两个电极（260,262）。在另一个实施例中，该装置包括包含第一通道的第一区域和包含流体连接到第一通道的至少两个通道的第二区域。还公开了一种方法，其中提供通道，该通道包括第一区域和第二区域，其中第一区域具有在垂直于流体流动方向的梯度定向上横过通道的第一pH梯度，并且第二区域 regin在垂直于流体流动方向的梯度方向上具有第二个pH梯度。

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