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1. 发明申请

WO2007038572A2 MICROBIOREACTOR FOR CONTINUOUS CELL CULTURE 审中-公开
标题翻译：连续细胞培养微生物
公开(公告)号：WO2007038572A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/037612
申请日：2006-09-26
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ZHANG, Zhiyu , BOCCAZZI, Paolo , CHOI, Hyun-goo , JENSEN, Klavs, F. , SINSKEY, Anthony, J.
发明人： ZHANG, Zhiyu , BOCCAZZI, Paolo , CHOI, Hyun-goo , JENSEN, Klavs, F. , SINSKEY, Anthony, J.
IPC分类号： C12M3/00 , C12M1/12
CPC分类号： C12M23/16 , B01F13/0059 , B01F13/0827 , B01L3/502707 , B01L3/502715 , B01L3/502723 , B01L7/00 , B01L2300/0822 , B01L2300/0887 , B01L2300/10 , B82Y30/00 , C12M23/24 , C12M23/34 , C12M27/02 , C12M29/04 , C12M41/26 , C12M41/32
摘要： The present invention microscale bioreactors (microfermentors) and microscale bioreactor arrays for use in culturing cells. The microfermentors include a vessel for culturing cells and means for providing oxygen to the interior of the vessel at a concentration sufficient to support cell growth, e.g., growth of bacterial cells. Depending on the embodiment, the microfermentor vessel may have various interior volumes of less than approximately 1 ml. The microfermentors may include an aeration membrane and optionally a variety of sensing devices. Methods of using the microfermentors, e.g., to select optimum cell strains or bioprocess parameters are provided. The microbioreactors having a variety of different designs, some of which incorporate active fluid mixing and/or have the capability to operate in batch, fed- batch, or continuous mode. In certain embodiments the microreactors operate as microchemostats. Methods for culturing cells under chemostat conditions in a microbioreactor are also provided.
摘要翻译：本发明的用于培养细胞的微生物生物反应器（微发酵器）和微生物生物反应器阵列。微发酵器包括用于培养细胞的容器和用于以足以支持细胞生长（例如细菌细胞生长）的浓度向容器内部提供氧气的装置。取决于实施方案，微发酵罐容器可以具有小于约1ml的各种内部体积。微发酵器可以包括曝气膜和任选的各种感测装置。提供了使用微发酵器的方法，例如选择最佳细胞株或生物过程参数。具有各种不同设计的微生物反应器，其中一些包括主动流体混合和/或具有以批量，补料或连续模式操作的能力。在某些实施方案中，微反应器作为微量化学剂操作。还提供了在微生物反应器中在恒化器条件下培养细胞的方法。

2. 发明申请

WO2006037022A3 MICROBIOREACTOR FOR CONTINUOUS CELL CULTURE 审中-公开
标题翻译：连续细胞培养微生物
公开(公告)号：WO2006037022A3
公开(公告)日：2009-04-23
申请号：PCT/US2005034774
申请日：2005-09-26
申请人： MASSACHUSETTS INST TECHNOLOGY , ZHANG ZHIYU , BOCCAZZI PAOLO , CHOI HYUN-GOO , JENSEN KLAVS F , SINSKEY ANTHONY J
发明人： ZHANG ZHIYU , BOCCAZZI PAOLO , CHOI HYUN-GOO , JENSEN KLAVS F , SINSKEY ANTHONY J
IPC分类号： C12M1/02 , C12M1/12 , C12M3/00 , C12M3/06 , C12N1/00
CPC分类号： C12M23/16 , B01L3/502707 , B01L3/502715 , B01L3/502723 , B01L2300/0654 , B01L2300/0816 , B01L2300/0877 , B01L2300/0887 , B01L2300/10 , B01L2300/185 , B01L2300/1883 , B01L2400/0466 , B01L2400/0487 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C12M29/04 , C12M29/10 , C12M37/00 , C12M41/26 , C12M41/34 , G01N21/03 , G01N2021/0346
摘要： The present invention microscale bioreactors (microfermentors) and microscale bioreactor arrays for use in culturing cells. The microfermentors include a vessel for culturing cells and means for providing oxygen to the interior of the vessel at a concentration sufficient to support cell growth, e.g., growth of bacterial cells. Depending on the embodiment, the microfermentor vessel may have various interior volumes of less than approximately 1 ml. The microfermentors may include an aeration membrane and optionally a variety of sensing devices. Methods of using the microfermentors, e.g., to select optimum cell strains or bioprocess parameters are provided. The microbioreactors having a variety of different designs, some of which incorporate active fluid mixing and/or have the capability to operate in batch, fed-batch, or continuous mode. In certain embodiments the microreactors operate as microchemostats. Methods for culturing cells under chemostat conditions in a microbioreactor are also provided.
摘要翻译：本发明的用于培养细胞的微生物生物反应器（微发酵器）和微生物生物反应器阵列。微发酵器包括用于培养细胞的容器和用于以足以支持细胞生长（例如细菌细胞生长）的浓度向容器内部提供氧气的装置。取决于实施方案，微发酵罐容器可以具有小于约1ml的各种内部体积。微发酵器可以包括曝气膜和任选的各种感测装置。提供了使用微发酵器的方法，例如选择最佳细胞株或生物过程参数。具有各种不同设计的微生物反应器，其中一些结合了活性流体混合和/或具有以批量，补料分批或连续模式操作的能力。在某些实施方案中，微反应器作为微量化学剂操作。还提供了在微生物反应器中在恒化器条件下培养细胞的方法。

3. 发明申请

WO2006037022A2 MICROBIOREACTOR FOR CONTINUOUS CELL CULTURE 审中-公开
标题翻译：连续细胞培养微生物
公开(公告)号：WO2006037022A2
公开(公告)日：2006-04-06
申请号：PCT/US2005/034774
申请日：2005-09-26
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ZHANG, Zhiyu , BOCCAZZI, Paolo , CHOI, Hyun-Goo , JENSEN, Klavs, F. , SINSKEY, Anthony, J.
发明人： ZHANG, Zhiyu , BOCCAZZI, Paolo , CHOI, Hyun-Goo , JENSEN, Klavs, F. , SINSKEY, Anthony, J.
IPC分类号： C12M3/00
CPC分类号： C12M23/16 , B01L3/502707 , B01L3/502715 , B01L3/502723 , B01L2300/0654 , B01L2300/0816 , B01L2300/0877 , B01L2300/0887 , B01L2300/10 , B01L2300/185 , B01L2300/1883 , B01L2400/0466 , B01L2400/0487 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C12M29/04 , C12M29/10 , C12M37/00 , C12M41/26 , C12M41/34 , G01N21/03 , G01N2021/0346
摘要： The present invention microscale bioreactors (microfermentors) and microscale bioreactor arrays for use in culturing cells. The microfermentors include a vessel for culturing cells and means for providing oxygen to the interior of the vessel at a concentration sufficient to support cell growth, e.g., growth of bacterial cells. Depending on the embodiment, the microfermentor vessel may have various interior volumes of less than approximately 1 ml. The microfermentors may include an aeration membrane and optionally a variety of sensing devices. Methods of using the microfermentors, e.g., to select optimum cell strains or bioprocess parameters are provided. The microbioreactors having a variety of different designs, some of which incorporate active fluid mixing and/or have the capability to operate in batch, fed-batch, or continuous mode. In certain embodiments the microreactors operate as microchemostats. Methods for culturing cells under chemostat conditions in a microbioreactor are also provided.
摘要翻译：本发明的用于培养细胞的微生物生物反应器（微发酵器）和微生物生物反应器阵列。微发酵器包括用于培养细胞的容器和用于以足以支持细胞生长（例如细菌细胞生长）的浓度向容器内部提供氧气的装置。取决于实施方案，微发酵罐容器可以具有小于约1ml的各种内部体积。微发酵器可以包括曝气膜和任选的各种感测装置。提供了使用微发酵器的方法，例如选择最佳细胞株或生物过程参数。具有各种不同设计的微生物反应器，其中一些结合有活性流体混合和/或具有以批量，补料分批或连续模式操作的能力。在某些实施方案中，微反应器作为微量化学剂操作。还提供了在微生物反应器中在恒化器条件下培养细胞的方法。

4. 发明申请

WO1991000917A1 METHOD FOR PRODUCING NOVEL POLYESTER BIOPOLYMERS 审中-公开
标题翻译：生产新型聚酯生物聚合物的方法
公开(公告)号：WO1991000917A1
公开(公告)日：1991-01-24
申请号：PCT/US1990003851
申请日：1990-07-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PEOPLES, Oliver, P. , SINSKEY, Anthony, J.
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
IPC分类号： C12P07/62
CPC分类号： C12N15/52 , C12P7/625
摘要： A method for controlling and modifying biopolymer synthesis by manipulation of the genetics and enzymology of synthesis of polyhydroxybutyrate (PHB) and polyhydroxyalkanoate (PHA) polyesters at the molecular level in procaryotic and eukaryotic cells, especially plants. Examples demonstrate the isolation, characterization, and expression of the genes involved in the production of PHB and PHA polymers. Genes encoding the enzymes in the PHB and PHA synthetic pathway (beta-ketothiolase, acetoacetyl-CoA reductase and PHB polymerase or PHA polymerase) from Zoogloea ramigera strain I-16-M, Alcaligenes eutrophus, Nocardia salmonicolur, and Pseudomonas oleovarans were identified or isolated and expressed in a non-PHB producing organism, E. coli. Specific modifications to the polymers include variation in the chain length of the polymers and incorporation of different monomers into the polymers to produce co-polymers with different physical properties.
摘要翻译：通过在原核和真核细胞，特别是植物中的分子水平处理聚羟基丁酸酯（PHB）和聚羟基链烷酸酯（PHA）聚酯的遗传学和酶学方法来控制和改变生物聚合物合成的方法。实施例证明参与PHB和PHA聚合物生产的基因的分离，表征和表达。鉴定或分离来自苎麻苎麻菌株I-16-M，产碱杆菌，嗜碱性亚油酸假单胞菌和油菜假单胞菌的PHB和PHA合成途径中的酶（β-酮硫解酶，乙酰乙酰辅酶A还原酶和PHB聚合酶或PHA聚合酶）的编码基因并在非PHB生物体大肠杆菌中表达。对聚合物的具体修饰包括聚合物链长度的变化以及将不同单体引入到聚合物中以产生具有不同物理性质的共聚物。

5. 发明申请

WO2009117036A3 BIOACTIVE MOLECULES FROM CO-CULTIVATION OF MICROBES 审中-公开
公开(公告)号：WO2009117036A3
公开(公告)日：2009-09-24
申请号：PCT/US2008/087936
申请日：2008-12-22
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SINSKEY, Anthony, J. , LESSARD, Philip, A. , KUROSAWA, Kazuhiko
发明人： SINSKEY, Anthony, J. , LESSARD, Philip, A. , KUROSAWA, Kazuhiko
IPC分类号： C07D498/12 , C07D405/12 , C07D498/02 , A61K31/7056
摘要： Certain aspects of the invention relates to antibiotics, as well as pharmaceutically acceptable salts, pro-drugs and/or analogs thereof. Another aspect of the inventions relates to methods of use of said antibiotics.

6. 发明申请

WO2007038572A3 MICROBIOREACTOR FOR CONTINUOUS CELL CULTURE 审中-公开
标题翻译：连续细胞培养微生物
公开(公告)号：WO2007038572A3
公开(公告)日：2009-04-23
申请号：PCT/US2006037612
申请日：2006-09-26
申请人： MASSACHUSETTS INST TECHNOLOGY , ZHANG ZHIYU , BOCCAZZI PAOLO , CHOI HYUN-GOO , JENSEN KLAVS F , SINSKEY ANTHONY J
发明人： ZHANG ZHIYU , BOCCAZZI PAOLO , CHOI HYUN-GOO , JENSEN KLAVS F , SINSKEY ANTHONY J
IPC分类号： C12M3/00
CPC分类号： C12M23/16 , B01F13/0059 , B01F13/0827 , B01L3/502707 , B01L3/502715 , B01L3/502723 , B01L7/00 , B01L2300/0822 , B01L2300/0887 , B01L2300/10 , B82Y30/00 , C12M23/24 , C12M23/34 , C12M27/02 , C12M29/04 , C12M41/26 , C12M41/32
摘要： The present invention microscale bioreactors (microfermentors) and microscale bioreactor arrays for use in culturing cells. The microfermentors include a vessel for culturing cells and means for providing oxygen to the interior of the vessel at a concentration sufficient to support cell growth, e.g., growth of bacterial cells. Depending on the embodiment, the microfermentor vessel may have various interior volumes of less than approximately 1 ml. The microfermentors may include an aeration membrane and optionally a variety of sensing devices. Methods of using the microfermentors, e.g., to select optimum cell strains or bioprocess parameters are provided. The microbioreactors having a variety of different designs, some of which incorporate active fluid mixing and/or have the capability to operate in batch, fed- batch, or continuous mode. In certain embodiments the microreactors operate as microchemostats. Methods for culturing cells under chemostat conditions in a microbioreactor are also provided.
摘要翻译：本发明的用于培养细胞的微生物生物反应器（微发酵器）和微生物生物反应器阵列。微发酵器包括用于培养细胞的容器和用于以足以支持细胞生长（例如细菌细胞生长）的浓度向容器内部提供氧气的装置。取决于实施方案，微发酵罐容器可以具有小于约1ml的各种内部体积。微发酵器可以包括曝气膜和任选的各种感测装置。提供了使用微发酵器的方法，例如选择最佳细胞株或生物过程参数。具有各种不同设计的微生物反应器，其中一些包括主动流体混合和/或具有以批量，补料或连续模式操作的能力。在某些实施方案中，微反应器作为微量化学剂操作。还提供了在微生物反应器中在恒化器条件下培养细胞的方法。

7. 发明申请

WO2009117036A2 BIOACTIVE MOLECULES FROM CO-CULTIVATION OF MICROBES 审中-公开
标题翻译：生物活性分子从微生物共培养
公开(公告)号：WO2009117036A2
公开(公告)日：2009-09-24
申请号：PCT/US2008087936
申请日：2008-12-22
申请人： MASSACHUSETTS INST TECHNOLOGY , SINSKEY ANTHONY J , LESSARD PHILIP A , KUROSAWA KAZUHIKO
发明人： SINSKEY ANTHONY J , LESSARD PHILIP A , KUROSAWA KAZUHIKO
IPC分类号： C07D498/12 , A61K31/7056
CPC分类号： C07D498/10
摘要： Certain aspects of the invention relates to antibiotics, as well as pharmaceutically acceptable salts, pro-drugs and/or analogs thereof. Another aspect of the inventions relates to methods of use of said antibiotics.
摘要翻译：本发明的某些方面涉及抗生素，以及其药学上可接受的盐，前药和/或其类似物。本发明的另一方面涉及使用所述抗生素的方法。

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