专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007038572A2 MICROBIOREACTOR FOR CONTINUOUS CELL CULTURE 审中-公开
标题翻译：连续细胞培养微生物
公开(公告)号：WO2007038572A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/037612
申请日：2006-09-26
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ZHANG, Zhiyu , BOCCAZZI, Paolo , CHOI, Hyun-goo , JENSEN, Klavs, F. , SINSKEY, Anthony, J.
发明人： ZHANG, Zhiyu , BOCCAZZI, Paolo , CHOI, Hyun-goo , JENSEN, Klavs, F. , SINSKEY, Anthony, J.
IPC分类号： C12M3/00 , C12M1/12
CPC分类号： C12M23/16 , B01F13/0059 , B01F13/0827 , B01L3/502707 , B01L3/502715 , B01L3/502723 , B01L7/00 , B01L2300/0822 , B01L2300/0887 , B01L2300/10 , B82Y30/00 , C12M23/24 , C12M23/34 , C12M27/02 , C12M29/04 , C12M41/26 , C12M41/32
摘要： The present invention microscale bioreactors (microfermentors) and microscale bioreactor arrays for use in culturing cells. The microfermentors include a vessel for culturing cells and means for providing oxygen to the interior of the vessel at a concentration sufficient to support cell growth, e.g., growth of bacterial cells. Depending on the embodiment, the microfermentor vessel may have various interior volumes of less than approximately 1 ml. The microfermentors may include an aeration membrane and optionally a variety of sensing devices. Methods of using the microfermentors, e.g., to select optimum cell strains or bioprocess parameters are provided. The microbioreactors having a variety of different designs, some of which incorporate active fluid mixing and/or have the capability to operate in batch, fed- batch, or continuous mode. In certain embodiments the microreactors operate as microchemostats. Methods for culturing cells under chemostat conditions in a microbioreactor are also provided.
摘要翻译：本发明的用于培养细胞的微生物生物反应器（微发酵器）和微生物生物反应器阵列。微发酵器包括用于培养细胞的容器和用于以足以支持细胞生长（例如细菌细胞生长）的浓度向容器内部提供氧气的装置。取决于实施方案，微发酵罐容器可以具有小于约1ml的各种内部体积。微发酵器可以包括曝气膜和任选的各种感测装置。提供了使用微发酵器的方法，例如选择最佳细胞株或生物过程参数。具有各种不同设计的微生物反应器，其中一些包括主动流体混合和/或具有以批量，补料或连续模式操作的能力。在某些实施方案中，微反应器作为微量化学剂操作。还提供了在微生物反应器中在恒化器条件下培养细胞的方法。

2. 发明申请

WO2006037022A2 MICROBIOREACTOR FOR CONTINUOUS CELL CULTURE 审中-公开
标题翻译：连续细胞培养微生物
公开(公告)号：WO2006037022A2
公开(公告)日：2006-04-06
申请号：PCT/US2005/034774
申请日：2005-09-26
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ZHANG, Zhiyu , BOCCAZZI, Paolo , CHOI, Hyun-Goo , JENSEN, Klavs, F. , SINSKEY, Anthony, J.
发明人： ZHANG, Zhiyu , BOCCAZZI, Paolo , CHOI, Hyun-Goo , JENSEN, Klavs, F. , SINSKEY, Anthony, J.
IPC分类号： C12M3/00
CPC分类号： C12M23/16 , B01L3/502707 , B01L3/502715 , B01L3/502723 , B01L2300/0654 , B01L2300/0816 , B01L2300/0877 , B01L2300/0887 , B01L2300/10 , B01L2300/185 , B01L2300/1883 , B01L2400/0466 , B01L2400/0487 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C12M29/04 , C12M29/10 , C12M37/00 , C12M41/26 , C12M41/34 , G01N21/03 , G01N2021/0346
摘要： The present invention microscale bioreactors (microfermentors) and microscale bioreactor arrays for use in culturing cells. The microfermentors include a vessel for culturing cells and means for providing oxygen to the interior of the vessel at a concentration sufficient to support cell growth, e.g., growth of bacterial cells. Depending on the embodiment, the microfermentor vessel may have various interior volumes of less than approximately 1 ml. The microfermentors may include an aeration membrane and optionally a variety of sensing devices. Methods of using the microfermentors, e.g., to select optimum cell strains or bioprocess parameters are provided. The microbioreactors having a variety of different designs, some of which incorporate active fluid mixing and/or have the capability to operate in batch, fed-batch, or continuous mode. In certain embodiments the microreactors operate as microchemostats. Methods for culturing cells under chemostat conditions in a microbioreactor are also provided.
摘要翻译：本发明的用于培养细胞的微生物生物反应器（微发酵器）和微生物生物反应器阵列。微发酵器包括用于培养细胞的容器和用于以足以支持细胞生长（例如细菌细胞生长）的浓度向容器内部提供氧气的装置。取决于实施方案，微发酵罐容器可以具有小于约1ml的各种内部体积。微发酵器可以包括曝气膜和任选的各种感测装置。提供了使用微发酵器的方法，例如选择最佳细胞株或生物过程参数。具有各种不同设计的微生物反应器，其中一些结合有活性流体混合和/或具有以批量，补料分批或连续模式操作的能力。在某些实施方案中，微反应器作为微量化学剂操作。还提供了在微生物反应器中在恒化器条件下培养细胞的方法。

3. 发明申请

WO2005097969A1 APPARATUS AND METHODS FOR SIMULTANEOUS OPERATION OF MINIATURIZED REACTORS 审中-公开
标题翻译：微型反应器同时运行的装置和方法
公开(公告)号：WO2005097969A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/011295
申请日：2005-04-01
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BOCCAZZI, Paolo , CHEN, Angela, Y. , JENSEN, Klavs, F. , SZITA, Nicolas , ZANZOTTO, Andrea , ZHANG, Zhiyu
发明人： BOCCAZZI, Paolo , CHEN, Angela, Y. , JENSEN, Klavs, F. , SZITA, Nicolas , ZANZOTTO, Andrea , ZHANG, Zhiyu
IPC分类号： C12M1/34
CPC分类号： C12M1/12 , B01F13/0059 , B01F13/0827 , B01J2219/00283 , B01J2219/00317 , B01J2219/00479 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00691 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L9/527 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0877 , B01L2300/10 , B01L2400/0466 , B01L2400/0487 , C12M23/16 , C12M35/08 , C12M41/48 , G01N2035/00326 , Y10S435/808 , Y10S435/809
摘要： The present invention provides a variety of microscale bioreactors (microfermentors) and microscale bioreactor arrays for use in culturing cells. The microfermentors include a vessel (2) for culturing cells and means for providing oxygen (6) to the interior of the vessel at a concentration sufficient to support cell growth, e.g., growth of bacterial cells. Depending on the embodiment, the microfermentor vessel may have various interior volumes less than approximately 1 ml. The microfermentors may include an aeration membrane (6) and optionally a variety of sensing devices (12). The invention further provides a chamber to contain the microfermentors and microfermentor arrays and to provide environmental control. The invention provides microreactors having a variety of different designs, some of which incorporate active stirring and/or have the capability to operate in batch or fed-batch mode. The invention further provides an apparatus and methods for simultaneous operation of a plurality of microreactors, with monitoring of the individual microreactors during a run. The invention further provides methods of performing gene expression analysis on cells cultured in microreactors.
摘要翻译：本发明提供用于培养细胞的各种微量生物反应器（微发酵器）和微生物生物反应器阵列。微发酵器包括用于培养细胞的容器（2）和用于以足以支持细胞生长（例如细菌细胞生长）的浓度向容器内部提供氧（6）的装置。根据实施方案，微发酵罐容器可以具有小于约1ml的各种内部容积。微发酵器可以包括曝气膜（6）和可选的各种感测装置（12）。本发明进一步提供了容纳微发射体和微发光体阵列并提供环境控制的腔室。本发明提供具有各种不同设计的微反应器，其中一些具有主动搅拌和/或具有以分批或分批模式操作的能力。本发明还提供了一种用于同时操作多个微反应器的装置和方法，其中在运行期间监测各个微反应器。本发明还提供了对在微反应器中培养的细胞进行基因表达分析的方法。

4. 发明申请

WO2006074227A2 HIGHLY ANTIPROLIFERATIVE, LOW-CALCEMIC, ANALOGS OF THE HORMONE 1α, 25-DIHYDROXYVITAMIN D3 WITH CARBONYL SIDE CHAINS 审中-公开
标题翻译：具有碳链侧链的氢键1a，25-二羟基维生素D3的高抗性，低计算，模拟
公开(公告)号：WO2006074227A2
公开(公告)日：2006-07-13
申请号：PCT/US2006/000183
申请日：2006-01-03
申请人： JOHNS HOPKINS UNIVERSITY , POSNER, Gary H. , SINISHTAJ, Sandra , SUH, Byung Chul , KIM, Hyung Jin , LEE, S.H. Tony , ZHANG, Zhiyu , JEON, Heung Bae , KAHRAMAN, Mehmet , LI, Hongbin , PETERSEN, Kimberly
发明人： POSNER, Gary H. , SINISHTAJ, Sandra , SUH, Byung Chul , KIM, Hyung Jin , LEE, S.H. Tony , ZHANG, Zhiyu , JEON, Heung Bae , KAHRAMAN, Mehmet , LI, Hongbin , PETERSEN, Kimberly
IPC分类号： A61K31/593
CPC分类号： C07C401/00
摘要： The present invention discloses a series of new carbonyl side chain anlogs of calcitriol (I). Unexpectedly, several of these ketone analogs, such as the 24- and 25-tert-butyl ketones, amides, hydroxymate esters and a hetero atom ketones even though lacking the classical side-chain tertiary hydroxyl group, are considerably more antiproliferative in vitro than the hormone calcitriol (I) even at physiologically relevant low nanomolar concentrations and are less calcemic than calcitriol (I) in vivo.
摘要翻译：本发明公开了一系列新的骨化三醇（I）的侧链侧链。出乎意料的是，即使缺乏经典的侧链叔羟基，这些酮类似物中的几种，例如24-和25-叔丁基酮，酰胺，羟基化合物酯和杂原子酮，在体外相比，其抗增殖能力激素骨化三醇（I）即使在生理相关的低纳摩尔浓度下，并且在体内比骨化三醇（I）更少的钙化。

5. 发明申请

WO2004059863A1 METHOD AND DEVICE FOR MULTI-USER DETECTION WITH SIMPLIFIED DE-CORRELATION IN A CDMA SYSTEM 审中-公开
标题翻译：用于多用户检测的方法和设备，其具有CDMA系统中的简化去相关
公开(公告)号：WO2004059863A1
公开(公告)日：2004-07-15
申请号：PCT/IB2003/006246
申请日：2003-12-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LIANG, Jingxin , YIN, Xiaojun , ZHANG, Zhiyu
发明人： LIANG, Jingxin , YIN, Xiaojun , ZHANG, Zhiyu
IPC分类号： H04B1/707
CPC分类号： H04B1/71052 , H04B2201/70707
摘要： A simplified de-correlation method in CDMA multi-user detection comprises: a. receive wireless symbols S; b. obtain a channel correlation matrix R, take a part from R to get a partial correlation matrix R P ; c. do inversion operation to the partial correlation matrix R P , then obtain matrix V (m) ; d. recover original data symbols D from received symbols S by V (m) that the location of original data symbols D corresponds to.
摘要翻译： CDMA多用户检测中的简化去相关方法包括：a。接收无线符号S; 湾获得信道相关矩阵R，从R中获取部分相关矩阵RP; C。对部分相关矩阵RP进行反演操作，然后获得矩阵V <（m）>; 天。从接收符号S通过V <（m）>恢复原始数据符号D的原始数据符号D的位置对应的原始数据符号D.

6. 发明申请

WO2004059864A1 METHOD AND DEVICE TO MAINTAIN SYNCHRONIZATION TRACKING IN TDD WIRELESS COMMUNICATION 审中-公开
标题翻译：在TDD无线通信中维护同步跟踪的方法和设备
公开(公告)号：WO2004059864A1
公开(公告)日：2004-07-15
申请号：PCT/IB2003/006248
申请日：2003-12-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LIANG, Jingxin , ZHANG, Zhiyu
发明人： LIANG, Jingxin , ZHANG, Zhiyu
IPC分类号： H04B1/707
CPC分类号： H04B1/7085 , H04L7/042
摘要： A Method to maintain Synchronization Tracking in TDD Wireless Communication comprises steps as follows: a. Dividing a midamble into two parts, then detecting the first one and the second one of the midamble one by one; b: The auto-correlation property operation between the two parts mention above and the corresponding to local midamble, then two peaks are got; c. compare the two peaks amplitude; d. confirming to advance or retard local time base on the result of the compare. Compare to the normal method, the novel interlaced sampling method harm the SNR of channel estimation using midamble very slightly. By using this novel method, the sample frequency can be decreased to only one time of the chip rate of TD-SCDMA system while still maintaining the ability to track the downlink synchronization.
摘要翻译：在TDD无线通信中维护同步跟踪的方法包括以下步骤：a。将midamble分为两部分，然后逐个检测中间码的第一个和第二个; b：上述两部分之间的自相关属性运算和对应的本地中序，得到两个峰; C。比较两个峰值振幅; 天。确认根据比较结果推迟或延缓当地时间。与正常方法相比，新颖的隔行扫描采样方法使用midamble非常轻微地损害信道估计的SNR。通过使用这种新颖的方法，采样频率可以降低到TD-SCDMA系统的码片速率的一个时间，同时仍然保持跟踪下行同步的能力。

7. 发明申请

WO2004021608A1 INITIAL SYNCHRONIZATION DEVICE AND METHOD 审中-公开
标题翻译：初始同步装置和方法
公开(公告)号：WO2004021608A1
公开(公告)日：2004-03-11
申请号：PCT/IB2003/003728
申请日：2003-07-31
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LI, Wei , ZHANG, Zhiyu
发明人： LI, Wei , ZHANG, Zhiyu
IPC分类号： H04B7/26
CPC分类号： H04B1/7083 , H04B2201/70702 , H04B2201/70707 , H04J3/0608
摘要： Disclosed is an initial synchronization device and method used in a mobile of a cellular telecommunication system, for identifying the frame boundary and which of a plurality of pre-defined complex valued SYNC-DL sequences is used so as to search for a cell, comprising a coefficient re-loadable match filter means, wherein said coefficient re-loadable match filter means is adapted to operate in a pipeline mode.
摘要翻译：公开了一种在蜂窝电信系统的移动台中使用的用于识别帧边界的初始同步装置和方法，并且使用多个预定义复值SYNC-DL序列中的哪一个来搜索小区，包括系数可重新加载匹配滤波器装置，其中所述系数可重新加载匹配滤波器装置适于在流水线模式下操作。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式