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1. 发明专利

NZ727659A Residence structures and related methods 未知
公开(公告)号：NZ727659A
公开(公告)日：2021-12-24
申请号：NZ72765915
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , THE BRIGHAM AND WOMEN’S HOSPITAL INC
发明人： LANGER ROBERT , BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN , DICICCIO ANGELA , WOOD LOWELL , ECKHOFF PHILIP
IPC分类号： C08F8/00 , A61K9/00 , A61K31/00 , A61K47/00 , A61M31/00 , C08G63/682 , C08G83/00
摘要： In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). The invention relates to a gastric residence structure comprising an active substance, the gastric residence structure comprising: one or more arms comprising a loadable polymeric component, wherein the loadable polymeric component comprises the active substance, and the active substance is a therapeutic agent or a diagnostic agent; an elastic polymeric component; and a separate linker component. The linker connects the one or more arms with the elastic polymeric component, the gastric residence structure is configured to be folded and physically constrained during administration and is configured to assume an open retention shape upon removal of a constraint. A change between the folded shape and the open retention shape is mediated by the elastic polymeric component that undergoes elastic deformation when the residence structure is in the folded shape and recoils when the gastric residence structure assumes the open retention shape. The linker degrades, dissolves, disassociates, or mechanically weakens in a gastric environment which results in loss of retention shape integrity and passage out of a gastric cavity.

2. 发明申请

WO2015191920A8 RESIDENCE STRUCTURES AND RELATED METHODS 审中-公开
标题翻译：居住结构和相关方法
公开(公告)号：WO2015191920A8
公开(公告)日：2016-02-04
申请号：PCT/US2015035423
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL , TOKITAE LLC
发明人： BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , DICICCIO ANGELA , WOOD LOWELL L JR , ECKHOFF PHILIP A
IPC分类号： C08F8/00 , C08G63/682
CPC分类号： A61K47/48776 , A61K9/0053 , A61K9/0065 , A61K9/48 , A61K31/357 , A61K31/65 , A61K31/7048 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/40 , A61K47/42 , A61K47/48176 , A61K47/58 , A61K47/6901 , A61M31/002 , C08G18/4277 , C08G18/73 , C08G63/08 , C08G83/006 , C08G2230/00 , C08L33/02 , C08L33/08 , C08L33/14 , C08L2203/02
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.
摘要翻译：通常提供住宅结构，系统和相关方法。某些实施方案包括将住院结构施用（例如，口服）给对象（例如，患者），使得住宿结构保持在受试者内部某一时间（例如，至少约24小时）在被释放之前。在一些情况下，住院结构可以是胃停留结构。在一些实施方案中，本文所述的结构和系统包括一种或多种配置用于在酸性环境中高水平的活性物质（例如治疗剂）负载，高活性物质和/或结构稳定性，在内部的机械柔性和强度孔（例如，胃腔），容易通过胃肠道直到输送到期望的内部孔口（例如胃腔），和/或在生理环境（例如，肠环境）中快速溶解/降解）和/或对化学刺激剂的反应（例如，摄入引起快速溶解/降解的溶液）。在某些实施方案中，该结构具有模块化设计，将配置用于控制释放治疗剂，诊断和/或增强剂的材料与胃停留所必需的结构材料组合，但被配置用于控制和/或可调节的降解/溶解以确定保留形状完整性丧失并且结构从胃腔排出的时间。例如，在某些实施方案中，宿主结构包括第一弹性组分，被配置成释放活性物质（例如治疗剂）的第二组分和任选的连接体。在一些这样的实施方案中，接头可以被配置为降解，使得停留结构在预定量的时间之后分裂并且从受试者内部的位置释放。

3. 发明申请

WO2015191925A8 SELF-ASSEMBLED RESIDENCE DEVICES AND RELATED METHODS 审中-公开
标题翻译：自组织住宅设备及相关方法
公开(公告)号：WO2015191925A8
公开(公告)日：2016-02-11
申请号：PCT/US2015035429
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL , TOKITAE LLC
发明人： BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY , LIN JIAQI , DICICCIO ANGELA , GLETTIG DEAN LIANG , WOOD LOWELL L JR , ECKHOFF PHILIP A
IPC分类号： A61M31/00 , A61M29/04
CPC分类号： A61K47/48776 , A61K9/0053 , A61K9/0065 , A61K9/48 , A61K31/357 , A61K31/65 , A61K31/7048 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/40 , A61K47/42 , A61K47/48176 , A61K47/58 , A61K47/6901 , A61M31/002 , C08G18/4277 , C08G18/73 , C08G63/08 , C08G83/006 , C08G2230/00 , C08L33/02 , C08L33/08 , C08L33/14 , C08L2203/02
摘要： Residence devices as well as their related methods of manufacture and use are generally provided. In some embodiments, a residence device includes a plurality of self-assembling structures that assemble in vivo to form an aggregate structure. Each structure of the plurality of structures includes a first side and a first attachment point that attaches to a second attachment point on another structure of the plurality of structures. The aggregate structure may be sized and shaped to maintain an in vivo position relative to an internal orifice of a subject. The attachment between the first and second attachment points may degrade after a period of time.
摘要翻译：通常提供住宅设备及其相关的制造和使用方法。在一些实施例中，居住装置包括在体内组装以形成聚集体结构的多个自组装结构。多个结构的每个结构包括附接到多个结构的另一结构上的第二附接点的第一侧和第一附接点。聚集体结构的尺寸和形状可以相对于受试者的内部孔口维持体内位置。在一段时间之后，第一和第二附着点之间的连接可能会降级。

4. 发明专利

DK3155024T3 OPHOLDSSTRUKTURER OG RELATEREDE FREMGANGSMÅDER 未知
公开(公告)号：DK3155024T3
公开(公告)日：2020-11-23
申请号：DK15806017
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： BELLINGER ANDREW , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , WOOD LOWELL L JR , ECKHOFF PHILIP A , ZHANG SHIYI , DICICCIO ANGELA
IPC分类号： A61K9/00

5. 发明专利

AU2016257711A1 Triggerable shape memory induction devices 未知
公开(公告)号：AU2016257711A1
公开(公告)日：2017-10-26
申请号：AU2016257711
申请日：2016-04-29
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： ZHANG SHIYI , ZHAO YIDA , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S
IPC分类号： A61L27/26 , A61K9/00 , A61K9/48 , A61L27/44 , A61L27/50 , A61L31/04 , A61L31/12 , A61L31/14
摘要： In accordance with the invention, compositions, devices, and related methods have been developed for medical-related and other applications. In some embodiments, the devices and compositions described herein comprise a triggerable shape memory polymer network. In certain embodiments, the polymer network comprises a covalently crosslinked polymeric material and a non-crosslinked polymeric material associated with the crosslinked polymeric material. In some cases, the polymer network has a first configuration (e.g., as polymerized), and a second configuration (e.g., upon heating and deformation), such that the polymer network can be triggered to recover the first configuration upon heating the polymeric material above a softening temperature of the polymeric material. In certain embodiments, the polymer network comprises a plurality of particles capable of increasing the temperature of the polymer network (e.g., above the softening temperature) in the presence of an external stimulus such as induction, radio frequency, or magnetic resonance, such that the polymer network changes configuration. The polymeric material may be molded into any suitable shape.

6. 发明专利

AU2019232862A1 RESIDENCE STRUCTURES AND RELATED METHODS 未知
公开(公告)号：AU2019232862A1
公开(公告)日：2019-10-10
申请号：AU2019232862
申请日：2019-09-19
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： LANGER ROBERT S , BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , DICICCIO ANGELA , WOOD LOWELL L , ECKHOFF PHILIP A
IPC分类号： C08F8/00 , C08G63/682
摘要： - 1 Abstract Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal 5 to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, 10 mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the 15 structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure 20 comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time. WO 2015/191920 5/52 PCT/US2OlS/035423 >13 I~ 120 13512 I* ~ 110 \ 130 FIG.lBE

7. 发明专利

AU2015274451C1 Residence structures and related methods 未知
公开(公告)号：AU2015274451C1
公开(公告)日：2019-09-12
申请号：AU2015274451
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , DICICCIO ANGELA , WOOD JR LOWELL L , ECKHOFF PHILIP A
IPC分类号： C08F8/00 , C08G63/682
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

8. 发明专利

CA2951902C ENTERIC ELASTOMERS 未知
公开(公告)号：CA2951902C
公开(公告)日：2022-08-23
申请号：CA2951902
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , THE BRIGHAM & WOMENS HOSPITAL INC , TOKITAE LLC
发明人： BELLINGER ANDREW , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , GLETTIG DEAN LIANG , WOOD LOWELL L JR , ECKHOFF PHILIP A , ZHANG SHIYI
IPC分类号： C08L33/26 , A61K9/00 , A61K47/32 , A61L27/26 , C08L33/02 , C08L33/08
摘要： Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.

9. 发明专利

SG11201610246PA RESIDENCE STRUCTURES AND RELATED METHODS 未知
公开(公告)号：SG11201610246PA
公开(公告)日：2017-01-27
申请号：SG11201610246P
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL
发明人： BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , DICICCIO ANGELA , WOOD LOWELL L JR , ECKHOFF PHILIP A
IPC分类号： C08F8/00 , C08G63/682
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

10. 发明专利

AU2015274453A2 Enteric elastomers 未知
公开(公告)号：AU2015274453A2
公开(公告)日：2017-01-19
申请号：AU2015274453
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC , TOKITAE LLC
发明人： ZHANG SHIYI , BELLINGER ANDREW , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , GLETTIG DEAN LIANG , WOOD JR LOWELL L , ECKHOFF PHILIP A
IPC分类号： C07C57/04 , A61K31/197 , A61K31/78
摘要： Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.

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