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1. 发明专利

AU2020330542A1 Articles and methods for administration of therapeutic agents 未知
公开(公告)号：AU2020330542A1
公开(公告)日：2022-02-17
申请号：AU2020330542
申请日：2020-08-12
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , KORZENIK JOSHUA , LANGER ROBERT S , STEIGER CHRISTOPH WINFRIED JOHANNES
IPC分类号： A61K31/375 , A61K33/00 , A61K33/04
摘要： Articles and methods for delivering a therapeutic agent to a subject are described. These articles and methods may be useful, in some cases, for the delivery of therapeutic agents to the colon of a subject. In some embodiments, an article is configured to release a secretion inducing agent e.g., to stimulate the release of intestinal fluids. The article, in some embodiments, comprises a therapeutic agent such that the stimulated release of intestinal fluid increases the amount of therapeutic agent available for absorption by the colon. For example, in some embodiments, the articles and methods described herein advantageously promote increased absorption of therapeutic agents in subjects as compared to traditionally administered therapeutic agents without additional components such as a secretion inducing agent. In some embodiments, articles and methods described herein may increase the motility of the colon of a subject. The increase in contractions and movement of fluidic in the colon caused by increase motility may advantageously facilitate the dissolution or absorption of the therapeutic agent.

2. 发明专利

CA3100710A1 SYSTEMS FOR ELECTRICAL STIMULATION 未知
公开(公告)号：CA3100710A1
公开(公告)日：2019-11-21
申请号：CA3100710
申请日：2019-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： LANGER ROBERT S , TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , DELLAL DAVID
IPC分类号： A61N1/05 , A61B5/00 , A61M31/00 , A61N1/372 , A61N1/375
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In certain embodiments, the self-righting article a tissue- interfacing components. In some embodiments, each tissue-interfacing component may comprise an electrically-conductive portion configured for electrical communication with tissue and an insulative portion configured to not be in electrical communication with tissue.

3. 发明专利

AU2018237324A1 Macro tissue explant, methods and uses therefor 未知
公开(公告)号：AU2018237324A1
公开(公告)日：2019-10-31
申请号：AU2018237324
申请日：2018-03-23
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , VON ERLACH THOMAS CHRISTIAN , LANGER ROBERT S , SAXTON SARAH , MINAHAN DANIEL
IPC分类号： C12N5/071 , G01N33/50
摘要： Tissue explants of the gastrointestinal tract are provided. Methods of making and using the tissue explants are also provided, along with substrates designed for the tissue explants described.

4. 发明专利

AU2019232862A1 RESIDENCE STRUCTURES AND RELATED METHODS 未知
公开(公告)号：AU2019232862A1
公开(公告)日：2019-10-10
申请号：AU2019232862
申请日：2019-09-19
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： LANGER ROBERT S , BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , DICICCIO ANGELA , WOOD LOWELL L , ECKHOFF PHILIP A
IPC分类号： C08F8/00 , C08G63/682
摘要： - 1 Abstract Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal 5 to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, 10 mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the 15 structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure 20 comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time. WO 2015/191920 5/52 PCT/US2OlS/035423 >13 I~ 120 13512 I* ~ 110 \ 130 FIG.lBE

5. 发明专利

AU2015274451C1 Residence structures and related methods 未知
公开(公告)号：AU2015274451C1
公开(公告)日：2019-09-12
申请号：AU2015274451
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , DICICCIO ANGELA , WOOD JR LOWELL L , ECKHOFF PHILIP A
IPC分类号： C08F8/00 , C08G63/682
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

6. 发明专利

CA3063713A1 COMPONENTS WITH HIGH API LOADING 未知
公开(公告)号：CA3063713A1
公开(公告)日：2018-11-22
申请号：CA3063713
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S
IPC分类号： A61M37/00 , A61M31/00
摘要： Components with relatively high loading of active pharmaceutical ingredients are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent and a supporting material such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt% versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, Gl mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle. In some cases, a physiologically relevant dose may be present in a single tissue interfacing component.

7. 发明专利

AU2020401226A1 Tissue catalyzed growth of polymer as epithelial linings for therapy 未知
公开(公告)号：AU2020401226A1
公开(公告)日：2022-06-09
申请号：AU2020401226
申请日：2020-12-10
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： LANGER ROBERT S , TRAVERSO CARLO GIOVANNI , LI JUNWEI , WANG THOMAS , SHI YUNHUA , KIRTANE AMEYA R
IPC分类号： A61K9/00 , A61L24/04 , A61L24/06 , A61L24/08 , A61L31/04 , A61L31/06 , A61L31/14
摘要： The present disclosure provides compositions, methods, and kits that enable the

8. 发明专利

CA3148226A1 ARTICLES AND METHODS FOR ADMINISTRATION OF THERAPEUTIC AGENTS 未知
公开(公告)号：CA3148226A1
公开(公告)日：2021-02-18
申请号：CA3148226
申请日：2020-08-12
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , KORZENIK JOSHUA , LANGER ROBERT S , STEIGER CHRISTOPH WINFRIED JOHANNES
IPC分类号： A61K31/375 , A61K33/00 , A61K33/04
摘要： Articles and methods for delivering a therapeutic agent to a subject are described. These articles and methods may be useful, in some cases, for the delivery of therapeutic agents to the colon of a subject. In some embodiments, an article is configured to release a secretion inducing agent e.g., to stimulate the release of intestinal fluids. The article, in some embodiments, comprises a therapeutic agent such that the stimulated release of intestinal fluid increases the amount of therapeutic agent available for absorption by the colon. For example, in some embodiments, the articles and methods described herein advantageously promote increased absorption of therapeutic agents in subjects as compared to traditionally administered therapeutic agents without additional components such as a secretion inducing agent. In some embodiments, articles and methods described herein may increase the motility of the colon of a subject. The increase in contractions and movement of fluidic in the colon caused by increase motility may advantageously facilitate the dissolution or absorption of the therapeutic agent.

9. 发明专利

DK3155024T3 OPHOLDSSTRUKTURER OG RELATEREDE FREMGANGSMÅDER 未知
公开(公告)号：DK3155024T3
公开(公告)日：2020-11-23
申请号：DK15806017
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： BELLINGER ANDREW , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , WOOD LOWELL L JR , ECKHOFF PHILIP A , ZHANG SHIYI , DICICCIO ANGELA
IPC分类号： A61K9/00

10. 发明专利

CA3117947A1 ACTUATING COMPONENTS AND RELATED METHODS 未知
公开(公告)号：CA3117947A1
公开(公告)日：2020-05-22
申请号：CA3117947
申请日：2019-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： LANGER ROBERT S , TRAVERSO CARLO GIOVANNI , MINAHAN DANIEL , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , SOARES VANCE
IPC分类号： A61K9/00 , A61M5/00 , A61M31/00
摘要： Actuating components and related methods are generally disclosed. Certain embodiments comprise an actuating component associated with a plurality of microneedles (e.g., for administering a therapeutic agent to a subject). In some embodiments, the actuating component may be administered to a subject such that the plurality of microneedles are deployed at a location internal to the subject (e.g., in the gastrointestinal tract). The actuating component may be contained within, in some embodiments, a capsule (e.g., for oral administration to a subject). In some embodiments, the actuating component has a pre-deployment configuration in which the plurality of microneedles have a first orientation and a deployed configuration in which the plurality of microneedles have a second orientation, different than the first orientation.

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