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1. 发明申请

WO2015191920A8 RESIDENCE STRUCTURES AND RELATED METHODS 审中-公开
标题翻译：居住结构和相关方法
公开(公告)号：WO2015191920A8
公开(公告)日：2016-02-04
申请号：PCT/US2015035423
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL , TOKITAE LLC
发明人： BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY , GRANT TYLER , JAFARI MOUSA , GLETTIG DEAN LIANG , DICICCIO ANGELA , WOOD LOWELL L JR , ECKHOFF PHILIP A
IPC分类号： C08F8/00 , C08G63/682
CPC分类号： A61K47/48776 , A61K9/0053 , A61K9/0065 , A61K9/48 , A61K31/357 , A61K31/65 , A61K31/7048 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/40 , A61K47/42 , A61K47/48176 , A61K47/58 , A61K47/6901 , A61M31/002 , C08G18/4277 , C08G18/73 , C08G63/08 , C08G83/006 , C08G2230/00 , C08L33/02 , C08L33/08 , C08L33/14 , C08L2203/02
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.
摘要翻译：通常提供住宅结构，系统和相关方法。某些实施方案包括将住院结构施用（例如，口服）给对象（例如，患者），使得住宿结构保持在受试者内部某一时间（例如，至少约24小时）在被释放之前。在一些情况下，住院结构可以是胃停留结构。在一些实施方案中，本文所述的结构和系统包括一种或多种配置用于在酸性环境中高水平的活性物质（例如治疗剂）负载，高活性物质和/或结构稳定性，在内部的机械柔性和强度孔（例如，胃腔），容易通过胃肠道直到输送到期望的内部孔口（例如胃腔），和/或在生理环境（例如，肠环境）中快速溶解/降解）和/或对化学刺激剂的反应（例如，摄入引起快速溶解/降解的溶液）。在某些实施方案中，该结构具有模块化设计，将配置用于控制释放治疗剂，诊断和/或增强剂的材料与胃停留所必需的结构材料组合，但被配置用于控制和/或可调节的降解/溶解以确定保留形状完整性丧失并且结构从胃腔排出的时间。例如，在某些实施方案中，宿主结构包括第一弹性组分，被配置成释放活性物质（例如治疗剂）的第二组分和任选的连接体。在一些这样的实施方案中，接头可以被配置为降解，使得停留结构在预定量的时间之后分裂并且从受试者内部的位置释放。

2. 发明专利

JP2015091893A ワクチンナノテクノロジー审中-公开
公开(公告)号：JP2015091893A
公开(公告)日：2015-05-14
申请号：JP2015025609
申请日：2015-02-12
申请人： MASSACHUSETTS INST TECHNOLOGY , HARVARD COLLEGE , BRIGHAM & WOMENS HOSPITAL , CHILDRENS MEDICAL CT CORP
发明人： VON ANDRIAN ULRICH H , FAROKHZAD OMID C , LANGER ROBERT S , JUNT TOBIAS , MOSEMAN ELLIOTT ASHLEY , ZHANG LIANGFANG , BASTO PAMELA , IANNACONE MATTEO , ALEXIS FRANK
IPC分类号： A61K39/00 , A61K9/107 , A61K9/127 , A61K9/28 , A61K39/002 , A61K39/02 , A61K39/04 , A61K39/08 , A61K39/085 , A61K39/09 , A61K39/104 , A61K39/106 , A61K39/108 , A61K39/112 , A61K39/12 , A61K39/125 , A61K39/13 , A61K39/145 , A61K39/15 , A61K39/155 , A61K39/165 , A61K39/20 , A61K39/205 , A61K39/21 , A61K39/23 , A61K39/235 , A61K39/245 , A61K39/25 , A61K39/275 , A61K39/285 , A61K39/29 , A61K39/39 , A61K45/00 , A61K47/18 , A61K47/24 , A61K47/28 , A61K47/32 , A61K47/34 , A61P1/04 , A61P3/10 , A61P5/00 , A61P11/06 , A61P17/00 , A61P25/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P37/04 , A61P37/06 , A61P37/08
摘要：【課題】ワクチンナノテクノロジーの提供。【解決手段】本発明は、ナノキャリアを免疫系の細胞に送達するための組成物および系を提供する。本発明は、T細胞および/またはB細胞において免疫応答を刺激することができ、いくつかの実施形態では、少なくとも1つの免疫調節剤を含み、そして必要に応じて少なくとも1つの標的化部分および必要に応じて少なくとも1つの免疫刺激剤を含む、ワクチンナノキャリアを提供する。本発明は、発明性のあるワクチンナノキャリアを含む薬学的組成物を提供する。本発明は、発明性のあるワクチンナノキャリアおよびその薬学的組成物を設計し、製造し、そして使用する方法を提供する。本発明は、疾患、障害および状態の予防および/または処置の方法を提供し、その方法は、少なくとも1つの発明性のあるワクチンナノキャリアを、それを必要とする被験体に投与する工程を包含する。【選択図】図1

3. 发明申请

WO2015191925A8 SELF-ASSEMBLED RESIDENCE DEVICES AND RELATED METHODS 审中-公开
标题翻译：自组织住宅设备及相关方法
公开(公告)号：WO2015191925A8
公开(公告)日：2016-02-11
申请号：PCT/US2015035429
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL , TOKITAE LLC
发明人： BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY , LIN JIAQI , DICICCIO ANGELA , GLETTIG DEAN LIANG , WOOD LOWELL L JR , ECKHOFF PHILIP A
IPC分类号： A61M31/00 , A61M29/04
CPC分类号： A61K47/48776 , A61K9/0053 , A61K9/0065 , A61K9/48 , A61K31/357 , A61K31/65 , A61K31/7048 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/40 , A61K47/42 , A61K47/48176 , A61K47/58 , A61K47/6901 , A61M31/002 , C08G18/4277 , C08G18/73 , C08G63/08 , C08G83/006 , C08G2230/00 , C08L33/02 , C08L33/08 , C08L33/14 , C08L2203/02
摘要： Residence devices as well as their related methods of manufacture and use are generally provided. In some embodiments, a residence device includes a plurality of self-assembling structures that assemble in vivo to form an aggregate structure. Each structure of the plurality of structures includes a first side and a first attachment point that attaches to a second attachment point on another structure of the plurality of structures. The aggregate structure may be sized and shaped to maintain an in vivo position relative to an internal orifice of a subject. The attachment between the first and second attachment points may degrade after a period of time.
摘要翻译：通常提供住宅设备及其相关的制造和使用方法。在一些实施例中，居住装置包括在体内组装以形成聚集体结构的多个自组装结构。多个结构的每个结构包括附接到多个结构的另一结构上的第二附接点的第一侧和第一附接点。聚集体结构的尺寸和形状可以相对于受试者的内部孔口维持体内位置。在一段时间之后，第一和第二附着点之间的连接可能会降级。

4. 发明专利

CA2951902C ENTERIC ELASTOMERS 未知
公开(公告)号：CA2951902C
公开(公告)日：2022-08-23
申请号：CA2951902
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , THE BRIGHAM & WOMENS HOSPITAL INC , TOKITAE LLC
发明人： BELLINGER ANDREW , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , GLETTIG DEAN LIANG , WOOD LOWELL L JR , ECKHOFF PHILIP A , ZHANG SHIYI
IPC分类号： C08L33/26 , A61K9/00 , A61K47/32 , A61L27/26 , C08L33/02 , C08L33/08
摘要： Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.

5. 发明专利

AU2015274453A2 Enteric elastomers 未知
公开(公告)号：AU2015274453A2
公开(公告)日：2017-01-19
申请号：AU2015274453
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC , TOKITAE LLC
发明人： ZHANG SHIYI , BELLINGER ANDREW , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , GLETTIG DEAN LIANG , WOOD JR LOWELL L , ECKHOFF PHILIP A
IPC分类号： C07C57/04 , A61K31/197 , A61K31/78
摘要： Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.

6. 发明专利

JP2015091892A ワクチンナノテクノロジー审中-公开
公开(公告)号：JP2015091892A
公开(公告)日：2015-05-14
申请号：JP2015025608
申请日：2015-02-12
申请人： MASSACHUSETTS INST TECHNOLOGY , HARVARD COLLEGE , BRIGHAM & WOMENS HOSPITAL , CHILDRENS MEDICAL CT CORP
发明人： VON ANDRIAN ULRICH H , FAROKHZAD OMID C , LANGER ROBERT S , JUNT TOBIAS , MOSEMAN ELLIOTT ASHLEY , ZHANG LIANGFANG , BASTO PAMELA , IANNACONE MATTEO , ALEXIS FRANK
IPC分类号： A61K39/00 , A61K9/127 , A61K9/16 , A61K38/00 , A61K39/002 , A61K39/02 , A61K39/05 , A61K39/08 , A61K39/085 , A61K39/09 , A61K39/104 , A61K39/106 , A61K39/108 , A61K39/112 , A61K39/118 , A61K39/12 , A61K39/125 , A61K39/145 , A61K39/15 , A61K39/155 , A61K39/193 , A61K39/20 , A61K39/205 , A61K39/21 , A61K39/235 , A61K39/245 , A61K39/25 , A61K39/275 , A61K39/285 , A61K39/29 , A61K39/39 , A61K39/395 , A61K45/00 , A61K47/14 , A61K47/18 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/32 , A61K47/34 , A61K47/48 , A61P1/04 , A61P3/00 , A61P3/10 , A61P5/14 , A61P11/06 , A61P25/00 , A61P25/30 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/06 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P33/00 , A61P33/02 , A61P33/06 , A61P35/00 , A61P37/02 , A61P37/08
摘要：【課題】ワクチンナノテクノロジーの提供。【解決手段】本発明は、ナノキャリアを免疫系の細胞に送達するための組成物および系を提供する。本発明は、T細胞および/またはB細胞において免疫応答を刺激することができ、いくつかの実施形態では、少なくとも1つの免疫調節剤を含み、そして必要に応じて少なくとも1つの標的化部分および必要に応じて少なくとも1つの免疫刺激剤を含む、ワクチンナノキャリアを提供する。本発明は、発明性のあるワクチンナノキャリアを含む薬学的組成物を提供する。本発明は、発明性のあるワクチンナノキャリアおよびその薬学的組成物を設計し、製造し、そして使用する方法を提供する。本発明は、疾患、障害および状態の予防および/または処置の方法を提供し、その方法は、少なくとも1つの発明性のあるワクチンナノキャリアを、それを必要とする被験体に投与する工程を包含する。【選択図】図1

7. 发明专利

AU2020200346B2 ENTERIC ELASTOMERS 未知
公开(公告)号：AU2020200346B2
公开(公告)日：2021-08-05
申请号：AU2020200346
申请日：2020-01-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC , TOKITAE LLC
发明人： ZHANG SHIYI , BELLINGER ANDREW , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , GLETTIG DEAN LIANG , WOOD JR LOWELL L , ECKHOFF PHILIP A
IPC分类号： C07C57/04 , A61K31/197 , A61K31/78
摘要： Abstract Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.

8. 发明专利

AU2020200346A1 ENTERIC ELASTOMERS 未知
公开(公告)号：AU2020200346A1
公开(公告)日：2020-02-06
申请号：AU2020200346
申请日：2020-01-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC , TOKITAE LLC
发明人： ZHANG SHIYI , BELLINGER ANDREW , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , GLETTIG DEAN LIANG , WOOD JR LOWELL L , ECKHOFF PHILIP A
IPC分类号： C07C57/04 , A61K31/197 , A61K31/78
摘要： Abstract Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.

9. 发明申请

WO2011084620A3 PARTICLES FOR MULTIPLE AGENT DELIVERY 审中-公开
标题翻译：多种代理商交付的颗粒
公开(公告)号：WO2011084620A3
公开(公告)日：2011-11-17
申请号：PCT/US2010060814
申请日：2010-12-16
申请人： BRIGHAM & WOMENS HOSPITAL , MASSACHUSETTS INST TECHNOLOGY , FAROKHZAD OMID C , KOLISHETTI NAGESH , DHAR SHANTA , LIPPARD STEPHEN J , LANGER ROBERT S
发明人： FAROKHZAD OMID C , KOLISHETTI NAGESH , DHAR SHANTA , LIPPARD STEPHEN J , LANGER ROBERT S
IPC分类号： A61K47/48 , A61K9/20 , A61K9/22 , A61K47/30 , A61P25/28 , A61P35/00
CPC分类号： A61K45/06 , A61K47/593 , A61K47/60 , A61K47/6937
摘要： Delivery compositions are provided that include two or more active agents, wherein at least one active agent is conjugated to a polymer. The delivery compositions allow for controlled release of multiple active agents, including active agents with varying solubility, charge, and/or molecular weight.
摘要翻译：提供包含两种或更多种活性剂的递送组合物，其中至少一种活性剂与聚合物缀合。递送组合物允许控制释放多种活性剂，包括具有不同溶解度，电荷和/或分子量的活性剂。

10. 发明公开

EP2512522A4 PARTICLES FOR MULTIPLE AGENT DELIVERY 审中-公开
标题翻译：粒子进行多次ACTIVE
公开(公告)号：EP2512522A4
公开(公告)日：2013-09-25
申请号：EP10842613
申请日：2010-12-16
申请人： BRIGHAM & WOMENS HOSPITAL , MASSACHUSETTS INST TECHNOLOGY
发明人： FAROKHZAD OMID C , KOLISHETTI NAGESH , DHAR SHANTA , LIPPARD STEPHEN J , LANGER ROBERT S , VALENCIA PEDRO M
IPC分类号： A61K47/48 , A61K9/20 , A61K9/22 , A61K47/30 , A61P25/28 , A61P35/00
CPC分类号： A61K45/06 , A61K47/593 , A61K47/60 , A61K47/6937

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