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1. 发明申请

WO2009039458A2 VIRUS/NANOWIRE ENCAPSULATION WITHIN POLYMER MICROGELS FOR 2D AND 3D DEVICES FOR ENERGY AND ELECTRONICS 审中-公开
标题翻译：用于能量和电子二维和三维设备的聚合物微镜中的病毒/纳米级封装
公开(公告)号：WO2009039458A2
公开(公告)日：2009-03-26
申请号：PCT/US2008077137
申请日：2008-09-19
申请人： MASSACHUSETTS INST TECHNOLOGY , NAM YOON SUNG , BELCHER ANGELA , MAGYAR ANDREW , LEE DAEYEON , KIM JIN-WOONG , WEITZ DAVID
发明人： NAM YOON SUNG , BELCHER ANGELA , MAGYAR ANDREW , LEE DAEYEON , KIM JIN-WOONG , WEITZ DAVID
IPC分类号： B01J13/02 , B82B1/00
CPC分类号： B01J13/0065 , B01F13/0062 , B01J13/14 , B82B3/00 , B82Y30/00 , B82Y40/00 , Y10S977/70 , Y10S977/762 , Y10S977/882 , Y10S977/902 , Y10S977/915 , Y10S977/962 , Y10T436/11
摘要： Methods and apparatuses for encapsulating inorganic micro- or nanostructures within polymeric microgels are described. In various embodiments, viruses are encapsulated with microgels during microgel formation. The viruses can provide a template for in situ synthesis of the inorganic structures within the microgel. The inorganic structures can be distributed substantially homogeneously throughout the microgel, or can be distributed non-uniformly within the microgel. The inventive microgel compositions can be used for a variety of applications including electronic devices, biotechnological devices, fuel cells, display devices and optical devices.
摘要翻译：描述了在聚合物微凝胶内封装无机微结构或纳米结构的方法和装置。在各种实施方案中，在微凝胶形成期间，病毒用微凝胶包封。病毒可以提供用于原位合成微凝胶内的无机结构的模板。无机结构可以基本均匀地分布在整个微凝胶中，或者可以非均匀地分布在微凝胶内。本发明的微凝胶组合物可用于各种应用，包括电子装置，生物技术装置，燃料电池，显示装置和光学装置。

2. 发明申请

WO0247665A3 METHODS AND COMPOSITIONS FOR ENCAPSULATING ACTIVE AGENTS 审中-公开
标题翻译：包封活性剂的方法和组合物
公开(公告)号：WO0247665A3
公开(公告)日：2003-07-24
申请号：PCT/US0146181
申请日：2001-12-07
申请人： HARVARD COLLEGE , BAUSCH ANDREAS , DINSMORE ANTHONY , HSU MING , NIKOLAIDES MICHAEL , WEITZ DAVID
发明人： BAUSCH ANDREAS , DINSMORE ANTHONY , HSU MING , NIKOLAIDES MICHAEL , WEITZ DAVID
IPC分类号： A61K9/50
CPC分类号： A61K9/5026 , A61K9/5089
摘要： Methods for making self-assembled, selectively permeable elastic microscopie structures, referred to herein as colloidosomes, that have controlled pore-size, porosity and advantageous mechanical properties are described. In one form of the invention, a method of forming colloidosomes includes providing particles formed from a biocompatible material in a first solvent and forming an emulsion by adding a first fluid to the first solvent wherein the emulsion is defined by droplets of the first fluid surrounded by the first solvent. The method includes coating the surface of droplet with the particles and the stabilizing the particles on the surface of droplet. The colloidosomes produced typically have a yield strength of at least about 20 Pascals. In certain forms of the invention, the particles are spherical and are formed of a biocompatible polymer. Colloidosomes formed according to the methods described herein are also provided. In one form, a colloidosome includes a shell formed of biocompatible, substantially spherical particles wherein each of the particles are linked to neighboring particles. The shell defines an inner chamber sized for housing a desired active agent and has a plurality of pores extending therethrough. The colloidosomes are structurally stable, typically having a yield strength of at least about 20 Pascals. Colloidal suspension and methods of encapsulating a desired active agent are also described.
摘要翻译：描述了具有受控的孔径，孔隙率和有利的机械性质的自组装，选择性渗透的弹性微观结构（本文称为胶体体）的方法。在本发明的一种形式中，形成胶体体的方法包括在第一溶剂中提供由生物相容性材料形成的颗粒，并通过向第一溶剂中加入第一流体形成乳液，其中乳液由第一流体的液滴限定，第一溶剂。该方法包括用颗粒涂覆液滴的表面，并将颗粒稳定在液滴的表面上。生产的胶体体通常具有至少约20帕斯卡的屈服强度。在本发明的某些形式中，颗粒是球形的并且由生物相容性聚合物形成。还提供根据本文所述方法形成的胶体细胞。在一种形式中，胶体体包括由生物相容的，基本上为球形的颗粒形成的壳，其中每个颗粒连接到相邻的颗粒。壳体限定了内室，其尺寸适于容纳期望的活性剂并具有延伸穿过其中的多个孔。胶体体系结构稳定，通常具有至少约20帕斯卡的屈服强度。还描述了胶体悬浮液和包封所需活性剂的方法。

3. 发明申请

WO2006040551A3 COMPARTMENTALISED SCREENING BY MICROFLUIDIC CONTROL 审中-公开
标题翻译：通过微流控制进行分层筛选
公开(公告)号：WO2006040551A3
公开(公告)日：2006-06-29
申请号：PCT/GB2005003924
申请日：2005-10-12
申请人： MEDICAL RES COUNCIL , HARVARD COLLEGE , GRIFFITHS ANDREW , WEITZ DAVID , LINK DARREN , AHN KEUNHO , BIBETTE JEROME
发明人： GRIFFITHS ANDREW , WEITZ DAVID , LINK DARREN , AHN KEUNHO , BIBETTE JEROME
IPC分类号： G01N33/543 , B01F3/08 , B01F5/02 , B01F5/06 , B01F13/00 , B01J19/00 , B01L3/00 , C12Q1/68 , C40B50/08 , G01N15/14 , G01N33/53 , G01N33/555
CPC分类号： G01N33/5432 , B01F3/0807 , B01F5/0256 , B01F5/0646 , B01F5/0647 , B01F5/0655 , B01F13/0062 , B01F13/0071 , B01F13/0076 , B01F2003/0834 , B01F2003/0842 , B01J19/0046 , B01J2219/00576 , B01J2219/00596 , B01J2219/00599 , B01J2219/00657 , B01J2219/00664 , B01J2219/00666 , B01J2219/00702 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , C12Q1/42 , C12Q2563/159 , C12Q2565/119 , C40B50/08 , G01N15/14 , G01N21/6428 , G01N33/5008 , G01N33/5044 , G01N33/573 , G01N2015/149 , G01N2021/6439 , G01N2333/916 , G01N2500/04 , G01N2500/10
摘要： The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.
摘要翻译：本发明描述了用于鉴定与生物化学体系的靶组分结合或调节靶的活性的化合物的方法，包括以下步骤：a）将化合物与靶一起分隔成微胶囊，使得只有子集在任何一个微胶囊中以多份拷贝表示; 和b）鉴定结合或调节靶标活性的化合物; 其中在微流控制下进行至少一个步骤。本发明能够筛选可用作药物开发潜力的大分子谱系。

4. 发明申请

WO2006038035A2 IN VITRO EVOLUTION IN MICROFLUIDIC SYSTEMS 审中-公开
标题翻译：在微流体系统中的体外发育
公开(公告)号：WO2006038035A2
公开(公告)日：2006-04-13
申请号：PCT/GB2005003889
申请日：2005-10-10
申请人： MEDICAL RES COUNCIL , HARVARD COLLEGE , GRIFFITHS ANDREW , WEITZ DAVID , LINK DARREN , AHN KEUNHO , BIBETTE JEROME
发明人： GRIFFITHS ANDREW , WEITZ DAVID , LINK DARREN , AHN KEUNHO , BIBETTE JEROME
CPC分类号： B01F3/0807 , B01F5/0646 , B01F5/0647 , B01F5/0655 , B01F13/0062 , B01F13/0071 , B01F13/0076 , B01J19/0046 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/0052 , B01J2219/00545 , B01J2219/00576 , B01J2219/00657 , B01J2219/00722 , B01L3/502746 , B01L3/502753 , B01L3/502776 , B01L3/502784 , B01L2200/0636 , B01L2200/0673 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , C12N15/1058 , C12N15/1075 , C12P21/00 , C12Q1/6874
摘要： The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.
摘要翻译：本发明描述了一种用于分离编码具有所需活性的基因产物的一种或多种遗传元件的方法，包括以下步骤：（a）将遗传元件分隔成微胶囊; 和（b）分选表达具有所需活性的基因产物的遗传元件; 其中至少一个步骤处于微流控制之下。本发明能够通过本发明方法的重复诱变和迭代应用来体外进化核酸和蛋白质。

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