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1. 发明申请

WO2012044522A1 MECHANICALLY STABLE NANOPARTICLE THIN FILM COATINGS AND METHODS OF PRODUCING THE SAME 审中-公开
标题翻译：机械稳定的纳米薄膜薄膜及其制造方法
公开(公告)号：WO2012044522A1
公开(公告)日：2012-04-05
申请号：PCT/US2011/052920
申请日：2011-09-23
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , LEE, Daeyeon
发明人： LEE, Daeyeon
IPC分类号： B32B3/00
CPC分类号： C23C16/44 , C03C17/007 , C03C17/3417 , C03C2217/445 , C03C2217/475 , C23C16/513 , C23C16/56 , G02B1/118 , Y10T428/24975 , Y10T428/249999
摘要： A method for treating a surface comprises depositing a first coating comprising a plurality of nanoparticles on a substrate, wherein the first coating defines a plurality of interstitial spaces; and depositing a second coating comprising metals, metal oxides, or mixtures thereof by atomic layer deposition (ALD) on the first coating and within the interstitial spaces defined by the first coating. A mechanically stable coated product comprises a substrate; a first coating comprising a plurality of nanoparticles deposited on the substrate; wherein the first coating defines a plurality of interstitial spaces; and a second coating comprising metals, metal oxides, or mixtures thereof deposited by atomic layer deposition (ALD) on the first coating and within the interstitial spaces defined by the first coating. The mechanically stable thin film coating imparts mechanical robustness to the nanoparticle thin film, and retains or improves the desired optical and wetting properties of the nanoparticle thin film.
摘要翻译：用于处理表面的方法包括在基底上沉积包含多个纳米颗粒的第一涂层，其中所述第一涂层限定多个间隙空间; 以及通过原子层沉积（ALD）沉积包含金属，金属氧化物或其混合物的第二涂层在第一涂层上以及在由第一涂层限定的间隙空间内。机械稳定的涂布产品包括基材; 第一涂层，其包含沉积在所述基材上的多个纳米颗粒; 其中所述第一涂层限定多个间隙空间; 以及第二涂层，其包含通过原子层沉积（ALD）在第一涂层上和在由第一涂层限定的间隙空间内沉积的金属，金属氧化物或其混合物。机械稳定的薄膜涂层对纳米颗粒薄膜赋予机械稳定性，并且保留或改善纳米颗粒薄膜所需的光学和润湿性能。

2. 发明申请

WO2009020633A3 METAL OXIDE COATING ON SURFACES 审中-公开
标题翻译：金属氧化物涂层在表面上
公开(公告)号：WO2009020633A3
公开(公告)日：2009-08-06
申请号：PCT/US2008009477
申请日：2008-08-07
申请人： HARVARD COLLEGE , WEITZ DAVID A , HOLTZE CHRISTIAN , ABATE ADAM R , LEE DAEYEON , DO THAO
发明人： WEITZ DAVID A , HOLTZE CHRISTIAN , ABATE ADAM R , LEE DAEYEON , DO THAO
IPC分类号： C23C18/12 , C03B19/12 , C03C1/00
CPC分类号： C23C18/1295 , C03C1/008 , C23C18/1216 , C23C18/1233 , C23C18/1254 , Y10T428/2457 , Y10T428/24612 , Y10T428/24744
摘要： The present invention provides a method for coating metal oxide on a PDMS surface. The method includes preparing a mixture that contains a sol-gel precursor, reacting the mixture to form a preconverted sol-gel precursor, where the preconverted sol-gel precursor does not diffuse into PDMS and is not in the form of a gel, forming a reactive PDMS surface, applying the preconverted sol-gel precursor onto the reactive PDMS surface, binding the preconverted sol-gel precursor to the reactive PDMS surface, and converting the bound preconverted sol-gel precursor to a metal oxide to form a metal oxide coating on the PDMS surface. The present invention also provides a PDMS microfiuidic device where one or more channels of the microfluidic device is provided with a metal oxide coating covalently bound only on the surface of the one or more channels.
摘要翻译：本发明提供一种在PDMS表面上涂覆金属氧化物的方法。该方法包括制备含有溶胶 - 凝胶前体的混合物，使混合物反应以形成预转化的溶胶 - 凝胶前体，其中预转化的溶胶 - 凝胶前体不扩散到PDMS中并且不是凝胶形式，将预转化的溶胶 - 凝胶前体施加到反应性PDMS表面上，将预转化的溶胶 - 凝胶前体与反应性PDMS表面结合，并将结合的预转化的溶胶 - 凝胶前体转化为金属氧化物，以形成金属氧化物涂层 PDMS表面。本发明还提供了一种PDMS微流体装置，其中微流体装置的一个或多个通道设置有仅在一个或多个通道的表面上共价结合的金属氧化物涂层。

3. 发明申请

WO2010110998A1 IMPRINTED BIOMIMETIC CATALYSTS FOR CELLULOSE HYDROLYSIS 审中-公开
标题翻译：用于纤维素水解的预处理生物催化剂
公开(公告)号：WO2010110998A1
公开(公告)日：2010-09-30
申请号：PCT/US2010/025912
申请日：2010-03-02
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , ROTH, Stephen , LEE, Daeyeon
发明人： ROTH, Stephen , LEE, Daeyeon
IPC分类号： C08G77/00
CPC分类号： C08G77/02 , B01J21/08 , B01J31/0225 , B01J31/0277 , B01J31/0284 , B01J31/067 , B01J31/069 , B01J31/10 , B01J37/0018 , B01J2231/40 , B01J2531/96 , C12P7/10 , C12P2203/00 , C13K1/02 , Y02E50/16
摘要： The present disclosure describes methods and biomimetic catalysts useful for hydrolyzing glucose polymers, such as cellulose, and oligomers, such as cellobiose, to glucose for the subsequent production of ethanol.
摘要翻译：本公开描述了用于水解葡萄糖聚合物（例如纤维素）和低聚物如纤维二糖的方法和仿生催化剂，用于随后生产乙醇的葡萄糖。

4. 发明申请

WO2009039458A2 VIRUS/NANOWIRE ENCAPSULATION WITHIN POLYMER MICROGELS FOR 2D AND 3D DEVICES FOR ENERGY AND ELECTRONICS 审中-公开
标题翻译：用于能量和电子二维和三维设备的聚合物微镜中的病毒/纳米级封装
公开(公告)号：WO2009039458A2
公开(公告)日：2009-03-26
申请号：PCT/US2008077137
申请日：2008-09-19
申请人： MASSACHUSETTS INST TECHNOLOGY , NAM YOON SUNG , BELCHER ANGELA , MAGYAR ANDREW , LEE DAEYEON , KIM JIN-WOONG , WEITZ DAVID
发明人： NAM YOON SUNG , BELCHER ANGELA , MAGYAR ANDREW , LEE DAEYEON , KIM JIN-WOONG , WEITZ DAVID
IPC分类号： B01J13/02 , B82B1/00
CPC分类号： B01J13/0065 , B01F13/0062 , B01J13/14 , B82B3/00 , B82Y30/00 , B82Y40/00 , Y10S977/70 , Y10S977/762 , Y10S977/882 , Y10S977/902 , Y10S977/915 , Y10S977/962 , Y10T436/11
摘要： Methods and apparatuses for encapsulating inorganic micro- or nanostructures within polymeric microgels are described. In various embodiments, viruses are encapsulated with microgels during microgel formation. The viruses can provide a template for in situ synthesis of the inorganic structures within the microgel. The inorganic structures can be distributed substantially homogeneously throughout the microgel, or can be distributed non-uniformly within the microgel. The inventive microgel compositions can be used for a variety of applications including electronic devices, biotechnological devices, fuel cells, display devices and optical devices.
摘要翻译：描述了在聚合物微凝胶内封装无机微结构或纳米结构的方法和装置。在各种实施方案中，在微凝胶形成期间，病毒用微凝胶包封。病毒可以提供用于原位合成微凝胶内的无机结构的模板。无机结构可以基本均匀地分布在整个微凝胶中，或者可以非均匀地分布在微凝胶内。本发明的微凝胶组合物可用于各种应用，包括电子装置，生物技术装置，燃料电池，显示装置和光学装置。

5. 发明申请

WO2008021817A3 SUPERHYDROPHILIC COATINGS 审中-公开
公开(公告)号：WO2008021817A3
公开(公告)日：2008-02-21
申请号：PCT/US2007/075341
申请日：2007-08-07
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LEE, Daeyeon , COHEN, Robert, E. , RUBNER, Michael, F.
发明人： LEE, Daeyeon , COHEN, Robert, E. , RUBNER, Michael, F.
IPC分类号： B32B5/16
摘要： A superhydrophilic coating on a substrate can be antireflective and antifogging. The coating can remain antireflective and antifogging for extended periods. The coating can include oppositely charge inorganic nanoparticles, and can be substantially free of an organic polymer.

6. 发明申请

WO2008021817A8 SUPERHYDROPHILIC COATINGS 审中-公开
标题翻译：超亲水涂料
公开(公告)号：WO2008021817A8
公开(公告)日：2008-05-08
申请号：PCT/US2007075341
申请日：2007-08-07
申请人： MASSACHUSETTS INST TECHNOLOGY , LEE DAEYEON , COHEN ROBERT E , RUBNER MICHAEL F
发明人： LEE DAEYEON , COHEN ROBERT E , RUBNER MICHAEL F
IPC分类号： B32B18/00
CPC分类号： C04B35/14 , C03C17/001 , C03C17/007 , C03C17/23 , C03C2217/212 , C03C2217/213 , C03C2217/42 , C03C2217/75 , C04B35/46 , G02B1/118 , G02B27/0006 , Y10T428/25
摘要： A superhydrophilic coating on a substrate can be antireflective and antifogging. The coating can remain antireflective and antifogging for extended periods. The coating can include oppositely charge inorganic nanoparticles, and can be substantially free of an organic polymer.
摘要翻译：基材上的超亲水涂层可以是抗反射和防雾的。涂层可以长时间保持抗反射和防雾。该涂层可以包含相反电荷的无机纳米粒子，并且可以基本上不含有机聚合物。

7. 发明申请

WO2008021817A2 SUPERHYDROPHILIC COATINGS 审中-公开
公开(公告)号：WO2008021817A2
公开(公告)日：2008-02-21
申请号：PCT/US2007075341
申请日：2007-08-07
申请人： MASSACHUSETTS INST TECHNOLOGY , LEE DAEYEON , COHEN ROBERT E , RUBNER MICHAEL F
发明人： LEE DAEYEON , COHEN ROBERT E , RUBNER MICHAEL F
IPC分类号： B32B18/00
CPC分类号： C04B35/14 , C03C17/001 , C03C17/007 , C03C17/23 , C03C2217/212 , C03C2217/213 , C03C2217/42 , C03C2217/75 , C04B35/46 , G02B1/118 , G02B27/0006 , Y10T428/25
摘要： A superhydrophilic coating on a substrate can be antireflective and antifogging. The coating can remain antireflective and antifogging for extended periods. The coating can include oppositely charge inorganic nanoparticles, and can be substantially free of an organic polymer.

8. 发明申请

WO2011017524A1 MICROFLUIDIC-BASED GENERATION OF FUNCTIONALIZED MICROBUBBLES FOR ULTRASOUND IMAGING AND THERAPY 审中-公开
标题翻译：用于超声成像和治疗的功能化微生物的基于微流体的生成
公开(公告)号：WO2011017524A1
公开(公告)日：2011-02-10
申请号：PCT/US2010/044555
申请日：2010-08-05
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , LEE, Daeyeon , SEHGAL, Chandra M. , LEE, Myung Han
发明人： LEE, Daeyeon , SEHGAL, Chandra M. , LEE, Myung Han
IPC分类号： A61K9/50
CPC分类号： A61K49/223 , B01L3/0241 , B01L3/502784
摘要： A method for generating stable encapsulated bubbles and dried encapsulated bubbles comprises introducing an inner stream of a gas into a liquid-filled chamber from an exit orifice of a capillary tube; introducing a middle stream of a water immiscible liquid into the exit orifice; and introducing an outer stream of an aqueous liquid to the exit orifice, to form compound bubbles. The encapsulated bubbles are formed after converting the middle phase of compound bubbles into a shell. The stable encapsulated bubbles or the stable dried encapsulated bubbles can be used in drug delivery and for enhancing ultrasound imaging.
摘要翻译：用于产生稳定的包封气泡和干燥的包封气泡的方法包括从毛细管的出口引入气体的内部流入液体填充的室; 将不混溶的液体的中流引入出口; 并将水性液体的外流引入出口，形成复合气泡。将复合气泡的中间相转化为壳体后形成封装的气泡。稳定的包封气泡或稳定的干燥的包封气泡可用于药物递送和用于增强超声成像。

9. 发明申请

WO2009148598A1 POLYMERSOMES, COLLOIDOSOMES, LIPOSOMES, AND OTHER SPECIES ASSOCIATED WITH FLUIDIC DROPLETS 审中-公开
标题翻译：聚合物，胶体，脂质体和其他与流体滴剂有关的物种
公开(公告)号：WO2009148598A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/003389
申请日：2009-06-04
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , SHUM, Ho, Cheung , LEE, Daeyeon , YOON, Insun , WEITZ, David, A. , KIM, Jin-woong
发明人： SHUM, Ho, Cheung , LEE, Daeyeon , YOON, Insun , WEITZ, David, A. , KIM, Jin-woong
IPC分类号： A61K9/51 , A61K49/00
CPC分类号： A61K47/34 , A61K9/1273 , A61K9/1277 , A61K9/16 , A61K9/501 , A61K9/5031 , A61K9/5089 , A61K47/6907 , A61K47/6915
摘要： The present invention relates generally to vesicles such as liposomes, colloidosomes, and polymersomes, as well as techniques for making and using such vesicles. In some cases, the vesicles may be at least partially biocompatible and/or biodegradable. The vesicles may be formed, according to one aspect, by forming a multiple emulsion comprising a first droplet surrounded by a second droplet, which in turn is surrounded by a third fluid, where the second droplet comprises lipids and/or polymers, and removing fluid from the second droplet, e.g., through evaporation or diffusion, until a vesicle is formed. In certain aspects, the size of the vesicle may be controlled, e.g., through osmolarity, and in certain embodiments, the vesicle may be ruptured through a change in osmolarity. In some cases, the vesicle may contain other species, such as fluorescent molecules, microparticles, pharmaceutical agents, etc., which may be released upon rupture. Yet other aspects of the invention are generally directed to methods of making such vesicles, kits involving such vesicles, or the like.
摘要翻译：本发明一般涉及囊泡，例如脂质体，胶体体和聚合物囊泡，以及制造和使用这些囊泡的技术。在一些情况下，囊泡可以是至少部分生物相容的和/或可生物降解的。根据一个方面，可以通过形成多个乳液来形成囊泡，所述多重乳液包括由第二液滴包围的第一液滴，第二液滴又由第三流体包围，其中第二液滴包括脂质和/或聚合物，以及除去流体从第二液滴，例如通过蒸发或扩散，直到形成囊泡。在某些方面，可以例如通过渗透压控制囊泡的尺寸，并且在某些实施方案中，泡囊可以通过渗透压的变化而破裂。在一些情况下，泡囊可以含有其它物质，例如荧光分子，微粒，药剂等，其可在破裂时释放。本发明的其它方面通常涉及制备这种囊泡的方法，涉及这种囊泡的试剂盒等。

10. 发明申请

WO2009039458A3 VIRUS/NANOWIRE ENCAPSULATION WITHIN POLYMER MICROGELS FOR 2D AND 3D DEVICES FOR ENERGY AND ELECTRONICS 审中-公开
公开(公告)号：WO2009039458A3
公开(公告)日：2009-03-26
申请号：PCT/US2008/077137
申请日：2008-09-19
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , NAM, Yoon, Sung , BELCHER, Angela , MAGYAR, Andrew , LEE, Daeyeon , KIM, Jin-Woong , WEITZ, David
发明人： NAM, Yoon, Sung , BELCHER, Angela , MAGYAR, Andrew , LEE, Daeyeon , KIM, Jin-Woong , WEITZ, David
IPC分类号： B01J13/02 , B82B1/00
摘要： Methods and apparatuses for encapsulating inorganic micro- or nanostructures within polymeric microgels are described. In various embodiments, viruses are encapsulated with microgels during microgel formation. The viruses can provide a template for in situ synthesis of the inorganic structures within the microgel. The inorganic structures can be distributed substantially homogeneously throughout the microgel, or can be distributed non-uniformly within the microgel. The inventive microgel compositions can be used for a variety of applications including electronic devices, biotechnological devices, fuel cells, display devices and optical devices.

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