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1. 发明申请

WO2008098165A3 OSCILLATING CELL CULTURE BIOREACTOR 审中-公开
标题翻译：振荡细胞培养生物反应器
公开(公告)号：WO2008098165A3
公开(公告)日：2008-10-02
申请号：PCT/US2008053411
申请日：2008-02-08
申请人： MASSACHUSETTS INST TECHNOLOGY , MORETTI MATTEO G , FREED LISA E , LANGER ROBERT S
发明人： MORETTI MATTEO G , FREED LISA E , LANGER ROBERT S
IPC分类号： C12M1/02
CPC分类号： C12M23/02 , A61L27/3895 , C12M21/08 , C12M23/06 , C12M23/24 , C12M25/14 , C12M27/10
摘要： Methods and devices for cell or tissue culture are provided. One aspect provides a bioreactor having a gas permeable, closed-loop chamber for cell or tissue culture, and an oscillating means for moving the gas permeable, closed-loop chamber bidirectionally along an axis horizontal to an axis normal to the closed-loop chamber to force convection of cells and fluid in the gas permeable, closed-loop chamber. The bioreactor optionally includes a tissue engineering scaffold, an inlet means, an outlet means, and integrated sensors. Another aspect provides a bioreactor having a plurality of gas permeable, closed-loop chambers for cell or tissue culture. Methods of culturing cells and producing tissue constructs are also provided.
摘要翻译：提供了用于细胞或组织培养的方法和装置。一个方面提供了具有用于细胞或组织培养的气体可渗透闭环腔室的生物反应器以及用于沿着水平方向垂直于闭环腔室的轴线双向移动气体可渗透闭环腔室的振荡装置，气体可渗透的闭环腔室中的细胞和流体的强制对流。生物反应器可选地包括组织工程支架，入口装置，出口装置和集成传感器。另一方面提供了具有用于细胞或组织培养的多个可透气的闭环室的生物反应器。还提供了培养细胞和产生组织构建体的方法。

2. 发明申请

WO2008098165A9 OSCILLATING CELL CULTURE BIOREACTOR 审中-公开
标题翻译：振荡细胞培养物生物反应器
公开(公告)号：WO2008098165A9
公开(公告)日：2008-11-27
申请号：PCT/US2008053411
申请日：2008-02-08
申请人： MASSACHUSETTS INST TECHNOLOGY , MORETTI MATTEO G , FREED LISA E , LANGER ROBERT S
发明人： MORETTI MATTEO G , FREED LISA E , LANGER ROBERT S
IPC分类号： C12M1/02
CPC分类号： C12M23/02 , A61L27/3895 , C12M21/08 , C12M23/06 , C12M23/24 , C12M25/14 , C12M27/10
摘要： Methods and devices for cell or tissue culture are provided. One aspect provides a bioreactor having a gas permeable, closed-loop chamber for cell or tissue culture, and an oscillating means for moving the gas permeable, closed-loop chamber bidirectionally along an axis horizontal to an axis normal to the closed-loop chamber to force convection of cells and fluid in the gas permeable, closed-loop chamber. The bioreactor optionally includes a tissue engineering scaffold, an inlet means, an outlet means, and integrated sensors. Another aspect provides a bioreactor having a plurality of gas permeable, closed-loop chambers for cell or tissue culture. Methods of culturing cells and producing tissue constructs are also provided.
摘要翻译：提供了细胞或组织培养的方法和装置。一个方面提供了一种生物反应器，其具有用于细胞或组织培养的气体可渗透的闭环腔室，以及用于沿着垂直于垂直于闭环腔室的轴线的轴线双向移动气体可渗透的闭环腔室的振荡装置，在气体可渗透的闭环室中强制对流细胞和流体。生物反应器任选地包括组织工程支架，入口装置，出口装置和集成的传感器。另一方面提供了一种生物反应器，其具有用于细胞或组织培养的多个可透气的闭环腔室。还提供了培养细胞和产生组织构建体的方法。

3. 发明申请

WO2012027675A3 POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF 审中-公开
标题翻译：聚（氨基 - 氨基醇），其制备及其用途
公开(公告)号：WO2012027675A3
公开(公告)日：2012-05-10
申请号：PCT/US2011049360
申请日：2011-08-26
申请人： MASSACHUSETTS INST TECHNOLOGY , MA MINGLIN , LIU WENDY F , LANGER ROBERT S , ANDERSON DANIEL GRIFFITH
发明人： MA MINGLIN , LIU WENDY F , LANGER ROBERT S , ANDERSON DANIEL GRIFFITH
IPC分类号： C08G73/00 , A61K31/16 , A61L31/10 , C08G65/22 , C09D5/14
CPC分类号： C08G73/0206 , A61K9/1273 , A61K31/7088 , A61K47/34 , A61K47/59 , A61L31/10 , C08G59/22 , C08G59/306 , C08G59/50 , C08G73/02 , C09D5/1637 , C09D179/02 , Y10T428/31725
摘要： A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.
摘要翻译：使用组合聚合制备了一类新的聚（β-氨基醇）（PBAAs）。本发明的PBAAs可用于生物技术和生物医学应用中，作为涂层（例如用于医疗装置或植入物的膜或多层膜的涂层），添加剂，材料，赋形剂，非生物污垢剂，微图案化剂和细胞包封剂。当用作表面涂层时，这些PBAAs根据其化学结构在体外和体内引起不同程度的炎症。这类材料的大化学多样性使我们能够鉴定体外抑制巨噬细胞活化的聚合物涂层。此外，在皮下植入羧化聚苯乙烯微粒之后，这些涂层减少了炎性细胞的募集，并减少了纤维化。这些聚合物可用于形成用于细胞包封的聚电解质复合物胶囊。本发明还可以具有许多其他生物学应用，例如抗微生物涂层，DNA或siRNA递送以及干细胞组织工程。

4. 发明申请

WO2011084620A3 PARTICLES FOR MULTIPLE AGENT DELIVERY 审中-公开
标题翻译：多种代理商交付的颗粒
公开(公告)号：WO2011084620A3
公开(公告)日：2011-11-17
申请号：PCT/US2010060814
申请日：2010-12-16
申请人： BRIGHAM & WOMENS HOSPITAL , MASSACHUSETTS INST TECHNOLOGY , FAROKHZAD OMID C , KOLISHETTI NAGESH , DHAR SHANTA , LIPPARD STEPHEN J , LANGER ROBERT S
发明人： FAROKHZAD OMID C , KOLISHETTI NAGESH , DHAR SHANTA , LIPPARD STEPHEN J , LANGER ROBERT S
IPC分类号： A61K47/48 , A61K9/20 , A61K9/22 , A61K47/30 , A61P25/28 , A61P35/00
CPC分类号： A61K45/06 , A61K47/593 , A61K47/60 , A61K47/6937
摘要： Delivery compositions are provided that include two or more active agents, wherein at least one active agent is conjugated to a polymer. The delivery compositions allow for controlled release of multiple active agents, including active agents with varying solubility, charge, and/or molecular weight.
摘要翻译：提供包含两种或更多种活性剂的递送组合物，其中至少一种活性剂与聚合物缀合。递送组合物允许控制释放多种活性剂，包括具有不同溶解度，电荷和/或分子量的活性剂。

5. 发明申请

WO2010053572A2 AMINOALCOHOL LIPIDOIDS AND USES THEREOF 审中-公开
标题翻译：氨基酚脂质体及其用途
公开(公告)号：WO2010053572A2
公开(公告)日：2010-05-14
申请号：PCT/US2009006018
申请日：2009-11-06
申请人： MASSACHUSETTS INST TECHNOLOGY , MAHON KERRY PETER , LOVE KEVIN THOMAS , LEVINS CHRISTOPHER G , WHITEHEAD KATHRYN ANN , LANGER ROBERT S , ANDERSON DANIEL GRIFFITH
发明人： MAHON KERRY PETER , LOVE KEVIN THOMAS , LEVINS CHRISTOPHER G , WHITEHEAD KATHRYN ANN , LANGER ROBERT S , ANDERSON DANIEL GRIFFITH
IPC分类号： C07C217/42 , A61K47/18 , B01J31/12 , C07D241/04
CPC分类号： C07D295/13 , A61K9/107 , A61K9/1271 , A61K9/5123 , A61K31/7088 , A61K38/02 , A61K47/16 , A61K47/48023 , A61K47/48061 , A61K47/54 , A61K47/545 , A61K48/0025 , B01J2531/0252 , B01J2531/845 , C07C215/14 , C07C217/08 , C12N15/111 , C12N15/1137 , C12N15/88 , C12N2310/14 , C12N2310/3515 , C12N2320/32
摘要： Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
摘要翻译：氨基醇类固醇通过使胺与环氧化物封端的化合物反应来制备。还提供了从市售的原料制备氨基醇类固醇的方法。氨基醇类固醇可以由外消旋或立体化学纯环氧化物制备。氨基醇类固醇或其盐形式优选是可生物降解的和生物相容的并且可以用于各种药物递送系统中。鉴于这些氨基醇类脂质化合物的氨基部分，它们特别适用于递送多核苷酸。已经制备了含有本发明的类脂和多核苷酸的复合物，胶束，脂质体或颗粒。本发明的类脂质也可用于制备用于药物递送的微粒。考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。

6. 发明申请

WO2010011327A3 RADIATIVE HEATING FOR DRUG DELIVERY AND OTHER APPLICATIONS 审中-公开
标题翻译：用于药物递送和其他应用的放射性加热
公开(公告)号：WO2010011327A3
公开(公告)日：2010-05-06
申请号：PCT/US2009004285
申请日：2009-07-23
申请人： CHILDRENS MEDICAL CENTER , MASSACHUSETTS INST TECHNOLOGY , GEN HOSPITAL CORP , HOARE TODD R , KOHANE DANIEL S , FENN ALAN J , NEELEY WILLIAM L , LANGER ROBERT S
发明人： HOARE TODD R , KOHANE DANIEL S , FENN ALAN J , NEELEY WILLIAM L , LANGER ROBERT S
IPC分类号： C08J3/28 , A61K41/00 , A61K47/02 , A61K47/32 , A61K47/34 , C08L33/26 , C08L39/04 , C08L49/00 , C08L79/02 , C08L81/02
CPC分类号： A61K41/0028 , A61K9/0002 , A61K9/0024 , A61K9/0097 , A61K47/32 , C08G73/0266 , C08L79/02
摘要： The present invention generally relates to systems and methods for releasing a releasable species from an article using an external trigger, for example, using microwave radiation or other forms of radiation, e.g., radiofrequency radiation. Such systems and methods may be useful, for example, in biological applications (e.g., as an implant within a subject), industrial applications, commercial applications, or the like. One aspect of the invention is generally directed to an article containing a radiation- sensitive polymer or other radiation-sensitive material. Exposure of the radiation- sensitive material to radiation such as microwave and/or radiofrequency radiation may cause the material to increase in temperature. This increase in temperature may be used, in some cases, to cause the release of a drug or other releasable species from the article. For instance, a drug may be contained in a heat-sensitive material positioned in thermal communication with the radiation-sensitive material, or a drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material positioned in thermal communication with the radiation-sensitive material. In another aspect of the invention, a receive antenna, such as a microwave receive antenna may be used to focus microwave and/or radiofrequency radiation on an article. For instance, the receive antenna may focus microwave and/or radiofrequency radiation on a radiation-sensitive material in the article. Such focusing may be useful, in some embodiments, to control release of a drug or other releasable species from the article. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, and the like.
摘要翻译：本发明一般涉及使用外部触发器（例如使用微波辐射或其他形式的辐射，例如射频辐射）从制品中释放可释放物质的系统和方法。这样的系统和方法可用于例如生物应用（例如，作为受试者内的植入物），工业应用，商业应用等。本发明的一个方面通常涉及含有辐射敏感聚合物或其它辐射敏感材料的制品。将辐射敏感材料暴露于辐射如微波和/或射频辐射可能导致材料温度升高。在某些情况下，可以使用这种温度升高来引起药物或其它可释放物质从制品中的释放。例如，药物可以包含在与辐射敏感材料热定位的热敏材料中，或者药物可以包含在外壳内，所述外壳至少部分地被定位的热敏材料隔离与辐射敏感材料进行热交换。在本发明的另一方面，诸如微波接收天线的接收天线可用于将微波和/或射频辐射聚焦在物品上。例如，接收天线可以将微波和/或射频辐射聚焦在制品中的辐射敏感材料上。在一些实施方案中，这种聚焦可能是有用的，以控制药物或其它可释放物质从制品的释放。本发明的其它方面涉及制造或使用这些制品的系统和方法，例如通过将物品植入受试者内，涉及这种制品的治疗方法，包括这种制品的试剂盒等。

7. 发明申请

WO2009142719A3 TYMPANIC MEMBRANE PERMEATING EAR DROPS AND USES THEREOF 审中-公开
标题翻译：透明膜渗透油墨及其用途
公开(公告)号：WO2009142719A3
公开(公告)日：2010-01-07
申请号：PCT/US2009003084
申请日：2009-05-19
申请人： MASSACHUSETTS INST TECHNOLOGY , CHILDRENS MEDICAL CENTER , SIMONS EMMANUEL JOHN , HOARE TODD R , KOHANE DANIEL S , LANGER ROBERT S
发明人： SIMONS EMMANUEL JOHN , HOARE TODD R , KOHANE DANIEL S , LANGER ROBERT S
IPC分类号： A61K8/00 , A61K8/18
CPC分类号： A61K9/0046 , A61K47/48023 , A61K47/48046 , A61K47/4823 , A61K47/48784 , A61K47/54 , A61K47/543 , A61K47/61 , A61K47/6903 , Y10S514/817
摘要： The present invention provides compositions and methods for noninvasive delivery of therapeutic agents across an intact tympanic membrane. For example, the compositions include a penetration enhancer which increases the flux of a therapeutic agent (e.g., antibiotic) across the tympanic membrane. Such compositions are particularly useful in the treatment of otitis media. Additionally, the composition may include a sustained release agents that, in some embodiments form sustained release reservoirs, in situ, once administered to a patient.
摘要翻译：本发明提供了用于在完整鼓膜上非侵入性递送治疗剂的组合物和方法。例如，组合物包括渗透促进剂，其增加穿过鼓膜的治疗剂（例如抗生素）的通量。这样的组合物特别可用于治疗中耳炎。另外，组合物可以包括在一些实施方案中形成持续释放储存器的持续释放剂，其一旦施用于患者就位。

8. 发明申请

WO2007082305A2 BIODEGRADABLE ELASTOMERS 审中-公开
标题翻译：生物可降解弹性体
公开(公告)号：WO2007082305A2
公开(公告)日：2007-07-19
申请号：PCT/US2007060532
申请日：2007-01-12
申请人： MASSACHUSETTS INST TECHNOLOGY , BETTINGER CHRISTOPHER J , KARP JEFFREY , KIM SONIA J , LANGER ROBERT S , ZUMBUEHL ANDREAS , BRUGGEMAN JOOST P , DA SILVA-FERREIRA LINO , NIJST CHRISTIAAN , BURDICK JASON
发明人： BETTINGER CHRISTOPHER J , KARP JEFFREY , KIM SONIA J , LANGER ROBERT S , ZUMBUEHL ANDREAS , BRUGGEMAN JOOST P , DA SILVA-FERREIRA LINO , NIJST CHRISTIAAN , BURDICK JASON
IPC分类号： C08G63/46
CPC分类号： A61L31/06 , A61K35/12 , A61K35/48 , A61K45/06 , A61L27/18 , A61L27/38 , A61L27/58 , A61L31/148 , C08G63/6854 , C08J3/24 , C08J3/246 , C08J2367/00 , C08J2367/07 , C08K5/0025 , C12N11/08 , C08L67/00 , C08L67/07
摘要： The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.
摘要翻译：本发明在各方面提供弹性可生物降解的聚合物。在各种实施方案中，聚合物通过多官能醇或醚和双官能或更高级酸的反应形成以形成预聚物，其被交联以形成弹性可生物降解的聚合物。在优选的实施方案中，通过用乙烯基官能化预聚物主链上的一个或多个OR基团进行交联，然后进行光聚合以形成弹性可生物降解的聚合物组合物或材料。优选地，使用丙烯酸酯将一种或多种乙烯基加成到预聚物的主链上以形成丙烯酸酯化的预聚物。在各种实施方案中，丙烯酸酯化的预聚物与一种或多种丙烯酸酯化共聚物共聚。

9. 发明申请

WO2007070682A2 SYSTEM FOR SCREENING PARTICLES 审中-公开
标题翻译：筛选颗粒系统
公开(公告)号：WO2007070682A2
公开(公告)日：2007-06-21
申请号：PCT/US2006047975
申请日：2006-12-15
申请人： MASSACHUSETTS INST TECHNOLOGY , FAROKHZAD OMID C , RADOVIC-MORENO ALEKSANDAR FILI , LANGER ROBERT S
发明人： FAROKHZAD OMID C , RADOVIC-MORENO ALEKSANDAR FILI , LANGER ROBERT S
IPC分类号： A61K49/22
CPC分类号： G01N33/5088 , A61K47/555 , A61K47/66 , A61K47/6891 , B82Y5/00 , B82Y15/00 , C40B30/06
摘要： Screening of a library of particles in vivo and/or in vitro using Polyplex Iterative Combinatorial Optimization (PICO) allows for the design of particles for targeting a specific organ, tissue (e.g., cancer), or cell. Particles may, for example, include different targeting agents (e.g., aptamers or plurality of aptamers) on their surfaces, and the aptamer or aptamers may be evolved to provide better targeting of the particles. Libraries of particles are enriched in characteristics of particles that have been found to migrate to a tissue of interest, be taken up by cells, etc. The process may be repeated to engineer particles of a desired specificity or biological function.
摘要翻译：使用Polyplex迭代组合优化（PICO）在体内和/或体外筛选粒子库允许设计用于靶向特定器官，组织（例如癌症）或细胞的颗粒。例如，颗粒可以在其表面上包括不同的靶向剂（例如适体或多个适体），并且适配体或适体可以进化以提供更好的颗粒靶向。已经发现已经发现迁移到感兴趣的组织，被细胞吸收的颗粒的特征的颗粒的富集等。可以重复该方法来设计具有所需特异性或生物学功能的颗粒。

10. 发明申请

WO2006138380A2 AMINE-CONTAINING LIPIDS AND USES THEREOF 审中-公开
标题翻译：含胺的脂肪及其用途
公开(公告)号：WO2006138380A2
公开(公告)日：2006-12-28
申请号：PCT/US2006023171
申请日：2006-06-14
申请人： MASSACHUSETTS INST TECHNOLOGY , ANDERSON DANIEL G , ZUMBUEHL ANDREAS , LESHCHINER ELIZAVETA SERGEYEVN , LANGER ROBERT S , GOLDBERG MICHAEL
发明人： ANDERSON DANIEL G , ZUMBUEHL ANDREAS , LESHCHINER ELIZAVETA SERGEYEVN , LANGER ROBERT S , GOLDBERG MICHAEL
IPC分类号： A61K48/00
CPC分类号： C07D233/61 , A61K9/1617 , A61K47/18 , A61K47/22 , A61K48/00 , A61K48/0033 , C07C227/10 , C07C229/12 , C07C229/14 , C07C229/16 , C07C229/18 , C07C231/12 , C07C237/06 , C07D211/26 , C07D243/08 , C07D295/12 , C07D307/14 , C07D317/28 , C12N15/88
摘要： Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
摘要翻译：描述了从共轭加成胺到丙烯酸酯，丙烯酰胺或与吸电子基团共轭的其它碳 - 碳双键制备的含氮脂质。还提供了从市售的起始原料制备这些脂质的方法。这些脂质的这些含胺脂质或盐形式优选是可生物降解的和生物相容的，并且可以用于各种药物递送系统中。鉴于这些脂质的氨基部分，它们特别适用于递送多核苷酸。已经制备了含有本发明的脂质和多核苷酸的复合物或纳米颗粒。本发明的脂质也可用于制备用于药物递送的微粒。考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。

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