专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006138380A2 AMINE-CONTAINING LIPIDS AND USES THEREOF 审中-公开
标题翻译：含胺的脂肪及其用途
公开(公告)号：WO2006138380A2
公开(公告)日：2006-12-28
申请号：PCT/US2006023171
申请日：2006-06-14
申请人： MASSACHUSETTS INST TECHNOLOGY , ANDERSON DANIEL G , ZUMBUEHL ANDREAS , LESHCHINER ELIZAVETA SERGEYEVN , LANGER ROBERT S , GOLDBERG MICHAEL
发明人： ANDERSON DANIEL G , ZUMBUEHL ANDREAS , LESHCHINER ELIZAVETA SERGEYEVN , LANGER ROBERT S , GOLDBERG MICHAEL
IPC分类号： A61K48/00
CPC分类号： C07D233/61 , A61K9/1617 , A61K47/18 , A61K47/22 , A61K48/00 , A61K48/0033 , C07C227/10 , C07C229/12 , C07C229/14 , C07C229/16 , C07C229/18 , C07C231/12 , C07C237/06 , C07D211/26 , C07D243/08 , C07D295/12 , C07D307/14 , C07D317/28 , C12N15/88
摘要： Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
摘要翻译：描述了从共轭加成胺到丙烯酸酯，丙烯酰胺或与吸电子基团共轭的其它碳 - 碳双键制备的含氮脂质。还提供了从市售的起始原料制备这些脂质的方法。这些脂质的这些含胺脂质或盐形式优选是可生物降解的和生物相容的，并且可以用于各种药物递送系统中。鉴于这些脂质的氨基部分，它们特别适用于递送多核苷酸。已经制备了含有本发明的脂质和多核苷酸的复合物或纳米颗粒。本发明的脂质也可用于制备用于药物递送的微粒。考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。

2. 发明申请

WO2007082305A2 BIODEGRADABLE ELASTOMERS 审中-公开
标题翻译：生物可降解弹性体
公开(公告)号：WO2007082305A2
公开(公告)日：2007-07-19
申请号：PCT/US2007060532
申请日：2007-01-12
申请人： MASSACHUSETTS INST TECHNOLOGY , BETTINGER CHRISTOPHER J , KARP JEFFREY , KIM SONIA J , LANGER ROBERT S , ZUMBUEHL ANDREAS , BRUGGEMAN JOOST P , DA SILVA-FERREIRA LINO , NIJST CHRISTIAAN , BURDICK JASON
发明人： BETTINGER CHRISTOPHER J , KARP JEFFREY , KIM SONIA J , LANGER ROBERT S , ZUMBUEHL ANDREAS , BRUGGEMAN JOOST P , DA SILVA-FERREIRA LINO , NIJST CHRISTIAAN , BURDICK JASON
IPC分类号： C08G63/46
CPC分类号： A61L31/06 , A61K35/12 , A61K35/48 , A61K45/06 , A61L27/18 , A61L27/38 , A61L27/58 , A61L31/148 , C08G63/6854 , C08J3/24 , C08J3/246 , C08J2367/00 , C08J2367/07 , C08K5/0025 , C12N11/08 , C08L67/00 , C08L67/07
摘要： The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.
摘要翻译：本发明在各方面提供弹性可生物降解的聚合物。在各种实施方案中，聚合物通过多官能醇或醚和双官能或更高级酸的反应形成以形成预聚物，其被交联以形成弹性可生物降解的聚合物。在优选的实施方案中，通过用乙烯基官能化预聚物主链上的一个或多个OR基团进行交联，然后进行光聚合以形成弹性可生物降解的聚合物组合物或材料。优选地，使用丙烯酸酯将一种或多种乙烯基加成到预聚物的主链上以形成丙烯酸酯化的预聚物。在各种实施方案中，丙烯酸酯化的预聚物与一种或多种丙烯酸酯化共聚物共聚。

3. 发明申请

WO2007095393A3 MEDICAL DEVICES AND COATINGS WITH NON-LEACHING ANTIMICROBIAL PEPTIDES 审中-公开
标题翻译：医疗器械和涂层与非浸出性抗微生物肽
公开(公告)号：WO2007095393A3
公开(公告)日：2008-09-25
申请号：PCT/US2007004394
申请日：2007-02-15
申请人： MASSACHUSETTS INST TECHNOLOGY , FERREIRA LINO , LANGER ROBERT S , LOOSE CHRISTOPHER R , O'SHAUGHNESSY WILLIAM SHANNAN , ZUMBUEHL ANDREAS , STEPHANOPOLOUS GREGORY
发明人： FERREIRA LINO , LANGER ROBERT S , LOOSE CHRISTOPHER R , O'SHAUGHNESSY WILLIAM SHANNAN , ZUMBUEHL ANDREAS , STEPHANOPOLOUS GREGORY
IPC分类号： A61L27/54 , A61L29/16
CPC分类号： A61L27/54 , A61K38/10 , A61L2/16 , A61L2/232 , A61L15/46 , A61L27/227 , A61L27/34 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/25 , A61L2300/404
摘要： Antimicrobial peptides enable an alternate approach to developing antimicrobial coatings due to their targeting of the membranes of the bacteria. High specific activity is achieved by orienting the peptides so that the antimicrobial ends of the peptides maximally contact the bacteria. In one embodiment, one end of the peptide is covalently attached directly to the substrate. In another embodiment, the peptides are immobilized on the substrate using a coupling agent or tether. Non-covalent methods include coating the peptide onto the substrate or physiochemically immobilizing the peptides on the substrate using highly specific interactions, such as the biotin/avidin or streptavidin system. The compositions are substantially non-leaching, antifouling, and non-hemolytic. The immobilized peptides retain sufficient flexibility and mobility to interact with and be endocytosed by the bacteria, viruses, and/or fungi upon exposure. Immobilizing the peptides to the substrate reduces concerns regarding toxicity of the peptides and the development of antimicrobial resistance, while presenting substantially all of the peptide at the site of action at the surface of the substrate.
摘要翻译：由于抗菌肽靶向细菌膜，抗菌肽能够开发抗微生物涂层。通过使肽定向以使肽的抗微生物末端最大程度地接触细菌来实现高比活性。在一个实施方案中，肽的一端直接共价连接到底物上。在另一个实施方案中，使用偶联剂或系链将肽固定在底物上。非共价方法包括将肽涂覆到底物上或者使用高度特异性相互作用如生物素/抗生物素蛋白或链霉亲和素系统在肽上生理化学地固定在底物上。组合物基本上是非浸出，防污和非溶血性的。固定的肽保持足够的灵活性和迁移性，以便在暴露时与细菌，病毒和/或真菌相互作用并内吞。将肽固定到底物可以减少对肽的毒性和抗微生物耐药性的发展的关注，同时在基底表面的作用部位呈现基本上所有的肽。

4. 发明申请

WO2007095393A2 MEDICAL DEVICES AND COATINGS WITH NON-LEACHING ANTIMICROBIAL PEPTIDES 审中-公开
标题翻译：医疗器械和涂层与非浸出抗菌肽
公开(公告)号：WO2007095393A2
公开(公告)日：2007-08-23
申请号：PCT/US2007004394
申请日：2007-02-15
申请人： MASSACHUSETTS INST TECHNOLOGY , FERREIRA LINO , LANGER ROBERT S , LOOSE CHRISTOPHER R , O'SHAUGHNESSY WILLIAM SHANNAN , ZUMBUEHL ANDREAS , STEPHANOPOLOUS GREGORY
发明人： FERREIRA LINO , LANGER ROBERT S , LOOSE CHRISTOPHER R , O'SHAUGHNESSY WILLIAM SHANNAN , ZUMBUEHL ANDREAS , STEPHANOPOLOUS GREGORY
CPC分类号： A61L27/54 , A61K38/10 , A61L2/16 , A61L2/232 , A61L15/46 , A61L27/227 , A61L27/34 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/25 , A61L2300/404
摘要： Antimicrobial peptides enable an alternate approach to developing antimicrobial coatings due to their targeting of the membranes of the bacteria. High specific activity is achieved by orienting the peptides so that the antimicrobial ends of the peptides maximally contact the bacteria. In one embodiment, one end of the peptide is covalently attached directly to the substrate. In another embodiment, the peptides are immobilized on the substrate using a coupling agent or tether. Non-covalent methods include coating the peptide onto the substrate or physiochemically immobilizing the peptides on the substrate using highly specific interactions, such as the biotin/avidin or streptavidin system. The compositions are substantially non-leaching, antifouling, and non-hemolytic. The immobilized peptides retain sufficient flexibility and mobility to interact with and be endocytosed by the bacteria, viruses, and/or fungi upon exposure. Immobilizing the peptides to the substrate reduces concerns regarding toxicity of the peptides and the development of antimicrobial resistance, while presenting substantially all of the peptide at the site of action at the surface of the substrate.
摘要翻译：由于抗菌肽靶向细菌膜，抗菌肽能够开发抗微生物涂层。通过使肽定向以使肽的抗微生物末端最大程度地接触细菌来实现高比活性。在一个实施方案中，肽的一端直接共价连接到底物上。在另一个实施方案中，使用偶联剂或系链将肽固定在底物上。非共价方法包括将肽涂覆到底物上或者使用高度特异性的相互作用例如生物素/抗生物素蛋白或链霉亲和素系统在肽上物理化学地固定在底物上。组合物基本上是非浸出，防污和非溶血性的。固定的肽保持足够的灵活性和迁移性，以便在暴露时与细菌，病毒和/或真菌相互作用并内吞。将肽固定到底物可降低对肽的毒性和抗微生物耐药性的发展的担忧，同时在基底表面的作用位点呈现基本上所有的肽。

5. 发明申请

WO2008005297A3 COATING OF DEVICES WITH EFFECTOR COMPOUNDS 审中-公开
标题翻译：具有效应化合物的器件涂层
公开(公告)号：WO2008005297A3
公开(公告)日：2008-12-11
申请号：PCT/US2007015052
申请日：2007-06-28
申请人： MASSACHUSETTS INST TECHNOLOGY , ZUMBUEHL ANDREAS , DA SILVA FERREIRA LINO , KOHANE DANIAL S , LANGER ROBERT S , FINK GERALD R
发明人： ZUMBUEHL ANDREAS , DA SILVA FERREIRA LINO , KOHANE DANIAL S , LANGER ROBERT S , FINK GERALD R
IPC分类号： A61F13/00 , A61F2/00 , A61F2/06
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/404 , A61L2300/602
摘要： This invention is directed to substrates, materials and devices coated with a gel, foam, film, particle or composition comprising a polymei solvent and effector compounds attached thereto, processes of producing the same, and methods of use thereof, of in,inter-alia, biological applications, including preventing infection and the treatment of various diseases.
摘要翻译：本发明涉及涂覆有凝胶，泡沫，薄膜，颗粒或包含聚合溶剂和与其连接的效应物化合物的组合物的基材，材料和装置，特别是其制备方法和其使用方法，生物应用，包括预防感染和治疗各种疾病。

6. 发明申请

WO2007082304A2 BIODEGRADABLE ELASTOMERS 审中-公开
标题翻译：生物可降解弹性体
公开(公告)号：WO2007082304A2
公开(公告)日：2007-07-19
申请号：PCT/US2007060529
申请日：2007-01-12
申请人： MASSACHUSETTS INST TECHNOLOGY , BETTINGER CHRISTOPHER J , KARP JEFFREY , KIM SONIA J , LANGER ROBERT S , ZUMBUEHL ANDREAS , BRUGGEMAN JOOST P , DA SILVA-FERREIRA LINO , NIJST CHRISTIAAN , BURDICK JASON
发明人： BETTINGER CHRISTOPHER J , KARP JEFFREY , KIM SONIA J , LANGER ROBERT S , ZUMBUEHL ANDREAS , BRUGGEMAN JOOST P , DA SILVA-FERREIRA LINO , NIJST CHRISTIAAN , BURDICK JASON
IPC分类号： C08G63/46
CPC分类号： A61L31/06 , A61K35/12 , A61K35/48 , A61K45/06 , A61L27/18 , A61L27/38 , A61L27/58 , A61L31/148 , C08G63/6854 , C08J3/24 , C08J3/246 , C08J2367/00 , C08J2367/07 , C08K5/0025 , C12N11/08 , C08L67/00 , C08L67/07
摘要： The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a prepolymer.. which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polyrøer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.
摘要翻译：本发明在各个方面提供弹性生物可降解聚合物。在各种实施方案中，聚合物通过多官能醇或醚与双官能或更高级酸反应形成预聚物而形成，所述预聚物交联形成弹性生物可降解聚合物。在优选的实施方案中，通过用乙烯基使预聚物骨架上的一个或多个OR基团官能化，然后光聚合形成弹性可生物降解的聚合物组合物或材料来进行交联。优选地，使用丙烯酸酯将一种或多种乙烯基添加到预聚物的骨架中以形成丙烯酸酯化预聚合物。在各种实施方案中，丙烯酸酯化预聚物与一种或多种丙烯酸酯化共聚物共聚。

7. 发明申请

WO2012125987A3 DELIVERY SYSTEM 审中-公开
标题翻译：输送系统
公开(公告)号：WO2012125987A3
公开(公告)日：2014-04-24
申请号：PCT/US2012029571
申请日：2012-03-17
申请人： MASSACHUSETTS INST TECHNOLOGY , LEE HYUKJIN , LYTTON-JEAN ABIGAIL K R , PARK ANGELA INOK , LANGER ROBERT S , ANDERSON DANIEL G
发明人： LEE HYUKJIN , LYTTON-JEAN ABIGAIL K R , PARK ANGELA INOK , LANGER ROBERT S , ANDERSON DANIEL G
IPC分类号： A61K31/70
CPC分类号： A61K9/146 , A61K9/0019 , A61K9/14 , A61K31/713 , A61K47/22 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2320/32 , C12N2810/10
摘要： Three-dimensional, nanoscale delivery systems, constructed from, particularly well adapted for delivery of, nucleic acids and/or nucleic acid associated entities are disclosed.
摘要翻译：公开了由特别适合于递送核酸和/或核酸相关实体构建的三维纳米尺度递送系统。

8. 发明申请

WO2012112982A3 HYDROGEL ENCAPSULATED CELLS AND ANTI-INFLAMMATORY DRUGS 审中-公开
标题翻译：水凝胶包封的细胞和抗炎药物
公开(公告)号：WO2012112982A3
公开(公告)日：2012-12-27
申请号：PCT/US2012025806
申请日：2012-02-20
申请人： MASSACHUSETTS INST TECHNOLOGY , ANDERSON DANIEL G , LANGER ROBERT S , DANG TRAM T
发明人： ANDERSON DANIEL G , LANGER ROBERT S , DANG TRAM T
IPC分类号： A61K9/16 , A61K9/50 , A61K31/12 , A61K31/573 , C12N5/00
CPC分类号： A61K9/1641 , A61K9/0019 , A61K31/573 , A61K35/39 , A61K45/06 , A61L27/3804 , A61L27/48 , A61L27/52 , A61L27/54 , A61L2300/41 , A61L2300/622 , A61L2300/64 , C12N5/0676 , C12N2502/1157 , C12N2533/40 , C12N2533/74 , G01N33/5088 , A61K2300/00 , C08L5/04 , C08L5/08
摘要： A composition containing biocompatible hydrogel encapsulating mammalian cells and anti-inflammatory drugs is disclosed. The encapsulated cells have reduced fibrotic overgrowth after implantation in a subject. The compositions contain a biocompatible hydrogel having encapsulated therein mammalian cells and anti-inflammatory drugs or polymeric particles loaded with anti-inflammatory drugs. The anti-inflammatory drugs are released from the composition after transplantation in an amount effective to inhibit fibrosis of the composition for at least ten days. Methods for identifying and selecting suitable anti-inflammatory drug-loaded particles to prevent fibrosis of encapsulated cells are also described. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
摘要翻译：公开了含有包封哺乳动物细胞和抗炎药物的生物相容性水凝胶的组合物。包埋的细胞在植入受试者后具有减少的纤维化过度生长。该组合物含有其中包封有哺乳动物细胞的生物相容性水凝胶和载有抗炎药的抗炎药或聚合物颗粒。移植后的组合物中的抗炎药物以有效抑制组合物纤维化至少十天的量释放。还描述了用于鉴定和选择合适的抗炎载药颗粒以防止包囊细胞纤维化的方法。还公开了治疗受试者中的疾病的方法，其涉及将治疗有效量的所公开的包囊细胞给予受试者。

9. 发明申请

WO2007078765A2 HIGH-THROUGHPUT FABRICATION OF MICROPARTICLES 审中-公开
标题翻译：高通量微波炉的制造
公开(公告)号：WO2007078765A2
公开(公告)日：2007-07-12
申请号：PCT/US2006047519
申请日：2006-12-13
申请人： MASSACHUSETTS INST TECHNOLOGY , LITTLE STEVEN R , ANDERSON DANIEL G , LANGER ROBERT S
发明人： LITTLE STEVEN R , ANDERSON DANIEL G , LANGER ROBERT S
IPC分类号： C08G77/42
CPC分类号： A61K9/1647 , A61K9/1694
摘要： The optimatization of microparticle formulations has become increasingly difficult given the numerous parameters (e.g., polymer, polymer blend, agent to be delivered, particle size, pharaceutical excipients) that can be varied in preparing microparticles. The high-throughput fabrication of microparticles based on the double emulsion/solvent evaporation technique is therefore a breakthrough in screening and optimizing microparticle formulations for particular characteristics. This new system allows for the preparation of multiple (e.g., over 20, over 50, over 100, over 500, etc.) microparticle formulations in parallel. The system involves the formation of an emulsion containing aqueous bubbles with the payload in an organic phase containing the polymer or polymer blend being used for the microparticles. This first emulsion is then transferred to a larger aqueous phase, and a second water- in-oil-in water emulsion is formed. The organic solvent is then removed, and the resulting particles are optionally washed and/or freeze dried. The resulting microparticles are similar or better than microparticles prepared using the traditional one formulation at a time approach. The high-throughput fabrication of microparticles is particularly useful in optimizing microparticles formulations for drug delivery.
摘要翻译：鉴于在制备微粒中可以变化的许多参数（例如，聚合物，聚合物共混物，待递送的试剂，粒径，药物赋形剂），微粒制剂的优化变得越来越困难。因此，基于双重乳液/溶剂蒸发技术的微粒的高通量制造是筛选和优化微粒制剂以获得特定特征的突破。该新系统允许并行制备多个（例如，超过20个，超过50个，超过100个，超过500个等等）微粒制剂。该系统包括在含有用于微粒的聚合物或聚合物共混物的有机相中形成含有水泡的含水气泡。然后将该第一乳液转移到较大的水相中，并形成第二水包油包水乳液。然后除去有机溶剂，任选地将所得颗粒洗涤和/或冷冻干燥。所得到的微粒类似于或优于使用传统的一种制剂在一段时间内制备的微粒。微粒的高通量制造特别可用于优化用于药物递送的微粒制剂。

10. 发明申请

WO2004043588A3 PRODUCTION OF POLYMERIC MICROARRAYS 审中-公开
标题翻译：聚合微生物的生产
公开(公告)号：WO2004043588A3
公开(公告)日：2004-08-19
申请号：PCT/US0324564
申请日：2003-08-06
申请人： MASSACHUSETTS INST TECHNOLOGY , ANDERSON DANIEL G , LANGER ROBERT S
发明人： ANDERSON DANIEL G , LANGER ROBERT S
IPC分类号： B01J19/00 , C40B40/06 , C40B40/10 , C40B40/14 , C40B50/14 , C40B60/14
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00378 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/00691 , B01J2219/00707 , B01J2219/00711 , B01J2219/00716 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/00743 , C40B40/06 , C40B40/10 , C40B40/14 , C40B50/14 , C40B60/14 , G01N2650/00
摘要： A method of preparing a microarray of polymer elements (6). The method includes providing a substrate surface (4), providing a plurality of individual monomers in a liquid phase, depositing said monomers as a plurality of discrete monomer elements on the substrate surface (4), and exposing the plurality of discrete monomer elements to initiating conditions to form polymer elements (6). A portion of the discrete monomer elements may include more than one type of monomer.
摘要翻译：制备聚合物元件（6）的微阵列的方法。该方法包括提供衬底表面（4），在液相中提供多个单独的单体，在衬底表面（4）上沉积作为多个离散单体元素的所述单体，以及将多个离散的单体元件暴露于起始形成聚合物元素的条件（6）。离散单体元件的一部分可以包括多于一种类型的单体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式