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1. 发明授权

US07749260B2 Devices and methods for treatment of skin conditions 有权
标题翻译：用于治疗皮肤病症的装置和方法
公开(公告)号：US07749260B2
公开(公告)日：2010-07-06
申请号：US11299284
申请日：2005-12-09
申请人： Luiz B. Da Silva , George Choi , Joseph Neev
发明人： Luiz B. Da Silva , George Choi , Joseph Neev
IPC分类号： A61F7/00
CPC分类号： A61B18/082 , A61B2017/00734 , A61B2017/00761 , A61B2018/00005 , A61B2018/0047 , A61B2018/00714 , A61B2018/00761 , A61B2018/00791
摘要： Devices and methods for the treatment of skin conditions and lesions are disclosed herein. One aspect of the invention is a compact hand held device that can be safely used by those suffering from skin conditions, such as acne, warts, cold blisters, blemished skin, or fine wrinkles. The devices described herein employ the application of heat for the treatment of skin conditions and lesions. Typically, the peak temperatures employed are about 70° C. to about 400° C. by the devices, are achieved in less than about 1 second, and maintained for less than about 1 second. In some embodiments, the skin surface is heated with heat pulses. Thermal conduction transfers heat from the device to the skin and causes a biological response that accelerates acne clearing, treats blemished skin, itching, or fine wrinkles. The total heat transferred is low enough to prevent burns.
摘要翻译：本文公开了用于治疗皮肤病况和损伤的装置和方法。本发明的一个方面是紧凑的手持装置，其可以被患有皮肤状况的人安全地使用，例如痤疮，疣，冷水泡，瑕疵的皮肤或细皱纹。本文描述的装置使用热量来治疗皮肤病症和损伤。通常，所用装置的峰值温度为约70℃至约400℃，在小于约1秒钟内实现，并保持少于约1秒。在一些实施方案中，用热脉冲加热皮肤表面。热传导将热量从设备传递到皮肤，并引起加速痤疮清除，治疗瑕疵皮肤，瘙痒或细皱纹的生物反应。传热的总热量足够低以防止灼伤。

2. 发明授权

US5720894A Ultrashort pulse high repetition rate laser system for biological tissue processing 失效
标题翻译：超短脉冲高重复率激光系统用于材料加工
公开(公告)号：US5720894A
公开(公告)日：1998-02-24
申请号：US584522
申请日：1996-01-11
申请人： Joseph Neev , Luiz B. Da Silva , Dennis L. Matthews , Michael E. Glinsky , Brent C. Stuart , Michael D. Perry , Michael D. Feit , Alexander M. Rubenchik
发明人： Joseph Neev , Luiz B. Da Silva , Dennis L. Matthews , Michael E. Glinsky , Brent C. Stuart , Michael D. Perry , Michael D. Feit , Alexander M. Rubenchik
IPC分类号： A61B18/20 , A61B18/26 , A61C3/02 , A61N5/06 , B23K26/03 , B23K26/06 , B23K26/18 , B23K26/36 , B23K26/40 , C06B21/00 , B44C1/22
CPC分类号： B23K26/0665 , A61B18/20 , A61B18/26 , A61C1/0046 , B23K26/032 , B23K26/0624 , B23K26/0643 , B23K26/0648 , B23K26/18 , B23K26/40 , B23K26/402 , C06B21/0033 , A61B2018/00636 , B23K2203/05 , B23K2203/10 , B23K2203/30
摘要： A method and apparatus is disclosed for fast, efficient, precise and damage-free biological tissue removal using an ultrashort pulse duration laser system operating at high pulse repetition rates. The duration of each laser pulse is on the order of about 1 fs to less than 50 ps such that energy deposition is localized in a small depth and occurs before significant hydrodynamic motion and thermal conduction, leading to collateral damage, can take place. The depth of material removed per pulse is on the order of about 1 micrometer, and the minimal thermal and mechanical effects associated with this ablation method allows for high repetition rate operation, in the region 10 to over 1000 Hertz, which, in turn, achieves high material removal rates. The input laser energy per ablated volume of tissue is small, and the energy density required to ablate material decreases with decreasing pulse width. The ablation threshold and ablation rate are only weakly dependent on tissue type and condition, allowing for maximum flexibility of use in various biological tissue removal applications. The use of a chirped-pulse amplified Titanium-doped sapphire laser is disclosed as the source in one embodiment.
摘要翻译：公开了使用以高脉冲重复率操作的超短脉冲持续时间激光系统来快速，有效，精确和无损伤的生物组织去除的方法和装置。每个激光脉冲的持续时间约为1fs至小于50ps，使得能量沉积位于较小的深度并发生在显着的水动力运动和热传导之间，导致附带损伤。每个脉冲去除的材料的深度约为1微米，并且与该消融方法相关的最小的热和机械效应允许在10至超过1000赫兹的区域中的高重复率操作，这进而达到高材料去除率。每个消融体积的组织的输入激光能量很小，消融材料所需的能量密度随着脉冲宽度的减小而减小。消融阈值和消融率只是弱取决于组织类型和条件，允许在各种生物组织去除应用中使用的最大灵活性。在一个实施例中公开了使用啁啾脉冲放大钛掺杂蓝宝石激光器作为源。

3. 发明授权

US07494492B2 Skin treatment device 有权
标题翻译：皮肤治疗装置
公开(公告)号：US07494492B2
公开(公告)日：2009-02-24
申请号：US11216595
申请日：2005-08-30
申请人： Luiz B. Da Silva , George Choi
发明人： Luiz B. Da Silva , George Choi
IPC分类号： A61B18/08
CPC分类号： A61B18/082 , A61B2017/00734 , A61B2017/00761
摘要： A compact hand held device is provided that can be safely used by those suffering from acne, blemished skin or fine wrinkles. The hand held device includes an on/off switch and a button that pulses the device when it is placed on the target site. A battery within the device powers a circuit board and drives a short pulse of current through a heating element, which heats up to approximately 300° C. in less than 0.1 sec. Thermal conduction transfers the heat to the skin and causes a biological response that accelerates acne clearing, treats blemished skin or fine wrinkles. The total heat transferred is low enough to prevent burns. Application of acne treatment creams and gels further accelerates treatment
摘要翻译：提供了一个紧凑的手持装置，可以被那些患有痤疮，瑕疵的皮肤或细皱纹的人安全使用。手持设备包括一个开/关开关和一个按钮，当设备放置在目标站点上时，该按钮将脉冲。设备内的电池为电路板供电，并通过加热元件驱动短脉冲电流，加热元件在小于0.1秒内加热至约300°C。热传导将热量转移到皮肤，并引起加速痤疮清除，治疗瑕疵皮肤或细皱纹的生物反应。传热的总热量足够低以防止灼伤。痤疮治疗霜和凝胶的应用进一步加速治疗

4. 发明授权

US06974450B2 Face-lifting device 有权
标题翻译：提升装置
公开(公告)号：US06974450B2
公开(公告)日：2005-12-13
申请号：US09749497
申请日：2000-12-22
申请人： Paul J. Weber , Luiz B. Da Silva , Alexander M. Rubenchik
发明人： Paul J. Weber , Luiz B. Da Silva , Alexander M. Rubenchik
IPC分类号： A45D44/22 , A61B17/00 , A61B18/00 , A61B18/08 , A61B18/12 , A61B18/14 , A61B18/18 , A61B18/20 , A61B18/22 , A61N7/02
CPC分类号： A61B18/1402 , A61B18/08 , A61B18/201 , A61B18/203 , A61B2017/00084 , A61B2017/0046 , A61B2017/00761 , A61B2017/00792 , A61B2017/00853 , A61B2018/00017 , A61B2018/00452 , A61B2018/1807 , A61B2018/2272 , A61N7/022 , A61N2007/0008
摘要： A device is described that can be used by surgeons to provide quick and accurate face-lifting maneuvers that minimize the amount of tissue that has to be removed. The device is comprised of a shaft with a relatively planar but possibly lenticulate and even slightly curved tip that can divide and energize various tissue planes causing contraction especially via the fibrous tissues. Various forms of energy can be delivered down the shaft to heat and cause desirable tissue contraction. The device can also include a temperature sensor that can be used to control power output.
摘要翻译：描述了一种可被外科医生用来提供快速和准确的提升操作的装置，其使得必须去除的组织的量最小化。该装置包括具有相对平面但可能是微透镜并且甚至略微弯曲的尖端的轴，其可以分开并激励各种组织平面，从而特别是通过纤维组织引起收缩。各种形式的能量可以沿着轴递送以加热并引起期望的组织收缩。该装置还可以包括可用于控制功率输出的温度传感器。

5. 发明授权

US06607500B2 Integrated cast and muscle stimulation system 失效
公开(公告)号：US06607500B2
公开(公告)日：2003-08-19
申请号：US09853440
申请日：2001-05-10
申请人： Luiz B. Da Silva , Michael R. Weber , David I. Blatt , Jeffrey S. Mannheimer
发明人： Luiz B. Da Silva , Michael R. Weber , David I. Blatt , Jeffrey S. Mannheimer
IPC分类号： A61F501
CPC分类号： A61N1/36003 , A61N1/0452 , A61N1/0456 , A61N1/0464 , A61N1/0472 , A61N1/32 , A61N1/326 , A61N1/36021
摘要： The present invention is a device that allows electrical stimulation to an anatomical site that is covered by a cast. The electrode is applied to achieve a desired physiological response (e.g., bone growth), treatment of pain, or the prevention of muscle atrophy.

6. 发明授权

US06538739B1 Bubble diagnostics 失效
标题翻译：气泡诊断
公开(公告)号：US06538739B1
公开(公告)日：2003-03-25
申请号：US08941015
申请日：1997-09-30
申请人： Steven R. Visuri , Beth M. Mammini , Luiz B. Da Silva , Peter M. Celliers
发明人： Steven R. Visuri , Beth M. Mammini , Luiz B. Da Silva , Peter M. Celliers
IPC分类号： G01B1100
CPC分类号： G01N21/431 , A61B18/20 , A61B18/26 , A61B2017/00057 , A61B2017/22008 , A61B2018/00636
摘要： The present invention is intended as a means of diagnosing the presence of a gas bubble and incorporating the information into a feedback system for opto-acoustic thrombolysis. In opto-acoustic thrombolysis, pulsed laser radiation at ultrasonic frequencies is delivered intraluminally down an optical fiber and directed toward a thrombus or otherwise occluded vessel. Dissolution of the occlusion is therefore mediated through ultrasonic action of propagating pressure or shock waves. A vapor bubble in the fluid surrounding the occlusion may form as a result of laser irradiation. This vapor bubble may be used to directly disrupt the occlusion or as a means of producing a pressure wave. It is desirable to detect the formation and follow the lifetime of the vapor bubble. Knowledge of the bubble formation and lifetime yields critical information as to the maximum size of the bubble, density of the absorbed radiation, and properties of the absorbing material. This information can then be used in a feedback system to alter the irradiation conditions.
摘要翻译：本发明旨在作为诊断气泡的存在并将该信息并入用于光声溶解的反馈系统中的手段。在光声波溶解中，超声频率下的脉冲激光辐射在光纤内向内递送并引向血栓或其它闭塞血管。因此，阻塞的溶解通过传播压力或冲击波的超声波作用来介导。作为激光照射的结果，可以形成围绕闭塞的流体中的蒸气泡。该气泡可用于直接破坏闭塞或产生压力波的手段。需要检测形成并遵循蒸气泡的寿命。关于气泡形成和寿命的知识产生关于气泡的最大尺寸，吸收辐射的密度和吸收材料的性质的关键信息。然后可以在反馈系统中使用该信息来改变照射条件。

7. 发明授权

US06522407B2 Optical detection dental disease using polarized light 有权
标题翻译：光学检测牙病使用偏振光
公开(公告)号：US06522407B2
公开(公告)日：2003-02-18
申请号：US10100824
申请日：2002-03-18
申请人： Matthew J. Everett , Billy W. Colston, Jr. , Ujwal S. Sathyam , Luiz B. Da Silva , Daniel Fried
发明人： Matthew J. Everett , Billy W. Colston, Jr. , Ujwal S. Sathyam , Luiz B. Da Silva , Daniel Fried
IPC分类号： G01J400
CPC分类号： A61B5/0088 , A61B5/0066 , A61B5/0073 , G01B9/02091 , G01B2290/70 , G01N21/4795
摘要： A polarization sensitive optical imaging system is used to detect changes in polarization in dental tissues to aid the diagnosis of dental disease such as caries. The degree of depolarization is measured by illuminating the dental tissue with polarized light and measuring the polarization state of the backscattered light. The polarization state of this reflected light is analyzed using optical polarimetric imaging techniques. A hand-held fiber optic dental probe is used in vivo to direct the incident beam to the dental tissue and collect the reflected light. To provide depth-resolved characterization of the dental tissue, the polarization diagnostics may be incorporated into optical coherence domain reflectometry and optical coherence tomography (OCDR/OCT) systems, which enables identification of subsurface depolarization sites associated with demineralization of enamel or bone.
摘要翻译：偏振敏感光学成像系统用于检测牙组织中极化的变化，以帮助牙科疾病如龋齿的诊断。通过用偏振光照射牙组织并测量背向散射光的偏振状态来测量去极化度。使用光学偏振成像技术分析该反射光的偏振状态。体内使用手持光纤牙科探针将入射光束引导到牙齿组织并收集反射光。为了提供牙科组织的深度分辨表征，偏振诊断可以被并入到光学相干畴反射测量和光学相干断层扫描（OCDR / OCT）系统中，其能够识别与釉质或骨的脱矿质相关的地下去极化位点。

8. 发明授权

US06341831B1 Skin decoration apparatus and method 失效
标题翻译：皮肤装饰装置及方法
公开(公告)号：US06341831B1
公开(公告)日：2002-01-29
申请号：US09475641
申请日：1999-12-30
申请人： Paul J. Weber , Luiz B. Da Silva , Michael R. Weber
发明人： Paul J. Weber , Luiz B. Da Silva , Michael R. Weber
IPC分类号： B41J2005
CPC分类号： A01K11/005 , A61M37/0084 , B41J3/4073
摘要： The human body is decorated with highly detailed, multicolored, personalized designs using Wirejet™ or electronically controlled ink ejection or similar printing technology. The designs are applied to the epidermal and upper dermal skin layers and last for at least several weeks. The decoration is produced by a print head comprising Wirejet™ nozzles, which spray biocompatible inks or dyes onto the skin. The Wirejet™ may be connected to a scanning mechanism to scan in one, two, or three directions. The decorations can be applied to contoured skin surfaces following flattening against a screen of intersecting wires, by robotic arm, or using z-axis technology. A computer stores the desired design and controls the firing of the Wirejet™ to produce the desired decoration or tattoo.
摘要翻译：人体使用Wirejet（TM）或电子控制喷墨或类似的打印技术以高度详细，多彩，个性化的设计进行装饰。这些设计应用于表皮和上皮肤层，并持续至少几周。装饰由包括Wirejet TM喷嘴的打印头产生，其将生物相容的油墨或染料喷射到皮肤上。 Wirejet TM可以连接到扫描机构以沿一个，两个或三个方向扫描。装饰品可以应用于通过机器人手臂或使用z轴技术平坦化的交叉电线屏幕之后的轮廓皮肤表面。计算机存储所需的设计并控制Wirejet（TM）的烧制以产生所需的装饰或纹身。

9. 发明授权

US06286517B1 Fingernail and toenail decoration using ink jets 失效
标题翻译：指甲和趾甲装饰使用喷墨
公开(公告)号：US06286517B1
公开(公告)日：2001-09-11
申请号：US09583008
申请日：2000-05-26
申请人： Paul J. Weber , Michael R. Weber , Luiz B. Da Silva
发明人： Paul J. Weber , Michael R. Weber , Luiz B. Da Silva
IPC分类号： A45D2900
CPC分类号： A45D29/00 , A45D34/04 , B41J3/407 , G05B2219/45186 , G05B2219/50066
摘要： Inkjet printing technology is used to apply selected designs on fingernails or toenails. The nail-printing device applies highly detailed, customized, multicolored designs that are scaled to precisely fit within the boundary of each individual nail. The device comprises an ink jet print head, a holder for aligning the digits or nails, a camera to image the nails, a computer to acquire, store and analyze the image, and a control system that directs the ink jet print head to apply the scaled design to the nails.
摘要翻译：喷墨打印技术用于将指定的设计应用于指甲或脚趾甲上。指甲打印设备应用高度详细，定制的多色设计，其被缩放以精确地配合在每个单独的钉子的边界内。该装置包括喷墨打印头，用于对准数字或指甲的保持器，用于对钉子进行成像的照相机，用于获取，存储和分析图像的计算机以及引导喷墨打印头施加照片的控制系统缩放设计到指甲。

10. 发明申请

US20080139974A1 Devices and Methods for Treatment of Skin Conditions 有权
标题翻译：用于治疗皮肤病症的装置和方法
公开(公告)号：US20080139974A1
公开(公告)日：2008-06-12
申请号：US11947607
申请日：2007-11-29
申请人： Luiz B. Da Silva
发明人： Luiz B. Da Silva
IPC分类号： A61N7/00 , A61B18/04 , A61H1/00
CPC分类号： A61N7/00 , A61B8/546 , A61B2017/00734 , A61B2018/00005 , A61N2007/0056
摘要： Devices and methods for the treatment of skin conditions and lesions are disclosed herein. A compact hand held device that can be safely used by those suffering from skin conditions, such as acne, warts, cold blisters, blemished skin, or fine wrinkles. The devices employ the application of ultrasound energy and heat for the treatment of skin conditions and lesions. Typically, the peak temperatures employed are about 40° C. to about 70° C. by the devices, are achieved in less than about 20 second, and maintained for less than about 40 second. Ultrasound absorption and thermal conduction transfers heat from the device to the skin and causes a biological response that accelerates acne clearing, treats blemished skin, itching, or fine wrinkles. The total heat transferred is low enough to prevent burns.
摘要翻译：本文公开了用于治疗皮肤病况和损伤的装置和方法。一种紧凑的手持式装置，可以被那些患有皮肤病症的人安全使用，如痤疮，疣，冷水泡，瑕疵的皮肤或细纹。这些装置采用超声能量和热量来治疗皮肤病症和病变。通常，所用装置的峰值温度为约40℃至约70℃，在小于约20秒内达到，并保持少于约40秒。超声吸收和热传导将热量从装置转移到皮肤，并引起加速痤疮清除，治疗瑕疵皮肤，瘙痒或细皱纹的生物反应。传热的总热量足够低以防止灼伤。

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