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1. 发明授权

US5720894A Ultrashort pulse high repetition rate laser system for biological tissue processing 失效
标题翻译：超短脉冲高重复率激光系统用于材料加工
公开(公告)号：US5720894A
公开(公告)日：1998-02-24
申请号：US584522
申请日：1996-01-11
申请人： Joseph Neev , Luiz B. Da Silva , Dennis L. Matthews , Michael E. Glinsky , Brent C. Stuart , Michael D. Perry , Michael D. Feit , Alexander M. Rubenchik
发明人： Joseph Neev , Luiz B. Da Silva , Dennis L. Matthews , Michael E. Glinsky , Brent C. Stuart , Michael D. Perry , Michael D. Feit , Alexander M. Rubenchik
IPC分类号： A61B18/20 , A61B18/26 , A61C3/02 , A61N5/06 , B23K26/03 , B23K26/06 , B23K26/18 , B23K26/36 , B23K26/40 , C06B21/00 , B44C1/22
CPC分类号： B23K26/0665 , A61B18/20 , A61B18/26 , A61C1/0046 , B23K26/032 , B23K26/0624 , B23K26/0643 , B23K26/0648 , B23K26/18 , B23K26/40 , B23K26/402 , C06B21/0033 , A61B2018/00636 , B23K2203/05 , B23K2203/10 , B23K2203/30
摘要： A method and apparatus is disclosed for fast, efficient, precise and damage-free biological tissue removal using an ultrashort pulse duration laser system operating at high pulse repetition rates. The duration of each laser pulse is on the order of about 1 fs to less than 50 ps such that energy deposition is localized in a small depth and occurs before significant hydrodynamic motion and thermal conduction, leading to collateral damage, can take place. The depth of material removed per pulse is on the order of about 1 micrometer, and the minimal thermal and mechanical effects associated with this ablation method allows for high repetition rate operation, in the region 10 to over 1000 Hertz, which, in turn, achieves high material removal rates. The input laser energy per ablated volume of tissue is small, and the energy density required to ablate material decreases with decreasing pulse width. The ablation threshold and ablation rate are only weakly dependent on tissue type and condition, allowing for maximum flexibility of use in various biological tissue removal applications. The use of a chirped-pulse amplified Titanium-doped sapphire laser is disclosed as the source in one embodiment.
摘要翻译：公开了使用以高脉冲重复率操作的超短脉冲持续时间激光系统来快速，有效，精确和无损伤的生物组织去除的方法和装置。每个激光脉冲的持续时间约为1fs至小于50ps，使得能量沉积位于较小的深度并发生在显着的水动力运动和热传导之间，导致附带损伤。每个脉冲去除的材料的深度约为1微米，并且与该消融方法相关的最小的热和机械效应允许在10至超过1000赫兹的区域中的高重复率操作，这进而达到高材料去除率。每个消融体积的组织的输入激光能量很小，消融材料所需的能量密度随着脉冲宽度的减小而减小。消融阈值和消融率只是弱取决于组织类型和条件，允许在各种生物组织去除应用中使用的最大灵活性。在一个实施例中公开了使用啁啾脉冲放大钛掺杂蓝宝石激光器作为源。

2. 发明授权

US06764493B1 Tissue removal using biocompatible materials 失效
标题翻译：使用生物相容性材料去除组织
公开(公告)号：US06764493B1
公开(公告)日：2004-07-20
申请号：US09710478
申请日：2000-11-10
申请人： Paul J. Weber , Luiz B. Da Silva , Alexander M. Rubenchik
发明人： Paul J. Weber , Luiz B. Da Silva , Alexander M. Rubenchik
IPC分类号： A61B1750
CPC分类号： A61M37/00
摘要： Biocompatible materials are propelled at the skin with sufficient velocity to cause desired resurfacing of tissue to the desired penetration depth. The materials, such as dry ice or water ice, are harmonious with the human body and thus eliminate foreign body reactions. Various materials may be used in combination, including local anesthetics and vasoconstrictors in solid or liquid form. The biocompatible solid or liquid particles are suspended in a cold carrier fluid and propelled through an insulated delivery system to the surface of the skin. The treatment of diseased skin lesions may be accomplished using the present invention as a drug delivery system.
摘要翻译：生物相容性材料以足够的速度在皮肤上推进，以使组织的所需表面重新形成所需的穿透深度。材料如干冰或水冰与人体和谐，从而消除异物反应。可以组合使用各种材料，包括固体或液体形式的局部麻醉剂和血管收缩剂。生物相容性固体或液体颗粒悬浮在冷载体流体中，并通过绝缘递送系统推进到皮肤表面。可以使用本发明作为药物递送系统来治疗患病的皮肤损伤。

3. 发明授权

US06974450B2 Face-lifting device 有权
标题翻译：提升装置
公开(公告)号：US06974450B2
公开(公告)日：2005-12-13
申请号：US09749497
申请日：2000-12-22
申请人： Paul J. Weber , Luiz B. Da Silva , Alexander M. Rubenchik
发明人： Paul J. Weber , Luiz B. Da Silva , Alexander M. Rubenchik
IPC分类号： A45D44/22 , A61B17/00 , A61B18/00 , A61B18/08 , A61B18/12 , A61B18/14 , A61B18/18 , A61B18/20 , A61B18/22 , A61N7/02
CPC分类号： A61B18/1402 , A61B18/08 , A61B18/201 , A61B18/203 , A61B2017/00084 , A61B2017/0046 , A61B2017/00761 , A61B2017/00792 , A61B2017/00853 , A61B2018/00017 , A61B2018/00452 , A61B2018/1807 , A61B2018/2272 , A61N7/022 , A61N2007/0008
摘要： A device is described that can be used by surgeons to provide quick and accurate face-lifting maneuvers that minimize the amount of tissue that has to be removed. The device is comprised of a shaft with a relatively planar but possibly lenticulate and even slightly curved tip that can divide and energize various tissue planes causing contraction especially via the fibrous tissues. Various forms of energy can be delivered down the shaft to heat and cause desirable tissue contraction. The device can also include a temperature sensor that can be used to control power output.
摘要翻译：描述了一种可被外科医生用来提供快速和准确的提升操作的装置，其使得必须去除的组织的量最小化。该装置包括具有相对平面但可能是微透镜并且甚至略微弯曲的尖端的轴，其可以分开并激励各种组织平面，从而特别是通过纤维组织引起收缩。各种形式的能量可以沿着轴递送以加热并引起期望的组织收缩。该装置还可以包括可用于控制功率输出的温度传感器。

4. 发明授权

US06729336B2 In-stent restenosis detection device 失效
标题翻译：支架内再狭窄检测装置
公开(公告)号：US06729336B2
公开(公告)日：2004-05-04
申请号：US10109150
申请日：2002-03-28
申请人： Luiz B. Da Silva , Victor C. Esch , Alexander M. Rubenchik , Jonathan Hares , Joseph D. Kilkenny , Gilbert W. Collins , Paul J. Weber
发明人： Luiz B. Da Silva , Victor C. Esch , Alexander M. Rubenchik , Jonathan Hares , Joseph D. Kilkenny , Gilbert W. Collins , Paul J. Weber
IPC分类号： A61B1900
CPC分类号： A61B5/02007 , A61B5/05 , A61B5/0507 , A61B8/08 , A61N1/40
摘要： A medical device is described that can be used to detect in stent restenosis. This invention consists of a stent of current or modified technology, an electromagnetic wave transmitter to excite the stent and an acoustic sensor to detect stent acoustic oscillations.
摘要翻译：描述了可用于检测支架再狭窄的医疗装置。本发明由电流或改进技术的支架，用于激励支架的电磁波发射器和用于检测支架声振荡的声传感器组成。

5. 发明授权

US06726693B2 Tissue resurfacing using biocompatible materials 失效
标题翻译：使用生物相容性材料进行组织重铺
公开(公告)号：US06726693B2
公开(公告)日：2004-04-27
申请号：US09820131
申请日：2001-03-28
申请人： Paul J. Weber , Luiz B. Da Silva , Alexander M. Rubenchik
发明人： Paul J. Weber , Luiz B. Da Silva , Alexander M. Rubenchik
IPC分类号： A61B1750
CPC分类号： A61M35/00 , A61B2017/00761
摘要： Tissue resurfacing is accomplished by propelling biocompatible, non-toxic materials at the tissue with sufficient velocity to cause destruction or loosening of tissues to a desired depth. The biocompatible materials are generated by abrading a solid frozen unit and propelling the abraded material onto the surface of the skin or tissue to be treated. A vacuum line near the delivery tip may used to remove excess materials or reaction by-products that build up on the surface of the skin. The treatment system generally consists of a control unit, a handheld particle generator and a cable that connects the control unit to the particle generator. The control unit can include user controls to select particle temperature, particle flux, particle velocity and vacuum. The handheld particle generator contains a mechanism to push the frozen biocompatible material against a rotating grinding wheel that produces small particles, which are propelled against tissue being treated.
摘要翻译：组织表面重建是通过以足够的速度在组织上推进生物相容的无毒材料来实现的，以使组织破坏或松动达到期望的深度。通过研磨固体冷冻单元并将磨损的材料推进到待处理的皮肤或组织的表面上来产生生物相容性材料。在输送尖端附近的真空管线可以用于去除积聚在皮肤表面上的过量材料或反应副产物。处理系统通常由控制单元，手持式颗粒发生器和将控制单元连接到颗粒发生器的电缆组成。控制单元可以包括用户控制以选择颗粒温度，颗粒通量，颗粒速度和真空度。手持式颗粒发生器含有将冷冻的生物相容性材料推向旋转的研磨轮的机构，其产生小的颗粒，所述小颗粒被推进抵抗被处理的组织。

6. 发明授权

US06663618B2 Thermal radiation facelift device 有权
公开(公告)号：US06663618B2
公开(公告)日：2003-12-16
申请号：US10151770
申请日：2002-05-21
申请人： Paul J. Weber , Luiz B. Da Silva , Alexander M. Rubenchik , Gennady Kochemasov , Stanislav Kulikov
发明人： Paul J. Weber , Luiz B. Da Silva , Alexander M. Rubenchik , Gennady Kochemasov , Stanislav Kulikov
IPC分类号： A61B1818
CPC分类号： A61B18/24 , A61B18/08 , A61B18/1402 , A61B18/201 , A61B18/203 , A61B2017/00084 , A61B2017/0046 , A61B2017/00761 , A61B2017/00792 , A61B2017/00853 , A61B2017/22014 , A61B2018/00017 , A61B2018/00452 , A61B2018/1807 , A61B2018/2272 , A61B2090/3614 , A61N7/022 , A61N2007/0008
摘要： A device is described that can be used by surgeons to provide quick and accurate face-lifting maneuvers that minimize the amount of tissue that has to be removed. The device comprised of a hollow undermining shaft with specially designed tip that can safely separate tissue planes and lyse fibrous tissue. Thermal radiation can be delivered down the shaft to heat and cause tissue contraction. The device can also include a temperature sensor that can be used to control the thermal radiation. Optionally, the device can also use ultrasound or electro surgical energy to improve tissue lysing.

7. 发明授权

US06524250B1 Fat layer thickness mapping system to guide liposuction surgery 失效
标题翻译：脂肪层厚度测绘系统指导吸脂手术
公开(公告)号：US06524250B1
公开(公告)日：2003-02-25
申请号：US09664943
申请日：2000-09-19
申请人： Paul J. Weber , Luiz B. Da Silva , Alexander M. Rubenchik
发明人： Paul J. Weber , Luiz B. Da Silva , Alexander M. Rubenchik
IPC分类号： A61B800
CPC分类号： A61B5/6842 , A61B5/4872 , A61B8/0858 , A61B8/582
摘要： A device is described that can be easily used by surgeons to measure and monitor changes before, during, and after a liposuction procedure and assist in producing symmetrical body contours. The device comprises a remote control and data processing unit, a handheld ultrasound transducer, a display monitor and means for marking anatomical points to be measured.
摘要翻译：描述了可以被外科医生容易地使用的装置来测量和监测在抽脂程序之前，之中和之后的变化，并且有助于产生对称的身体轮廓。该装置包括遥控和数据处理单元，手持超声波换能器，显示监视器和用于标记要测量的解剖点的装置。

8. 发明授权

US06391023B1 Thermal radiation facelift device 有权
标题翻译：热辐射整容装置
公开(公告)号：US06391023B1
公开(公告)日：2002-05-21
申请号：US09588436
申请日：2000-06-06
申请人： Paul J. Weber , Luiz B. Da Silva , Alexander M. Rubenchik
发明人： Paul J. Weber , Luiz B. Da Silva , Alexander M. Rubenchik
IPC分类号： A61B1818
CPC分类号： A61B18/24 , A61B18/08 , A61B18/1402 , A61B18/201 , A61B18/203 , A61B2017/00084 , A61B2017/0046 , A61B2017/00761 , A61B2017/00792 , A61B2017/00853 , A61B2017/22014 , A61B2018/00017 , A61B2018/00452 , A61B2018/1807 , A61B2018/2272 , A61B2090/3614 , A61N7/022 , A61N2007/0008
摘要： A device is described that can be used by surgeons to provide quick and accurate face-lifting maneuvers that minimize the amount of tissue that has to be removed. The device comprised of a hollow undermining shaft with specially designed tip that can safely separate tissue planes and lyse fibrous tissue. Thermal radiation can be delivered down the shaft to heat and cause tissue contraction. The device can also include a temperature sensor that can be used to control the thermal radiation. Optionally, the device can also use ultrasound or electro surgical energy to improve tissue lysing.
摘要翻译：描述了一种可被外科医生用来提供快速和准确的提升操作的装置，其使得必须去除的组织的量最小化。该装置包括具有特别设计的尖端的中空破坏轴，其可以安全地分离组织平面和裂解纤维组织。热辐射可以沿轴传送加热并导致组织收缩。该装置还可以包括可用于控制热辐射的温度传感器。可选地，该装置还可以使用超声波或电手术能量来改善组织裂解。

9. 发明授权

US07749260B2 Devices and methods for treatment of skin conditions 有权
标题翻译：用于治疗皮肤病症的装置和方法
公开(公告)号：US07749260B2
公开(公告)日：2010-07-06
申请号：US11299284
申请日：2005-12-09
申请人： Luiz B. Da Silva , George Choi , Joseph Neev
发明人： Luiz B. Da Silva , George Choi , Joseph Neev
IPC分类号： A61F7/00
CPC分类号： A61B18/082 , A61B2017/00734 , A61B2017/00761 , A61B2018/00005 , A61B2018/0047 , A61B2018/00714 , A61B2018/00761 , A61B2018/00791
摘要： Devices and methods for the treatment of skin conditions and lesions are disclosed herein. One aspect of the invention is a compact hand held device that can be safely used by those suffering from skin conditions, such as acne, warts, cold blisters, blemished skin, or fine wrinkles. The devices described herein employ the application of heat for the treatment of skin conditions and lesions. Typically, the peak temperatures employed are about 70° C. to about 400° C. by the devices, are achieved in less than about 1 second, and maintained for less than about 1 second. In some embodiments, the skin surface is heated with heat pulses. Thermal conduction transfers heat from the device to the skin and causes a biological response that accelerates acne clearing, treats blemished skin, itching, or fine wrinkles. The total heat transferred is low enough to prevent burns.
摘要翻译：本文公开了用于治疗皮肤病况和损伤的装置和方法。本发明的一个方面是紧凑的手持装置，其可以被患有皮肤状况的人安全地使用，例如痤疮，疣，冷水泡，瑕疵的皮肤或细皱纹。本文描述的装置使用热量来治疗皮肤病症和损伤。通常，所用装置的峰值温度为约70℃至约400℃，在小于约1秒钟内实现，并保持少于约1秒。在一些实施方案中，用热脉冲加热皮肤表面。热传导将热量从设备传递到皮肤，并引起加速痤疮清除，治疗瑕疵皮肤，瘙痒或细皱纹的生物反应。传热的总热量足够低以防止灼伤。

10. 发明授权

US5986234A High removal rate laser-based coating removal system 失效
标题翻译：高去除率激光基涂层去除系统
公开(公告)号：US5986234A
公开(公告)日：1999-11-16
申请号：US829519
申请日：1997-03-28
申请人： Dennis L. Matthews , Peter M. Celliers , Lloyd Hackel , Luiz B. Da Silva , C. Brent Dane , Stanley Mrowka
发明人： Dennis L. Matthews , Peter M. Celliers , Lloyd Hackel , Luiz B. Da Silva , C. Brent Dane , Stanley Mrowka
IPC分类号： B08B7/00 , B23K26/14 , B23K26/00
CPC分类号： B23K26/032 , B08B7/0042 , B23K26/066 , B23K26/0884 , B23K26/142 , B23K26/1476
摘要： A compact laser system that removes surface coatings (such as paint, dirt, etc.) at a removal rate as high as 1000 ft.sup.2 /hr or more without damaging the surface. A high repetition rate laser with multiple amplification passes propagating through at least one optical amplifier is used, along with a delivery system consisting of a telescoping and articulating tube which also contains an evacuation system for simultaneously sweeping up the debris produced in the process. The amplified beam can be converted to an output beam by passively switching the polarization of at least one amplified beam. The system also has a personal safety system which protects against accidental exposures.
摘要翻译：一种紧凑的激光系统，可以以高达1000 ft2 / hr或更高的去除率去除表面涂层（如油漆，污垢等），而不会损坏表面。使用通过至少一个光学放大器传播的具有多次放大的高重复率激光，以及包括伸缩和铰接管的输送系统，该输送系统还包含用于同时扫掠在该过程中产生的碎片的抽空系统。放大的光束可以通过被动地切换至少一个放大的光束的偏振而被转换成输出光束。该系统还具有防止意外暴露的个人安全系统。

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