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1. 发明授权

US5939485A Responsive polymer networks and methods of their use 失效
标题翻译：响应性聚合物网络及其使用方法
公开(公告)号：US5939485A
公开(公告)日：1999-08-17
申请号：US580986
申请日：1996-01-03
申请人： Lev Bromberg , Elmer Cornelius (E.C.) Lupton , Matthew E. Schiller , Mary Jo (M.J.) Timm , George McKinney
发明人： Lev Bromberg , Elmer Cornelius (E.C.) Lupton , Matthew E. Schiller , Mary Jo (M.J.) Timm , George McKinney
IPC分类号： A41C3/10 , A42B1/22 , A42B3/12 , A43B7/18 , A43B7/28 , A43B13/18 , A47C27/08 , A61K8/91 , A61K47/34 , A61Q7/00 , A61Q19/00 , A63B71/08 , A63B71/14 , B29D35/12 , C01F8/00
CPC分类号： A43B7/142 , A41C3/10 , A42B3/121 , A43B1/0036 , A43B1/0054 , A43B13/189 , A43B7/144 , A43B7/18 , A43B7/28 , A61K47/34 , A61K8/042 , A61K8/91 , A61Q19/00 , A63B71/143 , B29D35/126 , A61K2800/54 , A61Q7/00 , A63B71/081
摘要： A responsive polymer network exhibiting the property of reversible gelation in response to a change in an environmental stimulus is provided. The aqueous solution of the network polymer, comprises about 0.01 to 20 wt % by weight of a responsive component and about 0.01 to 20 wt % by weight of a structural component capable of supporting and interacting with the responsive component. The aqueous composition exhibits at least a five-fold increase in viscosity upon gelation. The gelation may be triggered by a change in an environmental stimulus, such as temperature, pH and ionic strength.
摘要翻译：提供响应于环境刺激的变化表现出可逆凝胶化性质的响应性聚合物网络。网状聚合物的水溶液包含约0.01至20重量％的响应组分和约0.01至20重量％的能够支持并与响应组分相互作用的结构组分。水性组合物在凝胶化时表现出至少五倍的粘度增加。凝胶化可以通过环境刺激的变化来触发，例如温度，pH和离子强度。

2. 发明授权

US5603955A Enhanced loading of solutes into polymer gels 失效
标题翻译：增加溶质进入聚合物凝胶
公开(公告)号：US5603955A
公开(公告)日：1997-02-18
申请号：US276462
申请日：1994-07-18
申请人： Stevin H. Gehrke , E. C. Lupton , Matthew E. Schiller , Lorelle Uhden , Nitin Vaid
发明人： Stevin H. Gehrke , E. C. Lupton , Matthew E. Schiller , Lorelle Uhden , Nitin Vaid
IPC分类号： A61K9/20 , A61K9/22 , A61L15/60 , A61K9/10 , A61K47/32 , A61K47/34 , A61K47/36
CPC分类号： A61K9/2054 , A61K9/205 , A61K9/2095 , A61L15/60 , Y10S514/944
摘要： A method of loading a drug into a crosslinked polymer network and protecting the drug from the effects of inactivation is described. The method includes the steps of contacting of a biologically active solute (i.e., drug) with:(i) a gel network; (ii) a second protectant polymer that is somewhat immiscible with the gel; and (iii) a protectant salt, under conditions sufficient for the biologically active solute to selectively partition into the gel and the protectants to be entrained in the gel. Most preferably, the gel network is a crosslinked gel responsive to a change in an environmental condition to which the gel is exposed.
摘要翻译：描述了将药物装载到交联聚合物网络中并保护药物免受灭活效果的方法。该方法包括使生物活性溶质（即药物）与（i）凝胶网络接触的步骤; （ii）与凝胶有些不混溶的第二保护剂聚合物; 和（iii）保护剂盐，在足以使生物活性溶质选择性分配到凝胶中的条件下，保护剂被夹带在凝胶中。最优选地，凝胶网络是响应凝胶暴露的环境条件的变化的交联凝胶。

3. 发明授权

US5674521A Enhanced loading of solutes into polymer gels and methods of use 失效
标题翻译：将溶质加入聚合物凝胶和使用方法
公开(公告)号：US5674521A
公开(公告)日：1997-10-07
申请号：US425275
申请日：1995-04-20
申请人： Steven Henry Gehrke , E. C. Lupton , Matthew E. Schiller , Lorelle Uhden , Nitin Vaid
发明人： Steven Henry Gehrke , E. C. Lupton , Matthew E. Schiller , Lorelle Uhden , Nitin Vaid
IPC分类号： A61K9/20 , A61K9/22 , A61L15/60 , A61F2/02 , A61K47/30
CPC分类号： A61K9/2054 , A61K9/205 , A61K9/2095 , A61L15/60 , Y10S514/944
摘要： A method of loading a drug into a crosslinked polymer network and protecting the drug from the effects of inactivation is described. The method includes the steps of contacting a biologically active solute (e.g. drug) with: (i) a gel network; (ii) a loading polymer that is somewhat immiscible with the gel; and (iii) a salt, under conditions sufficient for the biologically active solute to selectively partition into the gel and the salt and the loading polymer to be entrained in the gel. A drug delivery system including a polymer gel network and the drug to be delivered is also described. The system also includes a salt and/or a loading polymer. The system protects the drug from loss of activity. In one embodiment, the polymer gel network is capable of expanding or collapsing in response to a change in an environmental condition to which the gel is exposed, the expanding or collapsing sufficient to release the drug into an environment of use.
摘要翻译：描述了将药物装载到交联聚合物网络中并保护药物免受灭活效果的方法。该方法包括使生物活性溶质（例如药物）与以下物质接触的步骤：（i）凝胶网络; （ii）与凝胶有些不混溶的负载聚合物; 和（iii）盐，在足以使生物活性溶质选择性分配到凝胶中的条件下，盐和加载聚合物被夹带在凝胶中。还描述了包括聚合物凝胶网络和待递送药物的药物递送系统。该系统还包括盐和/或负载聚合物。该系统保护药物免受活动的损失。在一个实施方案中，聚合物凝胶网络能够响应于凝胶暴露于其中的环境条件的变化而膨胀或塌缩，足以将药物释放到使用环境中的膨胀或塌陷。

4. 发明授权

US5840338A Loading of biologically active solutes into polymer gels 失效
标题翻译：将生物活性溶质装载到聚合物凝胶中
公开(公告)号：US5840338A
公开(公告)日：1998-11-24
申请号：US556130
申请日：1995-11-06
申请人： Eric J. Roos , Matthew E. Schiller
发明人： Eric J. Roos , Matthew E. Schiller
IPC分类号： A61K8/02 , A61K8/04 , A61L15/44 , A61L15/60 , A61Q13/00 , A61Q19/00 , A61K9/10 , A61K47/36 , A61K47/34
CPC分类号： A61K8/042 , A61L15/44 , A61L15/60 , A61Q13/00 , A61Q19/00 , A61K2800/54 , A61L2300/254 , A61L2300/404 , C12N2533/30 , C12N2533/78 , Y10S514/944
摘要： Polymer gel networks loaded with biologically active solutes in a manner that solute activity is maintained and protected from thermal and/or chemical degradation while in the gel network are provided. The invention also provides for effects of modulating parameters for loading safe responsive gel networks using loading solutions containing phase separating polymers.
摘要翻译：提供了以固溶活性的方式装载生物活性溶质的聚合物凝胶网络，其在凝胶网络中被保持和保护免受热和/或化学降解。本发明还提供了使用含有相分离聚合物的加载溶液调节参数以加载安全响应凝胶网络的效果。

5. 发明授权

US5935593A Chemo-mechanical expansion delivery system 失效
标题翻译：化学机械膨胀输送系统
公开(公告)号：US5935593A
公开(公告)日：1999-08-10
申请号：US749758
申请日：1996-10-22
申请人： Eyal S. Ron , Eric Roos , Matthew E. Schiller , Michal Orkisz , Anne Staples
发明人： Eyal S. Ron , Eric Roos , Matthew E. Schiller , Michal Orkisz , Anne Staples
IPC分类号： A61K8/02 , A61K8/04 , A61K8/73 , A61K9/00 , A61K9/20 , A61K9/22 , A61K38/47 , A61K47/38 , A61L15/60 , A61L26/00 , A61L27/52 , A61L27/54 , A61L29/14 , A61L31/14 , A61Q13/00 , A61Q19/00 , C08B15/00 , C08B31/00 , C12N5/00 , A61F2/02
CPC分类号： C08B31/006 , A61K38/47 , A61K47/38 , A61K9/0004 , A61K9/0009 , A61K9/2054 , A61L15/60 , A61L26/008 , A61L27/52 , A61L27/54 , A61L29/145 , A61L31/145 , C08B15/005 , C08B31/003 , C12N5/0068 , A61L2300/602 , C12N2533/30 , C12N2533/78
摘要： System for delivery of a biologically active substance into an environment. First and second chambers are separated by a moveable partition. The first chamber includes a polymer gel network which undergoes a volume change in response to an environmental condition such as pH. The first compartment includes a screen or membrane for confining the polymer gel network while allowing communication with fluid in an environment. The second compartment contains a biologically active compound or drug which is delivered to the environment through an orifice in the second compartment. Upon the occurrence of the triggering environmental condition, the polymer gel network undergoes a volume change which moves the moveable partition expelling the drug through the orifice. Drug delivery is initiated and continues only when the appropriate environmental condition or trigger is met.
摘要翻译：将生物活性物质输送到环境中的系统。第一和第二腔室由可移动隔板分开。第一室包括聚合物凝胶网络，其响应于环境条件例如pH而经历体积变化。第一隔室包括用于限制聚合物凝胶网络的屏幕或膜，同时允许与环境中的流体通信。第二隔室含有生物活性化合物或药物，其通过第二隔室中的孔输送到环境中。当触发环境条件发生时，聚合物凝胶网络经历体积变化，从而移动可移动的分隔件，通过孔排出药物。只有在满足适当的环境条件或触发条件时才开始进行药物传递。

6. 发明授权

US5651979A Apparatus and method for delivering a biologically active compound into a biological environment 失效
标题翻译：将生物活性化合物递送到生物环境中的装置和方法
公开(公告)号：US5651979A
公开(公告)日：1997-07-29
申请号：US473218
申请日：1995-06-07
申请人： Eyal S. Ron , Matthew E. Schiller , Eric Roos
发明人： Eyal S. Ron , Matthew E. Schiller , Eric Roos
IPC分类号： A61K8/02 , A61K8/04 , A61K8/73 , A61K9/00 , A61K9/20 , A61K9/22 , A61K38/47 , A61K47/38 , A61L15/60 , A61L26/00 , A61L27/52 , A61L27/54 , A61L29/14 , A61L31/14 , A61Q13/00 , A61Q19/00 , C08B15/00 , C08B31/00 , C12N5/00 , A61F2/02
CPC分类号： C08B31/006 , A61K38/47 , A61K47/38 , A61K9/0004 , A61K9/0009 , A61K9/2054 , A61L15/60 , A61L26/008 , A61L27/52 , A61L27/54 , A61L29/145 , A61L31/145 , C08B15/005 , C08B31/003 , C12N5/0068 , A61L2300/602 , C12N2533/30 , C12N2533/78
摘要： System for delivery of a biologically active substance into an environment. First and second chambers are separated by a moveable partition. The first chamber includes a polymer gel network which undergoes a volume change in response to an environmental condition such as pH. The first compartment includes a screen or membrane for confining the polymer gel network while allowing communication with fluid in an environment. The second compartment contains a biologically active compound or drug which is delivered to the environment through an orifice in the second compartment. Upon the occurrence of the triggering environmental condition, the polymer gel network undergoes a volume change which moves the moveable partition expelling the drug through the orifice. Drug delivery is initiated and continues only when the appropriate environmental condition or trigger is met.
摘要翻译：将生物活性物质输送到环境中的系统。第一和第二腔室由可移动隔板分开。第一室包括聚合物凝胶网络，其响应于环境条件例如pH而经历体积变化。第一隔室包括用于限制聚合物凝胶网络的屏幕或膜，同时允许与环境中的流体通信。第二隔室含有生物活性化合物或药物，其通过第二隔室中的孔输送到环境中。当触发环境条件出现时，聚合物凝胶网络经历体积变化，从而使可移动的隔板移动通过孔排出药物。只有在满足适当的环境条件或触发条件时才开始进行药物传递。

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