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1. 发明授权

US5674521A Enhanced loading of solutes into polymer gels and methods of use 失效
标题翻译：将溶质加入聚合物凝胶和使用方法
公开(公告)号：US5674521A
公开(公告)日：1997-10-07
申请号：US425275
申请日：1995-04-20
申请人： Steven Henry Gehrke , E. C. Lupton , Matthew E. Schiller , Lorelle Uhden , Nitin Vaid
发明人： Steven Henry Gehrke , E. C. Lupton , Matthew E. Schiller , Lorelle Uhden , Nitin Vaid
IPC分类号： A61K9/20 , A61K9/22 , A61L15/60 , A61F2/02 , A61K47/30
CPC分类号： A61K9/2054 , A61K9/205 , A61K9/2095 , A61L15/60 , Y10S514/944
摘要： A method of loading a drug into a crosslinked polymer network and protecting the drug from the effects of inactivation is described. The method includes the steps of contacting a biologically active solute (e.g. drug) with: (i) a gel network; (ii) a loading polymer that is somewhat immiscible with the gel; and (iii) a salt, under conditions sufficient for the biologically active solute to selectively partition into the gel and the salt and the loading polymer to be entrained in the gel. A drug delivery system including a polymer gel network and the drug to be delivered is also described. The system also includes a salt and/or a loading polymer. The system protects the drug from loss of activity. In one embodiment, the polymer gel network is capable of expanding or collapsing in response to a change in an environmental condition to which the gel is exposed, the expanding or collapsing sufficient to release the drug into an environment of use.
摘要翻译：描述了将药物装载到交联聚合物网络中并保护药物免受灭活效果的方法。该方法包括使生物活性溶质（例如药物）与以下物质接触的步骤：（i）凝胶网络; （ii）与凝胶有些不混溶的负载聚合物; 和（iii）盐，在足以使生物活性溶质选择性分配到凝胶中的条件下，盐和加载聚合物被夹带在凝胶中。还描述了包括聚合物凝胶网络和待递送药物的药物递送系统。该系统还包括盐和/或负载聚合物。该系统保护药物免受活动的损失。在一个实施方案中，聚合物凝胶网络能够响应于凝胶暴露于其中的环境条件的变化而膨胀或塌缩，足以将药物释放到使用环境中的膨胀或塌陷。

2. 发明授权

US5603955A Enhanced loading of solutes into polymer gels 失效
标题翻译：增加溶质进入聚合物凝胶
公开(公告)号：US5603955A
公开(公告)日：1997-02-18
申请号：US276462
申请日：1994-07-18
申请人： Stevin H. Gehrke , E. C. Lupton , Matthew E. Schiller , Lorelle Uhden , Nitin Vaid
发明人： Stevin H. Gehrke , E. C. Lupton , Matthew E. Schiller , Lorelle Uhden , Nitin Vaid
IPC分类号： A61K9/20 , A61K9/22 , A61L15/60 , A61K9/10 , A61K47/32 , A61K47/34 , A61K47/36
CPC分类号： A61K9/2054 , A61K9/205 , A61K9/2095 , A61L15/60 , Y10S514/944
摘要： A method of loading a drug into a crosslinked polymer network and protecting the drug from the effects of inactivation is described. The method includes the steps of contacting of a biologically active solute (i.e., drug) with:(i) a gel network; (ii) a second protectant polymer that is somewhat immiscible with the gel; and (iii) a protectant salt, under conditions sufficient for the biologically active solute to selectively partition into the gel and the protectants to be entrained in the gel. Most preferably, the gel network is a crosslinked gel responsive to a change in an environmental condition to which the gel is exposed.
摘要翻译：描述了将药物装载到交联聚合物网络中并保护药物免受灭活效果的方法。该方法包括使生物活性溶质（即药物）与（i）凝胶网络接触的步骤; （ii）与凝胶有些不混溶的第二保护剂聚合物; 和（iii）保护剂盐，在足以使生物活性溶质选择性分配到凝胶中的条件下，保护剂被夹带在凝胶中。最优选地，凝胶网络是响应凝胶暴露的环境条件的变化的交联凝胶。

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