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1. 发明授权

US07833545B2 Methods and devices for the sustained release of multiple drugs 有权
公开(公告)号：US07833545B2
公开(公告)日：2010-11-16
申请号：US10835414
申请日：2004-04-29
申请人： Eyal S. Ron , Robert S. Langer , William F. Crowley, Jr.
发明人： Eyal S. Ron , Robert S. Langer , William F. Crowley, Jr.
IPC分类号： A61K9/00 , A61F6/08
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.

2. 发明申请

US20090060982A1 METHODS AND DEVICES FOR THE SUSTAINED RELEASE OF MULTIPLE DRUGS 审中-公开
公开(公告)号：US20090060982A1
公开(公告)日：2009-03-05
申请号：US12125629
申请日：2008-05-22
申请人： Eyal S. Ron , Robert S. Langer , William F. Crowley, JR.
发明人： Eyal S. Ron , Robert S. Langer , William F. Crowley, JR.
IPC分类号： A61K9/02 , A61K31/566 , A61P5/30 , A61P15/02 , A61P15/18 , A61F6/14
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.

3. 发明授权

US06818669B2 Increasing cerebral bioavailability of drugs 失效
标题翻译：增加药物的脑生物利用度
公开(公告)号：US06818669B2
公开(公告)日：2004-11-16
申请号：US09955485
申请日：2001-09-19
申请人： Michael A. Moskowitz , James K. Liao , Eyal S. Ron , Mary Nallin Omstead
发明人： Michael A. Moskowitz , James K. Liao , Eyal S. Ron , Mary Nallin Omstead
IPC分类号： A61K31351
CPC分类号： A61K31/7048 , A61K9/2018 , A61K9/2054 , A61K9/2846 , A61K31/198 , A61K31/505 , A61K31/519 , A61K31/525 , A61K31/7076 , A61K31/195 , A61K2300/00
摘要： A method and compositions are provided for increased cerebral bioavailability of blood-born compositions by administering the composition of interest while increasing brain NO levels. This increase in NO levels may be accomplished by stimulating increased production of NO by eNOS, especially by administering L-arginine, by administering agents that increase NO levels independent of ecNOS, or by any combination of these methods. As NO is increased, cerebral blood flow is consequently increased, and drugs in the blood stream are carried along with the increased flow into brain tissue. By increased flow, the site of action will be exposed to more drug molecules. By stimulating increased NO production, administration of drugs that are not easily introduced to the brain may be facilitated and/or the serum concentration necessary to achieve desired physiologic effects may be reduced.
摘要翻译：提供了通过在增加脑NO水平的同时施用感兴趣的组合物来提高血液出生组合物的脑生物利用度的方法和组合物。 NO水平的这种增加可以通过刺激通过eNOS增加NO的产生，特别是通过施用L-精氨酸，通过施用增加NO水平而不依赖于ecNOS的药剂或通过这些方法的任何组合来实现。随着NO增加，脑血流量增加，血液中的药物随着流入脑组织的增加而被携带。通过增加流动，作用部位将暴露于更多的药物分子。通过刺激增加的NO产生，可以促进不容易引入脑的药物的给药和/或可以降低达到所需生理学效果所需的血清浓度。

4. 发明授权

US6153211A Biodegradable macromers for the controlled release of biologically active substances 失效
标题翻译：可生物降解的大分子单体用于控制释放生物活性物质
公开(公告)号：US6153211A
公开(公告)日：2000-11-28
申请号：US118242
申请日：1998-07-17
申请人： Jeffrey A. Hubbell , Mark T. Kieras , Eyal S. Ron , Stephen C. Rowe
发明人： Jeffrey A. Hubbell , Mark T. Kieras , Eyal S. Ron , Stephen C. Rowe
IPC分类号： A61K9/50 , A61K9/16 , A61K9/22 , A61K38/00 , A61K38/04 , A61K38/21 , A61K38/27 , A61K38/28 , A61K47/30 , B01J13/02 , C08F290/06 , C08F299/02 , A61F2/00 , A61F13/00
CPC分类号： A61K9/1641 , A61K9/1635 , A61K9/1647 , B01J13/02
摘要： A method for delivering a biologically active substance including the steps of: (a) combining said biologically active substance with a macromer; (b) forming a mixture of the combination formed in step (a); (c) polymerizing said mixture to form articles; and (d) administering said articles, or a portion thereof, to a mammal, where step (c) takes place in the absence of a polymerizable monovinyl monomer, is disclosed.
摘要翻译：一种递送生物活性物质的方法，包括以下步骤：（a）将所述生物活性物质与大分子单体组合; （b）形成步骤（a）中形成的组合的混合物; （c）使所述混合物聚合以形成制品; 并且（d）将所述制品或其一部分给予哺乳动物，其中步骤（c）在不存在可聚合单乙烯基单体的情况下进行。

5. 发明授权

US5876741A Chemo-mechanical expansion delivery system 失效
标题翻译：化学机械膨胀输送系统
公开(公告)号：US5876741A
公开(公告)日：1999-03-02
申请号：US892920
申请日：1997-07-15
申请人： Eyal S. Ron
发明人： Eyal S. Ron
IPC分类号： A61K8/02 , A61K8/04 , A61K9/00 , A61K9/52 , A61L27/52 , A61L27/54 , A61L31/14 , A61L31/16 , A61Q13/00 , A61Q19/00 , C08B15/00 , C08B31/00 , A61F2/02 , A61K9/22
CPC分类号： C08B31/006 , A61K9/0004 , C08B15/005 , A61K2800/88 , C12N2533/30 , C12N2533/70
摘要： System for delivery of a biologically active substance into an environment. The container is comprised of a single member or two mated members and defines first and second compartments. The container includes pores in at least a portion of the container defining the first compartment. The first compartment contains a polymer gel network which undergoes a volume expansion in response to an environmental condition which varies in the biological environment. The second compartment contains an effective amount of a biologically active compound and may include at least one passageway communicating with the biological environment. Drug delivery is initiated and continues only when the appropriate environmental condition or trigger is met, whereupon volume expansion of the polymer gel network causes the biologically active compound to be discharged into the biological environment.
摘要翻译：将生物活性物质输送到环境中的系统。容器由单个构件或两个配合构件组成，并且限定第一和第二隔室。容器包括限定第一隔室的容器的至少一部分中的孔。第一隔室包含聚合物凝胶网络，其响应于在生物环境中变化的环境条件而经历体积膨胀。第二隔室包含有效量的生物活性化合物，并且可以包括与生物环境连通的至少一个通道。仅当适当的环境条件或触发条件被满足时才启动并继续给药，因此聚合物凝胶网络的体积膨胀导致生物活性化合物被排放到生物环境中。

6. 发明授权

US09353191B2 Method for producing hydrogels 有权
标题翻译：生产水凝胶的方法
公开(公告)号：US09353191B2
公开(公告)日：2016-05-31
申请号：US13491197
申请日：2012-06-07
申请人： Alessandro Sannino , Christian Demitri , Yishai Zohar , Barry Joseph Hand , Eyal S. Ron
发明人： Alessandro Sannino , Christian Demitri , Yishai Zohar , Barry Joseph Hand , Eyal S. Ron
IPC分类号： C08B3/12 , C08B15/00 , C08J3/075 , C08L1/28 , C08B11/12 , C08B11/08 , C08B11/20 , C08L1/08
CPC分类号： C08B3/12 , C08B11/08 , C08B11/12 , C08B11/20 , C08B15/005 , C08J3/075 , C08J2301/00 , C08J2301/08 , C08J2301/26 , C08J2301/28 , C08L1/08 , C08L1/284 , C08L1/286 , Y10T428/2982
摘要： The present invention provides a method of producing a polymer hydrogel comprising the steps of: (1) preparing an aqueous solution of a water soluble polysaccharide derivative and a polycarboxylic acid; (2) optionally agitating the solution, for example, by stirring; (3) isolating a polysaccharide derivative/polycarboxylic acid composite from the solution; and (4) heating the polysaccharide derivative/polycarboxylic acid composite at a temperature of at least about 80° C., thereby cross-linking the polysaccharide with the polycarboxylic acid. The invention also provides polymer hydrogels produced by the methods of the invention.
摘要翻译：本发明提供一种制备聚合物水凝胶的方法，包括以下步骤：（1）制备水溶性多糖衍生物和多元羧酸的水溶液; （2）任选地搅拌溶液，例如通过搅拌; （3）从溶液中分离多糖衍生物/多元羧酸复合物; 和（4）在至少约80℃的温度下加热多糖衍生物/多元羧酸复合物，从而使多糖与多元羧酸交联。本发明还提供了通过本发明的方法制备的聚合物水凝胶。

7. 发明申请

US20130089737A1 METHOD FOR PRODUCING HYDROGELS 有权
标题翻译：生产水凝胶的方法
公开(公告)号：US20130089737A1
公开(公告)日：2013-04-11
申请号：US13491197
申请日：2012-06-07
申请人： Alessandro Sannino , Christian Demitri , Yishai Zohar , Barry Joseph Hand , Eyal S. Ron
发明人： Alessandro Sannino , Christian Demitri , Yishai Zohar , Barry Joseph Hand , Eyal S. Ron
IPC分类号： C08B3/12
CPC分类号： C08B3/12 , C08B11/08 , C08B11/12 , C08B11/20 , C08B15/005 , C08J3/075 , C08J2301/00 , C08J2301/08 , C08J2301/26 , C08J2301/28 , C08L1/08 , C08L1/284 , C08L1/286 , Y10T428/2982
摘要： The present invention provides a method of producing a polymer hydrogel comprising the steps of: (1) preparing an aqueous solution of a water soluble polysaccharide derivative and a polycarboxylic acid; (2) optionally agitating the solution, for example, by stirring; (3) isolating a polysaccharide derivative/polycarboxylic acid composite from the solution; and (4) heating the polysaccharide derivative/polycarboxylic acid composite at a temperature of at least about 80° C., thereby cross-linking the polysaccharide with the polycarboxylic acid. The invention also provides polymer hydrogels produced by the methods of the invention.
摘要翻译：本发明提供一种制备聚合物水凝胶的方法，包括以下步骤：（1）制备水溶性多糖衍生物和多元羧酸的水溶液; （2）任选地搅拌溶液，例如通过搅拌; （3）从溶液中分离多糖衍生物/多元羧酸复合物; 和（4）在至少约80℃的温度下加热多糖衍生物/多元羧酸复合物，从而使多糖与多元羧酸交联。本发明还提供了通过本发明的方法制备的聚合物水凝胶。

8. 发明申请

US20120202742A1 METHODS AND DEVICES FOR THE SUSTAINED RELEASE OF MULTIPLE DRUGS 审中-公开
标题翻译：用于持续释放多种药物的方法和装置
公开(公告)号：US20120202742A1
公开(公告)日：2012-08-09
申请号：US13007222
申请日：2011-01-14
申请人： Eyal S. Ron , Robert S. Langer , William F. Crowley, JR.
发明人： Eyal S. Ron , Robert S. Langer , William F. Crowley, JR.
IPC分类号： A61K31/57 , A61P15/18 , A61P5/24 , A61K31/565 , A61K38/09
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.
摘要翻译：本发明涉及药物递送装置和用于在长时间内递送多种药物的方法。药物递送装置具有两个或多个包含药物可渗透的聚合物质的整体段，其中至少一个区段还包含药物活性剂。本发明还涉及治疗女性哺乳动物良性卵巢分泌障碍的方法，避孕方法以及缓解与女性绝经期，绝经期和绝经后期相关的症状的方法。

9. 发明申请

US20120052151A1 METHODS AND COMPOSITIONS FOR WEIGHT MANAGEMENT AND FOR IMPROVING GLYCEMIC CONTROL 审中-公开
标题翻译：重量管理和改进糖化控制的方法和组合
公开(公告)号：US20120052151A1
公开(公告)日：2012-03-01
申请号：US13106909
申请日：2011-05-13
申请人： Alessandro Sannino , Luigi Ambrosio , Eyal S. Ron , Yishai Zohar
发明人： Alessandro Sannino , Luigi Ambrosio , Eyal S. Ron , Yishai Zohar
IPC分类号： A23L1/307 , A23L2/52 , A23L1/10 , A21D13/00 , A23L1/16 , A23L1/0534 , A21D13/08
CPC分类号： A23L2/52 , A21D2/145 , A21D2/18 , A21D2/188 , A21D13/80 , A23G9/34 , A23L2/68 , A23L7/10 , A23L7/109 , A23L7/122 , A23L7/126 , A23L29/288 , A23L33/24 , A23L33/30 , A23V2002/00 , A61K47/38 , C08B13/00 , C08B15/005 , C08J3/075 , C08J2301/02 , C08J2301/10 , C08L1/32 , A23V2200/326 , A23V2200/32 , A23V2200/332 , A23V2200/328 , A23V2250/51082 , A23V2250/032 , A23V2200/244
摘要： The present invention provides methods, compositions and modified foods and foodstuffs useful for weight management and glycemic control.
摘要翻译：本发明提供了可用于体重管理和血糖控制的方法，组合物和改良食品和食品。

10. 发明授权

US07829112B2 Methods and devices for the sustained release of multiple drugs 有权
标题翻译：持续释放多种药物的方法和装置
公开(公告)号：US07829112B2
公开(公告)日：2010-11-09
申请号：US12125593
申请日：2008-05-22
申请人： Eyal S. Ron , Robert S. Langer , William F. Crowley, Jr.
发明人： Eyal S. Ron , Robert S. Langer , William F. Crowley, Jr.
IPC分类号： A61K9/00 , A61F6/08
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.
摘要翻译：本发明涉及药物递送装置和用于在长时间内递送多种药物的方法。药物递送装置具有两个或多个包含药物可渗透的聚合物质的整体段，其中至少一个区段还包含药物活性剂。本发明还涉及治疗女性哺乳动物良性卵巢分泌障碍的方法，避孕方法以及缓解与女性绝经期，绝经期和绝经后期相关的症状的方法。

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