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1. 发明申请

US20080064979A1 SYSTEM AND METHOD FOR PREBALANCING ELECTRICAL PROPERTIES TO DIAGNOSE DISEASE 审中-公开
标题翻译：用于预测电学特性以诊断疾病的系统和方法
公开(公告)号：US20080064979A1
公开(公告)日：2008-03-13
申请号：US11684994
申请日：2007-03-12
申请人： Zoran Pavlovic , Milan Graovac , Joel Ironstone
发明人： Zoran Pavlovic , Milan Graovac , Joel Ironstone
IPC分类号： A61B5/05
CPC分类号： A61B5/053
摘要： A system and method for diagnosing the possibility of disease by making electrical measurements in one of a first body part and a second substantially similar body part are described. The present invention balances out differences between homologous body parts that are due to natural factors unrelated to disease, such as differences in size or symmetry between left and right breasts. Once data are prebalanced, statistical analyses can be performed on the data to diagnose disease. The system includes a normalizing module for obtaining a normalizing factors database from a screening population group to account for differences in spatial separation of impedance measurements. Once a set of normalizing factors is obtained, a prebalancing factor can be obtained that can further be used to adjust raw electrical measurements. Normalizing factors are applied to a smaller subset of measurements that are likely to better represent the body part as a whole.: This set of measurements is reduced further by eliminating a set of the measurements that can be biased by a presence of a disease in a body part. The remaining measurements for each body part are then averaged to obtain an overall measure of a body part electrical property. The quotient between these measures is then used to adjust raw measurements. The adjusted measurements remove the imbalance that might exist due to natural differences between body parts. Adjusted measurements are then used as an input to other methods to obtain more accurate disease diagnostics.
摘要翻译：描述了通过在第一主体部分和第二基本上相似的身体部分中的一个中进行电测量来诊断疾病可能性的系统和方法。本发明平衡了归因于与疾病无关的自然因素的同源身体部位之间的差异，例如左乳房和右乳房之间的尺寸或对称性的差异。一旦数据进行前期平衡，就可以对数据进行统计分析以诊断疾病。该系统包括归一化模块，用于从筛选群体组获得归一化因子数据库，以解决阻抗测量的空间分离的差异。一旦获得了一组归一化因子，就可以获得可以进一步用于调整原始电气测量的预平衡因子。将归一化因子应用于可能更好地代表整体身体部位的较小的测量子集。通过消除可以通过在一种疾病中存在疾病而偏倚的一组测量来进一步降低该组测量值身体的一部分。然后对每个身体部位的剩余测量值进行平均，以获得身体部位电气性质的总体度量。然后使用这些措施之间的商来调整原始测量。调整后的测量可以消除由于身体部位之间的自然差异而可能存在的不平衡。然后将调整后的测量值用作其他方法的输入，以获得更准确的疾病诊断。

2. 发明申请

US20060151815A1 Weighted gradient method and system for diagnosing disease 有权
标题翻译：加权梯度法和诊断疾病系统
公开(公告)号：US20060151815A1
公开(公告)日：2006-07-13
申请号：US11287470
申请日：2005-11-28
申请人： Milan Graovac , James Martens , Zoran Pavlovic , Joel Ironstone
发明人： Milan Graovac , James Martens , Zoran Pavlovic , Joel Ironstone
IPC分类号： H01L29/80
CPC分类号： A61B5/0536 , A61B5/055
摘要： A method for detecting and diagnosing disease states in a body part is described. The method starts with a preparatory step of modeling the body part as a grid of many finite elements, then calculating an electrical property between two finite elements at which current from two corresponding electrodes flows through the body part. This is termed the weight (influence) of the element. With this baseline information, electrical impedance measurements made at the plurality of electrodes on the periphery of the body part can be used in a diagnostic module to calculate a Weighted Element Value (WEVal) for each element. In a preferred embodiment of invention, the difference in WEVal magnitude between corresponding elements of homologous body parts serves as an indicator of the presence of disease.
摘要翻译：描述了用于检测和诊断身体部位中的疾病状态的方法。该方法从将身体部分建模为许多有限元的网格的准备步骤开始，然后计算两个有限元素之间的电气特性，在两个有限元素之间，来自两个相应电极的电流流过身体部分。这被称为元件的重量（影响）。利用该基线信息，可以在诊断模块中使用在身体部位的周边上的多个电极处进行的电阻抗测量来计算每个元件的加权元素值（WEVal）。在本发明的优选实施方案中，同源体部分的相应元件之间的WEVal量值的差异用作疾病存在的指标。

3. 发明授权

US08103337B2 Weighted gradient method and system for diagnosing disease 有权
标题翻译：加权梯度法和诊断疾病系统
公开(公告)号：US08103337B2
公开(公告)日：2012-01-24
申请号：US11287470
申请日：2005-11-28
申请人： Milan Graovac , James Martens , Zoran Pavlovic , Joel Ironstone
发明人： Milan Graovac , James Martens , Zoran Pavlovic , Joel Ironstone
IPC分类号： A61B5/05 , G06T17/00 , G09G5/02
CPC分类号： A61B5/0536 , A61B5/055
摘要： A method for detecting and diagnosing disease states in a body part is described. The method starts with a preparatory step of modeling the body part as a grid of many finite elements, then calculating an electrical property between two finite elements at which current from two corresponding electrodes flows through the body part. This is termed the weight (influence) of the element. With this baseline information, electrical impedance measurements made at the plurality of electrodes on the periphery of the body part can be used in a diagnostic module to calculate a Weighted Element Value (WEVal) for each element. In a preferred embodiment of invention, the difference in WEVal magnitude between corresponding elements of homologous body parts serves as an indicator of the presence of disease.
摘要翻译：描述了用于检测和诊断身体部位中的疾病状态的方法。该方法从将身体部分建模为许多有限元的网格的准备步骤开始，然后计算两个有限元素之间的电气特性，在两个有限元素之间，来自两个相应电极的电流流过身体部分。这被称为元件的重量（影响）。利用该基线信息，可以在诊断模块中使用在身体部位的周边上的多个电极处进行的电阻抗测量来计算每个元件的加权元素值（WEVal）。在本发明的优选实施方案中，同源体部分的相应元件之间的WEVal量值的差异用作疾病存在的指标。

4. 发明申请

US20050197591A1 System and method for prebalancing electrical properties to diagnose disease 审中-公开
标题翻译：用于预测电气性能以诊断疾病的系统和方法
公开(公告)号：US20050197591A1
公开(公告)日：2005-09-08
申请号：US10790846
申请日：2004-03-03
申请人： Zoran Pavlovic , Milan Graovac , Joel Ironstone
发明人： Zoran Pavlovic , Milan Graovac , Joel Ironstone
IPC分类号： A61B5/00 , A61B5/05 , A61B5/053
CPC分类号： A61B5/053
摘要： A system and method for diagnosing the possibility of disease by making electrical measurements in one of a first body part and a second substantially similar body part are described. The present invention balances out differences between homologous body parts that are due to natural factors unrelated to disease, such as differences in size or symmetry between left and right breasts. Once data are prebalanced, statistical analyses can be performed on the data to diagnose disease. The system includes a normalizing module for obtaining a normalizing factors database from a screening population group to account for differences in spatial separation of impedance measurements. Once a set of normalizing factors is obtained, a prebalancing factor can be obtained that can further be used to adjust raw electrical measurements. Normalizing factors are applied to a smaller subset of measurements that are likely to better represent the body part as a whole. This set of measurements is reduced further by eliminating a set of the measurements that can be biased by a presence of a disease in a body part. The remaining measurements for each body part are then averaged to obtain an overall measure of a body part electrical property. The quotient between these measures is then used to adjust raw measurements. The adjusted measurements remove the imbalance that might exist due to natural differences between body parts. Adjusted measurements are then used as an input to other methods to obtain more accurate disease diagnostics.
摘要翻译：描述了通过在第一主体部分和第二基本上相似的身体部分中的一个中进行电测量来诊断疾病可能性的系统和方法。本发明平衡了归因于与疾病无关的自然因素的同源身体部位之间的差异，例如左乳房和右乳房之间的尺寸或对称性的差异。一旦数据进行前期平衡，就可以对数据进行统计分析以诊断疾病。该系统包括归一化模块，用于从筛选群体组获得归一化因子数据库，以解决阻抗测量的空间分离的差异。一旦获得了一组归一化因子，就可以获得可以进一步用于调整原始电气测量的预平衡因子。归一化因子被应用于可能更好地代表身体整体的较小的测量子集。通过消除可以通过身体部位中的疾病的存在而偏移的一组测量来进一步减少该组测量。然后对每个身体部位的剩余测量值进行平均，以获得身体部位电气性质的总体度量。然后使用这些措施之间的商来调整原始测量。调整后的测量可以消除由于身体部位之间的自然差异而可能存在的不平衡。然后将调整后的测量值用作其他方法的输入，以获得更准确的疾病诊断。

5. 发明申请

US20080076998A1 Breast electrode array and method of analysis for detecting and diagnosing diseases 审中-公开
标题翻译：乳房电极阵列及其分析方法，用于检测和诊断疾病
公开(公告)号：US20080076998A1
公开(公告)日：2008-03-27
申请号：US11896532
申请日：2007-09-04
申请人： Leslie Organ , Reza Safaee-Rad , Milan Graovac , Kenneth Smith , Joel Ironstone
发明人： Leslie Organ , Reza Safaee-Rad , Milan Graovac , Kenneth Smith , Joel Ironstone
IPC分类号： A61B5/04
CPC分类号： A61B5/053 , A61B5/061 , A61B2562/046
摘要： A breast electrode array and method of analysis for detecting and diagnosing diseases. In particular, the electrode array has a body, a plurality of flexible arms extending from the body, and a plurality of outer electrodes provided by the plurality of flexible arms, and a plurality of inner electrodes provided on at least one of the flexible arms and positioned partway between the body and the outer electrodes, and the outer electrodes and the inner electrodes are arranged on the arms to obtain impedance measurements between respective electrodes. Diagnostic methods based on homologous electrical difference analysis are also provided, utilizing the different topologies created by the inner and outer electrodes when taking impedance measurements.
摘要翻译：一种乳房电极阵列及其分析方法，用于检测和诊断疾病。特别地，电极阵列具有主体，从主体延伸的多个柔性臂和由多个柔性臂设置的多个外部电极，以及多个内部电极，设置在至少一个柔性臂和位于主体和外部电极之间，并且外部电极和内部电极布置在臂上以获得各个电极之间的阻抗测量。还提供了基于同源电差分析的诊断方法，利用内外电极在进行阻抗测量时产生的不同拓扑结构。

6. 发明申请

US20180169369A1 OXYGEN REBREATHING APPARATUS AND METHOD FOR USING THE SAME 审中-公开
公开(公告)号：US20180169369A1
公开(公告)日：2018-06-21
申请号：US15739058
申请日：2016-07-06
申请人： Joel Ironstone
发明人： Joel Ironstone
IPC分类号： A61M16/08 , A61M16/00 , A61M16/10 , A61M16/22
CPC分类号： A61M16/0891 , A61M16/0045 , A61M16/0078 , A61M16/101 , A61M16/12 , A61M16/22 , A61M2202/0208 , A61M2202/0007
摘要： The present invention relates to a system and method for delivering oxygen for breathing at a higher concentration than found in normal air and therapeutic applications of such a system and method, which improves on the limitations of the prior art by reducing and practically eliminating the waste of oxygen gas. The main benefit of this approach is a reduction in the amount of oxygen required which may result in secondary benefits such as simplifying the logistics of acquiring and storing oxygen, reducing cost, improving system portability, and allowing for the use of low-flow sources such as an oxygen concentrator instead of only using high-flow sources such as tanks of compressed oxygen.

7. 发明申请

US20150059744A1 ANESTHETIC DELIVERY SYSTEM 审中-公开
标题翻译： ANESTHETIC交付系统
公开(公告)号：US20150059744A1
公开(公告)日：2015-03-05
申请号：US14389329
申请日：2013-03-28
申请人： Joseph Fisher , James Duffin , Joel Ironstone
发明人： Joseph Fisher , James Duffin , Joel Ironstone
IPC分类号： A61M16/18 , A61M16/08 , A61M16/22 , A61M16/00
CPC分类号： A61M16/183 , A61B5/087 , A61B5/4821 , A61M16/0066 , A61M16/0075 , A61M16/0081 , A61M16/0093 , A61M16/01 , A61M16/024 , A61M16/0833 , A61M16/0891 , A61M16/18 , A61M16/22 , A61M2016/0027 , A61M2016/0039 , A61M2016/102 , A61M2016/1035 , A61M2202/048 , A61M2205/3334 , A61M2205/502 , A61M2230/437 , A61M2202/0007
摘要： An anesthetic delivery system for use in conjunction with an anesthetic return system for reutilizing anesthetic exhaled by a subject, the system including a measurement system operatively connected to a breathing circuit for continuously measuring at least one flow parameter and anesthetic content of a gas stream reaching the subject and a control system for receiving input from the measurement system and controlling the amount of anesthetic entering the system, the control system including an input device for inputting a setting that corresponds to a desired amount of anesthetic in the gas stream reaching the subject, and utilizing a control algorithm for controlling the amount of anesthetic entering the system based on said desired amount of anesthetic, and flow and anesthetic content parameters as determined by the measurement system, such that the control algorithm is adapted to supplement anesthetic already in gas stream flowing to the subject to attain a level of anesthetic reaching the subject that correspond to the desired amount set via the input device.
摘要翻译：一种与麻醉返回系统结合使用以麻醉受试者呼出的麻醉剂的麻醉剂递送系统，该系统包括可操作地连接到呼吸回路的测量系统，用于连续地测量至少一个流动参数和到达主体和用于接收来自测量系统的输入并控制进入系统的麻醉剂的量的控制系统，所述控制系统包括用于输入对应于到达对象的气流中的期望量的麻醉剂的设定的输入装置，以及利用控制算法来控制基于所述所需量的麻醉剂进入系统的麻醉剂的量，以及由测量系统确定的流量和麻醉剂含量参数，使得控制算法适于补充已经在气流中流动的麻醉剂达到一定程度的麻醉剂铰接对应于通过输入装置设定的期望量的对象。

8. 发明授权

US08487686B2 Active guarding for reduction of resistive and capacitive signal loading with adjustable control of compensation level 有权
标题翻译：主动防护用于减少电阻和电容信号负载，并可调整补偿电平
公开(公告)号：US08487686B2
公开(公告)日：2013-07-16
申请号：US12594075
申请日：2008-03-31
申请人： Joel Ironstone , David Wang , Frank Zhang , Chung Shing Fan , Morrie Altmejd , Kenneth Carless Smith
发明人： Joel Ironstone , David Wang , Frank Zhang , Chung Shing Fan , Morrie Altmejd , Kenneth Carless Smith
IPC分类号： H03L5/00
CPC分类号： H03F1/56 , H03F1/14
摘要： In various embodiments, applicants' teachings are related to an active guarding circuit and method for reducing parasitic impedance signal loading on a signal-transmission channel that is shunted by a parasitic impedance. The presence of an electrical signal on the signal-transmission channel causes a leakage current to flow through the parasitic impedance. In various embodiments, the circuit comprises an amplifier and an impedance, one terminal of the impedance is coupled to the signal-transmission channel. The input of the amplifier is coupled to the signal-transmission channel and the output is coupled to the other terminal of the impedance so as to cause a compensation current to flow through the impedance. The gain of the amplifier and the value of the impedance are selected so that the compensation current has a magnitude substantially equal to the leakage current magnitude.
摘要翻译：在各种实施例中，申请人的教导涉及用于减少由寄生阻抗分流的信号传输通道上的寄生阻抗信号负载的主动防护电路和方法。在信号传输通道上存在电信号会导致漏电流流过寄生阻抗。在各种实施例中，电路包括放大器和阻抗，阻抗的一个端子耦合到信号传输通道。放大器的输入耦合到信号传输通道，输出耦合到阻抗的另一端，以使补偿电流流过阻抗。选择放大器的增益和阻抗的值，使得补偿电流的幅度基本上等于泄漏电流大小。

9. 发明授权

US09585593B2 Signal distribution for patient-electrode measurements 有权
标题翻译：患者电极测量的信号分布
公开(公告)号：US09585593B2
公开(公告)日：2017-03-07
申请号：US13508655
申请日：2010-11-18
申请人： Chung Shing Fan , Joel Ironstone , Kenneth Carless Smith
发明人： Chung Shing Fan , Joel Ironstone , Kenneth Carless Smith
IPC分类号： A61B5/05 , A61B5/053 , G01R31/00 , G01R27/02 , A61B5/00 , H03F3/50 , H03F3/60 , G01R1/30
CPC分类号： A61B5/053 , A61B5/0537 , A61B5/4869 , A61B5/4875 , A61B5/4878 , A61B5/6843 , A61B5/6885 , A61B5/7203 , G01R1/30 , G01R27/02 , G01R31/00 , H03F3/50 , H03F3/602 , H03F2200/261
摘要： Apparatus for electrically connecting measurement apparatus to a biological subject, the apparatus including a signal delivery circuit including a current buffer having a current buffer input for receiving a signal from a signal source and a current buffer output for supplying a current to an electrode attached to the biological subject, and a voltage buffer having a voltage buffer input coupled to the current buffer output and a voltage buffer output for providing a voltage signal indicative of a voltage at the electrode, to a sensor.
摘要翻译：一种用于将测量装置电连接到生物学对象的装置，该装置包括信号传递电路，该信号传送电路包括具有用于从信号源接收信号的当前缓冲器输入端和用于向连接到生物学对象，以及具有耦合到当前缓冲器输出的电压缓冲器输入的电压缓冲器和用于将指示电极处的电压的电压信号提供给传感器的电压缓冲器输出。

10. 发明申请

US20100109739A1 ACTIVE GUARDING FOR REDUCTION OF RESISTIVE AND CAPACITIVE SIGNAL LOADING WITH ADJUSTABLE CONTROL OF COMPENSATION LEVEL 有权
标题翻译：用于减少电阻和电容信号的主动保护与补偿水平的可调控制
公开(公告)号：US20100109739A1
公开(公告)日：2010-05-06
申请号：US12594075
申请日：2008-03-31
申请人： Joel Ironstone , David Wang , Frank Zhang , Chung Shing Fan , Morrie Altmejd , Kenneth Carless Smith
发明人： Joel Ironstone , David Wang , Frank Zhang , Chung Shing Fan , Morrie Altmejd , Kenneth Carless Smith
IPC分类号： H03L5/00
CPC分类号： H03F1/56 , H03F1/14
摘要： In various embodiments, applicants' teachings are related to an active guarding circuit and method for reducing parasitic impedance signal loading on a signal-transmission channel that is shunted by a parasitic impedance. The presence of an electrical signal on the signal-transmission channel causes a leakage current to flow through the parasitic impedance. In various embodiments, the circuit comprises an amplifier and an impedance, one terminal of the impedance is coupled to the signal-transmission channel. The input of the amplifier is coupled to the signal-transmission channel and the output is coupled to the other terminal of the impedance so as to cause a compensation current to flow through the impedance. The gain of the amplifier and the value of the impedance are selected so that the compensation current has a magnitude substantially equal to the leakage current magnitude.
摘要翻译：在各种实施例中，申请人的教导涉及用于减少由寄生阻抗分流的信号传输通道上的寄生阻抗信号负载的主动防护电路和方法。在信号传输通道上存在电信号会导致漏电流流过寄生阻抗。在各种实施例中，电路包括放大器和阻抗，阻抗的一个端子耦合到信号传输通道。放大器的输入耦合到信号传输通道，输出耦合到阻抗的另一端，以使补偿电流流过阻抗。选择放大器的增益和阻抗的值，使得补偿电流的幅度基本上等于泄漏电流大小。

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