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1. 发明申请

US20060088140A1 System and method for performing scatter measurement in volumetric CT 审中-公开
标题翻译：在体积CT中进行散射测量的系统和方法
公开(公告)号：US20060088140A1
公开(公告)日：2006-04-27
申请号：US11240233
申请日：2005-09-30
申请人： Rebecca Fahrig , Norbert Strobel , Lei Zhu
发明人： Rebecca Fahrig , Norbert Strobel , Lei Zhu
IPC分类号： G21K1/00
CPC分类号： A61B6/06 , A61B6/583
摘要： The invention provides a system and method for reducing the affects of scattering in an image. The system and method comprises providing at least one blocker array between an x-ray source and an object, obtaining a first image of the via a detector and a first signal, rotationally displacing the at least one blocker array, wherein primary radiation is disrupted at different locations in each projection image, obtaining a second image of the object via the detector and a second signal, estimating the scatter based on a comparison of the first signal and the second signal, and reconstructing a final image by accounting for scatter.
摘要翻译：本发明提供了减少图像中散射影响的系统和方法。该系统和方法包括在x射线源和物体之间提供至少一个阻塞阵列，获得经由检测器的第一图像和第一信号，旋转移位所述至少一个阻断阵列，其中主辐射被破坏在每个投影图像中的不同位置，经由检测器获得对象的第二图像和第二信号，基于第一信号和第二信号的比较来估计散射，以及通过考虑散射来重构最终图像。

2. 发明授权

US07409033B2 Tomographic reconstruction for x-ray cone-beam scan data 有权
标题翻译： x射线锥束扫描数据的层析重建
公开(公告)号：US07409033B2
公开(公告)日：2008-08-05
申请号：US11557441
申请日：2006-11-07
申请人： Lei Zhu , Rebecca Fahrig
发明人： Lei Zhu , Rebecca Fahrig
IPC分类号： G01N23/00
CPC分类号： G06T11/006 , G06T2211/421
摘要： Disclosed is x-ray cone beam scan data reconstruction of an imaged object with a reconstruction algorithm using shift invariant filtering and backprojection with the maximum tomographic capability of a circular scan larger than p plus cone angle, when CB data is not truncated and data extrapolation is not allowed. The reconstruction scheme includes a conventional FDK reconstruction and a parallel reconstruction using differential back projection and 1D Hilbert transform to suppress the CB artifacts.
摘要翻译：公开了使用具有大于p加锥角的圆形扫描的最大断层能力的移位不变滤波和反投影的重建算法的X射线锥束扫描数据重建，当CB数据未被截断并且数据外推是不允许。重建方案包括传统的FDK重建和使用差分背投和1D希尔伯特变换来平衡重建以抑制CB伪像。

3. 发明申请

US20070297661A1 TOMOGRAPHIC RECONSTRUCTION FOR X-RAY CONE-BEAM SCAN DATA 有权
标题翻译： X射线光束扫描数据的TOMOGRAPHIC重建
公开(公告)号：US20070297661A1
公开(公告)日：2007-12-27
申请号：US11557441
申请日：2006-11-07
申请人： Lei Zhu , Rebecca Fahrig
发明人： Lei Zhu , Rebecca Fahrig
IPC分类号： G06K9/00
CPC分类号： G06T11/006 , G06T2211/421
摘要： Disclosed is x-ray cone beam scan data reconstruction of an imaged object with a reconstruction algorithm using shift invariant filtering and backprojection with the maximum tomographic capability of a circular scan larger than p plus cone angle, when CB data is not truncated and data extrapolation is not allowed. The reconstruction scheme includes a conventional FDK reconstruction and a parallel reconstruction using differential back projection and 1D Hilbert transform to suppress the CB artifacts.
摘要翻译：公开了使用具有大于p加锥角的圆形扫描的最大断层能力的移位不变滤波和反投影的重建算法的X射线锥束扫描数据重建，当CB数据未被截断并且数据外推是不允许。重建方案包括传统的FDK重建和使用差分背投和1D希尔伯特变换来平衡重建以抑制CB伪像。

4. 发明授权

US07463712B2 Scatter correction for x-ray imaging using modulation of primary x-ray spatial spectrum 有权
标题翻译：使用原始X射线空间光谱调制进行X射线成像的散射校正
公开(公告)号：US07463712B2
公开(公告)日：2008-12-09
申请号：US11557440
申请日：2006-11-07
申请人： Lei Zhu , Rebecca Fahrig
发明人： Lei Zhu , Rebecca Fahrig
IPC分类号： G01N23/00
CPC分类号： A61B6/5282 , A61B6/4291 , A61B6/583
摘要： Scatter radiation in an x-ray imaging system including an x-ray source and an x-ray detector is separated by using amplitude modulation to translate the spatial frequency of a detected x-ray beam to a higher frequency and provide separation from low frequency scatter signal. The low frequency content of the detected x-ray beam is then obtained by demodulating the detected modulated signal.
摘要翻译：通过使用幅度调制来分离包括X射线源和X射线检测器的X射线成像系统中的散射辐射，以将检测到的X射线束的空间频率转换到更高的频率，并提供与低频散射的分离信号。然后通过解调检测到的调制信号来获得检测到的X射线束的低频内容。

5. 发明申请

US20070268997A1 SCATTER CORRECTION FOR X-RAY IMAGING USING MODULATION OF PRIMARY X-RAY SPATIAL SPECTRUM 有权
标题翻译：使用主要X射线空间光谱调制的X射线成像的散射校正
公开(公告)号：US20070268997A1
公开(公告)日：2007-11-22
申请号：US11557440
申请日：2006-11-07
申请人： Lei Zhu , Rebecca Fahrig
发明人： Lei Zhu , Rebecca Fahrig
IPC分类号： H05G1/60 , A61B6/00 , G01N23/00 , G21K1/12
CPC分类号： A61B6/5282 , A61B6/4291 , A61B6/583
摘要： Scatter radiation in an x-ray imaging system including an x-ray source and an x-ray detector is separated by using amplitude modulation to translate the spatial frequency of a detected x-ray beam to a higher frequency and provide separation from low frequency scatter signal. The low frequency content of the detected x-ray beam is then obtained by demodulating the detected modulated signal.
摘要翻译：通过使用幅度调制来分离包括X射线源和X射线检测器的X射线成像系统中的散射辐射，以将检测到的X射线束的空间频率转换到更高的频率，并提供与低频散射的分离信号。然后通过解调检测到的调制信号来获得检测到的X射线束的低频内容。

6. 发明申请

US20180354957A1 SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE 审中-公开
公开(公告)号：US20180354957A1
公开(公告)日：2018-12-13
申请号：US16058299
申请日：2018-08-08
申请人： Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Rando Allikmets , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
发明人： Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Rando Allikmets , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; and B is a substituted or unsubstituted heterobicycle, wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.

7. 发明申请

US20180222919A1 N-ALKYL-2-PHENOXYETHANAMINES, THEIR PREPARATION AND USE 审中-公开
公开(公告)号：US20180222919A1
公开(公告)日：2018-08-09
申请号：US15944334
申请日：2018-04-03
申请人： Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Nicoleta Dobri , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
发明人： Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Nicoleta Dobri , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
IPC分类号： C07D498/04 , C07D213/79 , C07D213/80 , C07D231/56 , C07D237/24 , C07C233/56 , C07D249/04 , C07D471/04 , C07D487/04 , C07D491/052 , C07D239/28
CPC分类号： C07D498/04 , C07C233/56 , C07D213/79 , C07D213/80 , C07D231/56 , C07D237/24 , C07D239/28 , C07D249/04 , C07D471/04 , C07D487/04 , C07D491/052
摘要： The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is alkyl; A is absent or present, and when present is —C(O)— or —C(O)NH—; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is —C(O)—, or a pharmaceutically acceptable salt thereof.

8. 发明授权

US08995609B2 X-ray compton scatter imaging on volumetric CT systems 有权
标题翻译：体积CT系统的X射线压缩分散成像
公开(公告)号：US08995609B2
公开(公告)日：2015-03-31
申请号：US13565337
申请日：2012-08-02
申请人： Lei Zhu , Tianye Niu
发明人： Lei Zhu , Tianye Niu
IPC分类号： A61B6/00 , G01N23/04 , G21K1/02 , A61B6/03
CPC分类号： G01N23/046 , A61B6/032 , A61B6/4078 , A61B6/4233 , A61B6/483 , A61B6/508 , G01N2223/419 , G01N2223/612 , G21K1/02 , G21K2207/005
摘要： Briefly described, in an exemplary form, the present invention discloses a system, method and apparatus for X-ray Compton scatter imaging. In one exemplary embodiment, the present invention uses two detectors in a volumetric CT system. A first detector is positioned generally in-line with the angle of attack of the incoming energy, or, generally in-line of path x, where x is the path of the incoming energy. The first, or primary, detector detects various forms of radiation emanating from an object undergoing testing. In some embodiments, the present invention further comprises a Compton scattering system positioned generally normal to path x. In some embodiments, the Compton scattering subsystem comprises a second detector and a pin-hole collimator. The second detector detects Compton scattering energy from the object being tested.
摘要翻译：简要描述，在示例性形式中，本发明公开了一种用于X射线康普顿散射成像的系统，方法和装置。在一个示例性实施例中，本发明在体积CT系统中使用两个检测器。第一检测器通常与入射能量的迎角定位，或者通常沿着路径x排列，其中x是入射能量的路径。第一或第一检测器检测从经历测试的对象发出的各种形式的辐射。在一些实施例中，本发明还包括通常垂直于路径x定位的康普顿散射系统。在一些实施例中，康普顿散射子系统包括第二检测器和针孔准直器。第二个检测器检测来自被测物体的康普顿散射能量。

9. 发明授权

US08933225B2 Process for the synthesis of E1 activating enzyme inhibitors 有权
标题翻译：合成E1活化酶抑制剂的方法
公开(公告)号：US08933225B2
公开(公告)日：2015-01-13
申请号：US12221399
申请日：2008-08-01
申请人： Ian Armitage , Eric L. Elliott , Marianne Langston , Steven P. Langston , Quentin J. McCubbin , Hirotake Mizutani , Matthew Stirling , Lei Zhu
发明人： Ian Armitage , Eric L. Elliott , Marianne Langston , Steven P. Langston , Quentin J. McCubbin , Hirotake Mizutani , Matthew Stirling , Lei Zhu
IPC分类号： C07D487/04 , C07C219/24 , C07D241/50 , C07D211/96 , C07D295/22 , C07C217/52 , C07D471/08 , C07C215/44 , C07D213/89 , C07D239/30 , C07C211/35
CPC分类号： C07D487/04 , C07C215/44 , C07C217/52 , C07C219/24 , C07C315/04 , C07C317/50 , C07C2601/08 , C07D211/96 , C07D213/89 , C07D241/50 , C07D295/22 , C07D305/08 , C07D471/08 , Y02P20/55
摘要： Disclosed are processes and synthetic intermediates for the synthesis of compounds of formula (V) wherein the variables have the definitions contained herein. Such compounds are E1 activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with E1 activity.
摘要翻译：公开了用于合成式（V）化合物的方法和合成中间体，其中变量具有本文所含的定义。这些化合物是E1活化酶抑制剂，并且可用于治疗细胞增殖，特别是癌症和与E1活性相关的其它病症的病症。

10. 发明授权

US08809906B2 Semiconductor optical device 有权
标题翻译：半导体光学器件
公开(公告)号：US08809906B2
公开(公告)日：2014-08-19
申请号：US13613177
申请日：2012-09-13
申请人： Lei Zhu , Shigeaki Sekiguchi , Shinsuke Tanaka , Kenichi Kawaguchi
发明人： Lei Zhu , Shigeaki Sekiguchi , Shinsuke Tanaka , Kenichi Kawaguchi
IPC分类号： H01L31/102
CPC分类号： G02B6/122 , G02B6/29352 , G02B2006/121 , G02F1/025 , H01L31/105
摘要： A semiconductor optical device includes a first clad layer, a second clad layer and an optical waveguide layer sandwiched between the first clad layer and the second clad layer, wherein the optical waveguide layer includes a first semiconductor layer, a second semiconductor layer disposed on the first semiconductor layer and extending in one direction, and a third semiconductor layer covering a top surface of the second semiconductor layer, and wherein the first semiconductor layer includes an n-type region disposed on one side of the second semiconductor layer, a p-type region disposed on the other side of the second semiconductor layer, and an i-type region disposed between the n-type region and the p-type region, and wherein the second semiconductor layer has a band gap narrower than band gaps of the first semiconductor layer and the third semiconductor layer.
摘要翻译：半导体光学器件包括第一覆盖层，第二覆盖层和夹在第一覆盖层和第二覆盖层之间的光波导层，其中，光波导层包括第一半导体层，第二半导体层，设置在第一覆盖层半导体层并且沿一个方向延伸，以及覆盖第二半导体层的顶表面的第三半导体层，并且其中第一半导体层包括设置在第二半导体层一侧的n型区域，p型区域设置在第二半导体层的另一侧，以及设置在n型区域和p型区域之间的i型区域，并且其中第二半导体层具有比第一半导体层的带隙窄的带隙和第三半导体层。

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