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1. 发明授权

US07422693B2 Monitoring and control system for blood processing 有权
标题翻译：血液处理监控系统
公开(公告)号：US07422693B2
公开(公告)日：2008-09-09
申请号：US10884877
申请日：2004-07-01
申请人： Lee F. Carter , Jeremy P. Kolenbrander , James R. Ladtkow , Joseph A. Scibona , Jeffrey A. Steward , Chris Fletcher
发明人： Lee F. Carter , Jeremy P. Kolenbrander , James R. Ladtkow , Joseph A. Scibona , Jeffrey A. Steward , Chris Fletcher
IPC分类号： B04B9/10
CPC分类号： G01N15/042 , A61M1/3693 , B04B13/00 , B04B2013/006 , G01N15/05 , G01N2015/047
摘要： The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components. In one aspect, the invention relates to optical methods, devices and device components for measuring two-dimensional distributions of transmitted light intensities, scattered light intensities or both from a separation chamber of a density centrifuge. In embodiment, two-dimensional distributions of transmitted light intensities, scattered light intensities or both measured by the methods of the present invention comprise images of a separation chamber or component thereof, such as an optical cell of a separation chamber. In another aspect, the present invention relates to multifunctional monitoring and control systems for blood processing, particularly blood processing via density centrifugation. Feedback control systems are provided wherein two-dimensional distributions of transmitted light intensities, scattered light intensities or both are measured, processed in real time and are used as the basis of output signals for controlling blood processing. In another aspect, optical cells and methods of using optical cells for monitoring and control blood processing are provided.
摘要翻译：本发明一般涉及监测和控制血液和血液样品的处理，特别是将血液和血液样品分离成其组分的方法。一方面，本发明涉及用于测量来自密度离心机的分离室的透射光强度，散射光强度或二者的二维分布的光学方法，装置和装置部件。在实施例中，通过本发明的方法测量的透射光强度，散射光强度或二者的二维分布包括分离室或其分量（诸如分离室的光学单元）的图像。另一方面，本发明涉及用于血液处理的多功能监测和控制系统，特别是通过密度离心进行血液处理。提供反馈控制系统，其中测量透射光强度，散射光强度或二者的二维分布，实时处理，并用作控制血液处理的输出信号的基础。在另一方面，提供了光学单元和使用光学单元来监测和控制血液处理的方法。

2. 发明授权

US07943916B2 Method for controlling a blood processing system by observing a separation region and an extraction port 有权
标题翻译：通过观察分离区域和提取口来控制血液处理系统的方法
公开(公告)号：US07943916B2
公开(公告)日：2011-05-17
申请号：US12561479
申请日：2009-09-17
申请人： Lee F. Carter , Jeremy P. Kolenbrander , James R. Ladtkow , Joseph A. Scibona , Jeffrey A. Steward , Chris Fletcher
发明人： Lee F. Carter , Jeremy P. Kolenbrander , James R. Ladtkow , Joseph A. Scibona , Jeffrey A. Steward , Chris Fletcher
IPC分类号： B01D37/04
CPC分类号： G01N15/042 , A61M1/3693 , B04B13/00 , B04B2013/006 , G01N15/05 , G01N2015/047
摘要： The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components with a two-dimensional optical measurement and control device. The method may comprise the steps of providing a blood processing system comprising a density centrifuge blood processing system and an elutriation blood processing system; filling the elutriation blood processing system with a desired component; measuring a cellular flux of cells entering the elutriation blood processing system with a two-dimensional optical control system; and flushing the elutriation blood processing system.
摘要翻译：本发明一般涉及监测和控制血液和血液样本的处理方法，特别是利用二维光学测量和控制装置将血液和血液样品分离成其组分。该方法可以包括提供包括密度离心机血液处理系统和淘析血液处理系统的血液处理系统的步骤; 用所需组分填充淘析血液处理系统; 用二维光学控制系统测量进入淘析血液处理系统的细胞的细胞通量; 并冲洗淘析血液处理系统。

3. 发明授权

US07906771B2 Predictive method for controlling a blood processing system 有权
标题翻译：用于控制血液处理系统的预测方法
公开(公告)号：US07906771B2
公开(公告)日：2011-03-15
申请号：US12561419
申请日：2009-09-17
申请人： Lee F. Carter , Jeremy P. Kolenbrander , James R. Ladtkow , Joseph A. Scibona , Jeffrey A. Steward , Chris Fletcher
发明人： Lee F. Carter , Jeremy P. Kolenbrander , James R. Ladtkow , Joseph A. Scibona , Jeffrey A. Steward , Chris Fletcher
IPC分类号： B04B13/00
CPC分类号： G01N15/042 , A61M1/3693 , B04B13/00 , B04B2013/006 , G01N15/05 , G01N2015/047
摘要： The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components. In one aspect, the invention relates to optical methods for measuring two-dimensional distributions of transmitted light intensities, scattered light intensities or both from a separation chamber of a density centrifuge. The method may include performing first and second measurements of an operating condition; analyzing the first and second measurements using a predictive data analysis algorithm; comparing the predicted operating condition to a desired operating condition; and adjusting at least one setting.
摘要翻译：本发明一般涉及监测和控制血液和血液样品的处理，特别是将血液和血液样品分离成其组分的方法。一方面，本发明涉及用于测量来自密度离心机的分离室的透射光强度，散射光强度或二者的二维分布的光学方法。该方法可以包括执行操作条件的第一和第二测量; 使用预测数据分析算法分析第一和第二测量; 将预测的操作条件与期望的操作条件进行比较; 并调整至少一个设置。

4. 发明授权

US07605388B2 Monitoring and control system for blood processing 有权
标题翻译：血液处理监控系统
公开(公告)号：US07605388B2
公开(公告)日：2009-10-20
申请号：US12168192
申请日：2008-07-07
申请人： Lee F. Carter , Jeremy P. Kolenbrander , James R. Ladtkow , Joseph A. Scibona , Jeffrey A. Steward , Chris Fletcher
发明人： Lee F. Carter , Jeremy P. Kolenbrander , James R. Ladtkow , Joseph A. Scibona , Jeffrey A. Steward , Chris Fletcher
IPC分类号： G01N15/06 , G01N21/49 , G01N21/85
CPC分类号： G01N15/042 , A61M1/3693 , B04B13/00 , B04B2013/006 , G01N15/05 , G01N2015/047
摘要： The invention relates to an optical cell for a separation chamber of a density centrifuge blood processing system for separating fluid components comprising an extraction chamber having a first external optical surface for transmitting at least a portion of an incident optical beam; and an extraction port having an axial bore for passing fluid components and a first external optical surface for transmitting at least a portion of the incident optical beam; wherein said first external optical surface of said extraction chamber and said first external optical surface of said extraction port are both positioned within the depth of field of a light collection element.
摘要翻译：本发明涉及一种用于分离流体组分的密度离心机血液处理系统的分离室的光学单元，该液体组分包括具有第一外部光学表面的提取室，用于透射入射光束的至少一部分; 以及具有用于通过流体部件的轴向孔的抽出口和用于透射入射光束的至少一部分的第一外部光学表面; 其中所述提取室的所述第一外部光学表面和所述提取端口的所述第一外部光学表面都位于光采集元件的深度范围内。

5. 发明授权

US08535210B2 System for blood separation with shielded extraction port and optical control 有权
标题翻译：带屏蔽抽取口和光学控制的血液分离系统
公开(公告)号：US08535210B2
公开(公告)日：2013-09-17
申请号：US12959987
申请日：2010-12-03
申请人： Jeremy P. Kolenbrander , Brian M. Holmes , Thomas J. Felt , James R. Ladtkow
发明人： Jeremy P. Kolenbrander , Brian M. Holmes , Thomas J. Felt , James R. Ladtkow
IPC分类号： B04B7/12
CPC分类号： G01N21/51 , A61M1/3693 , A61M1/3696 , A61M2202/0439 , A61M2205/3306 , B04B13/00 , B04B2013/006 , G01N2035/00495 , A61M2202/0071
摘要： A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen.
摘要翻译：一种离心血液分离系统，包括转子，光源，光学传感器，控制系统，分离容器和分离容器上的光学单元。所述光学单元具有径向向外延伸到所述光学单元中的第一提取端口，所述第一提取端口下游并延伸到所述光学单元超出所述第一提取端口的红细胞提取端口; 以及位于所述第一提取口和所述红细胞提取口之间的坝，具有上边缘和下边缘，其中所述第一提取口和所述红细胞提取口径向地位于所述坝的上边缘和下边缘之间。此外，具有第一直径的孔，具有小于第一直径的第二直径的内腔的第一提取端口和将孔连接到内腔的截头圆锥形通道。

6. 发明授权

US08057376B2 Blood processing apparatus with sealed diffuser in optical control apparatus 有权
标题翻译：血液处理装置在光学控制装置中具有密封扩散器
公开(公告)号：US08057376B2
公开(公告)日：2011-11-15
申请号：US12241441
申请日：2008-09-30
申请人： James R. Ladtkow , Joseph A. Scibona , Jeremy Kolenbrander
发明人： James R. Ladtkow , Joseph A. Scibona , Jeremy Kolenbrander
IPC分类号： B04B15/00 , G02B5/02
CPC分类号： G01N33/491 , G01N15/05 , G01N21/51 , G02B19/0028 , G02B19/0061
摘要： A centrifugal blood separation apparatus having an optical camera control system with a focused, stationary light source. A diffusion plate mounted on a rotor, rather than on or near the light source, allows an intense light beam to be transmitted from the light source to the rotor and then diffused at the rotor across an observation region. Different characteristics of a diffusion surface allow different lighting regions within the observation region. The diffusion plate has upper and lower plates with a diffusion surface sealed between the plates. This prevents degradation or contamination of the diffusion surface by abrasion, dirt, blood components or other materials that might incidentally contact the diffusion surface.
摘要翻译：一种具有光学照相机控制系统的离心式血液分离装置，其具有聚焦的静止光源。安装在转子上，而不是在光源上或附近的扩散板允许强光束从光源传递到转子，然后在转子处在观察区域上扩散。扩散表面的不同特性允许观察区域内的不同照明区域。扩散板具有在板之间密封的扩散表面的上板和下板。这可防止由于磨损，污垢，血液成分或可能附带地接触扩散表面的其它材料而导致的扩散表面的降解或污染。

7. 发明授权

US5541376A Switch and connector 失效
标题翻译：开关和连接器
公开(公告)号：US5541376A
公开(公告)日：1996-07-30
申请号：US218786
申请日：1994-03-28
申请人： James R. Ladtkow , Glenn A. Horner , Richard W. Petersen
发明人： James R. Ladtkow , Glenn A. Horner , Richard W. Petersen
IPC分类号： A61B18/12 , A61B18/00 , H01H1/58 , H01H9/06 , H01H11/00 , H01R43/00 , H01H1/00
CPC分类号： H01H11/0056 , H01H1/585 , H01H9/06 , A61B2018/00928 , H01H2300/014
摘要： An insulating switch base with a top, bottom and an edge has openings through the top and one edge for a conductor. A conductive switch lead frame has proximal ends with insulation displacement connectors bent in the openings. A resilient member on the frame has a moveable contact and is conductively associated with a connector. A contoured arm on the frame is distal of, but conductive with, another connector. The arm is spaced from the resilient member as an open contact capable of momentary engagement. A frangible area on each frame is between the resilient member and the arm. Recesses in the top support retain the frame. A slot and barbs on each connector receive one conductor securely in an opening after aligned installation in an opening, seating of the frame in its recess and severing the area over a passage in the base. A membrane attaches over the frame and a molding is applied about the membrane leaving the resilient member open.
摘要翻译：具有顶部，底部和边缘的绝缘开关底座具有穿过顶部的开口和用于导体的一个边缘。导电开关引线框架具有近端，绝缘位移连接器弯曲在开口中。框架上的弹性构件具有可移动的接触并且与连接器导电地相关联。框架上的轮廓臂是远端的，但是与另一个连接器导通。臂与弹性构件间隔开，作为能够瞬时接合的开放接触。每个框架上的易碎区域在弹性构件和臂之间。顶部支架中的凹槽保持框架。每个连接器上的槽和倒钩在对准安装在开口中之后牢固地接纳在开口中的一个导体，将框架放置在其凹部中并且切断基座中的通道上的区域。膜连接在框架上，并且围绕膜施加模制件，使得弹性构件打开。

8. 发明授权

US09156039B2 System for blood separation with gravity valve for controlling a side-tapped separation chamber 有权
标题翻译：用于控制侧向分离室的重力阀进行血液分离的系统
公开(公告)号：US09156039B2
公开(公告)日：2015-10-13
申请号：US13494770
申请日：2012-06-12
申请人： Brian M. Holmes , James R. Ladtkow
发明人： Brian M. Holmes , James R. Ladtkow
IPC分类号： B04B5/04 , A61M1/36 , B01D21/26 , B01D21/30 , A61M1/38
CPC分类号： B04B11/04 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , A61M1/38 , B01D21/262 , B01D21/30 , B01D21/34 , B01D2221/10 , B04B5/0442 , B04B7/08 , B04B2005/045 , B04B2005/0471
摘要： A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, a primary outlet and a side tap outlet adjacent the inlet. A valve that is responsive to centrifugal force (a “gravity” valve) selects between the outlet and the side tap outlet. The gravity valve is mounted on the rotor. When the rotor spins at high speed, the gravity valve may open the primary outlet and close the side tap outlet. When the rotor spins at a lower speed, the gravity valve may open the side tap outlet and close the primary outlet.
摘要翻译：一种一次性血液分离装置和离心血液处理系统，包括适于安装在离心机的转子上的血液处理室; 与处理室流体连通的截头圆锥形细胞分离室，细胞分离室具有邻近入口的入口，主出口和侧排出口。响应于离心力的阀（“重力”阀）在出口和侧面出口之间进行选择。重力阀安装在转子上。当转子高速旋转时，重力阀可能会打开主出口并关闭侧面出水口。当转子以较低的速度旋转时，重力阀可能会打开侧面出口并关闭主出口。

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